Related Articles Id Proteins Promote a Cancer Stem Cell Phenotype in Mouse Models of Triple Negative Breast Cancer via Negative Regulation of Robo1. Front Cell Dev Biol. 2020;8:552 Authors: Teo WS, Holliday H, Karthikeyan N, Cazet AS, Roden DL, Harvey K, Konrad CV, Murali R, Varghese BA, Thankamony AP, Chan CL, McFarland A, Junankar S, Ye S, Yang J, Nikolic I, Shah JS, Baker LA, Millar EKA, Naylor MJ, Ormandy CJ, Lakhani SR, Kaplan W, Mellick AS, O'Toole SA,...
Related Articles Resistance to Both Chemotherapy and EGFR-TKI in Small Cell Lung Cancer With EGFR 19-Del Mutation: A Case Report. Front Oncol. 2020;10:1048 Authors: Wang L, Dong F, Su J, Du G, Shao Y, Liu Y, He X, Bao L, Wang W, Guo X, Wang X Abstract Epidermal growth factor receptor (EGFR) mutations are common in non-small cell lung cancers, but rare in small cell lung cancers (SCLCs). In previous reports, some SCLC patients with EGFR mutations...
Related Articles A Case of Male Breast Cancer Patient with CHEK2*1100delC Mutation. Cureus. 2020 Jul 02;12(7):e8972 Authors: Nguyen QD, Tavana A, Saenz Rios F, Posleman Monetto FE, Robinson AS Abstract Male breast cancer (MBC) is a rare disease that accounts for less than one percent of all breast cancers. The association between BRCA1 and BRCA2 mutations and MBC has been well-established; recent data suggest that CHEK2 1100delC heterozygosity...
Related Articles Clinical Outcome of Carotid Body Paraganglioma Management: A Review of 10-Year Experience. J Oncol. 2020;2020:6081273 Authors: Fathalla AE, Elalfy MA Abstract Background: Carotid body paragangliomas are rare neoplasms usually benign, however sometimes presenting as highly aggressive tumors. Surgery is the main line of treatment. Purpose: To study and describe clinical presentations, surgical approaches, postoperative...
Related Articles Laryngeal Neuroendocrine Tumor With Elevated Serum Calcitonin: A Diagnostic and Therapeutic Challenge. Case Report and Review of Literature. Front Endocrinol (Lausanne). 2020;11:397 Authors: Feola T, Puliani G, Sesti F, Modica R, Biffoni M, Di Gioia C, Carletti R, Anastasi E, Di Vito V, Centello R, Lenzi A, Isidori AM, Faggiano A, Giannetta E Abstract Introduction: Laryngeal neuroendocrine neoplasms (NENs) are a rare group of...
Simultaneously Inhibiting BCL2 and MCL1 Is a Therapeutic Option for Patients with Advanced Melanoma.
Related Articles Simultaneously Inhibiting BCL2 and MCL1 Is a Therapeutic Option for Patients with Advanced Melanoma. Cancers (Basel). 2020 Aug 05;12(8): Authors: Mukherjee N, Amato CM, Skees J, Todd KJ, Lambert KA, Robinson WA, Van Gulick R, Weight RM, Dart CR, Tobin RP, McCarter MD, Fujita M, Norris DA, Shellman YG Abstract There is an urgent need to develop treatments for patients with melanoma who are refractory to or ineligible for immune...
Related Articles [Pemetrexed-induced cutaneous sclerosis of the lower limbs]. Ann Dermatol Venereol. 2020 Aug 03;: Authors: Sarrazin M, Levavasseur M, Fadin A, Dezoteux F, Staumont-Sallé D Abstract BACKGROUND: Pemetrexed is an antifolate used to treat intrathoracic cancers. We report a rare case of cutaneous toxicity of pemetrexed with inflammatory cutaneous sclerosis of the lower limbs. PATIENTS AND METHODS: A 63-year-old man diagnosed...
Retrospective quality of life study in patients with retroperitoneal sarcoma in an Asian population.
Related Articles Retrospective quality of life study in patients with retroperitoneal sarcoma in an Asian population. Health Qual Life Outcomes. 2020 Aug 06;18(1):270 Authors: Lim HJ, Ong CJ, Skanthakumar T, Mak LYH, Wasudevan SD, Tan JW, Chia CS, Tan GHC, Teo MCC Abstract BACKGROUND: Retroperitoneal sarcoma represents 15% of sarcomas. The mainstay of treatment is surgery where a majority of patients require multi-visceral resections that may...
