Studying the inner ear of apes and humans could uncover new information on our species' evolutionary relationships, suggests a new study.
Tue Mar 03, 2020 18:33
Related ArticlesPharmacokinetics and pharmacodynamics of ropinirole in patients with prolactinomas. Br J Clin Pharmacol. 2019 02;85(2):366-376 Authors: Liu S, Hu C, Peters J, Tsang A, Cremers S, Bies R, Page-Wilson G Abstract AIMS: Treatment of prolactinomas with ergoline dopamine agonists can be complicated by intolerance and resistance. This study investigated the pharmacokinetics and pharmacodynamics of the nonergot dopamine agonist ropinirole,...
Wed Mar 04, 2020 13:28
Related ArticlesSystematic review of sentinel lymph node biopsy in Merkel cell carcinoma of the head and neck. Head Neck. 2018 12;40(12):2704-2713 Authors: Karunaratne YG, Gunaratne DA, Veness MJ Abstract BACKGROUND: Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous neuroendocrine tumor arising on the head and neck in 40%-50% of patients. Between 20% and 40% will harbor subclinical nodal metastasis. METHODS: Using search terms...
Wed Mar 04, 2020 13:28
Related ArticlespH-Sensitive chitosan-tripolyphosphate nanoparticles increase doxorubicin-induced growth inhibition of cervical HeLa tumor cells by apoptosis and cell cycle modulation. Colloids Surf B Biointerfaces. 2020 Feb 24;190:110897 Authors: Nogueira-Librelotto DR, Scheeren LE, Macedo LB, Vinardell MP, Rolim CMB Abstract Delivery systems responsive to pH variations might allow the exploitation of the various pH gradients within the body, e.g....
Wed Mar 04, 2020 13:27
Related ArticlesHuman umbilical cord mesenchymal stem cell-derived and dermal fibroblast-derived extracellular vesicles protect dermal fibroblasts from ultraviolet radiation-induced photoaging in vitro. Photochem Photobiol Sci. 2020 Mar 03;: Authors: Deng M, Yu Z, Li D, Wang X, Zhou G, Liu W, Cao Y, Xia W, Li W, Jie Zhang W Abstract Ultraviolet B (UVB) radiation is a major cause of aging in dermal fibroblasts. Human umbilical cord mesenchymal stem...
Wed Mar 04, 2020 13:27
Related ArticlesA caffeic acid phenethyl ester analog inhibits the proliferation of nasopharyngeal carcinoma cells via targeting epidermal growth factor receptor. J Biochem Mol Toxicol. 2020 Mar 03;:e22491 Authors: Ning X, Ren X, Xie X, Yan P, Wang D, Huang X Abstract A previous study reported that compound 5A, a caffeic acid phenethyl ester (CAPE) analog, exhibited obvious neuroprotective activity, in particular, compound 5A possessed higher stability...
Wed Mar 04, 2020 13:27
Related ArticlesTanshinone I induces apoptosis and protective autophagy in human glioblastoma cells via a reactive oxygen species‑dependent pathway. Int J Mol Med. 2020 Feb 13;: Authors: Jian S, Chen L, Minxue L, Hongmin C, Ronghua T, Xiaoxuan F, Binbin Z, Shiwen G Abstract Glioma is the most common primary malignancy of the central nervous system and is associated with high mortality rates. Despite the available treatment options including surgery,...
Wed Mar 04, 2020 13:27
Related ArticlesChromomycin A3 suppresses cholangiocarcinoma growth by induction of S phase cell cycle arrest and suppression of Sp1‑related anti‑apoptotic proteins. Int J Mol Med. 2020 Jan 29;: Authors: Saranaruk P, Kariya R, Sittithumcharee G, Boueroy P, Boonmars T, Sawanyawisuth K, Wongkham C, Wongkham S, Okada S, Vaeteewoottacharn K Abstract Cholangiocarcinoma (CCA) is a cancer of biliary epithelium. Late diagnosis and resistance to conventional...
