Abstract Emotional state, in particular anxiety, has been shown to constrain perceptual judgement of action capabilities. However, whether anxiety also constrains actual behaviour is unknown. The current study, therefore, aimed to determine whether state anxiety constrained firstly perceptual judgements of action capabilities and secondly actual behaviour. To do this, we asked participants to make perceptual judgements and perform action behaviours in relation to crossing ground-based...
Wed Mar 04, 2020 02:00
Abstract The perception of an event is strongly influenced by the context in which it occurs. Here, we examined the effect of a rhythmic context on detection of asynchrony in both the auditory and vibrotactile modalities. Using the method of constant stimuli and a two-alternative forced choice (2AFC), participants were presented with pairs of pure tones played either simultaneously or with various levels of stimulus onset asynchrony (SOA). Target stimuli in both modalities were...
Wed Mar 04, 2020 02:00
Abstract High-status individuals have been found to be less attuned to the behaviour of others in the social environment, at least in the absence of any specific instructions to pay attention to them. Previous work using neural measures has shown that socioeconomic status (SES) influences the degree to which people are attuned to the actions of others. In particular, individuals from low-SES backgrounds were found to exhibit more mu-suppression, which has been suggested to reflect...
Wed Mar 04, 2020 02:00
Abstract Background and aims Primary aldosteronism (PA) due to unilateral aldosterone-producing adenoma (APA) is preferentially treated by unilateral adrenalectomy (ADX), but little is known about the changes in lipid and glucose metabolism that may occur after ADX. Methods We studied 19 non-diabetic patients who did not use lipid-lowering drugs with...
Wed Mar 04, 2020 02:00
Abstract The Indian Council of Medical Research-National Institute of Cancer Prevention and Research (ICMR-NICPR) has been conducting online cancer screening training certificate courses since 2017. Thereafter, multiple cohorts have been trained successfully in cancer screening using the Extensions for Community Healthcare Outcomes (ECHO) platform. A 14-week course was designed for various cadres of healthcare professionals (HCP), through which they were trained in cancer screening...
Wed Mar 04, 2020 02:00
Abstract Trimodality bladder preservation (BP) is an accepted alternative to radical cystectomy for patients with muscle invasive bladder cancer (MIBC). The global utilization of BP is variable, and practice patterns have not been previously studied in Russia. We sought to elucidate the contemporary BP practice patterns in Russia and determine the impact of the BP workshop on attitudes of Russian radiation oncologists (ROs) towards BP. The workshop was focused on patient workup,...
Wed Mar 04, 2020 02:00
Abstract Receiving the HPV vaccine at a young age before being exposed to the virus is essential to improve HPV-related cancer prevention. In many countries in the world, like Italy, the HPV vaccine is offered free of charges to boys and girls aged 12–14. Despite this incentive, the HPV vaccine uptake in Italy remains low. Several interventions and campaigns have been implemented to educate parents and providers. However, children of 12–14 years old have been left out by prevention...
Wed Mar 04, 2020 02:00
Abstract Survivorship care plans (SCPs) serve to communicate critical information needed for cancer survivors’ long-term follow-up care. The extent to which SCPs are tailored to meet the specific needs of underserved patient populations is understudied. To fill this gap, this study aimed to assess the content and communication appropriateness of SCPs collected from diverse healthcare settings. We analyzed collected SCPs (n = 16) for concordance with Institute of Medicine (IOM)...
Wed Mar 04, 2020 02:00
Abstract This manuscript demonstrates the learning experiences of graduate public health students through mentored field research in cancer epidemiology and cancer prevention over the past 13 years. The program has been funded through an R25 grant from the National Cancer Institute (NCI) since 2006 and has supported nearly 200 students from different universities in the USA. Included are data on student recruitment, selection, mentorship, and evaluation of research training in...
Wed Mar 04, 2020 02:00
We describe here a method for growth of Neisseria gonorrhoeae in metal-restricted liquid medium to facilitate the expression of genes for metal uptake. We also outline downstream experiments to characterize the phenotype of gonococci grown in these conditions. These methods may be adapted to be suitable for characterization of metal-responsive genes in other bacteria.
