Biomolecules, Vol. 10, Pages 254: Dried Leaf Artemisia Annua Improves Bioavailability of Artemisinin via Cytochrome P450 Inhibition and Enhances Artemisinin Efficacy Downstream Biomolecules doi: 10.3390/biom10020254 Authors: Desrosiers Mittelman Weathers Artemisia annua L. and artemisinin, have been used for millennia to treat malaria. We used human liver microsomes (HLM) and rats to compare hepatic metabolism, tissue distribution, and inflammation attenuation by dried leaves...
Fri Feb 07, 2020 02:00
Biomolecules, Vol. 10, Pages 252: Integrated Analysis of Transcriptomic and Metabolomic Data Reveals the Mechanism by Which LED Light Irradiation Extends the Postharvest Quality of Pak-choi (Brassica campestris L. ssp. chinensis (L.) Makino var. communis Tsen et Lee) Biomolecules doi: 10.3390/biom10020252 Authors: Yan Zuo Zhou Shi Xu Hu Jiang Liu Wang Low-intensity (10 μmol m−2 s−1) white LED (light-emitting diode) light effectively...
Fri Feb 07, 2020 02:00
Biomolecules, Vol. 10, Pages 257: Proteomic Analysis of Human Serum from Patients with Chronic Kidney Disease Biomolecules doi: 10.3390/biom10020257 Authors: Romanova Laikov Markelova Khadiullina Makseev Hasanova Rizvanov Khaiboullina Salafutdinov Chronic kidney disease (CKD) is an important public health problem in the world. The aim of our research was to identify novel potential serum biomarkers of renal injury. ELISA assay showed that cytokines and...
Fri Feb 07, 2020 02:00
Brain Sciences, Vol. 10, Pages 92: The Maximum Eigenvalue of the Brain Functional Network Adjacency Matrix: Meaning and Application in Mental Fatigue Evaluation Brain Sciences doi: 10.3390/brainsci10020092 Authors: Li Jiang Jiao Xu Huang Gao Zhang Wang The maximum eigenvalue of the adjacency matrix (AM) has been supposed to contain rich information about the corresponding network. An experimental study focused on revealing the meaning and application of the...
Sun Feb 09, 2020 02:00
Brain Sciences, Vol. 10, Pages 91: Retrospective and Randomized Analysis of Influence and Correlation of Clinical and Molecular Prognostic Factors in a Mono-Operative Series of 122 Patients with Glioblastoma Treated with STR or GTR Brain Sciences doi: 10.3390/brainsci10020091 Authors: Maurizio Salvati Placido Bruzzaniti Michela Relucenti Mariagrazia Nizzola Pietro Familiari Marco Giugliano Anthony Kevin Scafa Santi Galletta Xiaobo Li Rui Chen Claudio Barbaranelli...
Sun Feb 09, 2020 02:00
Brain Sciences, Vol. 10, Pages 89: Application of Chaos Theory in the Assessment of Emotional Vulnerability and Emotion Dysregulation in Adults Brain Sciences doi: 10.3390/brainsci10020089 Authors: Cristina Ciuluvica (Neagu) Ioan Valeriu Grossu Paolo Amerio In this work, we propose an interdisciplinary chaos analysis of emotion dysregulation (ED) and emotional vulnerability in adults. One of the main goals was the assessment of incongruences that occur in the evaluation of one’s...
Sun Feb 09, 2020 02:00
Brain Sciences, Vol. 10, Pages 90: Cortical Oscillations during Gait: Wouldn't Walking be so Automatic? Brain Sciences doi: 10.3390/brainsci10020090 Authors: Delval Bayot Defebvre Dujardin Gait is often considered as an automatic movement but cortical control seems necessary to adapt gait pattern with environmental constraints. In order to study cortical activity during real locomotion, electroencephalography (EEG) appears to be particularly appropriate. It is now possible...
Sun Feb 09, 2020 02:00
Brain Sciences, Vol. 10, Pages 88: Exercise Training Results in Lower Amyloid Plaque Load and Greater Cognitive Function in an Intensity Dependent Manner in the Tg2576 Mouse Model of Alzheimer’s Disease Brain Sciences doi: 10.3390/brainsci10020088 Authors: Riya Thomas Scott D. Zimmerman Kayla M. Yuede John R. Cirrito Leon M. Tai Benjamin F. Timson Carla M. Yuede Three months of exercise training (ET) decreases soluble Aβ40 and Aβ42 levels in an intensity...
Sat Feb 08, 2020 02:00
Brain Sciences, Vol. 10, Pages 87: Synergistic Effects of Scalp Acupuncture and Repetitive Transcranial Magnetic Stimulation on Cerebral Infarction: A Randomized Controlled Pilot Trial Brain Sciences doi: 10.3390/brainsci10020087 Authors: Kim Han Song Park Lee This study investigated the synergistic effects of scalp acupuncture (SA) and repetitive transcranial magnetic stimulation (rTMS), known to be effective for cerebral infarction. This outcome-assessor-blinded, randomized...
Fri Feb 07, 2020 02:00
Cancers, Vol. 12, Pages 399: RAD52: Viral Friend or Foe? Cancers doi: 10.3390/cancers12020399 Authors: Hendrickson Mammalian Radiation Sensitive 52 (RAD52) is a gene whose scientific reputation has recently seen a strong resurgence. In the past decade, RAD52, which was thought to be dispensable for most DNA repair and recombination reactions in mammals, has been shown to be important for a bevy of DNA metabolic pathways. One of these processes is termed break-induced replication (BIR),...
