Background/Aim: This study aimed to determine whether a pelvic and para-aortic lymphadenectomy (PPAL) improves survival compared with a pelvic lymphadenectomy (PL) in patients with endometrial cancer. Patients and Methods: Data from all women operated for endometrial cancer between 1998 and 2013 were extracted from the Surveillance, Epidemiology and End Results database. Women treated with PL were matched with those treated with PPAL according to age and risk of recurrence. The primary endpoint was...
Wed Mar 04, 2020 12:40
Background/Aim: Anti-cancer drug resistance restricts the efficacy of chemotherapy in malignant tumors. Casein kinase 2α (CK2α) is highly expressed in 5-fluorouracil (5FU)-resistant colorectal cancer (CRC) cells. We hypothesized that inhibition of CK2α might reduce CRC resistance to 5FU. Materials and Methods: To investigate the role of CK2α in 5FU-resistant CRC cells, we assessed cell viability, apoptosis, cyclin-dependent kinase 4 (CDK4) activity, cell-cycle progression, invasion, and sphere formation...
Wed Mar 04, 2020 12:40
Background/Aim: The utility of nanoparticle albumin-bound paclitaxel (nab-PTX) monotherapy in patients with relapsed small-cell lung cancer (SCLC) has not been fully evaluated. We aimed to investigate the efficacy and safety of nab-PTX monotherapy in relapsed SCLC patients, including heavily treated patients. Patients and Methods: We retrospectively analysed data from 17 patients with relapsed SCLC who were treated with weekly nab-PTX monotherapy at our hospital. We also reviewed past studies on...
Wed Mar 04, 2020 12:40
Background/Aim: Cervical cancer is one of the most common cancers worldwide and a major cause of cancer-related mortality among women. Previous studies have reported that microRNA-miR-187*, which is one of the non-coding parts of the genome producing small conserved ribonucleic acids, is associated with various cancers. In this study, we explored the function of miR-187* in cervical cancer cells. Materials and Methods: miR-187* mimic, WWOX reporter constructs, siRNA and overexpression constructs...
Wed Mar 04, 2020 12:40
Abstract. Background/Aim: The incidence of oropharyngeal tumours induced by human papillomaviruses (HPV) is ever increasing. Information about oral HPV prevalence and its risk factors are very important for future screening and early diagnosis of the disease. The present study aimed to assess oral HPV prevalence in healthy population and risk factors for HPV infection, since this data is scarce or even missing in Central Europe. Patients and Methods: HPV prevalence in oral rinse and HPV-specific...
Wed Mar 04, 2020 12:40
Background/Aim. Polyamines are important for the growth of eukaryotic cells. At high levels, they promote proliferation, invasion and migration of tumour cells. Polyamine metabolism is an important new target for anticancer therapy. Some polyamine analogues can have an inhibitory effect on tumour cells. The aim of this study was to explore the potential of certain butylated derivatives of propanediamine for prostate cancer chemotherapy. Materials and Methods. Human prostate cancer cells, LNCaP, were...
Wed Mar 04, 2020 12:40
Background/Aim: To evaluate the efficacy and toxicity of paclitaxel, gemcitabine, and cisplatin (TGP) as second-line treatment for advanced urothelial carcinoma (UC). Patients and Methods: This study comprised advanced UC progressed after first-line cisplatin-based chemotherapy. Advanced UC was defined as a non-resectable (T4b, any N or any T, or N2-3) or metastatic disease. Twenty-one patients were included in this study. TGP was administered every 3 weeks. The primary endpoint was objective response...
Wed Mar 04, 2020 12:40
Background/Aim: Although numerous cytokines influence proliferation and progression of multiple myeloma (MM), a relevant action in the onset of the disease also seems to be played by the oxidative state. Patients and Methods: In the present study we evaluated the concentrations of interleukin-8 (IL-8) and soluble receptor of advanced glycation end products (sRAGE) in patients with MM, assessing the existing variations with respect to a control group and the possible existence of correlations between...
Wed Mar 04, 2020 12:40
Pulmonary sarcomatoid carcinoma is a rare variant of non-small cell lung cancer. Here, we report on the case of a 67-year-old male with a diagnosis of biopsy-proven moderately differentiated squamous cell carcinoma of the left lower lobe of the lung. The tumor cells on biopsy had epithelioid morphology with strong immunoreactivity for CK7 and p40. The mass was surgically removed one year later due to its poor response to stereotactic radiotherapy and chemotherapy. The lobectomy specimen revealed...