Wed Mar 04, 2020 13:27
Related ArticlesHistone chaperone HIRA dictate proliferation vs differentiation of chronic myeloid leukemia cells. FASEB Bioadv. 2019 Sep;1(9):525-537 Authors: Majumder A, Dharan AT, Baral I, Varghese PC, Mukherjee A, Subhadradevi L, Narayanan G, Dutta D Abstract Abnormal proliferation and disrupted differentiation of hematopoietic progenitors mark leukemia. Histone cell cycle regulator A (HIRA), a histone chaperone, regulates hemogenic to hematopoietic...
Wed Mar 04, 2020 13:27
Related ArticlesNF90 stabilizes cyclin E1 mRNA through phosphorylation of NF90-Ser382 by CDK2. Cell Death Discov. 2020;6:3 Authors: Ding D, Huang H, Li Q, Yu W, Wang C, Ma H, Wu J, Dang Y, Yu L, Jiang W Abstract Nuclear factor 90 (NF90), an RNA-binding protein, has been implicated in regulating interleukin-2 (IL-2) and the immune response. It was recently reported that NF90 is upregulated in hepatocellular carcinoma (HCC) tissues and promotes HCC...
Wed Mar 04, 2020 13:27
Related ArticlesModification of radiosensitivity by Curcumin in human pancreatic cancer cell lines. Sci Rep. 2020 Mar 02;10(1):3815 Authors: Schwarz K, Dobiasch S, Nguyen L, Schilling D, Combs SE Abstract Pancreatic cancer is one of the most aggressive malignancies and is characterized by a low 5-year survival rate, a broad genetic diversity and a high resistance to conventional therapies. As a result, novel therapeutic agents to improve the current...
Wed Mar 04, 2020 13:27
Related ArticlesNRF3-POMP-20S proteasome assembly axis promotes cancer development via ubiquitin-independent proteolysis of p53 and Rb. Mol Cell Biol. 2020 Mar 02;: Authors: Waku T, Nakamura N, Koji M, Watanabe H, Katoh H, Tatsumi C, Tamura N, Hatanaka A, Hirose S, Katayama H, Tani M, Kubo Y, Hamazaki J, Hamakubo T, Watanabe A, Murata S, Kobayashi A Abstract Proteasomes are essential protease complexes that maintain cellular homeostasis, and aberrant...
Wed Mar 04, 2020 13:27
Related ArticlesInhibition of miR-103a-3p suppresses the proliferation in oral squamous cell carcinoma cells via targeting RCAN1. Neoplasma. 2020 Feb 28;: Authors: Zhang G, Chen Z, Zhang Y, Li T, Bao Y, Zhang S Abstract Oral cancer is one of common cancers worldwide, among which over 90% are oral squamous cell carcinoma (OSCC). MicroRNAs act as critical regulators of cancer development and progression. MiR-103a-3p has been reported to be up-regulated...
Wed Mar 04, 2020 13:27
Related ArticlesDesign, Synthesis, and Biological Evaluation of Two Series of Novel A-Ring Fused Steroidal Pyrazines as Potential Anticancer Agents. Int J Mol Sci. 2020 Feb 28;21(5): Authors: Wang S, Yuan X, Qian H, Li N, Wang J Abstract BACKGROUND: Increasingly, different heterocyclic systems have been introduced into the steroid nucleus to significantly enhance the antitumor activities of steroid molecules. However, in this study, few literature...
Wed Mar 04, 2020 13:27
Related ArticlesBeta3-Tubulin is Critical for Microtubule Dynamics, Cell Cycle Regulation, and Spontaneous Release of Microvesicles in Human Malignant Melanoma Cells (A375). Int J Mol Sci. 2020 Feb 28;21(5): Authors: Altonsy MO, Ganguly A, Amrein M, Surmanowicz P, Li SS, Lauzon GJ, Mydlarski PR Abstract Microtubules (MTs), microfilaments, and intermediate filaments, the main constituents of the cytoskeleton, undergo continuous structural changes...
Wed Mar 04, 2020 13:27
Related ArticlesActivation of JNK and p38 in MCF-7 Cells and the In Vitro Anticancer Activity of Alnus hirsuta Extract. Molecules. 2020 Feb 27;25(5): Authors: Ryu M, Sung CK, Im YJ, Chun C Abstract JNK and p38 are important mitogen-activated protein kinases (MAPKs) that respond to stress stimuli. The stress-activated MAPKs associated with apoptotic cell death play vital roles in mammalian cells. Alnus hirsuta, which contains abundant diarylheptanoids...
