Τετάρτη 4 Μαρτίου 2020


Impact of Extent of Lymphadenectomy on Survival in Patients With Endometrial Cancer: A Matched Cohort Study
Background/Aim: This study aimed to determine whether a pelvic and para-aortic lymphadenectomy (PPAL) improves survival compared with a pelvic lymphadenectomy (PL) in patients with endometrial cancer. Patients and Methods: Data from all women operated for endometrial cancer between 1998 and 2013 were extracted from the Surveillance, Epidemiology and End Results database. Women treated with PL were matched with those treated with PPAL according to age and risk of recurrence. The primary endpoint was...
Hellenic Anticancer Institute
Wed Mar 04, 2020 12:40
Casein Kinase 2{alpha} Enhances 5-Fluorouracil Resistance in Colorectal Cancer Cells by Inhibiting Endoplasmic Reticulum Stress
Background/Aim: Anti-cancer drug resistance restricts the efficacy of chemotherapy in malignant tumors. Casein kinase 2α (CK2α) is highly expressed in 5-fluorouracil (5FU)-resistant colorectal cancer (CRC) cells. We hypothesized that inhibition of CK2α might reduce CRC resistance to 5FU. Materials and Methods: To investigate the role of CK2α in 5FU-resistant CRC cells, we assessed cell viability, apoptosis, cyclin-dependent kinase 4 (CDK4) activity, cell-cycle progression, invasion, and sphere formation...
Hellenic Anticancer Institute
Wed Mar 04, 2020 12:40
Nab-paclitaxel Monotherapy for Relapsed Small Cell Lung Cancer: Retrospective Analysis and Review
Background/Aim: The utility of nanoparticle albumin-bound paclitaxel (nab-PTX) monotherapy in patients with relapsed small-cell lung cancer (SCLC) has not been fully evaluated. We aimed to investigate the efficacy and safety of nab-PTX monotherapy in relapsed SCLC patients, including heavily treated patients. Patients and Methods: We retrospectively analysed data from 17 patients with relapsed SCLC who were treated with weekly nab-PTX monotherapy at our hospital. We also reviewed past studies on...
Hellenic Anticancer Institute
Wed Mar 04, 2020 12:40
miR-187* Enhances SiHa Cervical Cancer Cell Oncogenicity Via Suppression of WWOX
Background/Aim: Cervical cancer is one of the most common cancers worldwide and a major cause of cancer-related mortality among women. Previous studies have reported that microRNA-miR-187*, which is one of the non-coding parts of the genome producing small conserved ribonucleic acids, is associated with various cancers. In this study, we explored the function of miR-187* in cervical cancer cells. Materials and Methods: miR-187* mimic, WWOX reporter constructs, siRNA and overexpression constructs...
Hellenic Anticancer Institute
Wed Mar 04, 2020 12:40
Prevalence and Risk Factors for Oral HPV in Healthy Population, in Central Europe
Abstract. Background/Aim: The incidence of oropharyngeal tumours induced by human papillomaviruses (HPV) is ever increasing. Information about oral HPV prevalence and its risk factors are very important for future screening and early diagnosis of the disease. The present study aimed to assess oral HPV prevalence in healthy population and risk factors for HPV infection, since this data is scarce or even missing in Central Europe. Patients and Methods: HPV prevalence in oral rinse and HPV-specific...
Hellenic Anticancer Institute
Wed Mar 04, 2020 12:40
Polyamine Analogues of Propanediamine Series Inhibit Prostate Tumor Cell Growth and Activate the Polyamine Catabolic Pathway
Background/Aim. Polyamines are important for the growth of eukaryotic cells. At high levels, they promote proliferation, invasion and migration of tumour cells. Polyamine metabolism is an important new target for anticancer therapy. Some polyamine analogues can have an inhibitory effect on tumour cells. The aim of this study was to explore the potential of certain butylated derivatives of propanediamine for prostate cancer chemotherapy. Materials and Methods. Human prostate cancer cells, LNCaP, were...
