IJMS, Vol. 21, Pages 1100: The Effect of 3′-Hydroxy-3,4,5,4′-Tetramethoxy -stilbene, the Metabolite of the Resveratrol Analogue DMU-212, on the Motility and Proliferation of Ovarian Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21031100 Authors: Andrzej Nowicki Paulina Skupin-Mrugalska Malgorzata Jozkowiak Marcin Wierzchowski Marcin Rucinski Piotr Ramlau Violetta Krajka-Kuzniak Jadwiga Jodynis-Liebert Hanna Piotrowska-Kempisty Targeting...
Fri Feb 07, 2020 02:00
IJMS, Vol. 21, Pages 1101: Adaptation of Mitochondrial Substrate Flux in a Mouse Model of Nonalcoholic Fatty Liver Disease International Journal of Molecular Sciences doi: 10.3390/ijms21031101 Authors: Staňková Kučera Peterová Lotková Maseko Nožičková Červinková Maladaptation of mitochondrial oxidative flux seems to be a considerable feature of nonalcoholic fatty liver disease (NAFLD). The aim of this work was to induce NAFLD in mice fed a Western-style diet...
Fri Feb 07, 2020 02:00
IJMS, Vol. 21, Pages 1102: Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity International Journal of Molecular Sciences doi: 10.3390/ijms21031102 Authors: Lee Rauch Kolch Mitogen‐activated protein kinase (MAPK) pathways represent ubiquitous signal transductionpathways that regulate all aspects of life and are frequently altered in disease. Here, we focus on the role ofMAPK pathways in modulating drug sensitivity and resistance in cancer. We briefly...
Fri Feb 07, 2020 02:00
IJMS, Vol. 21, Pages 1106: STAT3/5 Inhibitors Suppress Proliferation in Bladder Cancer and Enhance Oncolytic Adenovirus Therapy International Journal of Molecular Sciences doi: 10.3390/ijms21031106 Authors: Sruthi V. Hindupur Sebastian C. Schmid Jana Annika Koch Ahmed Youssef Eva-Maria Baur Dongbiao Wang Thomas Horn Julia Slotta-Huspenina Juergen E. Gschwend Per Sonne Holm Roman Nawroth The JAK-STAT signalling pathway regulates cellular processes like cell...
Fri Feb 07, 2020 02:00
IJMS, Vol. 21, Pages 1103: Inflammasome and Cognitive Symptoms in Human Diseases: Biological Evidence from Experimental Research International Journal of Molecular Sciences doi: 10.3390/ijms21031103 Authors: Cheon Kim Kim Kim Koo Cognitive symptoms are prevalent in the elderly and are associated with an elevated risk of developing dementia. Disease-driven changes can cause cognitive disabilities in memory, attention, and language. The inflammasome is an innate immune...
Fri Feb 07, 2020 02:00
IJMS, Vol. 21, Pages 1104: Construction and Analysis of GmFAD2-1A and GmFAD2-2A Soybean Fatty Acid Desaturase Mutants Based on CRISPR/Cas9 Technology International Journal of Molecular Sciences doi: 10.3390/ijms21031104 Authors: Wu Lu Wang Zhang Zhang Qu Wang The soybean fatty acid desaturase family is composed of seven genes, but the function of each gene has not been reported. Bioinformatics was used to analyse the structure of genes in this family, as well...
Fri Feb 07, 2020 02:00
IJMS, Vol. 21, Pages 1099: Knockdown of Atg7 Induces Nuclear-LC3 Dependent Apoptosis and Augments Chemotherapy in Colorectal Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21031099 Authors: Scherr Jassowicz Pató Elssner Ismail Schmitt Hoffmeister Neukirch Gdynia Goeppert Schulze-Bergkamen Jäger Köhler Autophagy is a catabolic process that enables cells to degrade obsolete content and refuel energy depots. In...
Fri Feb 07, 2020 02:00
IJMS, Vol. 21, Pages 1098: The Role Played by Wnt/β-Catenin Signaling Pathway in Acute Lymphoblastic Leukemia International Journal of Molecular Sciences doi: 10.3390/ijms21031098 Authors: Francesca Chiarini Francesca Paganelli Alberto M. Martelli Camilla Evangelisti Acute lymphoblastic leukemia (ALL) is an aggressive hematologic neoplastic disorder that arises from the clonal expansion of transformed T-cell or B-cell precursors. Thanks to progress in chemotherapy protocols,...
Fri Feb 07, 2020 02:00
IJMS, Vol. 21, Pages 1097: Plasma Membrane Ca2+ Permeable Mechanosensitive Channel OsDMT1 Is Involved in Regulation of Plant Architecture and Ion Homeostasis in Rice International Journal of Molecular Sciences doi: 10.3390/ijms21031097 Authors: Liang He Zhang Wang Zhang Plant architecture is an important factor for crop production. Plant height, tiller pattern, and panicle morphology are decisive factors for high grain yield in rice. Here, we isolated and characterized...
Fri Feb 07, 2020 02:00
IJMS, Vol. 21, Pages 1096: Evaluation of the Use of Formalin-Fixed and Paraffin-Embedded Archive Gastric Tissues for Microbiota Characterization Using Next-Generation Sequencing International Journal of Molecular Sciences doi: 10.3390/ijms21031096 Authors: Pinto-Ribeiro Ferreira Pereira-Marques Pinto Macedo Carneiro Figueiredo Large numbers of well-characterized clinical samples are fundamental to establish relevant associations between the microbiota and disease....
Fri Feb 07, 2020 02:00
IJMS, Vol. 21, Pages 1095: Small Vessel Disease-Related Dementia: An Invalid Neurovascular Coupling?
IJMS, Vol. 21, Pages 1095: Small Vessel Disease-Related Dementia: An Invalid Neurovascular Coupling? International Journal of Molecular Sciences doi: 10.3390/ijms21031095 Authors: Moretti Caruso The arteriosclerosis-dependent alteration of brain perfusion is one of the major determinants in small vessel disease, since small vessels have a pivotal role in the brain’s autoregulation. Nevertheless, as far as we know, endothelium distress can potentiate the flow dysregulation...
Fri Feb 07, 2020 02:00
IJNS, Vol. 6, Pages 10: Incorporation of Second-Tier Biomarker Testing Improves the Specificity of Newborn Screening for Mucopolysaccharidosis Type I International Journal of Neonatal Screening doi: 10.3390/ijns6010010 Authors: Peck Lacey White Pino Studinski Fisher Ahmad Spencer Viall Shallow Siemon Hamm Murray Jones Gavrilov Oglesbee Raymond Matern Rinaldo Tortorelli Enzyme-based newborn screening for Mucopolysaccharidosis...
Fri Feb 07, 2020 02:00
IJNS, Vol. 6, Pages 9: The First Year Experience of Newborn Screening for Pompe Disease in California International Journal of Neonatal Screening doi: 10.3390/ijns6010009 Authors: Tang Feuchtbaum Sciortino Matteson Mathur Bishop Olney The California Department of Public Health started universal newborn screening for Pompe disease in August 2018 with a two-tier process including: 1) acid alpha-glucosidase (GAA) enzyme activity assay followed by, 2) GAA gene sequencing...