Sat Feb 08, 2020 02:00
Cancers, Vol. 12, Pages 394: PARP Inhibitors as Therapeutics: Beyond Modulation of PARylation Cancers doi: 10.3390/cancers12020394 Authors: Ahrum Min Seock-Ah Im Poly (ADP-ribose) polymerase (PARP) 1 is an essential molecule in DNA damage response by sensing DNA damage and docking DNA repair proteins on the damaged DNA site through a type of posttranslational modification, poly (ADP-Ribosyl)ation (PARylation). PARP inhibitors, which inhibit PARylation through competitively binding...
Sat Feb 08, 2020 02:00
Cancers, Vol. 12, Pages 397: Predictors of Postoperative Seizure Outcome in Low Grade Glioma: From Volumetric Analysis to Molecular Stratification Cancers doi: 10.3390/cancers12020397 Authors: Tamara Ius Giada Pauletto Barbara Tomasino Marta Maieron Riccardo Budai Miriam Isola Daniela Cesselli Christian Lettieri Miran Skrap The importance of the extent of resection (EOR) has been widely demonstrated as the main predictor for survival, nevertheless its effect on...
Sat Feb 08, 2020 02:00
Cancers, Vol. 12, Pages 395: Establishment of a Temperature-Sensitive Model of Oncogene-Induced Senescence in Angiosarcoma Cells Cancers doi: 10.3390/cancers12020395 Authors: Costa Bonner Rao Gilbert Sasaki Elsey MacKelfresh Arbiser : Lesions with driver mutations, including atypical nevi and seborrheic keratoses, are very common in dermatology, and are prone to senescence. The molecular events that prevent senescent lesions from becoming malignant are not...
Sat Feb 08, 2020 02:00
Cancers, Vol. 12, Pages 396: Emerging Role of Podocalyxin in the Progression of Mature B-Cell Non-Hodgkin Lymphoma Cancers doi: 10.3390/cancers12020396 Authors: Tamayo-Orbegozo Amo Díez-García Amutio Riñón Alonso Arana Maruri Larrucea Mature B-cell non-Hodgkin lymphoma (B-NHL) constitutes a group of heterogeneous malignant lymphoproliferative diseases ranging from indolent to highly aggressive forms. Although the survival after chemo-immunotherapy treatment...
Sat Feb 08, 2020 02:00
Cancers, Vol. 12, Pages 398: PSA and PSA Kinetics Thresholds for the Presence of 68Ga-PSMA-11 PET/CT-Detectable Lesions in Patients With Biochemical Recurrent Prostate Cancer Cancers doi: 10.3390/cancers12020398 Authors: Hoffmann Buchholz Wieler Miederer Rosar Fischer Müller-Hübenthal Trampert Pektor Schreckenberger 68Ga-PSMA-11 positron-emission tomography/computed tomography (PET/CT) is commonly used for restaging recurrent prostate cancer (PC)...
Sat Feb 08, 2020 02:00
Cancers, Vol. 12, Pages 393: Stage IV Colorectal Cancer Patients with High Risk Mutation Profiles Survived 16 Months Longer with Individualized Therapies Cancers doi: 10.3390/cancers12020393 Authors: Alexander Hendricks Anu Amallraja Tobias Meißner Peter Forster Philip Rosenstiel Greta Burmeister Clemens Schafmayer Andre Franke Sebastian Hinz Michael Forster Casey B. Williams Personalized treatment vs. standard of care is much debated, especially in clinical...
Sat Feb 08, 2020 02:00
Cancers, Vol. 12, Pages 392: Immunomodulatory Roles of PARP-1 and PARP-2: Impact on PARP-Centered Cancer Therapies Cancers doi: 10.3390/cancers12020392 Authors: José Yélamos Lucia Moreno-Lama Jaime Jimeno Syed O. Ali Poly(ADP-ribose) polymerase-1 (PARP-1) and PARP-2 are enzymes which post-translationally modify proteins through poly(ADP-ribosyl)ation (PARylation)—the transfer of ADP-ribose chains onto amino acid residues—with a resultant modulation of protein...
Sat Feb 08, 2020 02:00
Cancers, Vol. 12, Pages 391: T-Type Calcium Channels: A Potential Novel Target in Melanoma Cancers doi: 10.3390/cancers12020391 Authors: Carla Barceló Pol Sisó Oscar Maiques Inés de la Rosa Rosa M. Martí Anna Macià T-type calcium channels (TTCCs) are overexpressed in several cancers. In this review, we summarize the recent advances and new insights into TTCC biology, tumor progression, and prognosis biomarker and therapeutic potential in the melanoma field. We describe...
Sat Feb 08, 2020 02:00
Cancers, Vol. 12, Pages 387: Effects of Andrographolide on Intracellular pH Regulation, Cellular Migration, and Apoptosis in Human Cervical Cancer Cells † Cancers doi: 10.3390/cancers12020387 Authors: Loh Tsai Huang Yu Kuo Chao Chou Tsai Lee Cancer cells have been characterized with alkaline intracellular pH (pHi) values (≥7.2) to enable cancer proliferation, migration, and progression. The aim of the present study was to explore the concentration-dependent...
Fri Feb 07, 2020 02:00
Cancers, Vol. 12, Pages 389: Checkpoint Defects Elicit a WRNIP1-Mediated Response to Counteract R-Loop-Associated Genomic Instability Cancers doi: 10.3390/cancers12020389 Authors: Marabitti Lillo Malacaria Palermo Pichierri Franchitto Conflicts between replication and transcription are a common source of genomic instability, a characteristic of almost all human cancers. Aberrant R-loops can cause a block to replication fork progression. A growing number of factors...