Related Articles Mucinous appendiceal neoplasms with or without pseudomyxoma peritonei: a review. ANZ J Surg. 2020 Aug 05;: Authors: Soucisse ML, Lansom J, Alshahrani MS, Morris DL Abstract Mucinous appendiceal neoplasms (MANs) are rare tumours and the primary cause of pseudomyxoma peritonei. These tumours have a much more benign course than typical colorectal cancers, generally growing for many years before giving any clinical signs. The spectrum...
Related Articles Current State of Target Treatment in BRAF Mutated Melanoma. Front Mol Biosci. 2020;7:154 Authors: Tanda ET, Vanni I, Boutros A, Andreotti V, Bruno W, Ghiorzo P, Spagnolo F Abstract Incidence of melanoma has been constantly growing during the last decades. Although most of the new diagnoses are represented by thin melanomas, the number of melanoma-related deaths in 2018 was 60,712 worldwide (Global Cancer Observatory, 2019)....
Related Articles Role of Radiation Therapy Differs Between Stages in Primary Bone Large B-Cell Lymphoma in Rituximab Era: A Population-Based Analysis. Front Oncol. 2020;10:1157 Authors: Ma S, Zhang Y, Li Z, Yan H, Xia L, Shi W, Hu Y Abstract Background: Primary bone B-cell lymphoma (PB-DLBCL) is a rare entity for which existing data is limited. Whether radiotherapy (RT) should be omitted in the modern treatment of PB-DLBCL is still under debate....
Related Articles Leiomyosarcoma of the Vulva Mimicking as Chronic Bartholin Cyst: A Case Report. Oman Med J. 2020 Jul;35(4):e153 Authors: Saquib S, Cherawala M, Abdel Rahman O, Keloth TE Abstract Smooth muscle neoplasms of the vulva are rare, and when localized in the Bartholin's gland, it can be mistaken as a benign lesion leading to a delay in diagnosis. We report a case of leiomyosarcoma of the Bartholin's gland in a 63-year-old postmenopausal...
Related Articles Multiple peritoneal dissemination of T2 colorectal cancer without lymph node metastases: a case report. J Surg Case Rep. 2020 Jul;2020(7):rjaa118 Authors: Namba Y, Hirata Y, Mukai S, Nishida T, Ishikawa S, Kai A, Kohata A, Okimoto S, Fujisaki S, Fukuda S, Takahashi M, Fukuda T Abstract Most cases of peritoneal dissemination of colorectal cancers are from T3 or T4 tumors. A 61-year-old woman was admitted for examination of a...
Related Articles The Pathologic and Molecular Landscape of Esophageal Squamous Cell Carcinogenesis. Cancers (Basel). 2020 Aug 04;12(8): Authors: Businello G, Parente P, Mastracci L, Pennelli G, Traverso G, Milione M, Bellan E, Michelotto M, Kotsafti A, Grillo F, Fassan M Abstract Esophageal squamous cell carcinoma represents the most common histotype of epithelial neoplasm occurring within esophageal mucosa worldwide. Despite the comprehensive...
Related Articles Brain Metastases from Ovarian Cancer: Current Evidence in Diagnosis, Treatment, and Prognosis. Cancers (Basel). 2020 Aug 04;12(8): Authors: Borella F, Bertero L, Morrone A, Gambella A, Bovetti M, Cosma S, Carosso A, Katsaros D, Gemmiti S, Preti M, Valabrega G, Scotto G, Cassoni P, Benedetto C Abstract With this review, we provide the state of the art concerning brain metastases (BMs) from ovarian cancer (OC), a rare condition....
Related Articles Clinical and morphological features of the ovarian brenner tumour: current state of the problem. Wiad Lek. 2020;73(7):1420-1426 Authors: Myroshnychenko MS, Dyadyk OO, Urzhumov VD, Kapustnyk NV, Borzenkova IV, Selivanova LI, Torianyk II, Fedulenkova YY, Kalashnyk IM, Tkachenko PV, Hryhorenko VR, Molodan DV, Myroshnychenko SS Abstract OBJECTIVE: Introduction: Ovarian tumours are an actual problem of present-day medicine, being...