Fri Feb 07, 2020 02:00
JCM, Vol. 9, Pages 481: Acute Alcohol Effects on Response Inhibition Depend on Response Automatization, but not on GABA or Glutamate Levels in the ACC and Striatum Journal of Clinical Medicine doi: 10.3390/jcm9020481 Authors: Wiebke Bensmann Nicolas Zink Annett Werner Christian Beste Ann-Kathrin Stock Alcohol increases GABAergic signaling and decreases glutamatergic signaling in the brain. Variations in these neurotransmitter levels may modulate/predict executive functioning....
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JCM, Vol. 9, Pages 478: Osteo-Compatibility of 3D Titanium Porous Coating Applied by Direct Energy Deposition (DED) for a Cementless Total Knee Arthroplasty Implant: in Vitro and in Vivo Study Journal of Clinical Medicine doi: 10.3390/jcm9020478 Authors: Ryu Ban Jung Sonn Hong Ahmad Gweon Lim Wang : Direct energy deposition (DED) technology has gained increasing attention as a new implant surface technology that replicates the porous structure of natural...
Sun Feb 09, 2020 02:00
JCM, Vol. 9, Pages 480: Clinical Performance of Zygomatic Implants—Retrospective Multicenter Study Journal of Clinical Medicine doi: 10.3390/jcm9020480 Authors: Ruben Davó Simonas Bankauskas Remigijus Laurincikas Ismail Doruk Koçyigit José Eduardo Mate Sanchez de Val The main objective of this analysis was to evaluate (1) implant survival, (2) biologic complications, and (3) demographics associated with zygomatic implants placed according to the zygomatic anatomy-guided approach...
Sun Feb 09, 2020 02:00
JCM, Vol. 9, Pages 477: Effects of Physical Exercises and Verbal Stimulation on the Functional Efficiency and Use of Free Time in an Older Population under Institutional Care: A Randomized Controlled Trial Journal of Clinical Medicine doi: 10.3390/jcm9020477 Authors: Wiśniowska-Szurlej Ćwirlej-Sozańska Wołoszyn Sozański Wilmowska-Pietruszyńska Older people in institutional care are, for the most part, physically inactive and do not interact with each other or medical...
Sun Feb 09, 2020 02:00
JCM, Vol. 9, Pages 479: Role of Endogenous Regulators of Hem- And Lymphangiogenesis in Corneal Transplantation Journal of Clinical Medicine doi: 10.3390/jcm9020479 Authors: Clahsen Büttner Hatami Reis Cursiefen Under normal conditions, the cornea, being the transparent “windscreen” of the eye, is free of both blood and lymphatic vessels. However, various diseases of the eye, like infections, can interfere with the balance between promoting and inhibiting...
Sun Feb 09, 2020 02:00
JCM, Vol. 9, Pages 476: Pilot Study of Aerosolised Plus Intravenous Vancomycin in Mechanically Ventilated Patients with Methicillin-Resistant Staphylococcus Aureus Pneumonia Journal of Clinical Medicine doi: 10.3390/jcm9020476 Authors: Jun Yeun Cho Hyung-Sook Kim Hye-Joo Yang Yeon Joo Lee Jong Sun Park Ho Il Yoon Hong Bin Kim Jae-Joon Yim Jae-Ho Lee Choon-Taek Lee Young-Jae Cho Treatment of methicillin-resistant Staphylococcus aureus (MRSA) pneumonia in...
Sun Feb 09, 2020 02:00
JCM, Vol. 9, Pages 474: Strength of the Association of Elevated Vitamin B12 and Solid Cancers: An Adjusted Case-Control Study Journal of Clinical Medicine doi: 10.3390/jcm9020474 Authors: Geoffrey Urbanski Jean-François Hamel Benoît Prouveur Cédric Annweiler Alaa Ghali Julien Cassereau Pierre Lozac’h Christian Lavigne Valentin Lacombe The association between elevated plasma vitamin B12 (B12) level and solid cancers has been documented by two national registries....
Sun Feb 09, 2020 02:00
JCM, Vol. 9, Pages 475: Electrochemical Disinfection of Dental Implants Experimentally Contaminated with Microorganisms as a Model for Periimplantitis Journal of Clinical Medicine doi: 10.3390/jcm9020475 Authors: Koch Göltz Xiangjun Karl Rosiwal Burkovski Despite several methods having been described for disinfecting implants affected by periimplantitis, none of these are universally effective and may even alter surfaces and mechanical properties of implants. Boron-doped...
Sun Feb 09, 2020 02:00
JCM, Vol. 9, Pages 473: Sirtuin 1: Endocan and Sestrin 2 in Different Biological Samples in Patients with Asthma. Does Severity Make the Difference? Journal of Clinical Medicine doi: 10.3390/jcm9020473 Authors: Zoe Tsilogianni Jonathan R Baker Anastasia Papaporfyriou Andrianna I Papaioannou Evgenia Papathanasiou Nikolaos G Koulouris Leah Daly Kazuhiro Ito Georgios Hillas Spyridon Papiris Petros Bakakos Stelios Loukides Background: Sestrin 2, Endocan,...
Sun Feb 09, 2020 02:00
JCM, Vol. 9, Pages 469: Association of rs699947 (−2578 C/A) and rs2010963 (−634 G/C) Single Nucleotide Polymorphisms of the VEGF Gene, VEGF-A and Leptin Serum Level, and Cardiovascular Risk in Patients with Excess Body Mass: A Case–Control Study Journal of Clinical Medicine doi: 10.3390/jcm9020469 Authors: Skrypnik Mostowska Jagodziński Bogdański Background: Two single nucleotide polymorphisms (SNPs) of the VEGF gene, rs699947 and rs2010963, are responsible for differentiated...
Sat Feb 08, 2020 02:00
JCM, Vol. 9, Pages 471: Mechanisms of Testicular Disruption from Exposure to Bisphenol A and Phtalates Journal of Clinical Medicine doi: 10.3390/jcm9020471 Authors: Pallotti Pelloni Gianfrilli Lenzi Lombardo Paoli Great attention has been paid in recent years to the harmful effects of various chemicals that interfere with our natural hormone balance, collectively known as endocrine-disrupting chemicals (EDCs) or endocrine disruptors. The effects on the reproductive...
Sat Feb 08, 2020 02:00
JCM, Vol. 9, Pages 470: Regulation of Oligodendrocyte Functions: Targeting Lipid Metabolism and Extracellular Matrix for Myelin Repair Journal of Clinical Medicine doi: 10.3390/jcm9020470 Authors: Marangon Boccazzi Lecca Fumagalli : Myelin is an essential structure that protects axons, provides metabolic support to neurons and allows fast nerve transmission. Several neurological diseases, such as multiple sclerosis, are characterized by myelin damage, which is responsible...