Fri Feb 07, 2020 02:00
Cancers, Vol. 12, Pages 385: Modeling Spontaneous Bone Metastasis Formation of Solid Human Tumor Xenografts in Mice Cancers doi: 10.3390/cancers12020385 Authors: Labitzky Baranowsky Maar Hanika Starzonek Ahlers Stübke Koziolek Heine Schäfer Windhorst Jücker Riecken Amling Schinke Schumacher Valentiner Lange The majority of cancer-related deaths are due to hematogenous metastases, and the bone marrow (BM) represents...
Fri Feb 07, 2020 02:00
Cancers, Vol. 12, Pages 388: DNA Damage in Blood Leukocytes of Prostate Cancer Patients Undergoing PET/CT Examinations with [68Ga]Ga-PSMA I&T Cancers doi: 10.3390/cancers12020388 Authors: Schumann Scherthan Frank Lapa Müller Seifert Lassmann Eberlein The aim was to investigate the induction and repair of radiation-induced DNA double-strand breaks (DSBs) as a function of the absorbed dose to the blood of patients undergoing PET/CT examinations with [68Ga]Ga-PSMA....
Fri Feb 07, 2020 02:00
Cancers, Vol. 12, Pages 383: Intratumoral Genetic Heterogeneity in Papillary Thyroid Cancer: Occurrence and Clinical Significance Cancers doi: 10.3390/cancers12020383 Authors: Fugazzola Muzza Pogliaghi Vitale Intratumoral heterogeneity (ITH) refers to a subclonal genetic diversity observed within a tumor. ITH is the consequence of genetic instability and accumulation of genetic alterations, two mechanisms involved in the progression from an early tumor stage to a more aggressive...
Fri Feb 07, 2020 02:00
Cancers, Vol. 12, Pages 386: A Novel Comprehensive Clinical Stratification Model to Refine Prognosis of Glioblastoma Patients Undergoing Surgical Resection Cancers doi: 10.3390/cancers12020386 Authors: Ius Pignotti Della Pepa La Rocca Somma Isola Battistella Gaudino Polano Dal Bo Bagatto Pegolo Chiesa Arcicasa Olivi Skrap Sabatino Despite recent discoveries in genetics and molecular fields, glioblastoma (GBM) prognosis...
Fri Feb 07, 2020 02:00
Cancers, Vol. 12, Pages 384: Role of Polymer Micelles in the Delivery of Photodynamic Therapy Agent to Liposomes and Cells Cancers doi: 10.3390/cancers12020384 Authors: Gibot Demazeau Pimienta Mingotaud Vicendo Collin Martins-Froment Dejean Nottelet Roux Lonetti The use of nanocarriers for hydrophobic photosensitizers, in the context of photodynamic therapy (PDT) to improve pharmacokinetics and bio-distribution, is well-established. However, the...
Fri Feb 07, 2020 02:00
Cancers, Vol. 12, Pages 390: Multiparametric MRI for Prostate Cancer Detection: New Insights into the Combined Use of a Radiomic Approach with Advanced Acquisition Protocol Cancers doi: 10.3390/cancers12020390 Authors: Monti Brancato Di Costanzo Basso Puglia Ragozzino Salvatore Cavaliere Prostate cancer (PCa) is a disease affecting an increasing number of men worldwide. Several efforts have been made to identify imaging biomarkers to non-invasively detect...
Fri Feb 07, 2020 02:00
Cancers, Vol. 12, Pages 382: The Impact of IL-6 and IL-10 Gene Polymorphisms in Diffuse Large B-Cell Lymphoma Risk and Overall Survival in an Arab Population: A Case-Control Study Cancers doi: 10.3390/cancers12020382 Authors: Sohaib M. Al-Khatib Nour Abdo Laith N. AL-Eitan Abdel-Hameed Al-Mistarehi Deeb Jamil Zahran Tariq Zuheir Kewan B-cell lymphomas can be classified as Hodgkin and non-Hodgkin lymphomas. Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin...
Fri Feb 07, 2020 02:00
Cancers, Vol. 12, Pages 381: NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models Cancers doi: 10.3390/cancers12020381 Authors: McDonald Stainforth Miller Cahill da Silveira Rathi Hardiman Taylor Costes Chauhan Meller Beheshti Background: Ionizing radiation from galactic cosmic rays (GCR) is one of the major risk factors that will impact the health of astronauts on extended missions outside the protective...
Fri Feb 07, 2020 02:00
Cancers, Vol. 12, Pages 380: Monocarboxylate Transporter 4 Regulates Glioblastoma Motility and Monocyte Binding Ability Cancers doi: 10.3390/cancers12020380 Authors: Lai Lin Liu Yang Lu Glioblastoma (GBM) is characterized by severe hypoxic and acidic stress in an abnormal microenvironment. Monocarboxylate transporter (MCT)4, a pH-regulating protein, plays an important role in pH homeostasis of the glycolytic metabolic pathways in cancer cells. The present study showed...
Fri Feb 07, 2020 02:00
Cells, Vol. 9, Pages 397: BGN/TLR4/NF-B Mediates Epigenetic Silencing of Immunosuppressive Siglec Ligands in Colon Cancer Cells Cells doi: 10.3390/cells9020397 Authors: Huang Cai Suen Lee Hwang Liu Kannagi Human Toll-like receptor (TLR) signaling plays a vital role in intestinal inflammation by activating the NF-B pathway. By querying GENT2 datasets, we identified the gene expression level of TLR2 and TLR4 as being substantially increased in colorectal cancer....