Wed Mar 04, 2020 21:00
Here, we describe the immunoprecipitation of ribosomes and associated RNA from select populations of adult male mouse germ cells using the RiboTag system. Strategic breeding and careful immunoprecipitation result in clean, reproducible results that inform on the germ cell translatome and provide insight into the mechanisms of mutant phenotypes.
Wed Mar 04, 2020 21:00
This article describes a transplantation method to graft donor rat mammary epithelial cells into the interscapular white fat pad of recipient animals. This method can be used to examine host and/or donor effects on mammary epithelium development and eliminates the need for pre-clearing, thereby extending the usefulness of this technique.
Wed Mar 04, 2020 20:00
This protocol was generated as a means to produce brain organoids in a simplified, low cost manner without exogenous growth factors or basement membrane matrix while still maintaining the diversity of brain cell types and many features of cellular organization.
Wed Mar 04, 2020 19:00
Publication date: April 2020Source: European Journal of Cancer, Volume 129Author(s): Capucine Baldini, Patricia Martin Romano, Anne-Laure Voisin, François-Xavier Danlos, Stéphane Champiat, Salim Laghouati, Maria Kfoury, Hélène Vincent, Sophie Postel-Vinay, Andreea Varga, Perrine Vuagnat, Vincent Ribrag, Laura Mezquita, Benjamin Besse, Antoine Hollebecque, Olivier Lambotte, Jean-Marie Michot, Jean-Charles Soria, Christophe Massard, Aurélien Marabelle
Wed Mar 04, 2020 21:21
Abstract Neuraxial anesthesia is a common practice in obstetrics. Evidence suggests that preprocedural ultrasound versus the conventional landmark location method accurately identifies a given intervertebral space and predicts the needle insertion depth required to reach the spinal canal. However, whether the preprocedural ultrasound examination improves the first-pass success (FPS) rate remains elusive. Major databases were systematically searched for all relevant studies published...
Wed Mar 04, 2020 02:00
Background. Vitamin A deficiency is a major nutritional concern in lower-income countries. The aim of this systematic review and meta-analysis was to show the magnitude of vitamin A deficiency among preschoolers in Ethiopia. Objective. The present study was aimed at synthesizing qualitatively and quantitatively the existing literature on the prevalence of VAD in preschool children in Ethiopia. Methods. Studies were searched through the search engine of Google Scholar, Hinari, MEDLINE/PubMed, Cochrane...
Wed Mar 04, 2020 17:50
Objectives. To reveal the molecular mechanisms of ulcerative colitis (UC) and provide potential biomarkers for UC gene therapy. Methods. We downloaded the GSE87473 microarray dataset from the Gene Expression Omnibus (GEO) and identified the differentially expressed genes (DEGs) between UC samples and normal samples. Then, a module partition analysis was performed based on a weighted gene coexpression network analysis (WGCNA), followed by pathway and functional enrichment analyses. Furthermore, we...
Wed Mar 04, 2020 17:05
A cattle-yak, which is a hybrid between a yak (Bos grunniens) and cattle (Bos taurus), is an important livestock animal, but basic questions regarding its physiology and environmental adaptation remain unanswered. To address this issue, the present study examined the species composition and functional characteristics of rumen microorganisms in the cattle-yak of different ages (2 and 3 years old) by metagenomic analysis. We found that rumen microbial community composition was similar at the two ages....
Wed Mar 04, 2020 17:05
Astragalus membranaceus polysaccharide (APS) components are main ingredients of TCM and have proven efficacy to activate T cells and B cells, enhancing immunity in humans. In this study, elevated cytokine and anti-PD-1 antibody titers were found in mice after immunization with APS. Therefore, phage-display technology was utilized to isolate specific anti-programmed death-1 (PD-1) antibodies from mice stimulated by APS and to confirm whether the isolated anti-PD-1 antibody could inhibit the interaction...
Wed Mar 04, 2020 16:50
Exosomes are extracellular membranous nanovesicles that mediate local and systemic cell-to-cell communication by transporting functional molecules, such as proteins, into target cells, thereby affecting the behavior of receptor cells. Exosomes originating from adipose-derived mesenchymal stem cells (ADSCs) are considered a multipotent and abundant therapeutic tool for tissue injury. To investigate ADSC-secreted exosomes and their potential function in tissue repair, we isolated exosomes from the...