Sat Feb 08, 2020 02:00
JCM, Vol. 9, Pages 472: Matrix Metalloproteinases in Diabetic Kidney Disease Journal of Clinical Medicine doi: 10.3390/jcm9020472 Authors: Garcia-Fernandez Jacobs-Cachá Mora-Gutiérrez Vergara Orbe Soler Around the world diabetic kidney disease (DKD) is the main cause of chronic kidney disease (CKD), which is characterized by mesangial expansion, glomerulosclerosis, tubular atrophy, and interstitial fibrosis. The hallmark of the pathogenesis of DKD is an increased...
Sat Feb 08, 2020 02:00
JCM, Vol. 9, Pages 468: Microglial Function in the Effects of Early-Life Stress on Brain and Behavioral Development Journal of Clinical Medicine doi: 10.3390/jcm9020468 Authors: Catale Gironda Iacono Carola The putative effects of early-life stress (ELS) on later behavior and neurobiology have been widely investigated. Recently, microglia have been implicated in mediating some of the effects of ELS on behavior. In this review, findings from preclinical and clinical literature...
Sat Feb 08, 2020 02:00
JCM, Vol. 9, Pages 467: Objective Assessment of Counselling for Fetal Heart Defects: An Interdisciplinary Multicenter Study Journal of Clinical Medicine doi: 10.3390/jcm9020467 Authors: Alexander Kovacevic Stefan Bär Sebastian Starystach Andreas Simmelbauer Michael Elsässer Andreas Müller Aida Mohammadi Motlagh Renate Oberhoffer-Fritz Eva Ostermayer Peter Ewert Matthias Gorenflo Annette Wacker-Gussmann The objective of this study was to analyze parental...
Sat Feb 08, 2020 02:00
JCM, Vol. 9, Pages 466: Saliva and Oral Diseases Journal of Clinical Medicine doi: 10.3390/jcm9020466 Authors: Emanuela Martina Anna Campanati Federico Diotallevi Annamaria Offidani Saliva is a fascinating biological fluid which has all the features of a perfect diagnostic tool. In fact, its collection is rapid, simple, and noninvasive. Thanks to several transport mechanisms and its intimate contact with crevicular fluid, saliva contains hundreds of proteins deriving from plasma....
Sat Feb 08, 2020 02:00
JCM, Vol. 9, Pages 463: Left Atrial Volumetric and Deformation Analysis in Adult Patients with Dextro-Transposition of the Great Arteries (Insights from the CSONGRAD Registry and MAGYAR-Path Study) Journal of Clinical Medicine doi: 10.3390/jcm9020463 Authors: Nemes Rácz Kormányos Domsik Kalapos Gyenes Ambrus Bogáts Hartyánszky Havasi Background: In complete or dextro-transposition of the great arteries (dTGA), the aorta and the pulmonary artery are...
Fri Feb 07, 2020 02:00
JCM, Vol. 9, Pages 465: Whole Genome Sequencing Results Associated with Minimum Inhibitory Concentrations of 14 Anti-Tuberculosis Drugs among Rifampicin-Resistant Isolates of Mycobacterium Tuberculosis from Iran Journal of Clinical Medicine doi: 10.3390/jcm9020465 Authors: Kardan-Yamchi Kazemian Battaglia Abtahi Foroushani Hamzelou Cirillo Ghodousi Feizabadi Accurate and timely detection of drug resistance can minimize the risk of further resistance development...
Fri Feb 07, 2020 02:00
JCM, Vol. 9, Pages 461: Body Weight as a Determining Factor in the Predominance of Adverse Drug Reactions Induced by Fixed-Dose Adalimumab Injections in Female Patients in a Korean Hospital Setting Journal of Clinical Medicine doi: 10.3390/jcm9020461 Authors: Kim Choi Moon Kim Adalimumab is used at 40-mg dose to treat systemic inflammatory diseases. Given the impact of adverse drug reactions (ADRs), which particularly result in the discontinuation of adalimumab therapy in...
Fri Feb 07, 2020 02:00
JCM, Vol. 9, Pages 462: Estimation of the Transmission Risk of the 2019-nCoV and Its Implication for Public Health Interventions Journal of Clinical Medicine doi: 10.3390/jcm9020462 Authors: Tang Wang Li Bragazzi Tang Xiao Wu Since the emergence of the first cases in Wuhan, China, the novel coronavirus (2019-nCoV) infection has been quickly spreading out to other provinces and neighboring countries. Estimation of the basic reproduction number by means of mathematical...
Fri Feb 07, 2020 02:00
JCM, Vol. 9, Pages 464: The Clinical Impact of Flow Titration on Epoprostenol Delivery via High Flow Nasal Cannula for ICU Patients with Pulmonary Hypertension or Right Ventricular Dysfunction: A Retrospective Cohort Comparison Study Journal of Clinical Medicine doi: 10.3390/jcm9020464 Authors: Li Gurnani Roberts Fink Vines (1) Background: inhaled epoprostenol (iEPO) delivered via high-flow nasal cannula (HFNC) has been reported to be effective for pulmonary hypertension...
Fri Feb 07, 2020 02:00
JCM, Vol. 9, Pages 457: Prevalence of Bacteria of Genus Actinomyces in Persistent Extraradicular Lesions—Systematic Review Journal of Clinical Medicine doi: 10.3390/jcm9020457 Authors: Mario Dioguardi Vito Crincoli Luigi Laino Mario Alovisi Diego Sovereto Lorenzo Lo Muzio Giuseppe Troiano Actinomyces are anaerobic, rod-shaped, Gram-positive bacteria. They are associated with persistent extraradicular endodontic infections, with possible involvement of the soft tissues...
Fri Feb 07, 2020 02:00
JCM, Vol. 9, Pages 458: Inflammatory Targets in Diabetic Nephropathy Journal of Clinical Medicine doi: 10.3390/jcm9020458 Authors: Donate-Correa Luis-Rodríguez Martín-Núñez Tagua Hernández-Carballo Ferri Rodríguez-Rodríguez Mora-Fernández Navarro-González One of the most frequent complications in patients with diabetes mellitus is diabetic nephropathy (DN). At present, it constitutes the first cause of end stage renal disease, and the main cause of cardiovascular...
Fri Feb 07, 2020 02:00
JCM, Vol. 9, Pages 460: An Introduction to High Intensity Focused Ultrasound: Systematic Review on Principles, Devices, and Clinical Applications Journal of Clinical Medicine doi: 10.3390/jcm9020460 Authors: Izadifar Izadifar Chapman Babyn Ultrasound can penetrate deep into tissues and interact with human tissue via thermal and mechanical mechanisms. The ability to focus an ultrasound beam and its energy onto millimeter-size targets was a significant milestone in the development...