Related Articles Combining BRAF inhibition with oncolytic herpes simplex virus enhances the immune-mediated antitumor therapy of BRAF-mutant thyroid cancer. J Immunother Cancer. 2020 Aug;8(2): Authors: Crespo-Rodriguez E, Bergerhoff K, Bozhanova G, Foo S, Patin EC, Whittock H, Buus R, Haider S, Muirhead G, Thway K, Newbold K, Coffin RS, Vile RG, Kim D, McLaughlin M, Melcher AA, Harrington KJ, Pedersen M Abstract BACKGROUND: The aggressive clinical...
Related Articles Right atrial blood cyst in elderly patient: the timing of surgery. Asian Cardiovasc Thorac Ann. 2020 Aug 05;:218492320949406 Authors: Imai A, Enomoto Y, Shigeta O, Suzuki Y Abstract A regular check up on a 59-year-old man showed a high carcinoembryonic antigen level in his blood. A computed tomography scan showed tumors in the right atrium. We performed tumor resection successfully. The resected specimen was found to be blood...
Related Articles Signet ring cells in carcinomatous lymphangitis due to gastric adenocarcinoma. An Bras Dermatol. 2020 Jul - Aug;95(4):490-492 Authors: Souza BDS, Bonamigo RR, Viapiana GL, Cartell A Abstract Cutaneous metastases are rare. They usually present as nodules or tumors. Diagnosis is based on histopathological examination and prognosis is unfavorable. This report describes the case of a female patient, 72 years old, with surgically...
Related Articles Atypical lymphangioma and hyperkeratosis in a patient with morbid obesity. An Bras Dermatol. 2020 Jul - Aug;95(4):477-479 Authors: Morán-Mariños C, Nieto-Gutierrez W, Pacheco-Mendoza J Abstract Lymphangioma is a rare and understudied pathology that is usually detected in the first decade of life, and its appearance in adults is rare. This report details a 51-year-old man with morbid obesity who presented, for the last eight...
Related Articles Management of NK/T-Cell Lymphoma, Nasal Type. J Oncol Pract. 2019 10;15(10):513-520 Authors: Allen PB, Lechowicz MJ Abstract Extranodal natural killer (NK)/T-cell lymphoma, nasal type, is a rare peripheral T-cell lymphoma associated with Epstein-Barr virus. It most often presents as limited-stage disease in patients of East Asian descent with a palatal deformity caused by erosion of the tumor through the hard palate. Limited-stage...
Related Articles Ovarian and uterine leiomyosarcoma: which one is the primary? Horm Mol Biol Clin Investig. 2019 Aug 09;41(2): Authors: Shafiee MN, Kah Teik C, Md Zain RR, Kampan N Abstract Uterine leiomyosarcoma (LMS) is rare but primary ovarian LMS is even rarer constituting less than 0.1% of all gynecologic disorders. Neither histologic features nor immunohistochemistry could be utilized to distinguish between uterine or ovarian origin. We...
Related Articles Medulloblastoma With Metastasis to the Jaw in a Child With Nevoid Basal Cell Carcinoma Syndrome: A Case Report. J Oral Maxillofac Surg. 2019 Nov;77(11):2279-2284 Authors: Cartrite M, Yang D, Farr B, Stone J Abstract Medulloblastoma is the most common childhood malignant brain tumor and is considered a minor criterion in the diagnosis of nevoid basal cell carcinoma syndrome (NBCCS). Metastasis of this primitive neuroectodermal...
Related Articles Urothelial Carcinoma of the Bladder, Lipid Cell Variant: Case Report and Literature Review. J Nippon Med Sch. 2020 Jan 10;86(6):349-351 Authors: Takahashi K, Kimura G, Endo Y, Akatsuka J, Hayashi T, Toyama Y, Hamasaki T, Kondo Y Abstract The lipid cell variant of urethral carcinoma (UC) is rare and poorly understood clinicopathologically. A nodular tumor detected in the bladder of an 87-year-old man with asymptomatic gross...