Sun Feb 09, 2020 02:00
Cells, Vol. 9, Pages 398: Differential Regulation of circRNA, miRNA, and piRNA during Early Osteogenic and Chondrogenic Differentiation of Human Mesenchymal Stromal Cells Cells doi: 10.3390/cells9020398 Authors: Della Bella Menzel Basoli Tourbier Alini Stoddart The goal of the present study is to identify the differential expression of circular RNA (circRNA), miRNA, and piwi-interacting RNA (piRNA) after lineage commitment towards osteo- and chondrogenesis of human...
Sun Feb 09, 2020 02:00
Cells, Vol. 9, Pages 396: Secreted Phospholipase A2-IIA Modulates Transdifferentiation of Cardiac Fibroblast through EGFR Transactivation: An Inflammation–Fibrosis Link Cells doi: 10.3390/cells9020396 Authors: Martin Gutierrez Cordova Roman Alvarez Hernandez Cachofeiro Nieto Secreted phospholipase A2-IIA (sPLA2-IIA) is a pro-inflammatory protein associated with cardiovascular disorders, whose functions and underlying mechanisms in cardiac remodelling are...
Sat Feb 08, 2020 02:00
Cells, Vol. 9, Pages 393: Myelin Measurement Using Quantitative Magnetic Resonance Imaging: A Correlation Study Comparing Various Imaging Techniques in Patients with Multiple Sclerosis Cells doi: 10.3390/cells9020393 Authors: Laetitia Saccenti Akifumi Hagiwara Christina Andica Kazumasa Yokoyama Shohei Fujita Shimpei Kato Tomoko Maekawa Koji Kamagata Alice Le Berre Masaaki Hori Akihiko Wada Ukihide Tateishi Nobutaka Hattori Shigeki Aoki Evaluation...
Sat Feb 08, 2020 02:00
Cells, Vol. 9, Pages 394: The Extracellular Matrix: An Accomplice in Gastric Cancer Development and Progression Cells doi: 10.3390/cells9020394 Authors: Moreira Pereira Melo Fernandes Carneiro Seruca Figueiredo The extracellular matrix (ECM) is a dynamic and highly organized tissue structure, providing support and maintaining normal epithelial architecture. In the last decade, increasing evidence has emerged demonstrating that alterations in ECM composition and...
Sat Feb 08, 2020 02:00
Cells, Vol. 9, Pages 395: Metabolic Dysfunction in Hutchinson–Gilford Progeria Syndrome Cells doi: 10.3390/cells9020395 Authors: Kreienkamp Gonzalo Hutchinson–Gilford Progeria Syndrome (HGPS) is a segmental premature aging disease causing patient death by early teenage years from cardiovascular dysfunction. Although HGPS does not totally recapitulate normal aging, it does harbor many similarities to the normal aging process, with patients also developing cardiovascular...
Sat Feb 08, 2020 02:00
Cells, Vol. 9, Pages 392: p32-Dependent p38 MAPK Activation by Arginase II Downregulation Contributes to Endothelial Nitric Oxide Synthase Activation in HUVECs Cells doi: 10.3390/cells9020392 Authors: Koo Won Kim Ryoo Arginase II reciprocally regulates endothelial nitric oxide synthase (eNOS) through a p32-dependent Ca2+ control. We investigated the signaling pathway of arginase II-dependent eNOS phosphorylation. Western blot analysis was applied for examining protein activation...
Sat Feb 08, 2020 02:00
Cells, Vol. 9, Pages 391: Quantitative Connection between Cell Size and Growth Rate by Phospholipid Metabolism Cells doi: 10.3390/cells9020391 Authors: Zhichao Zhang Qing Zhang Shaohua Guan Hualin Shi The processes involved in cell growth are extremely complicated even for a single cell organism such as Escherichia coli, while the relationship between growth rate and cell size is simple. We aimed to reveal the systematic link between them from the aspect of the genome-scale...
Sat Feb 08, 2020 02:00
Cells, Vol. 9, Pages 388: The Role of TRPC1 in Modulating Cancer Progression Cells doi: 10.3390/cells9020388 Authors: Elzamzamy Penner Hazlehurst Calcium ions (Ca2+) play an important role as second messengers in regulating a plethora of physiological and pathological processes, including the progression of cancer. Several selective and non-selective Ca2+-permeable ion channels are implicated in mediating Ca2+ signaling in cancer cells. In this review, we are focusing on TRPC1,...
Fri Feb 07, 2020 02:00
Cells, Vol. 9, Pages 389: Astroglial Connexin 43 Deficiency Protects against LPS-Induced Neuroinflammation: A TSPO Brain µPET Study with [18F]FEPPA Cells doi: 10.3390/cells9020389 Authors: Vignal Boulay San Cohen-Salmon Rizzo-Padoin Sarda-Mantel Declèves Cisternino Hosten Astroglial connexin 43 (Cx43) has been recognized as a crucial immunoregulating factor in the brain. Its inactivation leads to a continuous immune recruitment, cytokine expression modification...
Fri Feb 07, 2020 02:00
Cells, Vol. 9, Pages 390: A PP2A-B56—Centered View on Metaphase-to-Anaphase Transition in Mouse Oocyte Meiosis I Cells doi: 10.3390/cells9020390 Authors: Keating Touati Wassmann Meiosis is required to reduce to haploid the diploid genome content of a cell, generating gametes—oocytes and sperm—with the correct number of chromosomes. To achieve this goal, two specialized cell divisions without intermediate S-phase are executed in a time-controlled manner. In...
Fri Feb 07, 2020 02:00
Cells, Vol. 9, Pages 387: Separated Siamese Twins: Intronic Small Nucleolar RNAs and Matched Host Genes May be Altered in Conjunction or Separately in Multiple Cancer Types Cells doi: 10.3390/cells9020387 Authors: Penzo Clima Trerè Montanaro Small nucleolar RNAs (snoRNAs) are non-coding RNAs involved in RNA modification and processing. Approximately half of the so far identified snoRNA genes map within the intronic regions of host genes, and their expression, as well as...
