Background. Periodontitis is a kind of chronic infectious disease, affecting the health of billions of people. In recent years, a number of studies have shown that multiple immune gene polymorphisms are associated with the susceptibility to periodontitis, among which TLR-2 plays a critical role in periodontitis. But most of the studies reported TLR-2 gene polymorphism and susceptibility to periodontitis are not consistent. Therefore, we included all eligible studies in our study for further meta-analysis....
Sat Aug 08, 2020 10:20
Abstract Targeting the MAPK signaling pathway has transformed the treatment of metastatic melanoma. CRISPR‐Cas9 viability screens provide a genome‐wide approach to uncover novel genetic dependencies. Here we analyzed recently reported CRISPR‐Cas9 screens comparing data from 28 melanoma cell lines and 313 cell lines of other tumor types in order to identify fitness genes related to melanoma. We found an average of 1,494 fitness genes in each melanoma cell line. We identified 33 genes inactivation...
Fri Aug 07, 2020 22:45
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. A 66-year-old male patient with coronavirus disease-19 (COVID-19) developed cardiogenic shock with echocardiographic evidence of decreased left ventricular ejection fraction and global hypokinesia concomitant with a robust systemic inflammatory response. Following the administration of convalescent plasma therapy and inotropic support, left ventricular function recovered fully in accordance with the...
Fri Aug 07, 2020 13:01
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Leukocytoclastic vasculitis (LCV) is a rare vascular inflammatory condition that affects post-capillary venules. Its incidence in the pediatric population is unknown. However, its incidence has been shown to increase with age. The causes of LCV can be varied, ranging from drugs to infections to systemic disease. LCV as a presenting symptom of inflammatory bowel disease (IBD) is rare, especially in...
Fri Aug 07, 2020 13:01
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Recent reports have suggested an increased risk of QT prolongation and subsequent life-threatening ventricular arrhythmias, particularly torsade de pointes, in patients with coronavirus disease-2019 (COVID-19) treated with hydroxychloroquine and azithromycin. In this article, we report the case of a 75-year-old female with a baseline prolonged QT interval in whom the COVID-19 illness resulted in further...
Fri Aug 07, 2020 13:01
Exp Clin Endocrinol DiabetesDOI: 10.1055/a-1163-7304 Objective Clinical data on primary hypophysitis are still scarce. Especially non-surgical cases are underreported. We sought to analyse clinical characteristics of primary hypophysitis, particularly in clinically diagnosed patients. Design Retrospective single centre study in 60 patients with primary hypophysitis. ...
Fri Aug 07, 2020 02:00
Image description: A dark-haired man in a black suit poses, leaning on his forearm with his other hand propped up under his chin. Caption: Álvaro Ínsua 1935–2019 Álvaro Ínsua, born February 15, 1935, died in Miami, Florida, nearing his 84th birthday on January 13, 2019. Ínsua’s historical connection to anthropology was his association with famed anthropologist Oscar Lewis and wife Ruth in the ill-fated “Project Cuba.” With the approval of the United States and Cuban governments, Lewis went to...
Sat Aug 08, 2020 01:00
Around the world we all get the same directives—stay physically distant, wash your hands—but there is privilege behind those directives. The pandemic of 2020 is witness to unfairness, social strata that discriminate in the form of pollution, wasteful consumerism, neglect of the elderly, and exhaustion from our packed schedules and our competitiveness. The authors came together as friends, each from a different continent, now seeing our own homes from a new perspective. As practicing business anthropologists,...
Sat Aug 08, 2020 00:30
Objectives: Tinnitus is the perception of sound in the absence of an external physical sound source, for some people it can severely reduce the quality of life. Acoustic residual inhibition (ARI) is a suppression of tinnitus following the cessation of a sound. The present study investigated the effect of ARI on brain activity measured using EEG. Design: Thirty adult participants (mean age of 58 years) experiencing chronic tinnitus (minimum 2 years) participated. Participants were presented...