Wed Mar 04, 2020 13:27
Related ArticlesTesticular expression of TDRD1, TDRD5, TDRD9 and TDRD12 in azoospermia. BMC Med Genet. 2020 02 14;21(1):33 Authors: Babakhanzadeh E, Khodadadian A, Rostami S, Alipourfard I, Aghaei M, Nazari M, Hosseinnia M, Mehrjardi MYV, Jamshidi Y, Ghasemi N Abstract BACKGROUND: Tudor domain-containing proteins (TDRDs) play a critical role in piRNA biogenesis and germ cell development. piRNAs, small regulatory RNAs, act by silencing of transposons...
Wed Mar 04, 2020 13:27
Related ArticlesBiphasic in vitro maturation with C-type natriuretic peptide enhances the developmental competence of juvenile-goat oocytes. PLoS One. 2019;14(8):e0221663 Authors: Soto-Heras S, Menéndez-Blanco I, Catalá MG, Izquierdo D, Thompson JG, Paramio MT Abstract In vitro embryo production success in juvenile animals is compromised due to their intrinsic lower oocyte quality. Conventional in vitro maturation (IVM) impairs oocyte competence by...
Wed Mar 04, 2020 13:27
Vorinostat in patients with resistant BRAFV600E mutated advanced melanoma: a proof of concept study.
Related ArticlesVorinostat in patients with resistant BRAFV600E mutated advanced melanoma: a proof of concept study. Future Oncol. 2020 Mar 03;: Authors: Huijberts S, Wang L, de Oliveira RL, Rosing H, Nuijen B, Beijnen J, Bernards R, Schellens J, Wilgenhof S Abstract The clinical benefit of treatment with BRAF- and MEK-inhibitors in melanoma is limited due to resistance associated with emerging secondary mutations. Preclinical and clinical studies have...
Wed Mar 04, 2020 13:26
Publication date: March 2020Source: Gait & Posture, Volume 77Author(s):
Wed Mar 04, 2020 13:24
Publication date: May 2020Source: International Immunopharmacology, Volume 82Author(s): Hong-tao Li, Yu-sen Lin, Qi-mei Ye, Xue-na Yang, Xiao-ling Zou, Hai-ling Yang, Tian-tuo Zhang
Wed Mar 04, 2020 13:18
Publication date: May 2020Source: International Immunopharmacology, Volume 82Author(s): Shafat Ali, Sabhiya Majid, Md. Niamat Ali, Shahnaz Taing
Wed Mar 04, 2020 13:18
Publication date: May 2020Source: International Immunopharmacology, Volume 82Author(s): Huanhuan Jiang, Kaihuan Bi, Kangxia Wang, Zhimin Lu, Yuping Xu, Peipei Guo, Caihua Li, Zhaolian Wei, Ya Chen, Yunxia Cao
Wed Mar 04, 2020 13:18
Publication date: May 2020Source: International Immunopharmacology, Volume 82Author(s): Meng Wang, Hang-Fan Zong, Ke-Wei Chang, Hua Han, Mohammad Yasir Rizvi, Saema Iffat Neha, Zhi-Yi Li, Wei-Na Yang, Yi-Hua Qian
Wed Mar 04, 2020 13:18
Publication date: May 2020Source: International Immunopharmacology, Volume 82Author(s): Xiufang Li, Bin Xiang, Ting Shen, Chun Xiao, Rong Dai, Fangyan He, Qing Lin
Wed Mar 04, 2020 13:18
Publication date: May 2020Source: International Immunopharmacology, Volume 82Author(s): Yue Shi, Xiaoping Men, Xueting Li, Zhicun Yang, Hongjuan Wen
Wed Mar 04, 2020 13:18
Publication date: May 2020Source: International Immunopharmacology, Volume 82Author(s): Fen Liu, Yun-Xiao Shang
Wed Mar 04, 2020 13:18
Publication date: May 2020Source: International Immunopharmacology, Volume 82Author(s): Prem Kumar Govindappa, M.A. Hassan Talukder, Anagha A. Gurjar, John P. Hegarty, John C. Elfar
Wed Mar 04, 2020 13:18
Publication date: May 2020Source: International Immunopharmacology, Volume 82Author(s): Xing-zhe Zhang, Feng Han, Chen-guang Ding, Meng Dou, Yu-xiang Wang, Wu-jun Xue, Xiao-ming Ding, Jin Zheng, Cui-xiang Xu, Pu-xun Tian
Wed Mar 04, 2020 13:18
Publication date: May 2020Source: International Immunopharmacology, Volume 82Author(s): Di Mu, Chunmu Miao, Yao Cheng, Peizhi Li, Jianping Gong, Wenfeng Zhang