Wed Mar 04, 2020 12:40
Background/Aim: Resistance to chemotherapeutic agents is the main cause of reduced survival in non-small cell lung cancer (NSCLC) patients. The Hedgehog (HH) pathway has been shown to be crucial in cell development and survival. Activated in several types of cancer it might be a potent bypass mechanism mediating chemotherapy resistance. Materials and Methods: HCC827 NSCLC cells were treated with sub-lethal doses of pemetrexed to produce pemetrexed resistance. RT-qPCR was performed to measure gene...
Wed Mar 04, 2020 12:40
Background: Reconstruction after wide resection of a malignant musculoskeletal tumor is challenging. We performed biological reconstruction with an extracorporeally-irradiated autograft in combination with a vascularized bone graft. Patients and Methods: Fifteen patients who underwent curative resection of malignant musculoskeletal tumor followed by reconstruction with this method were included. Oncological outcomes, survival of the graft, radiological findings and functional outcomes were reviewed....
Wed Mar 04, 2020 12:40
Background/Aim: We have previously found elevated levels of endoglin (CD105) in the prostate cancer (PC) tissue of men with poor prognosis, compared to men with indolent disease. Herein, we examined whether plasma levels of the soluble form of CD105 (sCD105) differ according to the PC grade at diagnosis. Patients and Methods: We measured sCD105 in 73 subjects with biopsy-confirmed PC at the Durham, North Carolina, Veteran Affairs Health System. The association between sCD105 and intermediate/high-grade...
Wed Mar 04, 2020 12:40
Background/Aim: The purpose of this study was to investigate the clinical, pathological, and prognostic differences between adenocarcinoma (ADC) and mucinous adenocarcinoma (MUC) in colorectal cancer (CRC). Patients and Methods: This was a retrospective study of a Japanese high-volume cancer Center over a 10-year period. From April 2007 to December 2016, a total of 3,296 patients with primary CRC were included in the study. The clinical characteristics of MUC and ADC were compared. Then, propensity...
Wed Mar 04, 2020 12:40
Background/Aim: Radiotherapy for soft tissue sarcomas (STS) of the hand is thought to be associated with poor function. The aim of this study was to compare the long-term functional outcome in patients with and without radiotherapy. Patients and Methods: At long–term follow-up (mean 10±5 years), 33 (13 males, 20 female) patients, were alive for review. The mean patient age at surgery was 33±17 years and 13 (39%) patients received radiotherapy (mean dose 55±6 Gy). Results: Postoperatively, the mean...
Wed Mar 04, 2020 12:40
Background/Aim: Treatment of elderly patients with cancer has increasing importance. Since many of these patients may not tolerate standard treatments, they might benefit from personalized approaches. This study was performed to identify characteristics that allow estimation of survival in elderly patients with prostate cancer with cerebral metastases. Patients and Methods: Data of 21 elderly patients (≥65 years) receiving whole-brain radiotherapy (WBRT) for cerebral metastases from prostate cancer...
Wed Mar 04, 2020 12:40
Background: BTH1677 is a beta-glucan pathogen-associated molecular pattern (PAMP) being evaluated as a novel immunotherapy of cancer. We previously described that the presence of antibodies against beta-glucan (ABA) in serum is necessary for BTH1677 antitumoral activity. We hypothesized that infusion of immunoglobulin can reinstate responses to BTH1677 in individuals with low ABA levels. Patients and Methods: We report two single-patient studies: one in a patient with metastatic colorectal cancer...
Wed Mar 04, 2020 12:40
Background: The present study aimed to estimate geometric changes in applicators and prostate over 3 days in patients with high-dose-rate brachytherapy (HDR-BT) and to assess the need for daily replanning. Patients and Methods: This study retrospectively investigated 18 patients who underwent HDR-BT as monotherapy from February 2016 to October 2018. Results: Without replanning, the planning target volume coverage significantly worsened on day 2 (p<0.001) and day 3 (p=0.003). The minimum dose distributed...
Wed Mar 04, 2020 12:40
Background/Aim: An increasing number of patients undergo surgical treatment for metastatic spinal cord compression (MSCC). However, the possible role of sex as an independent predictor of long-term survival has not been studied. This study aimed to examine whether sex is associated with long-term survival after surgical treatment in patients with MSCC. Patients and Methods: A total of 110 patients were operated on for MSCC from 2005 through 2006. The relation between sex and overall survival was...