Fri Feb 07, 2020 02:00
JCM, Vol. 9, Pages 459: Application of Fisetin to the Quantitation of Serum Albumin Journal of Clinical Medicine doi: 10.3390/jcm9020459 Authors: Park Do Seo Duong Ahn Huh Lee Fisetin (3,3′,4′,7-tetrahydroxyflavone) is a widely distributed natural flavonol. It interacts with albumin, and thereby generates a fluorescence signal quantitatively. Based on such optical characteristics, we postulated that fisetin was applicable to the quantitation...
Fri Feb 07, 2020 02:00
JCM, Vol. 9, Pages 456: GDNF, A Neuron-Derived Factor Upregulated in Glial Cells during Disease Journal of Clinical Medicine doi: 10.3390/jcm9020456 Authors: Marcelo Duarte Azevedo Sibilla Sander Liliane Tenenbaum In a healthy adult brain, glial cell line-derived neurotrophic factor (GDNF) is exclusively expressed by neurons, and, in some instances, it has also been shown to derive from a single neuronal subpopulation. Secreted GDNF acts in a paracrine fashion by forming a complex...
Fri Feb 07, 2020 02:00
Life, Vol. 10, Pages 14: Synthetic Biology for Terraformation Lessons from Mars, Earth, and the Microbiome Life doi: 10.3390/life10020014 Authors: Nuria Conde-Pueyo Blai Vidiella Josep Sardanyés Miguel Berdugo Fernando T. Maestre Victor de De Lorenzo Ricard Solé What is the potential for synthetic biology as a way of engineering, on a large scale, complex ecosystems? Can it be used to change endangered ecological communities and rescue them to prevent their collapse?...
Sun Feb 09, 2020 02:00
Medicina, Vol. 56, Pages 67: Safety and Tolerability of Ketamine Use in Treatment-Resistant Bipolar Depression Patients with Regard to Central Nervous System Symptomatology: Literature Review and Analysis Medicina doi: 10.3390/medicina56020067 Authors: Adam Włodarczyk Wiesław Jerzy Cubała The current psychopharmacological treatment approaches for major depression focus on monoaminergic interventions, which are ineffective in a large proportion of patients. Globally, treatment-resistant...
Sun Feb 09, 2020 02:00
Medicina, Vol. 56, Pages 66: Quality of Life in Patients with Surgically Removed Skin Tumors Medicina doi: 10.3390/medicina56020066 Authors: Răducu Avino Purnichescu Purtan Balcangiu-Stroescu Bălan Timofte Ionescu Jecan Background and Objectives: Skin cancer is one of the most frequently diagnosed malignancies. The main goal of the therapeutic management is total excision with the prevention of recurrence and metastasis. The quality of life of the patients...
Sun Feb 09, 2020 02:00
Medicina, Vol. 56, Pages 65: Evaluation of Pain Management after Surgery: An Observational Study Medicina doi: 10.3390/medicina56020065 Authors: Regina Sierżantowicz Jolanta Lewko Dorota Bitiucka Karolina Lewko Bianka Misiak Jerzy Robert Ładny Background and Objectives: Choosing a pain management strategy is essential for improving recovery after surgery. Effective pain management reduces the stress response, facilitates mobilization, and improves the quality of the postoperative...
Fri Feb 07, 2020 02:00
Membranes, Vol. 10, Pages 27: Permeation Properties of Ions through Inorganic Silica-Based Membranes
Membranes, Vol. 10, Pages 27: Permeation Properties of Ions through Inorganic Silica-Based Membranes Membranes doi: 10.3390/membranes10020027 Authors: Junko Yoshiura Katsunori Ishii Yuta Saito Takaya Nagataki Yuhei Nagataki Ayumi Ikeda Mikihiro Nomura The development of inorganic membranes has mainly found applicability in liquid separation technologies. However, only a few reports cite the permeation and separation of liquids through inorganic nanofiltration membranes...
Sat Feb 08, 2020 02:00
Membranes, Vol. 10, Pages 26: Control of Sequential MTO Reactions through an MFI-Type Zeolite Membrane Contactor Membranes doi: 10.3390/membranes10020026 Authors: Tanizume Yoshimura Ishii Nomura A membrane for controlling methanol-to-olefin (MTO) reactions was developed, which featured an MFI-type zeolite membrane (Si/Al = 25) that was synthesized on a porous α-alumina substrate using a secondary growth method. Here, the H2/SF6 permeance ratios were between 150...
Fri Feb 07, 2020 02:00
Metabolites, Vol. 10, Pages 60: Systemic Effects of Radiotherapy and Concurrent Chemo-Radiotherapy in Head and Neck Cancer Patients—Comparison of Serum Metabolome Profiles Metabolites doi: 10.3390/metabo10020060 Authors: Jelonek Krzywon Jablonska Slominska Smolenski Polanska Rutkowski Mrochem-Kwarciak Skladowski Widlak Anticancer treatment induces systemic molecular changes that could be detected at the level of biofluids. Understanding how human...
Fri Feb 07, 2020 02:00
Metabolites, Vol. 10, Pages 59: TGF-ß1 Induces Changes in the Energy Metabolism of White Adipose Tissue-Derived Human Adult Mesenchymal Stem/Stromal Cells In Vitro Metabolites doi: 10.3390/metabo10020059 Authors: Hahn Ingwersen Soliman Hamed Fuellen Wolfien Scheel Wolkenhauer Koczan Kamp Peters Adipose tissue plays an active role in the regulation of the body´s energy balance. Mesenchymal stem/stromal cells from adipose tissue (adMSC)...
Fri Feb 07, 2020 02:00
Microorganisms, Vol. 8, Pages 233: High Throughput Sediment DNA Sequencing Reveals Azo Dye Degrading Bacteria Inhabit Nearshore Sediments Microorganisms doi: 10.3390/microorganisms8020233 Authors: Zhuang Sanganyado Xu Zhu Li Liu Estuaries and coastal environments are often regarded as a critical resource for the bioremediation of organic pollutants such as azo dyes due to their high abundance and diversity of extremophiles. Bioremediation through the activities of...
Sun Feb 09, 2020 02:00
Microorganisms, Vol. 8, Pages 232: In Vitro and Ex Vivo Antibiofilm Activity of a Lipopeptide Biosurfactant Produced by the Entomopathogenic Beauveria bassiana Strain against Microsporum canis Microorganisms doi: 10.3390/microorganisms8020232 Authors: Abdel-Aziz Al-Omar Mohammed Emam Microsporum canis is one of the most important dermatophyte causing tinea corporis and tinea capitis and its biofilm-form has a poor therapeutic response. The biosurfactant production by entomopathogenic...
Sun Feb 09, 2020 02:00
Microorganisms, Vol. 8, Pages 231: Synchrony Degree of Dietary Energy and Nitrogen Release Influences Microbial Community, Fermentation, and Protein Synthesis in a Rumen Simulation System Microorganisms doi: 10.3390/microorganisms8020231 Authors: Zhang Zheng Shen Zhao Wang Synchrony of energy and nitrogen release in rumen has been proposed to maximize ruminal microbial fermentation. However, the information regarding bacterial community composition and its metabolism...