Wed Mar 04, 2020 13:18
Publication date: May 2020Source: International Immunopharmacology, Volume 82Author(s): Han Shao, Xu Zhang, Linxing Ruan, Jinbao Li, Feng Chen, Long Guo, Jiali Zhu
Wed Mar 04, 2020 13:18
Publication date: May 2020Source: International Immunopharmacology, Volume 82Author(s): Jiang Liang, Shiwen Yuan, Xiaohua Wang, Yan Lei, Xuemei Zhang, Mingcheng Huang, Hui Ouyang
Wed Mar 04, 2020 13:18
Publication date: May 2020Source: International Immunopharmacology, Volume 82Author(s): Iftekhar Mahmood, Million A. Tegenge, Basil Golding
Wed Mar 04, 2020 13:18
Publication date: Available online 3 March 2020Source: International ImmunopharmacologyAuthor(s): Qiaoling Sun, Yuanyuan Zheng, Qiuyan Liu, Xuetao Cao
Wed Mar 04, 2020 13:18
Background/Aim: The aim of this study was to evaluate the current role of frozen section in identifying patients who could benefit from an immediate axillary lymph node dissection (ALND), following the criteria of the ASOCOG Z0011 and IBCSG 23-10 trials. Patients and Methods: A retrospective review was performed involving 2,079 patients with early breast cancer who underwent conservative surgery or total mastectomy with sentinel lymph node biopsy. Results: Sensitivity and diagnostic accuracy were...
Wed Mar 04, 2020 12:40
Background: Patients with cancer who are treated with monoclonal antibodies are at risk for developing infusion reactions. However, for some monoclonal antibodies, the incidence of infusion reactions is low or can be lowered by the use of adequate premedication schedules. It is often feasible to increase the infusion rate/lower the post-administration observation time. This review gives an overview of infusion reactions and the possibility of accelerating infusion rates. Materials and Methods: Data...
Wed Mar 04, 2020 12:40
Background/Aim: The aim of this study was to clarify the risk benefits of folinic acid, fluorouracil, and irinotecan (FOLFIRI) plus ramucirumab (F-RAM) as third-line and later-line treatment for metastatic colorectal cancer (mCRC). Patients and Methods: We compared the overall survival (OS), adverse events (AEs), and cost of F-RAM to those of trifluridine/tipiracil combination tablet (TAS-102). Results: There was no significant difference in the median OS [6.1 (range=1.2-16.3) months vs. 6.1 (range=1.2-22.3)...
Wed Mar 04, 2020 12:40
Immunotherapy based on immune checkpoint inhibitors (ICIs) represents a novel anticancer treatment strategy. Monoclonal antibodies targeting cytotoxic T-lymphocyte antigen-4 (CTLA4), programmed cell death-1 receptor (PD1) and programmed cell death-1 ligand (PD-L1) have shown efficacy and safety in the treatment of various malignancies. Some of them have recently found their place in a routine clinical practice, while others are at different phases of clinical trials. Treatment with ICIs may be accompanied...
Wed Mar 04, 2020 12:40
Background/Aim: The aim of the study was to assess the outcome of advanced ovarian cancer patients who i) underwent primary surgery followed by carboplatin/paclitaxel–based chemotherapy with or without bevacizumab, ii) were in complete response after chemotherapy, iii) and subsequently recurred. Patients and Methods: The hospital records of 138 complete responders after chemotherapy with (n=58) or without (n=80) bevacizumab were reviewed. Results: Both survival after recurrence and overall survival...
Wed Mar 04, 2020 12:40
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