Hellenic Anticancer Institute
Wed Mar 04, 2020 12:40
Phase II Study of Second-line Chemotherapy With Paclitaxel, Gemcitabine, and Cisplatin for Advanced Urothelial Carcinoma
Background/Aim: To evaluate the efficacy and toxicity of paclitaxel, gemcitabine, and cisplatin (TGP) as second-line treatment for advanced urothelial carcinoma (UC). Patients and Methods: This study comprised advanced UC progressed after first-line cisplatin-based chemotherapy. Advanced UC was defined as a non-resectable (T4b, any N or any T, or N2-3) or metastatic disease. Twenty-one patients were included in this study. TGP was administered every 3 weeks. The primary endpoint was objective response...
Hellenic Anticancer Institute
Wed Mar 04, 2020 12:40
Changes in Serum Interleukin-8 and sRAGE Levels in Multiple Myeloma Patients
Background/Aim: Although numerous cytokines influence proliferation and progression of multiple myeloma (MM), a relevant action in the onset of the disease also seems to be played by the oxidative state. Patients and Methods: In the present study we evaluated the concentrations of interleukin-8 (IL-8) and soluble receptor of advanced glycation end products (sRAGE) in patients with MM, assessing the existing variations with respect to a control group and the possible existence of correlations between...
Hellenic Anticancer Institute
Wed Mar 04, 2020 12:40
Rapid Sarcomatoid Transformation of Lung Squamous Cell Carcinoma After Neoadjuvant Therapy: A Case Report
Pulmonary sarcomatoid carcinoma is a rare variant of non-small cell lung cancer. Here, we report on the case of a 67-year-old male with a diagnosis of biopsy-proven moderately differentiated squamous cell carcinoma of the left lower lobe of the lung. The tumor cells on biopsy had epithelioid morphology with strong immunoreactivity for CK7 and p40. The mass was surgically removed one year later due to its poor response to stereotactic radiotherapy and chemotherapy. The lobectomy specimen revealed...
Hellenic Anticancer Institute
Wed Mar 04, 2020 12:40
Hedgehog Pathway Activation Might Mediate Pemetrexed Resistance in NSCLC Cells
Background/Aim: Resistance to chemotherapeutic agents is the main cause of reduced survival in non-small cell lung cancer (NSCLC) patients. The Hedgehog (HH) pathway has been shown to be crucial in cell development and survival. Activated in several types of cancer it might be a potent bypass mechanism mediating chemotherapy resistance. Materials and Methods: HCC827 NSCLC cells were treated with sub-lethal doses of pemetrexed to produce pemetrexed resistance. RT-qPCR was performed to measure gene...
Hellenic Anticancer Institute
Wed Mar 04, 2020 12:40
Combination of Extracorporeally-irradiated Autograft and Vascularized Bone Graft for Reconstruction of Malignant Musculoskeletal Tumor
Background: Reconstruction after wide resection of a malignant musculoskeletal tumor is challenging. We performed biological reconstruction with an extracorporeally-irradiated autograft in combination with a vascularized bone graft. Patients and Methods: Fifteen patients who underwent curative resection of malignant musculoskeletal tumor followed by reconstruction with this method were included. Oncological outcomes, survival of the graft, radiological findings and functional outcomes were reviewed....
Hellenic Anticancer Institute
Wed Mar 04, 2020 12:40
Soluble Endoglin (sCD105) as a Novel Biomarker for Detecting Aggressive Prostate Cancer
Background/Aim: We have previously found elevated levels of endoglin (CD105) in the prostate cancer (PC) tissue of men with poor prognosis, compared to men with indolent disease. Herein, we examined whether plasma levels of the soluble form of CD105 (sCD105) differ according to the PC grade at diagnosis. Patients and Methods: We measured sCD105 in 73 subjects with biopsy-confirmed PC at the Durham, North Carolina, Veteran Affairs Health System. The association between sCD105 and intermediate/high-grade...
Hellenic Anticancer Institute
Wed Mar 04, 2020 12:40
Mucinous Adenocarcinoma as a High-risk Factor in Stage II Colorectal Cancer: A Propensity Score-matched Study from Japan
Background/Aim: The purpose of this study was to investigate the clinical, pathological, and prognostic differences between adenocarcinoma (ADC) and mucinous adenocarcinoma (MUC) in colorectal cancer (CRC). Patients and Methods: This was a retrospective study of a Japanese high-volume cancer Center over a 10-year period. From April 2007 to December 2016, a total of 3,296 patients with primary CRC were included in the study. The clinical characteristics of MUC and ADC were compared. Then, propensity...