Sun Feb 09, 2020 02:00
Microorganisms, Vol. 8, Pages 229: The Secretion of Toxins and Other Exoproteins of Cronobacter: Role in Virulence, Adaption, and Persistence Microorganisms doi: 10.3390/microorganisms8020229 Authors: Jang Gopinath Eshwar Srikumar Nguyen Gangiredla Patel Finkelstein Negrete Woo Lee Fanning Stephan Tall Lehner : Cronobacter species are considered an opportunistic group of foodborne pathogenic bacteria capable of causing both intestinal...
Sat Feb 08, 2020 02:00
Microorganisms, Vol. 8, Pages 230: Formation of Common Mycorrhizal Networks Significantly Affect Plant Biomass and Soil Properties of the Neighboring Plants under Various Nitrogen Levels Microorganisms doi: 10.3390/microorganisms8020230 Authors: Muneer Wang Zhang Li Munir Ji Common mycorrhizal networks (CMNs) allow the transfer of nutrients between plants, influencing the growth of the neighboring plants and soil properties. Cleistogene squarrosa (C. squarrosa) is...
Sat Feb 08, 2020 02:00
Microorganisms, Vol. 8, Pages 228: Cording Mycobacterium tuberculosis Bacilli Have a Key Role in the Progression towards Active Tuberculosis, Which is Stopped by Previous Immune Response Microorganisms doi: 10.3390/microorganisms8020228 Authors: Arias Cardona Català Campo-Pérez Prats Vilaplana Julián Cardona Cording was the first virulence factor identified in Mycobacterium tuberculosis (Mtb). We aimed to ascertain its role in the induction of active tuberculosis...
Sat Feb 08, 2020 02:00
Microorganisms, Vol. 8, Pages 227: The Pattern and Function of DNA Methylation in Fungal Plant Pathogens Microorganisms doi: 10.3390/microorganisms8020227 Authors: He Zhang Li Tian To successfully infect plants and trigger disease, fungal plant pathogens use various strategies that are dependent on characteristics of their biology and genomes. Although pathogenic fungi are different from animals and plants in the genomic heritability, sequence feature, and epigenetic modification,...
Sat Feb 08, 2020 02:00
Microorganisms, Vol. 8, Pages 226: Characterization of Fungal Endophytes Isolated from the Metal Hyperaccumulator Plant Vachellia farnesiana Growing in Mine Tailings Microorganisms doi: 10.3390/microorganisms8020226 Authors: Salazar-Ramírez Flores-Vallejo Rivera-Leyva Tovar-Sánchez Sánchez-Reyes Mena-Portales Sánchez-Carbente Gaitán-Rodríguez Batista-García Villarreal Mussali-Galante Folch-Mallol Heavy metal pollution has become an environmental...
Sat Feb 08, 2020 02:00
Microorganisms, Vol. 8, Pages 225: Diversity and Bioactive Potential of Actinobacteria from Unexplored Regions of Western Ghats, India Microorganisms doi: 10.3390/microorganisms8020225 Authors: Siddharth Vittal Wink Steinert The search for novel bioactive metabolites continues to be of much importance around the world for pharmaceutical, agricultural, and industrial applications. Actinobacteria constitute one of the extremely interesting groups of microorganisms widely used...
Fri Feb 07, 2020 02:00
Microorganisms, Vol. 8, Pages 224: Host Innate Immune Response of Geese Infected with Clade 2.3.4.4 H5N6 Highly Pathogenic Avian Influenza Viruses Microorganisms doi: 10.3390/microorganisms8020224 Authors: Wu Huang Huang Zhang Liu Xue Li Liao Jiao Since 2014, highly pathogenic avian influenza (HPAI) H5N6 viruses have circulated in waterfowls and caused human infections in China, posing significant threats to the poultry industry and the public health....
Fri Feb 07, 2020 02:00
Microorganisms, Vol. 8, Pages 222: Prevalence, Population Diversity and Antimicrobial Resistance of Campylobacter coli Isolated in Italian Swine at Slaughterhouse Microorganisms doi: 10.3390/microorganisms8020222 Authors: Di Donato Marotta Nuvoloni Zilli Neri Di Sabatino Calistri Di Giannatale Campylobacter spp. are among the microorganisms most commonly associated with foodborne disease. Swine are known to be the main reservoir of Campylobacter coli and...
Fri Feb 07, 2020 02:00
Microorganisms, Vol. 8, Pages 223: Enhanced Cypermethrin Degradation Kinetics and Metabolic Pathway in Bacillus thuringiensis Strain SG4 Microorganisms doi: 10.3390/microorganisms8020223 Authors: Bhatt Huang Zhang Sharma Chen Cypermethrin is popularly used as an insecticide in households and agricultural fields, resulting in serious environmental contamination. Rapid and effective techniques that minimize or remove insecticidal residues from the environment are urgently...
Fri Feb 07, 2020 02:00
Molecules, Vol. 25, Pages 756: An Interpenetrating Alginate/Gelatin Network for Three-Dimensional (3D) Cell Cultures and Organ Bioprinting Molecules doi: 10.3390/molecules25030756 Authors: Qiuhong Chen Xiaohong Tian Jun Fan Hao Tong Qiang Ao Xiaohong Wang Crosslinking is an effective way to improve the physiochemical and biochemical properties of hydrogels. In this study, we describe an interpenetrating polymer network (IPN) of alginate/gelatin hydrogels (i.e., A-G-IPN)...
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Molecules, Vol. 25, Pages 754: Effect of Polyvinyl Alcohol on the Rheological Properties of Cement Mortar Molecules doi: 10.3390/molecules25030754 Authors: Fang Liu Baomin Wang Yunqing Xing Kunkun Zhang Wei Jiang Polyvinyl alcohol (PVA) is a kind of water-soluble polymer, which has been widely used in different industries due to its excellent mechanical and chemical properties. In this paper, the effects of polyvinyl alcohol with different hydrolysis and polymerization degrees...
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Molecules, Vol. 25, Pages 755: An Optimised Di-Boronate-ChemMatrix Affinity Chromatography to Trap Deoxyfructosylated Peptides as Biomarkers of Glycation Molecules doi: 10.3390/molecules25030755 Authors: Monika Kijewska Francesca Nuti Magdalena Wierzbicka Mateusz Waliczek Patrycja Ledwoń Agnieszka Staśkiewicz Feliciana Real-Fernandez Giuseppina Sabatino Paolo Rovero Piotr Stefanowicz Zbigniew Szewczuk Anna Maria Papini We report herein a novel ChemMatrix®...
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Molecules, Vol. 25, Pages 753: Melatonin Accumulation in Sweet Cherry and Its Influence on Fruit Quality and Antioxidant Properties Molecules doi: 10.3390/molecules25030753 Authors: Hui Xia Yanqiu Shen Tian Shen Xin Wang Xuefeng Zhang Peng Hu Dong Liang Lijin Lin Honghong Deng Jin Wang Qunxian Deng Xiulan Lv Although the effects of melatonin on plant abiotic and biotic stress resistance have been explored in recent decades, the accumulation of endogenous...