Fri Feb 07, 2020 02:00
Cells, Vol. 9, Pages 385: Mechanistic Roles of Matrilin-2 and Klotho in Modulating the Inflammatory Activity of Human Aortic Valve Cells Cells doi: 10.3390/cells9020385 Authors: The Yao Zhang Zhai Ao Fullerton Meng Background: Calcific aortic valve disease (CAVD) is a chronic inflammatory disease. Soluble extracellular matrix (ECM) proteins can act as damage-associated molecular patterns and may induce valvular inflammation. Matrilin-2 is an ECM protein and has...
Fri Feb 07, 2020 02:00
Cells, Vol. 9, Pages 384: WNT5a-ROR Signaling Is Essential for Alveologenesis Cells doi: 10.3390/cells9020384 Authors: Li Smith Peinado Gao Li Lee Zhou Bellusci Pryhuber Ho Borok Minoo WNT5a is a mainly “non-canonical” WNT ligand whose dysregulation is observed in lung diseases such as idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD) and asthma. Germline deletion of Wnt5a disrupts embryonic...
Fri Feb 07, 2020 02:00
Cells, Vol. 9, Pages 386: Evolving Cell-Based and Cell-Free Clinical Strategies for Treating Severe Human Liver Diseases Cells doi: 10.3390/cells9020386 Authors: Cernigliaro Peluso Zedda Silengo Tolosano Pellicano Altruda Fagoonee Liver diseases represent a major global health issue, and currently, liver transplantation is the only viable alternative to reduce mortality rates in patients with end-stage liver diseases. However, scarcity of donor organs and...
Fri Feb 07, 2020 02:00
Cells, Vol. 9, Pages 383: Impact of HMGB1, RAGE, and TLR4 in Alzheimer’s Disease (AD): From Risk Factors to Therapeutic Targeting Cells doi: 10.3390/cells9020383 Authors: Yam Nath Paudel Efthalia Angelopoulou Christina Piperi Iekhsan Othman Khurram Aamir Mohd. Farooq Shaikh Alzheimer’s disease (AD) is a devastating neurodegenerative disorder and a leading cause of dementia, with accumulation of amyloid-beta (Aβ) and neurofibrillary tangles (NFTs) as...
Fri Feb 07, 2020 02:00
Cells, Vol. 9, Pages 382: Uncoupling of the Astrocyte Syncytium Differentially Affects AQP4 Isoforms
Cells, Vol. 9, Pages 382: Uncoupling of the Astrocyte Syncytium Differentially Affects AQP4 Isoforms Cells doi: 10.3390/cells9020382 Authors: Katoozi Skauli Zahl Deshpande Ezan Palazzo Steinhäuser Frigeri Cohen-Salmon Ottersen Amiry-Moghaddam The water channel protein aquaporin-4 (AQP4) and the gap junction forming proteins connexin-43 (Cx43) and connexin-30 (Cx30) are astrocytic proteins critically involved in brain water and ion homeostasis....
Fri Feb 07, 2020 02:00
Cells, Vol. 9, Pages 381: Implications of Selective Autophagy Dysfunction for ALS Pathology Cells doi: 10.3390/cells9020381 Authors: Vicencio Beltrán Labrador Manque Nassif Woehlbier Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disorder that progressively affects motor neurons in the brain and spinal cord. Due to the biological complexity of the disease, its etiology remains unknown. Several cellular mechanisms involved in the neurodegenerative...
Fri Feb 07, 2020 02:00
Cells, Vol. 9, Pages 380: Silencing of PARP2 Blocks Autophagic Degradation Cells doi: 10.3390/cells9020380 Authors: Laura Jankó Zsanett Sári Tünde Kovács Gréta Kis Magdolna Szántó Miklós Antal Gábor Juhász Péter Bai Poly(ADP-Ribose) polymerases (PARPs) are enzymes that metabolize NAD+. PARP1 and PARP10 were previously implicated in the regulation of autophagy. Here we showed that cytosolic electron-dense particles appear in the cytoplasm of C2C12 myoblasts in which...
Fri Feb 07, 2020 02:00
Climate, Vol. 8, Pages 30: Water Balance and Soil Moisture Deficit of Different Vegetation Units under Semiarid Conditions in the Andes of Southern Ecuador Climate doi: 10.3390/cli8020030 Authors: Andreas Fries Karen Silva Franz Pucha-Cofrep Fernando Oñate-Valdivieso Pablo Ochoa-Cueva Water availability in semiarid regions is endangered, which is not only due to changing climate conditions, but also to anthropogenic land use changes. The present study analyzed the annual...
Sat Feb 08, 2020 02:00
Climate, Vol. 8, Pages 29: The Role of Individual and Small-Area Social and Environmental Factors on Heat Vulnerability to Mortality Within and Outside of the Home in Boston, MA Climate doi: 10.3390/cli8020029 Authors: Williams Allen Catalano Spengler Climate change is resulting in heatwaves that are more frequent, severe, and longer lasting, which is projected to double-to-triple the heat-related mortality in Boston, MA if adequate climate change mitigation and adaptation...
Fri Feb 07, 2020 02:00
Dentistry Journal, Vol. 8, Pages 17: Biocompatibility of Biodentine™ ® with Periodontal Ligament Stem Cells: In Vitro Study Dentistry Journal doi: 10.3390/dj8010017 Authors: Abuarqoub Aslam Jafar Abu Harfil Awidi : Biodentine™ is a tricalcium silicate-based cement material that has a great impact on different biological processes of dental stem cells, compared to other biomaterials. Therefore, we aimed to investigate the optimum biocompatible concentration...