Related Articles Microcystic Adnexal Carcinoma: A Rare, Commonly Misdiagnosed Malignancy. Mil Med. 2019 12 01;184(11-12):948-950 Authors: Gerall CD, Sippel MR, Yracheta JL, Hogan FS Abstract Microcystic adnexal carcinoma (MAC) is a rare, malignant cutaneous neoplasm that often presents as an inconspicuous, benign appearing lesion. Patients most commonly are asymptomatic and present for improved cosmesis, however perineural invasion may result...
Related Articles Robot-assisted nephroureterectomy for upper tract urothelial carcinoma: results from three high-volume robotic surgery institutions. J Robot Surg. 2020 Feb;14(1):211-219 Authors: De Groote R, Decaestecker K, Larcher A, Buelens S, De Bleser E, D'Hondt F, Schatteman P, Lumen N, Montorsi F, Mottrie A, De Naeyer G, YAU Robotic and Urothelial Group Abstract Robot-Assisted NephroUreterectomy (RANU) represents a minimally invasive...
Related Articles Laryngeal Spindle Cell/Pleomorphic Lipoma: A Case Report. An In-Depth Review of the Adipocytic Tumors. J Oral Maxillofac Surg. 2019 Jul;77(7):1401-1410 Authors: Burkes JN, Campos L, Williams FC, Kim RY Abstract Spindle cell and pleomorphic lipomas (SC/PLs) are a rare form of lipomatous tumors. They typically occur as a slow-growing localized mass in the subcutaneous fatty tissue of the posterior neck, back, and shoulders. This...
Related Articles Oropharyngeal adenoid cystic carcinoma invading the mandibular bone through the mandibular foramen. Oral Radiol. 2019 09;35(3):335-340 Authors: Takeshita Y, Okada S, Hisatomi M, Matsuzaki H, Kawai H, Noda Y, Murakami J, Fujita M, Nagatsuka H, Yanagi Y, Asaumi J Abstract Adenoid cystic carcinoma (ACC) is a rare epithelial tumor of the head and neck region, and one of the most common malignant tumors of the salivary glands. ACC...
Related Articles Schwannoma assumedly originating from the submandibular ganglion or glandular branches radiologically mimicking a submandibular gland tumor. Oral Radiol. 2019 05;35(2):189-193 Authors: Baba A, Sakai K, Okuyama Y, Yamauchi H, Ogino N, Hashimoto K, Hasegawa Y, Seto Y, Yamazoe S, Kobashi Y, Mogami T, Nomura T, Ojiri H Abstract Schwannoma is a benign nerve sheath tumor composed of Schwann cells. Schwannomas originating from ganglia...
Related Articles Oncogenic mutations within the β3-αC loop of EGFR/ERBB2/BRAF/MAP2K1 predict response to therapies. Mol Genet Genomic Med. 2020 Aug 05;:e1395 Authors: Zhang B, Chen Y, Dai P, Yu H, Ma J, Chen C, Zhang Y, Guan Y, Chen R, Liu T, Wang J, Yang L, Yi X, Xia X, Ma H Abstract BACKGROUND: β3-αC loop is a highly conserved structural domain across oncogene families, which is a switch for kinase activity. There have been numerous researches...
Related Articles Mucinous cystic neoplasms of the pancreas associated with pregnancy: Two case reports. Medicine (Baltimore). 2020 Jul 31;99(31):e21471 Authors: Revoredo F, de Vinatea J, Reaño G, Villanueva L, Kometter F, Arenas J, Polanco PM Abstract RATIONALE: Although rare, pancreatic neoplasms can occur during pregnancy, both in benign and malignant forms. Mucinous cystic neoplasms (MCNs) of the pancreas, a type of these neoplasms, are precursor...
Related Articles Statin-Induced Rhabdomyolysis Due to Pharmacokinetic Changes From Biliary Obstruction in a Patient With Metastatic Prostate Cancer. J Investig Med High Impact Case Rep. 2020 Jan-Dec;8:2324709620947275 Authors: Desikan SP, Sobash P, Fisher A, Desikan R Abstract Statins work synergistically with androgen receptor blockers and androgen biosynthesis inhibitors, improving survival in patients with metastatic castration resistant...
Related Articles EGFR Mutated Lung Adenocarcinoma Metastasis to the Pancreas Mimicking Primary Pancreatic Ductal Carcinoma. Anticancer Res. 2020 Aug;40(8):4401-4404 Authors: Cao C, Kong MX, Kapali M, Moezardalan K, Shi Q, Azarm A, Lai J Abstract BACKGROUND: The occurrence of lung adenocarcinoma metastasizing to the pancreas is overall rare and can histologically imitate primary pancreatic ductal carcinoma (PDAC). CASE REPORT: This...