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Molecules, Vol. 25, Pages 752: Analytical Approaches for Analysis of Safety of Modern Food Packaging: A Review Molecules doi: 10.3390/molecules25030752 Authors: Magdalena Wrona Cristina Nerín Nowadays, food packaging is a crucial tool for preserving food quality and has become an inseparable part of our daily life. Strong consumer demand and market trends enforce more advanced and creative forms of food packaging. New packaging development requires safety evaluations that always implicate...
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Molecules, Vol. 25, Pages 751: Organic Salts of p-Coumaric Acid and Trans-Ferulic Acid with Aminopicolines Molecules doi: 10.3390/molecules25030751 Authors: Sosthene Nyomba Kamanda Ayesha Jacobs p-Coumaric acid (pCA) and trans-ferulic acid (TFA) were co-crystallised with 2-amino-4-picoline (2A4MP) and 2-amino-6-picoline (2A6MP) producing organic salts of (pCA−)(2A4MP+) (1), (pCA̶ )(2A6MP+) (2) and (TFA̶ )(2A4MP+)·( 3 2 H2O) (3). For salt 3, water was included...
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Molecules, Vol. 25, Pages 750: Assessment of the Quality of Polluted Areas in Northwest Romania Based on the Content of Elements in Different Organs of Grapevine (Vitis vinifera L.) Molecules doi: 10.3390/molecules25030750 Authors: Bora Bunea Chira Bunea The purpose of this study was to evaluate the environmental quality of polluted areas near the Baia Mare Mining and Smelting Complex for future improvements the quality of the environment in polluted areas, such as the city...
Sun Feb 09, 2020 02:00
Molecules, Vol. 25, Pages 749: Health Properties and Composition of Honeysuckle Berry Lonicera caerulea L. An Update on Recent Studies Molecules doi: 10.3390/molecules25030749 Authors: Gołba Sokół-Łętowska Kucharska Lonicera caerulea L., also known as haskap or honeysuckle berry, is a fruit commonly planted in eastern Europe, Canada and Asia. The fruit was registered as a traditional food from a third country under European Union regulations only on December 2018. It is resistant...
Sun Feb 09, 2020 02:00
Molecules, Vol. 25, Pages 748: Recent Advances in Copper Catalyzed Alcohol Oxidation in Homogeneous Medium Molecules doi: 10.3390/molecules25030748 Authors: Silva Martins The development of sustainable processes and products through innovative catalytic materials and procedures that allow a better use of resources is undoubtedly one of the most significant issues facing researchers nowadays. Environmental and economically advanced catalytic processes for selective oxidation of alcohols...
Sun Feb 09, 2020 02:00
Molecules, Vol. 25, Pages 746: A Novel Dimeric Exoglucanase (GH5_38): Biochemical and Structural Characterisation towards its Application in Alkyl Cellobioside Synthesis Molecules doi: 10.3390/molecules25030746 Authors: Mpho S. Mafa Heinrich W. Dirr Samkelo Malgas Rui W. M. Krause Konanani Rashamuse Brett I. Pletschke An exoglucanase (Exg-D) from the glycoside hydrolase family 5 subfamily 38 (GH5_38) was heterologously expressed and structurally and biochemically characterised...
Sun Feb 09, 2020 02:00
Molecules, Vol. 25, Pages 745: The Pharmaceutical Industry in 2019. An Analysis of FDA Drug Approvals from the Perspective of Molecules Molecules doi: 10.3390/molecules25030745 Authors: Beatriz G. de la Torre Fernando Albericio During 2019, the US Food and Drug Administration (FDA) approved 48 new drugs (38 New Chemical Entities and 10 Biologics). Although this figure is slightly lower than that registered in 2018 (59 divided between 42 New Chemical Entities and 17 Biologics), a year...
Sun Feb 09, 2020 02:00
Molecules, Vol. 25, Pages 747: Selection of Aptamers Specific for DEHP Based on ssDNA Library Immobilized SELEX and Development of Electrochemical Impedance Spectroscopy Aptasensor Molecules doi: 10.3390/molecules25030747 Authors: Lu Liu Hou Yuan Li Chen A selection of aptamers specific for di(2-ethylhexyl) phthalate (DEHP) and development of electrochemical impedance spectroscopy (EIS) aptasensor are described in this paper. The aptamers were selected from an immobilized...
Sun Feb 09, 2020 02:00
Molecules, Vol. 25, Pages 744: Identification and Characterization of Nnematicidal Volatile Organic Compounds from Deep-Sea Virgibacillus dokdonensis MCCC 1A00493 Molecules doi: 10.3390/molecules25030744 Authors: Dian Huang Chen Yu Zongze Shao Minmin Cai Guangyu Li Longyu Zheng Ziniu Yu Jibin Zhang Root-knot nematode diseases cause severe yield and economic losses each year in global agricultural production. Virgibacillus dokdonensis MCCC 1A00493, a deep-sea bacterium,...
Sun Feb 09, 2020 02:00
Molecules, Vol. 25, Pages 743: Temperature Effect on the Adsorption and Volumetric Properties of Aqueous Solutions of Kolliphor®ELP Molecules doi: 10.3390/molecules25030743 Authors: Szymczyk Szaniawska Krawczyk Density, viscosity and surface tension of Kolliphor® ELP, the nonionic surfactant aqueous solutions were measured at temperature T = 293–318 K and at 5K interval. Steady-state fluorescence measurements have been also made using pyrene as a probe. On...
Sun Feb 09, 2020 02:00
Molecules, Vol. 25, Pages 741: Synthesis, Structural, and Cytotoxic Properties of New Water-Soluble Copper(II) Complexes based on 2,9-Dimethyl-1,10-Phenanthroline and Their One Derivative Containing 1,3,5-Triaza-7-Phosphaadamantane-7-Oxide Molecules doi: 10.3390/molecules25030741 Authors: Śliwa Śliwińska-Hill Bażanów Siczek Kłak Smoleński A series of water-soluble copper(II) complexes based on 2,9-dimethyl-1,10-phenanthroline (dmphen) and mixed-ligands, containing...
Sat Feb 08, 2020 02:00
Molecules, Vol. 25, Pages 742: Sterically Stabilised Polymeric Mesoporous Silica Nanoparticles Improve Doxorubicin Efficiency: Tailored Cancer Therapy Molecules doi: 10.3390/molecules25030742 Authors: Moodley Singh The fruition, commercialisation and clinical application combining nano-engineering, nanomedicine and material science for utilisation in drug delivery is becoming a reality. The successful integration of nanomaterial in nanotherapeutics requires their critical development...