Sat Feb 08, 2020 02:00
Diagnostics, Vol. 10, Pages 92: Biomedical Insights that Inform the Diagnosis of ME/CFS Diagnostics doi: 10.3390/diagnostics10020092 Authors: Lidbury Fisher It is well known that myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS) [...]
Sat Feb 08, 2020 02:00
Diagnostics, Vol. 10, Pages 91: The Relationship between Coronary Artery Wall Shear Strain and Plaque Morphology: A Systematic Review and Meta-Analysis Diagnostics doi: 10.3390/diagnostics10020091 Authors: Bajraktari Bytyçi Henein : Background and Aim: Arterial wall shear strain (WSS) has been proposed to impact the features of atherosclerotic plaques. The aim of this meta-analysis was to assess the impact of different types of WSS on plaque features in coronary artery disease...
Sat Feb 08, 2020 02:00
Diagnostics, Vol. 10, Pages 90: Transmission of X-linked Ovarian Cancer: Characterization and Implications Diagnostics doi: 10.3390/diagnostics10020090 Authors: Etter Moysich Kohli Lele Odunsi Eng We recently reported evidence that a strong, BRCA-independent locus on the X-chromosome may contribute to ovarian cancer predisposition in families ascertained from the Familial Ovarian Cancer Registry (Buffalo, NY, USA). While it has been estimated that approximately 20%...
Fri Feb 07, 2020 02:00
Diagnostics, Vol. 10, Pages 88: Craniofacial Morphology in Children with Growth Hormone Deficiency and Turner Syndrome Diagnostics doi: 10.3390/diagnostics10020088 Authors: Wójcik Beń-Skowronek The review aims to collect and demonstrate recent knowledge about craniofacial morphology in growth hormone (GH)-deficient children and children with Turner syndrome. The review describes also the effects of growth hormone treatment on craniofacial morphology of children with growth hormone...
Fri Feb 07, 2020 02:00
Diagnostics, Vol. 10, Pages 89: Socioeconomic Status and Ovarian Cancer Stage at Diagnosis: A Study Nested Within UKCTOCS Diagnostics doi: 10.3390/diagnostics10020089 Authors: Karpinskyj Burnell Gonzalez-Izquierdo Ryan Kalsi Jacobs Parmar Menon Gentry-Maharaj Background: Tubo-ovarian cancer (OC) continues to be the most lethal of all gynaecological cancers. Over half of women are diagnosed with late stage (III/IV) disease, which has a five-year survival...
Fri Feb 07, 2020 02:00
Diseases, Vol. 8, Pages 4: One Single Nucleotide Polymorphism of the TRPM2 Channel Gene Identified as a Risk Factor in Bipolar Disorder Associates with Autism Spectrum Disorder in a Japanese Population Diseases doi: 10.3390/diseases8010004 Authors: Mahmuda Yokoyama Munesue Hayashi Yagi Tsuji Higashida The transient receptor potential melastatin 2 (TRPM2) is a non-specific cation channel, resulting in Ca2+ influx at warm temperatures from 34 °C to 47 °C,...
Fri Feb 07, 2020 02:00
Diversity, Vol. 12, Pages 68: Domestic Free-Range Pig Genetic Resources in Southern Africa: Progress and Prospects Diversity doi: 10.3390/d12020068 Authors: Halimani Mapiye Marandure Januarie Imbayarwo-Chikosi Dzama Pig genetic resources in Africa originate from different regions and were introduced through several migration pathways. Genetic analysis has shown a strong phylogeographic pattern, with pigs on the eastern parts showing a high frequency of alleles from...
Fri Feb 07, 2020 02:00
Diversity, Vol. 12, Pages 66: Knowledge Gaps or Change of Distribution Ranges? Explaining New Records of Birds in the Ecuadorian Tumbesian Region of Endemism Diversity doi: 10.3390/d12020066 Authors: Orihuela-Torres Tinoco Ordóñez-Delgado Espinosa The change in the distribution range is a common response of various species facing the effects of anthropogenic global change. We used new distribution records of birds reported during the last two decades from the Ecuadorian...
Fri Feb 07, 2020 02:00
Diversity, Vol. 12, Pages 69: Venomous Snake Abundance Within Snake Species’ Assemblages Worldwide Diversity doi: 10.3390/d12020069 Authors: Luiselli Sale Akani Amori Venomous snakes are among the main sources of mortality for humans in rural regions, especially in tropical countries. In this study, a meta-analysis of quantitative community ecology studies on snake assemblages throughout the world was conducted in order to evaluate variation in the frequency of occurrence...
Fri Feb 07, 2020 02:00
Diversity, Vol. 12, Pages 67: Effects of Forest Fragmentation on the Vertical Stratification of Neotropical Bats Diversity doi: 10.3390/d12020067 Authors: Silva Rocha López-Baucells Farneda Meyer Vertical stratification is a key component of the biological complexity of rainforests. Understanding community- and species-level responses to disturbance across forest strata is paramount for evidence-based conservation and management. However, even for bats, known to extensively...
Fri Feb 07, 2020 02:00
Diversity, Vol. 12, Pages 70: Phylogenomic Reconstruction Sheds Light on New Relationships and Timescale of Rails (Aves: Rallidae) Evolution Diversity doi: 10.3390/d12020070 Authors: Garcia-R Lemmon Lemmon French The integration of state-of-the-art molecular techniques and analyses, together with a broad taxonomic sampling, can provide new insights into bird interrelationships and divergence. Despite their evolutionary significance, the relationships among several rail lineages...