Related Articles A case of mammary analogue secretory carcinoma of the parotid gland: A case report. Medicine (Baltimore). 2020 Jul 10;99(28):e20218 Authors: Kim SH, Hong ME, Lee DJ Abstract RATIONALE: Mammary analogue secretory carcinoma is a low grade salivary gland malignancy, first described by Skalova et al in 2010. The histological, immunohistochemical, and molecular characteristics of this tumor resemble those of secretory carcinoma...
Related Articles [Clinical study of 21 cases of sacral cysts containing fila terminale]. Beijing Da Xue Xue Bao Yi Xue Ban. 2020 Jun 18;52(3):582-585 Authors: Lin GZ, Wang ZY, Xie JC, Liu B, Ma CC, Chen XD Abstract OBJECTIVE: To summarize the characteristics of sacral cysts containing fila terminale and to explore the surgical treatment methods. METHODS: The clinical features, imaging characteristics and surgical methods of 21 cases...
Related Articles Mycosis Fungoides of the True Vocal Folds: A Case Report. Ann Otol Rhinol Laryngol. 2020 Sep;129(9):930-934 Authors: Qualliotine JR, Ahluwalia R, Tzachanis D, Sanghvi P, Weissbrod PA Abstract OBJECTIVES: To report a case of laryngeal involvement of mycosis fungoides and its symptomatic treatment with laser-assisted surgical ablation. METHODS: Case report and literature review. RESULTS: A 76-year-old woman...
Related Articles Brain Metastases From Gynecologic Malignancies: Prevalence and Management. Am J Clin Oncol. 2020 06;43(6):418-421 Authors: Nasioudis D, Persaud A, Taunk NK, Latif NA Abstract OBJECTIVE: The objective of this study was to investigate the prevalence, clinicopathologic characteristics, management, and outcomes of patients with brain metastasis (BM) from gynecologic malignancies in a large hospital-based database. MATERIALS...
Related Articles Thyroid carcinoma metastasizing to the submandibular gland: Sonographic findings. J Clin Ultrasound. 2020 May;48(4):227-230 Authors: Golant BT, Velez-Perez A, Krishnamurthy S, Guo M, Mousavi S, Hu MI, Varghese JM, Zafereo ME, Debnam JM Abstract Metastases to the submandibular gland are extremely rare; a literature search retuned only three previously reported cases from a thyroid gland primary site. Herein, we report two cases...
Related Articles Papillary endothelial hyperplasia (Masson's tumor) developed in the capsule of the implant in a breast cancer patient treated with mastectomy and radiation therapy. J Clin Ultrasound. 2020 May;48(4):222-226 Authors: Lorente-Ramos RM, Azpeitia Armán J, Martínez Izquierdo MA, Pérez Quintanilla A Abstract Papillary endothelial hyperplasia (PEH) is an uncommon benign vascular proliferation appearing in soft tissues in different...
Related Articles Cavernous hemangioma of the left atrium: A rare tumor. J Card Surg. 2020 Jan;35(1):202-203 Authors: Kotoulas C, Georgiou C, Grapatsas K, Kotoulas S, Theodosiadis N, Panagiotou I PMID: 31765014 [PubMed - indexed for MEDLINE]
Related Articles Hepatic hemangioma supplied by abnormal portal vein: A case report. J Clin Ultrasound. 2020 May;48(4):231-234 Authors: Ogawa M, Matsumoto N, Kaneko M, Kumagawa M, Watanabe Y, Hirayama M, Moriyama M, Higaki T, Takayama T, Sugitani M Abstract Hepatic hemangioma is the most common hepatic tumor with a prevalence of approximately 3%. It is typically supplied by the hepatic artery as evident from findings of abdominal angiography,...
Related Articles Rosette-forming glioneuronal tumors share a distinct DNA methylation profile and mutations in FGFR1, with recurrent co-mutation of PIK3CA and NF1. Acta Neuropathol. 2019 09;138(3):497-504 Authors: Sievers P, Appay R, Schrimpf D, Stichel D, Reuss DE, Wefers AK, Reinhardt A, Coras R, Ruf VC, Schmid S, de Stricker K, Boldt HB, Kristensen BW, Petersen JK, Ulhøi BP, Gardberg M, Aronica E, Hasselblatt M, Brück W, Bielle F, Mokhtari K, Lhermitte B,...