Wed Mar 04, 2020 12:40
Background/Aim: As of 2020, carbohydrate antigen 72.4 (Ca 72.4) has been rarely investigated in the gastric juice (GJ) of patients with gastric cancer (GC). Our aim was to analyze the significance and role of this tumor antigen in the GJ of our GC population. Patients and Methods: Between April 2012 and July 2013, 37 patients with operable GC were prospectively investigated to determine the GJ Ca 72.4 levels before surgical manipulation. Results: GJ Ca 72.4 ≥6.49 ng/ml strongly correlated with the...
Wed Mar 04, 2020 12:40
Background/Aim: Peritoneal carcinomatosis is a sign of advanced ovarian cancer. If cytoreductive surgery results in a tumor-free situation with the remaining tumor being less than 0.25 cm, Hyperthermic intraperitoneal chemotherapy (HIPEC) may further improve prognosis. Patients and Methods: Patients with ovarian cancer and peritoneal carcinomatosis underwent cytoreductive surgery. In 43 patients with optimal tumor debulking, HIPEC was performed. The peri- and post-operative course was observed. Adverse...
Wed Mar 04, 2020 12:40
Background/Aim: To investigate factors that affect colorectal polyp or colorectal cancer (CRC) detection amongst patients referred urgently to colorectal services for suspected bowel cancer. Patients and Methods: This was a prospective observational study at a UK colorectal centre (2017-2018). Logistic regression determined odds ratios for colorectal polyp or CRC according to age, gender, previous polyp or cancer, and the 6 NICE referral (NG12) categories. Results: A total of 605 patients were included...
Wed Mar 04, 2020 12:40
Background/Aim: The clinicopathological and prognostic significances of programmed death ligand 1 (PD-L1) expression in triple-negative breast carcinoma (TNBC) are still unclear. We investigated whether PD-L1 expression is associated with clinicopathological characteristics and outcomes of TNBC patients. Materials and Methods: We performed immunostaining for PD-L1 (SP142) in 83 TNBCs. Staining proportion of ≥1% was regarded as positive PD-L1 expression. Results: Positive intratumoral (IT) PD-L1 expression...
Wed Mar 04, 2020 12:40
Aim: To assess the ability of ultrasound (US)-guided vacuum-assisted breast excision (VAE) to remove Breast Imaging Reporting and Data System (BI-RADS) ≥3 breast lesions in order to analyze US features most frequently associated with complete excision. Materials and Methods: A total of 266 BI-RADS ≥3 lesions without microcalcifications underwent US-VAE. US-VAE and gold standard pathological results were compared. US features of lesions were analyzed. Results: The complete excision rate was 93.61%;...
Wed Mar 04, 2020 12:40
Background/Aim: Previous association studies have linked the functional miR-146a SNP rs2910164 with risk of digestive system cancer; however, the results of these studies are inconclusive and inconsistent. The objective of the following study is to provide an up-to-date and comprehensive meta-analysis of the association of miR-146a rs2910164 and digestive system cancer risk. Patients and Methods: We searched the PUBMED/MEDLINE and Cochrane/EBM databases. The following inclusion criteria were used...
Wed Mar 04, 2020 12:40
Background/Aim: The present study examined the impact of systemic inflammatory markers including C-reactive protein (CRP)/Albumin (Alb) and neutrophil lymphocyte ratio (NLR)/Alb on the prognosis of patients treated with first line molecular targeted therapy for advanced RCC. Patients and Methods: A total of 131 patients with advanced RCC treated with molecular targeted therapy as first line treatment from May 2008 to April 2019 were retrospectively analyzed. Results: High CRP, high NLR, low Alb and...
Wed Mar 04, 2020 12:40
Aim: We examined whether the perioperative systemic inflammation score (SIS), which describes systemic inflammation and/or malnutrition, affected the tumor recurrence and survival in advanced gastric cancer patients. Patients and Methods: The study retrospectively analyzed 160 patients with stage II/III gastric cancer who underwent curative resection at the Kanagawa Cancer Center. The SIS was evaluated before surgery, one week after surgery and one month after surgery, as determined by the serum...
Wed Mar 04, 2020 12:40
Background/Aim: Esophagectomy is a major surgical procedure associated with a significant risk of morbidity and mortality that has traditionally been performed by an open approach. Although minimally invasive procedures for benign esophageal disease have been widely accepted worldwide, they have not yet been established for the treatment of malignancy. Patients and Methods: A total of 137 consecutive hybrid esophagectomies for cancer were performed by the same surgical team. Surgical approach included...