Hellenic Anticancer Institute
Wed Mar 04, 2020 12:40
Radiotherapy Does Not Impact Long-term Function Following Resection of Soft-tissue Sarcomas of the Hand
Background/Aim: Radiotherapy for soft tissue sarcomas (STS) of the hand is thought to be associated with poor function. The aim of this study was to compare the long-term functional outcome in patients with and without radiotherapy. Patients and Methods: At long–term follow-up (mean 10±5 years), 33 (13 males, 20 female) patients, were alive for review. The mean patient age at surgery was 33±17 years and 13 (39%) patients received radiotherapy (mean dose 55±6 Gy). Results: Postoperatively, the mean...
Hellenic Anticancer Institute
Wed Mar 04, 2020 12:40
Performance Status Is Associated With Survival in Elderly Patients Irradiated for Cerebral Metastases from Prostate Cancer
Background/Aim: Treatment of elderly patients with cancer has increasing importance. Since many of these patients may not tolerate standard treatments, they might benefit from personalized approaches. This study was performed to identify characteristics that allow estimation of survival in elderly patients with prostate cancer with cerebral metastases. Patients and Methods: Data of 21 elderly patients (≥65 years) receiving whole-brain radiotherapy (WBRT) for cerebral metastases from prostate cancer...
Hellenic Anticancer Institute
Wed Mar 04, 2020 12:40
Immunoglobulin Restores Immune Responses to BTH1677 in Patients With Low Levels of Antibodies to Beta-glucan
Background: BTH1677 is a beta-glucan pathogen-associated molecular pattern (PAMP) being evaluated as a novel immunotherapy of cancer. We previously described that the presence of antibodies against beta-glucan (ABA) in serum is necessary for BTH1677 antitumoral activity. We hypothesized that infusion of immunoglobulin can reinstate responses to BTH1677 in individuals with low ABA levels. Patients and Methods: We report two single-patient studies: one in a patient with metastatic colorectal cancer...
Hellenic Anticancer Institute
Wed Mar 04, 2020 12:40
Assessment of Daily Replanning and Geometrical Variation of High-dose-rate Brachytherapy for the Prostate
Background: The present study aimed to estimate geometric changes in applicators and prostate over 3 days in patients with high-dose-rate brachytherapy (HDR-BT) and to assess the need for daily replanning. Patients and Methods: This study retrospectively investigated 18 patients who underwent HDR-BT as monotherapy from February 2016 to October 2018. Results: Without replanning, the planning target volume coverage significantly worsened on day 2 (p<0.001) and day 3 (p=0.003). The minimum dose distributed...
Hellenic Anticancer Institute
Wed Mar 04, 2020 12:40
Long-term Survival After Surgical Treatment of Spinal Metastasis - The Predictive Role of Sex
Background/Aim: An increasing number of patients undergo surgical treatment for metastatic spinal cord compression (MSCC). However, the possible role of sex as an independent predictor of long-term survival has not been studied. This study aimed to examine whether sex is associated with long-term survival after surgical treatment in patients with MSCC. Patients and Methods: A total of 110 patients were operated on for MSCC from 2005 through 2006. The relation between sex and overall survival was...
Hellenic Anticancer Institute
Wed Mar 04, 2020 12:40
Elevated Gastric Juice Carbohydrate Antigen 72.4 (Ca 72.4) Is an Independent Prognostic Factor of Poor Survival for Gastric Cancer Patients
Background/Aim: As of 2020, carbohydrate antigen 72.4 (Ca 72.4) has been rarely investigated in the gastric juice (GJ) of patients with gastric cancer (GC). Our aim was to analyze the significance and role of this tumor antigen in the GJ of our GC population. Patients and Methods: Between April 2012 and July 2013, 37 patients with operable GC were prospectively investigated to determine the GJ Ca 72.4 levels before surgical manipulation. Results: GJ Ca 72.4 ≥6.49 ng/ml strongly correlated with the...