Sat Feb 08, 2020 02:00
Molecules, Vol. 25, Pages 740: Ultrasound and Radiation-Induced Catalytic Oxidation of 1-Phenylethanol to Acetophenone with Iron-Containing Particulate Catalysts Molecules doi: 10.3390/molecules25030740 Authors: Mohamed M. A. Soliman Maximilian N. Kopylovich Elisabete C. B. A. Alegria Ana P. C. Ribeiro Ana M. Ferraria Ana M. Botelho do Rego Luís M. M. Correia Marta S. Saraiva Armando J. L. Pombeiro Iron-containing particulate catalysts of 0.1–1 µm...
Sat Feb 08, 2020 02:00
Molecules, Vol. 25, Pages 738: Current Approaches to and Future Perspectives on Methomyl Degradation in Contaminated Soil/Water Environments Molecules doi: 10.3390/molecules25030738 Authors: Ziqiu Lin Wenping Zhang Shimei Pang Yaohua Huang Sandhya Mishra Pankaj Bhatt Shaohua Chen Methomyl is a broad-spectrum oxime carbamate commonly used to control arthropods, nematodes, flies, and crop pests. However, extensive use of this pesticide in agricultural practices has led...
Sat Feb 08, 2020 02:00
Molecules, Vol. 25, Pages 737: Spider Silk for Tissue Engineering Applications Molecules doi: 10.3390/molecules25030737 Authors: Sahar Salehi Kim Koeck Thomas Scheibel Due to its properties, such as biodegradability, low density, excellent biocompatibility and unique mechanics, spider silk has been used as a natural biomaterial for a myriad of applications. First clinical applications of spider silk as suture material go back to the 18th century. Nowadays, since natural production...
Sat Feb 08, 2020 02:00
Molecules, Vol. 25, Pages 739: Towards an Understanding of the Mode of Action of Human Aromatase Activity for Azoles through Quantum Chemical Descriptors-Based Regression and Structure Activity Relationship Modeling Analysis Molecules doi: 10.3390/molecules25030739 Authors: Chayawan Chayawan Cosimo Toma Emilio Benfenati Ana Y. Caballero Alfonso Aromatase is an enzyme member of the cytochrome P450 superfamily coded by the CYP19A1 gene. Its main action is the conversion of androgens...
Sat Feb 08, 2020 02:00
Molecules, Vol. 25, Pages 735: Peptide Nucleic Acids and Gene Editing: Perspectives on Structure and Repair Molecules doi: 10.3390/molecules25030735 Authors: Nicholas G. Economos Stanley Oyaghire Elias Quijano Adele S. Ricciardi W. Mark Saltzman Peter M. Glazer Unusual nucleic acid structures are salient triggers of endogenous repair and can occur in sequence-specific contexts. Peptide nucleic acids (PNAs) rely on these principles to achieve non-enzymatic gene editing....
Sat Feb 08, 2020 02:00
Molecules, Vol. 25, Pages 736: Smart, Tunable CQDs with Antioxidant Properties for Biomedical Applications—Ecofriendly Synthesis and Characterization Molecules doi: 10.3390/molecules25030736 Authors: Łukasz Janus Julia Radwan-Pragłowska Marek Piątkowski Dariusz Bogdał Carbon quantum dots (CQDs) are nanoobjects of a size below 10 nm. Due to their favorable features, such as tunable luminescence, unique optical properties, water solubility, and lack of cytotoxicity, they are willingly...
Sat Feb 08, 2020 02:00
Molecules, Vol. 25, Pages 733: Synthesis of Bisphenol Neolignans Inspired by Honokiol as Antiproliferative Agents Molecules doi: 10.3390/molecules25030733 Authors: Nunzio Cardullo Vincenza Barresi Vera Muccilli Giorgia Spampinato Morgana D’Amico Daniele Filippo Condorelli Corrado Tringali Honokiol (2) is a natural bisphenol neolignan showing a variety of biological properties, including antitumor activity. Some studies pointed out 2 as a potential anticancer agent in...
Fri Feb 07, 2020 02:00
Molecules, Vol. 25, Pages 727: Regioselective and Stereodivergent Synthesis of Enantiomerically Pure Vic-Diamines from Chiral β-Amino Alcohols with 2-Pyridyl and 6-(2,2′-Bipyridyl) Moieties Molecules doi: 10.3390/molecules25030727 Authors: Marzena Wosińska-Hrydczuk Przemysław J. Boratyński Jacek Skarżewski In this report, we describe the synthetic elaboration of the easily available enantiomerically pure β-amino alcohols. Attempted direct substitution of the hydroxyl group...
Fri Feb 07, 2020 02:00
Molecules, Vol. 25, Pages 734: Flavonoids as Novel Efflux Pump Inhibitors and Antimicrobials against Both Environmental and Pathogenic Intracellular Mycobacterial Species Molecules doi: 10.3390/molecules25030734 Authors: Solnier Martin Bhakta Bucar Therapeutic treatment options for opportunistic non-tuberculous mycobacterial (NTM) infection and/or serious mycobacterial infections such as tuberculosis (TB) and leprosy are limited due to the spread of antimicrobial resistance...
Fri Feb 07, 2020 02:00
Molecules, Vol. 25, Pages 732: Impact of Perovskite Composition on Film Formation Quality and Photophysical Properties for Flexible Perovskite Solar Cells Molecules doi: 10.3390/molecules25030732 Authors: Guangdong Li Xiaoping Zou Jin Cheng Dan Chen Yujun Yao Chuangchuang Chang Xing Yu Zixiao Zhou Junqi Wang Baoyu Liu In recent years, flexible perovskite solar cells have drawn tremendous attention in the field of wearable devices, and optimization of perovskite...
Fri Feb 07, 2020 02:00
Molecules, Vol. 25, Pages 730: Essential Oils as Natural Biocides in Conservation of Cultural Heritage Molecules doi: 10.3390/molecules25030730 Authors: Palla Bruno Mercurio Tantillo Rotolo Essential oils (EOs) have been known for a long time, and they are used in several fields such as medicine and aromatherapy, as well as in the food and pharmaceutical industries. In the last decade, EOs have also been applied to contrast the biodeterioration of cultural heritage,...
Fri Feb 07, 2020 02:00
Molecules, Vol. 25, Pages 729: Brownian Motion and Thermophoresis Effects on MHD Three Dimensional Nanofluid Flow with Slip Conditions and Joule Dissipation Due to Porous Rotating Disk Molecules doi: 10.3390/molecules25030729 Authors: Nasser Aedh Alreshidi Zahir Shah Abdullah Dawar Poom Kumam Meshal Shutaywi Wiboonsak Watthayu This paper examines the time independent and incompressible flow of magnetohydrodynamic (MHD) nanofluid through a porous rotating disc with velocity...
Fri Feb 07, 2020 02:00
Molecules, Vol. 25, Pages 731: Value-Added Lager Beer Enriched with Eggplant (Solanum melongena L.) Peel Extract Molecules doi: 10.3390/molecules25030731 Authors: Georgiana Horincar Elena Enachi Carmen Bolea Gabriela Râpeanu Iuliana Aprodu Manufacturing beer with a high biological value requires identifying new methods for increasing the health-enhancing compounds level. The aim of this study was to increase the biological value of beer by adding antioxidant-rich eggplant...