Tue Aug 04, 2020 03:00
Objectives: Congenital cytomegalovirus (cCMV) infection is the leading cause of nonhereditary sensorineural hearing loss in childhood and is also associated with CNS abnormalities. The main objective is to investigate the prognostic value of neonatal cranial ultrasound (cUS) and cranial magnetic resonance imaging (cMRI) in predicting long-term hearing outcome in a large cohort of cCMV-infected symptomatic and asymptomatic patients. Design: Data were prospectively collected from a multicentre...
Tue Aug 04, 2020 03:00
Objectives: The present study aimed to (1) evaluate the accuracy of envelope following responses (EFRs) in predicting speech audibility as a function of the statistical indicator used for objective response detection, stimulus phoneme, frequency, and level, and (2) quantify the minimum sensation level (SL; stimulus level above behavioral threshold) needed for detecting EFRs. Design: In 21 participants with normal hearing, EFRs were elicited by 8 band-limited phonemes in the male-spoken token...
Tue Aug 04, 2020 03:00
Objectives: Audiologists and hearing aid users (HAUs) generally agree that an adaptation period is needed following the first hearing aid (HA) experience. The main purpose of this study is to investigate the acclimatization of older adult listeners with hearing loss to HAs using listening effort and behavioral measures. Design: Participants (N=47) were older adults with mild to moderately severe sensorineural hearing loss. Thirty-two participants were new HAUs and 15 participants were experienced...
Tue Aug 04, 2020 03:00
Objectives: To understand the varying levels of daily cochlear implant (CI) use in children, previous studies have investigated factors that may be of influence. The objective of this study was to investigate the degree with which new child-related and environment-related characteristics were associated with consistent CI use. Design: The design of this study was retrospective. Data were reviewed of 81 children (51% females, mean age 6.4 years with a range of 1.3 to 17.7 years) who received...
Tue Aug 04, 2020 03:00
Objectives: Children with hearing loss (HL), in spite of early cochlear implantation, often struggle considerably with language acquisition. Previous research has shown a benefit of rhythmic training on linguistic skills in children with HL, suggesting that improving rhythmic capacities could help attenuating language difficulties. However, little is known about general rhythmic skills of children with HL and how they relate to speech perception. The aim of this study is twofold: (1) to assess...
Tue Aug 04, 2020 03:00
Objectives: Preservation of residual hearing is one of the main goals in present cochlear implantation surgery. Especially for this purpose, smaller and softer electrode carriers were developed that are to be inserted through the round window membrane to minimize trauma. By using these electrodes and insertion technique, residual hearing can be preserved in a large number of patients. Unfortunately, some of these patients with initially preserved residual hearing after cochlear implantation lose...
Tue Aug 04, 2020 03:00
Purpose of review To discuss the association between the common dominantly inherited genetic trait hereditary alpha-tryptasemia (HαT) and hymenoptera venom-induced anaphylaxis (HVA). Recent findings Elevated BST has been correlated with more severe systemic anaphylaxis in humans in a number of settings – most notably in HVA. Clonal mast cell disease, in particular, systemic mastocytosis, is frequently associated with elevated BST, and is a major risk factor for severe HVA. However, clonal...
Thu Aug 06, 2020 03:00
Purpose of review To evaluate the indication to perform venom immunotherapy (VIT) during pregnancy considering the risks of adverse events during the build-up phase or the maintenance phase and analyzing specific articles and guidelines on VIT. Recent findings Only few studies treat this argument and literature only counts one recent study on the topic, whereas recent guidelines state the behavior to keep in pregnancy. Summary Hymenoptera venom allergy (HVA) affects about 7.5% of the...
Thu Aug 06, 2020 03:00
Purpose of review Allergen immunotherapy (AIT) is a well-known disease-modifying intervention for allergic diseases. Its benefit in allergic asthma, ranging from prevention to facilitating asthma control, is yet to be clarified. Recent findings In 2017, following several well-designed randomised controlled trials (RCTs) with house-dust mites (HDM) sublingual (SLIT) tablets in asthma, global initiative for asthma (GINA) guidelines highlighted the need to treat the allergic component of asthma....
Thu Aug 06, 2020 03:00
Purpose of review This article reviews the ocular findings in patients with a myriad of autoimmune syndromes. This review will provide guidance and heighten awareness for the allergist or eye care provider to pay heed to the manifestations and treatments of autoimmune syndromes. Recent findings Autoimmune syndromes can present with varied manifestations on the ocular surface known to potentially cause significant visual morbidity. In particular, sterile corneal ulcers are the most devastating...