Hellenic Anticancer Institute
Wed Mar 04, 2020 12:40
Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Ovarian Cancer: Evaluation of Side Effects in a Single Institution Cohort
Background/Aim: Peritoneal carcinomatosis is a sign of advanced ovarian cancer. If cytoreductive surgery results in a tumor-free situation with the remaining tumor being less than 0.25 cm, Hyperthermic intraperitoneal chemotherapy (HIPEC) may further improve prognosis. Patients and Methods: Patients with ovarian cancer and peritoneal carcinomatosis underwent cytoreductive surgery. In 43 patients with optimal tumor debulking, HIPEC was performed. The peri- and post-operative course was observed. Adverse...
Hellenic Anticancer Institute
Wed Mar 04, 2020 12:40
Factors Affecting Colorectal Polyp and Cancer Detection Rates in Patients Referred Urgently for Suspected Bowel Cancer
Background/Aim: To investigate factors that affect colorectal polyp or colorectal cancer (CRC) detection amongst patients referred urgently to colorectal services for suspected bowel cancer. Patients and Methods: This was a prospective observational study at a UK colorectal centre (2017-2018). Logistic regression determined odds ratios for colorectal polyp or CRC according to age, gender, previous polyp or cancer, and the 6 NICE referral (NG12) categories. Results: A total of 605 patients were included...
Hellenic Anticancer Institute
Wed Mar 04, 2020 12:40
Clinicopathological and Prognostic Significance of Programmed Death Ligand 1 Expression in Korean Patients With Triple-negative Breast Carcinoma
Background/Aim: The clinicopathological and prognostic significances of programmed death ligand 1 (PD-L1) expression in triple-negative breast carcinoma (TNBC) are still unclear. We investigated whether PD-L1 expression is associated with clinicopathological characteristics and outcomes of TNBC patients. Materials and Methods: We performed immunostaining for PD-L1 (SP142) in 83 TNBCs. Staining proportion of ≥1% was regarded as positive PD-L1 expression. Results: Positive intratumoral (IT) PD-L1 expression...
Hellenic Anticancer Institute
Wed Mar 04, 2020 12:40
Evaluation of Ultrasound-guided 8-Gauge Vacuum-assisted Excision System for the Removal of US-detectable Breast Lesions
Aim: To assess the ability of ultrasound (US)-guided vacuum-assisted breast excision (VAE) to remove Breast Imaging Reporting and Data System (BI-RADS) ≥3 breast lesions in order to analyze US features most frequently associated with complete excision. Materials and Methods: A total of 266 BI-RADS ≥3 lesions without microcalcifications underwent US-VAE. US-VAE and gold standard pathological results were compared. US features of lesions were analyzed. Results: The complete excision rate was 93.61%;...
Hellenic Anticancer Institute
Wed Mar 04, 2020 12:40
Association Between the Functional miR-146a SNP rs2910164 and Risk of Digestive System Cancer: Updated Meta-analysis
Background/Aim: Previous association studies have linked the functional miR-146a SNP rs2910164 with risk of digestive system cancer; however, the results of these studies are inconclusive and inconsistent. The objective of the following study is to provide an up-to-date and comprehensive meta-analysis of the association of miR-146a rs2910164 and digestive system cancer risk. Patients and Methods: We searched the PUBMED/MEDLINE and Cochrane/EBM databases. The following inclusion criteria were used...
Hellenic Anticancer Institute
Wed Mar 04, 2020 12:40
The Prognostic Value of Systemic Inflammatory Markers in Advanced Renal Cell Carcinoma Patients Treated With Molecular Targeted Therapies
Background/Aim: The present study examined the impact of systemic inflammatory markers including C-reactive protein (CRP)/Albumin (Alb) and neutrophil lymphocyte ratio (NLR)/Alb on the prognosis of patients treated with first line molecular targeted therapy for advanced RCC. Patients and Methods: A total of 131 patients with advanced RCC treated with molecular targeted therapy as first line treatment from May 2008 to April 2019 were retrospectively analyzed. Results: High CRP, high NLR, low Alb and...