Wed Mar 04, 2020 16:20
Probiotics may offer an attractive alternative for standard antibiotic therapy to treat Clostridium difficile infections (CDI). In this study, the antibacterial mechanism in vitro of newly isolated B. amyloliquefaciens C-1 against C. difficile was investigated. The lipopeptides surfactin, iturin, and fengycin produced by C-1 strongly inhibited C. difficile growth and viability. Systematic research of the bacteriostatic mechanism showed that the C-1 lipopeptides damage the integrity of the C. difficile...
Wed Mar 04, 2020 16:20
Breast cancer is the most common cancer observed in adult females, worldwide. Due to the heterogeneity and varied molecular subtypes of breast cancer, the molecular mechanisms underlying carcinogenesis in different subtypes of breast cancer are distinct. Recently, long noncoding RNAs (lncRNAs) have been shown to be oncogenic or play important roles in cancer suppression and are used as biomarkers for diagnosis and therapy. In this study, we identified 134 lncRNAs and 6,414 coding genes were differentially...
Wed Mar 04, 2020 16:05
Heightened activity of osteoclast is considered to be the culprit in breaking the balance during bone remodeling in pathological conditions, such as osteoporosis. As a “foe” of skeletal health, many antiosteoporosis therapies aim to inhibit osteoclastogenesis. However, bone remodeling is a dynamic process that requires the subtle coordination of osteoclasts and osteoblasts. Severe suppression of osteoclast differentiation will impair bone formation because of the coupling effect. Thus, understanding...
Wed Mar 04, 2020 14:50
How to Stimulate Myocardial Regeneration in Adult Mammalian Heart: Existing Views and New Approaches
Stem cell-based therapy has been considered as a promising option in the treatment of ischemic heart disease. Although stem cell administration resulted in the temporary improvement of myocardial contractility in the majority of studies, the formation of new cardiomyocytes within the injured myocardium has not been conclusively demonstrated. Consequently, the focus of research in the field has since shifted to stem cell-derived paracrine factors, including cytokines, growth factors, mRNA, and miRNA....
Wed Mar 04, 2020 13:35
In vitro 3D hepatocyte culture constitutes a core aspect of liver tissue engineering. However, conventional 3D cultures are unable to maintain hepatocyte polarity, functional phenotype, or viability. Here, we employed microfluidic chip technology combined with natural alginate hydrogels to construct 3D liver tissues mimicking hepatic plates. We comprehensively evaluated cultured hepatocyte viability, function, and polarity. Transcriptome sequencing was used to analyze changes in hepatocyte polarity...
Wed Mar 04, 2020 13:20
Purpose. Breast invasive carcinoma (BRCA) is the most common malignant tumor. MiR-124 plays a tumor-suppressive role in human cancer. However, the clinical significance of miR-124 in BRCA remains unclear. The aim of this study was to evaluate the association of hsa-mir-124 expression and the clinicopathological characteristics in BRCA using database analysis. Methods. The clinical data and expression profiles of hsa-mir-124 were obtained from the cancer genome atlas for BRCA (TCGA_BRCA). Then, the...
Wed Mar 04, 2020 12:05
Objective. To compare the effectiveness of arthroscopic partial meniscectomy (APM) and physical therapy (PT) for degenerative meniscus tears. Method. We conducted a literature search through PubMed, Embase, the Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov. Randomized controlled trials in adults with degenerative meniscal tears without symptoms of locking were considered for inclusion. Two researchers independently performed the literature search, assessed the risk of bias,...
Wed Mar 04, 2020 12:05
Background. The healing process following tooth extraction results in alveolar ridge resorption. The dimensional changes may complicate the subsequent implant procedure. Socket preservation using absorbable collagen membranes or a combination of membranes with calcium phosphate cement (CPC) particles might ensure that the alveolar ridge retains a suitable morphology for implant placement. Objective. To evaluate the quality and quantity of new bone regenerated after application of either collagen...