Wed Mar 04, 2020 12:40
Background/Aim: Cervical cancer is the most common cancer among women in Ethiopia. The objective was to evaluate the participation rate of a free of charge vaginal self-sample (Aptima multitest swab, Hologic) for the detection of human papillomavirus (HPV) in an Ethiopian cohort. Patients and Methods: Specimens were collected from women employed by Ethiopian Airlines in Addis Abeba (N=5950). Samples were analysed for the presence of high-risk (HR) HPV mRNA by the Aptima HPV assay (Hologic) and HPV...
Wed Mar 04, 2020 12:40
Background/Aim: To validate the effect of treatment intensification on survival in esophageal squamous cell carcinoma (ESCC) patients undergoing definitive concurrent chemoradiotherapy (dCCRT). Patients and Methods: We reviewed the medical records of 73 ESCC patients who underwent dCCRT between 2006 and 2017 in 3 institutions. Results: The median follow-up time was 13.3 months. The median overall survival (OS) and locoregional recurrence-free survival (LRFS) were 13.3 and 11.2 months, respectively....
Wed Mar 04, 2020 12:40
Background/Aim: Chondrosarcomas (CS) of the chest wall are rare, but present an aggressive biological behavior compared to CS of the extremities. The aims of the present study were to determine factors associated with oncological outcomes as well as complications. Patients and Methods: We retrospectively analyzed 53 patients (42 primary, 11 recurrent tumors). In total, 39 central CS, 10 peripheral CS, 3 dedifferentiated CS and 1 mesenchymal CS were included. The ribs were most commonly affected (68%)....
Wed Mar 04, 2020 12:40
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Wed Mar 04, 2020 13:15
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Wed Mar 04, 2020 13:15
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Wed Mar 04, 2020 13:15
Related ArticlesFetal anatomy of parathyroid glands. Wiad Lek. 2020;73(1):52-57 Authors: Lopushniak LY, Khmara ТV, Boichuk ОМ, Ryznychuk MA, Shvyhar LV, Kryvchanska MI Abstract OBJECTIVE: The aim: To study the forms of anatomical variability of the external structure of the upper and lower parathyroid glands in the fetal period of human ontogenesis. PATIENTS AND METHODS: Materials and methods: The study involved 48 specimens of human fetuses...
Wed Mar 04, 2020 13:13
Related ArticlesThe Nerve to Thyrohyoid Muscle as a Novel Donor Nerve for Laryngeal Reinnervation. Ann Otol Rhinol Laryngol. 2020 Apr;129(4):355-360 Authors: Graham ME, Smith ME Abstract OBJECTIVES: Recurrent laryngeal nerve (RLN) injury may be a consequence of surgical procedures of the skull base, neck, and chest, with adverse consequences to function and quality of life. Laryngeal reinnervation offers a potentially stable improvement in vocal fold...
Wed Mar 04, 2020 13:13
Related ArticlesInterarytenoid botulinum toxin A injection for the treatment of vocal process granuloma. J Laryngol Otol. 2019 Dec;133(12):1041-1045 Authors: Hamdan AL, Khalifee E, Jaffal H, Ghanem A Abstract OBJECTIVES: To report on the efficacy and adverse effects of interarytenoid botulinum toxin A injection for the treatment of vocal process granuloma. METHODS: A retrospective chart review was conducted of eight patients with vocal process...
Wed Mar 04, 2020 13:13
Related ArticlesExtracellular voltage thresholds for maximizing information extraction in primate auditory cortex: implications for a brain computer interface. J Neural Eng. 2020 Mar 03;: Authors: Bigelow J, Malone B Abstract OBJECTIVE: Research by Oby et al (2016) demonstrated that the optimal threshold for extracting information from visual and motor cortices may differ from the optimal threshold for identifying single neurons via spike sorting methods....
Wed Mar 04, 2020 13:10
Related ArticlesModulation of muscle synergies for multiple forearm movements under variant force and arm position constraints. J Neural Eng. 2020 Mar 03;: Authors: Geng Y, Deng H, Samuel OW, Cheung VCK, Xu L, Li G Abstract OBJECTIVE: To promote clinical applications of muscle-synergy-based neurorehabilitation techniques, this study aims to clarify any potential modulations of both the muscular compositions and temporal activations of forearm muscle...
Wed Mar 04, 2020 13:10
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