Hellenic Anticancer Institute
Wed Mar 04, 2020 12:40
The Prognostic Value of the Perioperative Systemic Inflammation Score for Patients With Advanced Gastric Cancer
Aim: We examined whether the perioperative systemic inflammation score (SIS), which describes systemic inflammation and/or malnutrition, affected the tumor recurrence and survival in advanced gastric cancer patients. Patients and Methods: The study retrospectively analyzed 160 patients with stage II/III gastric cancer who underwent curative resection at the Kanagawa Cancer Center. The SIS was evaluated before surgery, one week after surgery and one month after surgery, as determined by the serum...
Hellenic Anticancer Institute
Wed Mar 04, 2020 12:40
Hybrid Minimally-invasive Esophagectomy for Esophageal Cancer: Clinical and Oncological Outcomes
Background/Aim: Esophagectomy is a major surgical procedure associated with a significant risk of morbidity and mortality that has traditionally been performed by an open approach. Although minimally invasive procedures for benign esophageal disease have been widely accepted worldwide, they have not yet been established for the treatment of malignancy. Patients and Methods: A total of 137 consecutive hybrid esophagectomies for cancer were performed by the same surgical team. Surgical approach included...
Hellenic Anticancer Institute
Wed Mar 04, 2020 12:40
Detection of HPV mRNA in Self-collected Vaginal Samples Among Urban Ethiopian Women
Background/Aim: Cervical cancer is the most common cancer among women in Ethiopia. The objective was to evaluate the participation rate of a free of charge vaginal self-sample (Aptima multitest swab, Hologic) for the detection of human papillomavirus (HPV) in an Ethiopian cohort. Patients and Methods: Specimens were collected from women employed by Ethiopian Airlines in Addis Abeba (N=5950). Samples were analysed for the presence of high-risk (HR) HPV mRNA by the Aptima HPV assay (Hologic) and HPV...
Hellenic Anticancer Institute
Wed Mar 04, 2020 12:40
Adjuvant Chemotherapy and Dose Escalation in Definitive Concurrent Chemoradiotherapy for Esophageal Squamous Cell Carcinoma
Background/Aim: To validate the effect of treatment intensification on survival in esophageal squamous cell carcinoma (ESCC) patients undergoing definitive concurrent chemoradiotherapy (dCCRT). Patients and Methods: We reviewed the medical records of 73 ESCC patients who underwent dCCRT between 2006 and 2017 in 3 institutions. Results: The median follow-up time was 13.3 months. The median overall survival (OS) and locoregional recurrence-free survival (LRFS) were 13.3 and 11.2 months, respectively....
Hellenic Anticancer Institute
Wed Mar 04, 2020 12:40
Chondrosarcoma of the Chest Wall: A Review of 53 Cases from Two Institutions
Background/Aim: Chondrosarcomas (CS) of the chest wall are rare, but present an aggressive biological behavior compared to CS of the extremities. The aims of the present study were to determine factors associated with oncological outcomes as well as complications. Patients and Methods: We retrospectively analyzed 53 patients (42 primary, 11 recurrent tumors). In total, 39 central CS, 10 peripheral CS, 3 dedifferentiated CS and 1 mesenchymal CS were included. The ribs were most commonly affected (68%)....
Hellenic Anticancer Institute
Wed Mar 04, 2020 12:40
Erratum
Hellenic Anticancer Institute
Wed Mar 04, 2020 12:40
Obstructive sleep apnea in children with down syndrome - Prevalence and evaluation of surgical treatment.
Related ArticlesObstructive sleep apnea in children with down syndrome - Prevalence and evaluation of surgical treatment. Int J Pediatr Otorhinolaryngol. 2020 Feb 26;133:109968 Authors: Nerfeldt P, Sundelin A Abstract INTRODUCTION: The prevalence of obstructive sleep apnea (OSA) in the pediatric population with Down syndrome (DS) is reported to be 45-76%. The criterion "gold" standard for diagnosing OSA is polysomnography (PSG). First-hand surgical treatment...
International journal of pediatric otorhinolaryngology,http://goo.gl/4YdRhz
Wed Mar 04, 2020 13:15
Geswein hole: A fanciful Wikipedian medical eponym for preauricular sinus.