Fri Feb 07, 2020 02:00
Environments, Vol. 7, Pages 11: In Situ Acoustic Treatment of Anaerobic Digesters to Improve Biogas Yields Environments doi: 10.3390/environments7020011 Authors: John Loughrin Stacy Antle Karamat Sistani Nanh Lovanh Sound has the potential to increase biogas yields and enhance wastewater degradation in anaerobic digesters. To assess this potential, two pilot-scale digestion systems were operated, with one exposed to sound at less than 10 kHz and with one acting as a control....
Sat Feb 08, 2020 02:00
Fermentation, Vol. 6, Pages 22: Modulating Wine Pleasantness Throughout Wine-Yeast Co-Inoculation or Sequential Inoculation Fermentation doi: 10.3390/fermentation6010022 Authors: Vilela Wine sensory experience includes flavor, aroma, color, and (for some) even acoustic traits, which impact consumer acceptance. The quality of the wine can be negatively impacted by the presence of off-flavors and aromas, or dubious colors, or sediments present in the bottle or glass, after pouring (coloring...
Sun Feb 09, 2020 02:00
Foods, Vol. 9, Pages 164: Optimization of the Formulation and Properties of 3D-Printed Complex Egg White Protein Objects Foods doi: 10.3390/foods9020164 Authors: Liu Yang Bhandari Meng Prakash The 3D printing of foods is an emerging technique for producing unique and complex food items. This study presents the optimization of a new formulation for 3D printing foods on the basis of a complex system, which contains egg white protein (EWP), gelatin, cornstarch, and sucrose....
Sat Feb 08, 2020 02:00
Foods, Vol. 9, Pages 163: Bio-Functional and Structural Properties of Pasta Enriched with a Debranning Fraction from Purple Wheat Foods doi: 10.3390/foods9020163 Authors: Parizad Marengo Bonomi Scarafoni Cecchini Pagani Marti Iametti A colored and fiber-rich fraction from the debranning of purple wheat was incorporated at 25% into semolina- and flour-based pasta produced on a pilot-plant scale, with the aim of increasing anthocyanin and total phenolic content...
Sat Feb 08, 2020 02:00
Foods, Vol. 9, Pages 162: Rapid PCR Method for the Selection of 1,3-Pentadiene Non-Producing Debaryomyces hansenii Yeast Strains Foods doi: 10.3390/foods9020162 Authors: Rivas Wrent de Silóniz To prevent microbial growth and its consequences, preservatives such as sorbic acid or its salts, commonly known as sorbates, are added to foods. However, some moulds and yeasts are capable of decarboxylating sorbates and producing 1,3-pentadiene. This is a volatile compound with an unpleasant...
Fri Feb 07, 2020 02:00
Foods, Vol. 9, Pages 161: Segmentation of Potato Consumers Based on Sensory and Attitudinal Aspects Foods doi: 10.3390/foods9020161 Authors: Sharma Jayanty Chambers IV Talavera Consumer hedonic scores for potatoes were linked to sensory characteristics to understand the underlying consumer segments, flavor and texture preferences and attitudinal associations regarding potatoes. Consumers were asked to evaluate liking on a 9-point hedonic scale for 12 cultivars of potatoes....
Fri Feb 07, 2020 02:00
Foods, Vol. 9, Pages 160: Effects of Various Drying Methods on Some Physico-Chemical Properties and the Antioxidant Profile and ACE Inhibition Activity of Oyster Mushrooms (Pleurotus Ostreatus) Foods doi: 10.3390/foods9020160 Authors: Piskov Timchenko Grimm Rzhepakovsky Avanesyan Sizonenko Kurchenko In food biotechnology, Pleurotus ostreatus is of great interest as a source of natural antioxidants and angiotensin-converting enzyme (ACE) inhibitors. However, research...
Fri Feb 07, 2020 02:00
Fractal Fract, Vol. 4, Pages 5: Non-Differentiable Solution of Nonlinear Biological Population Model on Cantor Sets Fractal and Fractional doi: 10.3390/fractalfract4010005 Authors: Djelloul Ziane Mountassir Hamdi Cherif Dumitru Baleanu Kacem Belghaba The main objective of this study is to apply the local fractional homotopy analysis method (LFHAM) to obtain the non-differentiable solution of two nonlinear partial differential equations of the biological population model on...
Sun Feb 09, 2020 02:00
Healthcare, Vol. 8, Pages 36: Barriers to Early Utilization of Palliative Care in Heart Failure: A Narrative Review Healthcare doi: 10.3390/healthcare8010036 Authors: Romanò Palliative care is indicated in patients with heart failure since the early phases of the disease, as suggested by international guidelines. However, patients are referred to palliative care very late. Many barriers could explain the gap between the guidelines’ indications and clinical practice. The term...
Fri Feb 07, 2020 02:00
Healthcare, Vol. 8, Pages 35: Relationship between Air Temperature Parameters and the Number of Deaths Stratified by Cause in Gifu Prefecture, Japan Healthcare doi: 10.3390/healthcare8010035 Authors: Bando Miyatake Kataoka Kinoshita Tanaka Suzuki Katayama Objective: It is well known that air temperature is closely related to health outcomes. We investigated the relationship between air temperature parameters and the number of deaths stratified by cause in Gifu...
Fri Feb 07, 2020 02:00
Healthcare, Vol. 8, Pages 34: 3D Textural, Morphological and Statistical Analysis of Voxel of Interests in 3T MRI Scans for the Detection of Parkinson’s Disease Using Artificial Neural Networks Healthcare doi: 10.3390/healthcare8010034 Authors: Sabyasachi Chakraborty Satyabrata Aich Hee-Cheol Kim Parkinson’s disease is caused due to the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNc). Presently, with the exponential growth of the aging...
