Deep neuromuscular blockade during spinal surgery reduces intra-operative blood loss: A randomised clinical trial

Deep neuromuscular blockade during spinal surgery reduces intra-operative blood loss: A randomised clinical trial: BACKGROUND

Spinal surgery is usually performed in the prone position using a posterior approach. However, the prone position may cause venous engorgement in the back and thus increase surgical bleeding with interruption of surgery. The prone position also affects cardiac output since large vessels are compressed decreasing venous return to the heart.

OBJECTIVE

We hypothesised that deep neuromuscular blockade would be associated with less surgical bleeding during spinal surgery in the prone position.

DESIGN

Randomised, single blinded trial.

SETTING

University teaching hospital.

PARTICIPANTS

Eighty-eight patients in two groups.

INTERVENTIONS

Patients were randomly assigned to moderate neuromuscular blockade or deep neuromuscular blockade. In the moderate neuromuscular blockade group, administration of rocuronium was adjusted such that the train-of-four count was one to two. In the deep neuromuscular blockade group, rocuronium administration was adjusted such that the train-of-four count was zero with a posttetanic count 2 or less.

MAIN OUTCOME MEASURES

The primary outcome was the volume of intra-operative surgical bleeding. The surgeon's satisfaction with operating conditions, haemodynamic and respiratory status, and postoperative pain scores were evaluated.

RESULTS

The median [IQR] volume of intra-operative surgical bleeding was significantly less in the deep neuromuscular blockade group than in the moderate neuromuscular blockade group; 300 ml [200 to 494] vs. 415 ml [240 to 601]; difference: 117 ml (95% CI, 9 to 244; P = 0.044). The mean ± SD surgeon's satisfaction with the intra-operative surgical conditions was greater in the deep neuromuscular blockade group than in the moderate neuromuscular blockade group; 3.5 ± 1.0 vs. 2.9 ± 0.9 (P = 0.004). In intergroup comparisons of respiratory variables, peak inspiratory pressure was lower in the deep neuromuscular blockade group overall (P