Wed Mar 04, 2020 11:35
Introduction. In the field of orthopaedic surgery, the use of osteogenic material in larger defects is essential. Autograft and allograft are both known methods, and autograft is believed to be the best choice. But autograft is associated with additional invasive procedures which can prove difficult in fragile patients and can cause local side effect after bone harvest. For feasible purposes, the use of allograft is hereby rising and comparing efficacies, and the differences between autograft and...
Wed Mar 04, 2020 11:05
Abstract The present study examined the role of attention in unconscious inhibitory visuomotor processes in three experiments that employed a mixed paradigm including a spatial cueing task and masked prime task. Spatial attention to the prime was manipulated. Specifically, the valid‐cue condition (in which the prime obtained more attentional resources) and invalid‐cue condition (in which the prime obtained fewer attentional resources) were included. The behavioral results showed that the negative...
Wed Mar 04, 2020 20:56
Abstract Motor actions can be suppressed with varying degrees of success, but this variability is not often captured as responses are typically represented as binary (response vs. no‐response). Although the Stop/No‐go P300 has been implicated as an index of inhibitory‐control, it is unclear how the range of motor outputs relates to the P300. We examined the nature of this association in two experiments using an Anticipatory Timing and a Go/No‐go Task, while measuring peak force, movement onset...
Wed Mar 04, 2020 20:56
Cardiovalve announced that it received FDA Breakthrough Device Designation for its Transcatheter Tricuspid Valve Replacement System. The company also received approval for an Early Feasibility Study of the device for tricuspid and mitral valve regurgitation indications. The Cardiovalve transcatheter system is designed for treatment of mitral and tricuspid regurgitation by replacement of the native valves via a transfemoral approach. Using a transfemoral procedure allows surgeons to offer...
Wed Mar 04, 2020 20:36
Fluoroscopy is used in surgical procedures to visualize structures and tools in real-time, allowing surgeons to monitor the movement of a device, instrument, or body part. However, fluoroscopy is a 2D technology that can lead to surgical inaccuracies. Alternative 3D imaging systems provide higher accuracy, but they sometimes require pausing the surgery and exposing patients to significant radiation. nView medical Inc. is developing an intraoperative imaging system that is better than traditional...
Wed Mar 04, 2020 19:10
A team of researchers headed by groups at University of Nottingham and Queen Mary University London have come up with a smart material that forms into new blood vessels. Made out of graphene oxide and a protein, the material is 3D printed and naturally forms into tubular shapes that are very similar to blood vessels. “This work offers opportunities in biofabrication by enabling simultaneous top-down 3D bioprinting and bottom-up self-assembly of synthetic and biological components in an orderly...
Wed Mar 04, 2020 18:49
Altair Medical recently announced that it received FDA Breakthrough Device status for its RESPMETER wearable biosensor. The biosensor is a chest-worn wireless sensor that can detect Opioid Indused Respiratory Depression (OIRD), a common and often fatal side effect of using opioid drugs. The biosensor monitors respiratory patterns and analyses them using proprietary algorithms. When the device detects OIRD in the wearer, it sends an alert to designated first responders, who can...
Wed Mar 04, 2020 08:52
Combination antiretroviral therapy can significantly prolong the life expectancy of people living with human immunodeficiency virus (HIV), but HIV infection remains a chronic condition that requires lifelong daily oral treatment. Current antiretroviral regimens are highly effective, and one focus…
Wed Mar 04, 2020 02:00
Combination antiretroviral therapy for human immunodeficiency virus type 1 (HIV-1) infection provides durable viral suppression, which is associated with improved immunologic function and extended survival. Current guideline-recommended first-line regimens require lifelong daily oral therapy that…
Wed Mar 04, 2020 02:00
Abstract Injurious mechanical ventilation has been shown to directly affect pulmonary and systemic immune responses. How these responses propagate or attenuate remains unknown. The goal of this study was to further determine whether toll-like receptor (TLR) 4 and WNT1-inducible signaling pathway protein 1 (WISP1) could contribute to injurious mechanical ventilation, especially focusing on the role of macrophages during experimental ventilator-induced...
Wed Mar 04, 2020 02:00
Following the massive earthquake that struck eastern Japan on March 11, 2011, a large amount of radioactive material was released into the environment from the damaged reactor of the Fukushima Daiichi Nuclear ...
Mon Mar 02, 2020 02:00
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