Fri Feb 07, 2020 02:00
Heritage, Vol. 3, Pages 68-97: Exploring the “Cozy Cabal of Academics, Dealers and Collectors” through the Schøyen Collection Heritage doi: 10.3390/heritage3010005 Authors: Prescott Rasmussen In the wake of the trade in ancient materials, several ethical and political issues arise that merit concern: The decimation of the cultural heritage of war-torn countries, proliferation of corruption, ideological connotations of orientalism, financial support of terrorism, and participation...
Sun Feb 09, 2020 02:00
Humanities, Vol. 9, Pages 17: Something Super-Wicked This Way Comes: Genre, Emergency, Expectation, and Learning to Die in Climate-Change Scotland Humanities doi: 10.3390/h9010017 Authors: Hinde This article approaches the issue of climate change and the response to it in Scotland from the perspective of genres of expectation and normality, focusing in particular on the relationship between genre, the political imagination, and calls for ‘climate realism’. Functioning...
Fri Feb 07, 2020 02:00
IJERPH, Vol. 17, Pages 1108: Comparison of Two Bayesian-MCMC Inversion Methods for Laboratory Infiltration and Field Irrigation Experiments International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17031108 Authors: Qinghua Guo Fuchu Dai Zhiqiang Zhao Bayesian parameter inversion approaches are dependent on the original forward models linking subsurface physical properties to measured data, which usually require a large number of iterations. Fast alternative...
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IJERPH, Vol. 17, Pages 1105: Postpartum Physical Activity and Weight Retention within One Year: A Prospective Cohort Study in Vietnam International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17031105 Authors: Anh Vo Van Ha Yun Zhao Colin W. Binns Ngoc Minh Pham Phung Thi Hoang Nguyen Cong Luat Nguyen Tan Khac Chu Andy H. Lee After delivery, mothers are encouraged to increase physical activity (PA) gradually to regulate body weight; however,...
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IJERPH, Vol. 17, Pages 1103: Assessment of the Nutrient Removal Potential of Floating Native and Exotic Aquatic Macrophytes Cultured in Swine Manure Wastewater International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17031103 Authors: Lei Xu Siyu Cheng Ping Zhuang Dongsheng Xie Shiyu Li Dongming Liu Zhian Li Faguo Wang Fuwu Xing Although eutrophication and biological invasion have caused serious harm to aquatic ecosystems, exotic and...
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IJERPH, Vol. 17, Pages 1104: Design of a Network Optimization Platform for the Multivehicle Transportation of Hazardous Materials International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17031104 Authors: Sheng Dong Jibiao Zhou Changxi Ma With economic development, the volume of hazardous materials is increasing, and the potential risks to human beings and the natural environment are expanding. Road transportation has become the main mode of transportation...
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IJERPH, Vol. 17, Pages 1102: Parent and Clinician Perspectives on the Participation of Children with Cerebral Palsy in Community-Based Football: A Qualitative Exploration in a Regional Setting International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17031102 Authors: Carmel Sivaratnam Katherine Howells Nicole Stefanac Kelly Reynolds Nicole Rinehart The current study aimed to qualitatively explore parent and clinician perspectives on the factors...
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IJERPH, Vol. 17, Pages 1101: Decrease in Serum HDL-C Level Is Associated with Elevation of Blood Pressure: Correlation Analysis from the Korean National Health and Nutrition Examination Survey 2017 International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17031101 Authors: Kyung-Hyun Cho Hye-Jeong Park Jae-Ryong Kim A low-serum, high-density lipoproteins–cholesterol (HDL-C) level and high blood pressure (BP) are independent risk factors for...
Sun Feb 09, 2020 02:00
IJERPH, Vol. 17, Pages 1097: Co-Creating a Virtual Alcohol Prevention Simulation with Young People International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17031097 Authors: Lotte Vallentin-Holbech Julie Dalgaard Guldager Timo Dietrich Sharyn Rundle-Thiele Gunver Majgaard Patricia Lyk Christiane Stock Collaborative knowledge generation and involvement of users is known to improve health promotion intervention development, but research about...
Sun Feb 09, 2020 02:00
IJERPH, Vol. 17, Pages 1099: Quantifying the Health Burden Misclassification from the Use of Different PM2.5 Exposure Tier Models: A Case Study of London International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17031099 Authors: Vasilis Kazakos Zhiwen Luo Ian Ewart Exposure to PM2.5 has been associated with increased mortality in urban areas. Hence, reducing the uncertainty in human exposure assessments is essential for more accurate health burden estimates....
Sun Feb 09, 2020 02:00
IJERPH, Vol. 17, Pages 1100: Physical Exercise, Fitness, Cognitive Functioning, and Psychosocial Variables in an Adolescent Sample International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17031100 Authors: Rafael E. Reigal Luna Moral-Campillo Juan P. Morillo-Baro Rocío Juárez-Ruiz de Mier Antonio Hernández-Mendo Verónica Morales-Sánchez The objective of this paper was to evaluate the relationship between physical exercise and physical fitness...
Sun Feb 09, 2020 02:00
IJERPH, Vol. 17, Pages 1096: Investigating Industrial Effluent Impact on Municipal Wastewater Treatment Plant in Vaal, South Africa International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17031096 Authors: Eunice Iloms Olusolao O. Ololade Henry J. O. Ogola Ramganesh Selvarajan Industrial effluents with high concentrations of toxic heavy metals are of great concern because of their persistence and non-degradability. However, poor operation and maintenance...
Sun Feb 09, 2020 02:00
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