Thu Aug 06, 2020 03:00
Abstract Coronavirus disease 2019 (COVID-19) has affected anesthetic care worldwide, including the provision of anesthesia for pediatric patients. Hospitals have balanced the risks associated with the potential surges of resource-intensive COVID-19 patients against the probable morbidity of delaying elective surgical procedures. These decisions are complicated by the unclear influence that COVID-19 has on the perioperative risk for disease-positive pediatric patients. We conducted...
Fri Aug 07, 2020 03:00
IntroductionInflammatory biomarkers are associated with negative health outcomes. In this study, we investigated the associations between airborne occupational exposures and levels and changes in inflammatory biomarkers.MethodsWe included 79 604 adults at baseline from the Lifelines cohort of which 48 403 (60.8%) subjects were followed for a median of 4.5 years. Airborne occupational exposures at the current or last-held job at baseline were estimated with the occupational asthma-specific job-exposure...
Fri Aug 07, 2020 19:00
Chemical reactions driven by the geological conditions on the early Earth might have led to the prebiotic evolution of self-replicating molecules. Scientists now report on a hydrothermal mechanism that could have promoted the process.
Fri Aug 07, 2020 16:38
Publication date: Available online 6 August 2020Source: Behavioural Brain ResearchAuthor(s): Yujuan Zhao, Ge Yang, Zijian Zhao, Chao Wang, Cuicui Duan, Lei Gao, Shengyu Li
Fri Aug 07, 2020 18:02
Related Articles [Determination of UV-327 and UV-328 in mouse plasma by high performance liquid chromatography]. Beijing Da Xue Xue Bao Yi Xue Ban. 2020 Jun 18;52(3):591-596 Authors: Zhu MQ, Cui R Abstract OBJECTIVE: To establish a high performance liquid chromatography (HPLC) method for the determination of ultraviolet (UV) absorbers UV-327 and UV-328 in mouse plasma. METHODS: N-hexane-acetone (volume ratio 1 ∶1) was added to a mouse...
Fri Aug 07, 2020 16:43
Publication date: Available online 6 August 2020Source: Archives of Physical Medicine and RehabilitationAuthor(s): Lance E. Trexler, John D. Corrigan, Shashank Davé, Flora M. Hammond
Fri Aug 07, 2020 14:19
Abstract Purpose This study was done to compare the survival rates of cast gold and ceramic onlays placed in a dental school setting. Material and Methods An electronic search was conducted in the patient records at Adams School of Dentistry, University of North Carolina at Chapel Hill for onlay codes that were in the database (From 1998 until 2018). Progress notes and radiographs were scrutinized to establish the survival time of the restorations. Any complications that occurred during...
Fri Aug 07, 2020 11:01
Abstract Sleep‐disordered breathing (SDB) causes hypoxic stress and can trigger uric acid (UA) overproduction. We comprehensively investigated whether SDB, interacting with components of metabolic syndrome, hepatic and renal dysfunctions, low physical fitness, sedentary lifestyle, disrupted sleep, and chronic systemic inflammation (CSI), is directly associated with hyperuricaemia. In 528 community‐based males (mean [SD ] age 46.2 [7.4] years), we cross‐sectionally analysed measures of anthropometry;...
Thu Aug 06, 2020 20:48
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Spinal metastases are a common manifestation of malignant tumors that can cause severe pain, spinal cord compression, pathological fractures, and hypercalcemia, and these clinical manifestations will ultimately reduce the health-related quality of life and even shorten life expectancy in patient with cancer. Effective management of spinal bone metastases requires multidisciplinary collaboration, including radiologists,...
Thu Aug 06, 2020 14:34
High Altitude Medicine &Biology, Ahead of Print.
Tue Aug 04, 2020 10:00
High Altitude Medicine &Biology, Ahead of Print.
Tue Aug 04, 2020 10:00
High Altitude Medicine &Biology, Ahead of Print.
Fri Jul 31, 2020 10:00
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