Related ArticlesGeswein hole: A fanciful Wikipedian medical eponym for preauricular sinus. Int J Pediatr Otorhinolaryngol. 2020 Feb 18;133:109958 Authors: Mudry A Abstract In the English version of the online encyclopaedia, Wikipedia, we find the term "Geswein hole" mentioned as another name for preauricular sinus. On the Wikipedia page, the following note "Geswein, a familial name of German descent" is used as a reference. The aim of this study is to...
International journal of pediatric otorhinolaryngology,http://goo.gl/4YdRhz
Wed Mar 04, 2020 13:15
Application of mesenchymal stem cell for tympanic membrane regeneration by tissue engineering approach.
Related ArticlesApplication of mesenchymal stem cell for tympanic membrane regeneration by tissue engineering approach. Int J Pediatr Otorhinolaryngol. 2020 Feb 25;133:109969 Authors: Maharajan N, Cho GW, Jang CH Abstract Regeneration is a biological process of cell renewal that takes place in damaged tissues or organs. It is naturally stimulated by the release of different growth factors, cytokines, surface molecules, and stem cells at the wounded sites....
International journal of pediatric otorhinolaryngology,http://goo.gl/4YdRhz
Wed Mar 04, 2020 13:15
Fetal anatomy of parathyroid glands.
Related ArticlesFetal anatomy of parathyroid glands. Wiad Lek. 2020;73(1):52-57 Authors: Lopushniak LY, Khmara ТV, Boichuk ОМ, Ryznychuk MA, Shvyhar LV, Kryvchanska MI Abstract OBJECTIVE: The aim: To study the forms of anatomical variability of the external structure of the upper and lower parathyroid glands in the fetal period of human ontogenesis. PATIENTS AND METHODS: Materials and methods: The study involved 48 specimens of human fetuses...
Larynx
Wed Mar 04, 2020 13:13
The Nerve to Thyrohyoid Muscle as a Novel Donor Nerve for Laryngeal Reinnervation.
Related ArticlesThe Nerve to Thyrohyoid Muscle as a Novel Donor Nerve for Laryngeal Reinnervation. Ann Otol Rhinol Laryngol. 2020 Apr;129(4):355-360 Authors: Graham ME, Smith ME Abstract OBJECTIVES: Recurrent laryngeal nerve (RLN) injury may be a consequence of surgical procedures of the skull base, neck, and chest, with adverse consequences to function and quality of life. Laryngeal reinnervation offers a potentially stable improvement in vocal fold...
Larynx
Wed Mar 04, 2020 13:13
Interarytenoid botulinum toxin A injection for the treatment of vocal process granuloma.
Related ArticlesInterarytenoid botulinum toxin A injection for the treatment of vocal process granuloma. J Laryngol Otol. 2019 Dec;133(12):1041-1045 Authors: Hamdan AL, Khalifee E, Jaffal H, Ghanem A Abstract OBJECTIVES: To report on the efficacy and adverse effects of interarytenoid botulinum toxin A injection for the treatment of vocal process granuloma. METHODS: A retrospective chart review was conducted of eight patients with vocal process...
Larynx
Wed Mar 04, 2020 13:13
Extracellular voltage thresholds for maximizing information extraction in primate auditory cortex: implications for a brain computer interface.
Related ArticlesExtracellular voltage thresholds for maximizing information extraction in primate auditory cortex: implications for a brain computer interface. J Neural Eng. 2020 Mar 03;: Authors: Bigelow J, Malone B Abstract OBJECTIVE: Research by Oby et al (2016) demonstrated that the optimal threshold for extracting information from visual and motor cortices may differ from the optimal threshold for identifying single neurons via spike sorting methods....
J Neural Eng
Wed Mar 04, 2020 13:10
Modulation of muscle synergies for multiple forearm movements under variant force and arm position constraints.
Related ArticlesModulation of muscle synergies for multiple forearm movements under variant force and arm position constraints. J Neural Eng. 2020 Mar 03;: Authors: Geng Y, Deng H, Samuel OW, Cheung VCK, Xu L, Li G Abstract OBJECTIVE: To promote clinical applications of muscle-synergy-based neurorehabilitation techniques, this study aims to clarify any potential modulations of both the muscular compositions and temporal activations of forearm muscle...
J Neural Eng
Wed Mar 04, 2020 13:10

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