Related Articles A rare solitary duodenum plasmacytoma. Rev Esp Enferm Dig. 2019 Jul;111(7):563 Authors: Wang NN, Ou SQ, Yao J, Li DF Abstract Multiple myeloma (MM) is typical of uncontrolled and clonal growth of malignant plasma cells in the bone marrow, then leads to primary symptoms related to bone narrow infiltration and destruction bone lesion. The term of extramedullary plasmacytoma is used to defined malignant plasma cells are found...
Related Articles Pancreatobiliary maljunction: association with gallbladder cancer. Rev Esp Enferm Dig. 2019 Jul;111(7):568-570 Authors: Garzón Benavides M, Núñez Ortiz A, López Ruiz T, Cepeda Franco C, Gómez Izquierdo L Abstract BACKGROUND: Pancreatobiliary maljunction is a rare disease characterized by the junction of the pancreatic and biliary ducts outside of the duodenal wall, which normally results in a large common duct. As a result,...
Related Articles Primary squamous cell carcinoma of the stomach: a rare case report. Rev Esp Enferm Dig. 2019 07;111(7):571-572 Authors: Tejedor Tejada J, Núñez Rodríguez H, González González D Abstract Primary squamous cell carcinoma (SCC) of stomach is a rare disease. There are fewer than 100 cases published in the literatura. The pathogenesis remains to be elucidated and the prognosis is poor. In the case presented here, clínical, endosopy,...
Related Articles Clinical Pharmacokinetics and Pharmacodynamics of Transarterial Chemoembolization and Targeted Therapies in Hepatocellular Carcinoma. Clin Pharmacokinet. 2019 08;58(8):983-1014 Authors: Hulin A, Stocco J, Bouattour M Abstract The management of hepatocellular carcinoma (HCC) is based on a multidisciplinary decision tree. Treatment includes loco-regional therapy, mainly transarterial chemoembolization, for intermediate-stage...
Recent Therapeutic Advances and Change in Treatment Paradigm of Patients with Merkel Cell Carcinoma.
Related Articles Recent Therapeutic Advances and Change in Treatment Paradigm of Patients with Merkel Cell Carcinoma. Oncologist. 2019 10;24(10):1375-1383 Authors: Garcia-Carbonero R, Marquez-Rodas I, de la Cruz-Merino L, Martinez-Trufero J, Cabrera MA, Piulats JM, Capdevila J, Grande E, Martin-Algarra S, Berrocal A Abstract Merkel cell carcinoma (MCC) is a rare, aggressive, primary cutaneous neuroendocrine tumor that typically presents as...
Related Articles Prediction of Bone Metastasis in Inflammatory Breast Cancer Using a Markov Chain Model. Oncologist. 2019 10;24(10):1322-1330 Authors: Fujii T, Mason J, Chen A, Kuhn P, Woodward WA, Tripathy D, Newton PK, Ueno NT Abstract BACKGROUND: Inflammatory breast cancer (IBC) is a rare yet aggressive variant of breast cancer with a high recurrence rate. We hypothesized that patterns of metastasis differ between IBC and non-IBC. We focused...
Septum Pellucidum Cavernoma: A Case Report and Anatomical Consideration of an Extremely Rare Lesion.
Related Articles Septum Pellucidum Cavernoma: A Case Report and Anatomical Consideration of an Extremely Rare Lesion. Turk Neurosurg. 2020;30(1):145-148 Authors: Paiva A, Lovato RM, Araujo JO, Veiga J Abstract Cavernous angiomas (cavernomas) are vascular malformations of the brain characterized by abnormal capillaries. Ventricular cavernomas are considered rare; however, an extremely unusual topography is the septum pellucidum, with only five...
Related Articles Uterine colorectal metastatic disease: a rare occurrence. ANZ J Surg. 2019 07;89(7-8):963-964 Authors: Reynolds L, Kenny S, Crozier-Shaw G, Connolly C, Joyce WP PMID: 29415367 [PubMed - indexed for MEDLINE]
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