Fri Feb 07, 2020 02:00
Molecules, Vol. 25, Pages 728: Development of RNA/DNA Hydrogel Targeting Toll-Like Receptor 7/8 for Sustained RNA Release and Potent Immune Activation Molecules doi: 10.3390/molecules25030728 Authors: Fusae Komura Kana Okuzumi Yuki Takahashi Yoshinobu Takakura Makiya Nishikawa Guanosine- and uridine-rich single-stranded RNA (GU-rich RNA) is an agonist of Toll-like receptor (TLR) 7 and TLR8 and induces strong immune responses. A nanostructured GU-rich RNA/DNA assembly prepared...
Fri Feb 07, 2020 02:00
Molecules, Vol. 25, Pages 726: Quality Enhancement Mechanism of Alkali-Free Chinese Northern Steamed Bread by Sourdough Acidification Molecules doi: 10.3390/molecules25030726 Authors: Bowen Yan Huayu Yang Yejun Wu Huizhang Lian Hao Zhang Wei Chen Daming Fan Jianxin Zhao Alkali was used to adjust the pH and neutralize the excess acids of dough in the processing of Chinese northern steamed bread (CNSB). However, extra alkali addition generally resulted in alkalic flavor...
Fri Feb 07, 2020 02:00
Molecules, Vol. 25, Pages 725: GPR6 Structural Insights: Homology Model Construction and Docking Studies Molecules doi: 10.3390/molecules25030725 Authors: Isawi Morales Sotudeh Hurst Lynch Reggio GPR6 is an orphan G protein-coupled receptor that has been associated with the cannabinoid family because of its recognition of a sub-set of cannabinoid ligands. The high abundance of GPR6 in the central nervous system, along with high constitutive activity and a link to...
Fri Feb 07, 2020 02:00
Molecules, Vol. 25, Pages 724: Curcumin, an Active Constituent of Turmeric Spice: Implication in the Prevention of Lung Injury Induced by Benzo(a) Pyrene (BaP) in Rats Molecules doi: 10.3390/molecules25030724 Authors: Almatroodi Alrumaihi Alsahli Alhommrani Khan Rahmani Benzo(a)pyrene (BaP) is a well-known carcinogen and enhances oxidative stress and apoptosis and also alters several molecular pathways. Curcumin is an active ingredient of Curcuma longa, and it has...
Fri Feb 07, 2020 02:00
Molecules, Vol. 25, Pages 722: Microencapsulation of Anthocyanin Extracted from Purple Flesh Cultivated Potatoes by Spray Drying and Its Effects on In Vitro Gastrointestinal Digestion Molecules doi: 10.3390/molecules25030722 Authors: Cristina Vergara María Teresa Pino Olga Zamora Javier Parada Ricardo Pérez Marco Uribe Julio Kalazich Purple flesh cultivated potato (PP) is a foodstuff scarcely cultivated in the world but with high potential because of its anthocyanin...
Fri Feb 07, 2020 02:00
Molecules, Vol. 25, Pages 721: Harnessing Ionic Interactions and Hydrogen Bonding for Nucleophilic Fluorination Molecules doi: 10.3390/molecules25030721 Authors: Oh Choi Park Kim Lee We review recent works for nucleophilic fluorination of organic compounds in which the Coulombic interactions between ionic species and/or hydrogen bonding affect the outcome of the reaction. SN2 fluorination of aliphatic compounds promoted by ionic liquids is first discussed, focusing on...
Fri Feb 07, 2020 02:00
Molecules, Vol. 25, Pages 723: Iron-Catalyzed Cross-Coupling of Bis-(aryl)manganese Nucleophiles with Alkenyl Halides: Optimization and Mechanistic Investigations Molecules doi: 10.3390/molecules25030723 Authors: Rousseau Desaintjean Knochel Lefèvre Various substituted bis-(aryl)manganese species were prepared from aryl bromides by one-pot insertion of magnesium turnings in the presence of LiCl and in situ trans-metalation with MnCl2 in THF at −5 °C within...
Fri Feb 07, 2020 02:00
Molecules, Vol. 25, Pages 716: Microwave Assisted Reactions of Azaheterocycles Formedicinal Chemistry Applications Molecules doi: 10.3390/molecules25030716 Authors: Amariucai-Mantu Mangalagiu Danac Mangalagiu Microwave (MW) assisted reactions have became a powerful tool in azaheterocycles chemistry during the last decades. Five and six membered ring azaheterocycles are privileged scaffolds in modern medicinal chemistry possessing a large variety of biological activity. This...
Fri Feb 07, 2020 02:00
Molecules, Vol. 25, Pages 719: Continuous Flow Esterification of a H-Phosphinic Acid, and Transesterification of H-phosphinates and H-Phosphonates under Microwave Conditions Molecules doi: 10.3390/molecules25030719 Authors: Kiss Henyecz Keglevich The microwave (MW)-assisted direct esterification of phenyl-H-phosphinic acid, transesterification of the alkyl phenyl-H-phosphinates so obtained, and the similar reaction of dibenzyl phosphite (DBP) were investigated in detail, and...
Fri Feb 07, 2020 02:00
Molecules, Vol. 25, Pages 718: Quantification of Residual Perfume by Py-GC-MS in Fragrance Encapsulate Polymeric Materials Intended for Biodegradation Tests Molecules doi: 10.3390/molecules25030718 Authors: Giulio Gasparini Sarah Semaoui Jessica Augugliaro Alain Boschung Damien Berthier Markus Seyfried Frédéric Begnaud Perfume encapsulates are widely used in commercial products to control the kinetic release of odorant molecules, increase storage stability and/or improve...
Fri Feb 07, 2020 02:00
Molecules, Vol. 25, Pages 717: Development of Coumarin-Based Hydroxamates as Histone Deacetylase Inhibitors with Antitumor Activities Molecules doi: 10.3390/molecules25030717 Authors: Zhao Yang Han Qu Ge Zhang Histone deacetylases (HDACs) have been proved to be promising targets for the treatment of cancer, and five histone deacetylase inhibitors (HDACis) have been approved on the market for the treatment of different lymphomas. In our previous work, we designed...
Fri Feb 07, 2020 02:00
Molecules, Vol. 25, Pages 720: Use of Alginate Extracted from Moroccan Brown Algae to Stimulate Natural Defense in Date Palm Roots Molecules doi: 10.3390/molecules25030720 Authors: Bouissil El Alaoui-Talibi Pierre Michaud El Modafar Delattre Our study aimed to search for seaweed polysaccharides able to stimulate date palm defense mechanisms. Extraction, purification, characterization, and elicitor activity of sodium alginate (FSSA and BBSA) from Moroccan brown seaweeds...
Fri Feb 07, 2020 02:00
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