Objectives: Gemcitabine plus cisplatin (GC) is recommended as first-line treatment for advanced cholangiocarcinoma. We investigated the impact of GC in patients with unresectable hilar cholangiocarcinoma (HC) based on the time taken for effective biliary drainage (EBD). Materials and Methods: We retrospectively enrolled 113 patients with unresectable HC. Thirty-nine and 74 patients received GC chemotherapy and best supportive care (BSC), respectively. EBD was defined as a reduction...
Fri Feb 28, 2020 02:00
Background: To analyze the final visual acuity (VA) of neuro-ophthalmologic injuries (NOI) in combat ocular trauma and to study the association of NOI with systemic neurologic injury (SNI) and traumatic brain injury (TBI). Methods: The Walter Reed Ocular Trauma Database was reviewed. Inclusion criteria were any US service member and Department of Defense civilians who suffered NOI, SNI, or TBI in Operation Iraqi Freedom or Operation Enduring Freedom. The primary outcome measure was...
Thu Feb 27, 2020 02:00
No abstract available
Thu Feb 27, 2020 02:00
No abstract available
Thu Feb 27, 2020 02:00
No abstract available
Thu Feb 27, 2020 02:00
Background: Conventional treatment options for trochlear pain arising from trochleitis or primary trochlear headache include oral anti-inflammatory medications and/or local injection of corticosteroids and local anesthetic. Trochleaectomy is an additional option to consider for monocular patients with intractable trochlear pain. Methods: We report 3 patients undergoing trochleaectomy for refractory trochlear pain syndromes. Results: Trochleaectomy resulted in resolution of...
Thu Feb 27, 2020 02:00
Background: The purpose of the study was to examine 5-year changes in eyes with optic disc drusen at baseline on optical coherence tomography (OCT) scans and the relation of incident drusen to hyperreflective prelaminar lines. Methods: The study included children who presented at baseline, when participants were aged 11–12 years, and again 5 years later. Grading for optic disc drusen was made in all. Grading for prelaminar lines was made in all children at follow-up and in eyes with...
Thu Feb 27, 2020 02:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b13508
Wed Mar 04, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b13082
Wed Mar 04, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b10377
Wed Mar 04, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b12980
Wed Mar 04, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00849
Wed Mar 04, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b11935
Wed Mar 04, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00190
Wed Mar 04, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00434
Wed Mar 04, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00005
Wed Mar 04, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b13503
Wed Mar 04, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00250
Wed Mar 04, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00520
Wed Mar 04, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b12675
Wed Mar 04, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b12280
Wed Mar 04, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b13077
Wed Mar 04, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b13753
Wed Mar 04, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01330
Wed Mar 04, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00181
Wed Mar 04, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04999
Wed Mar 04, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05232
Wed Mar 04, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00018
Wed Mar 04, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00163
Wed Mar 04, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05850
Wed Mar 04, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05722
Wed Mar 04, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05193
Wed Mar 04, 2020 07:00
Abstract Objective Rett syndrome (RTT) is an X‐linked dominant neurodevelopmental disorder due to pathogenic mutations in the MECP2 gene. Motor impairment constitutes the core diagnostic feature of RTT. Preclinical studies have consistently demonstrated alteration of excitation/inhibition (E/I) balance and aberrant synaptic plasticity at cortical level. Herein we aimed at understanding neurobiological mechanisms underlying motor deficit by assessing in “vivo” synaptic plasticity and E/I balance...
Wed Mar 04, 2020 23:09
Combination antiretroviral therapy (ART) for the treatment of human immunodeficiency virus (HIV) infection is one of the most important advances in medicine in the past quarter century. The availability of several single-tablet multidrug treatment regimens that effectively control the replication…
Wed Mar 04, 2020 02:00
Combination antiretroviral therapy can significantly prolong the life expectancy of people living with human immunodeficiency virus (HIV), but HIV infection remains a chronic condition that requires lifelong daily oral treatment. Current antiretroviral regimens are highly effective, and one focus…
Wed Mar 04, 2020 02:00
Combination antiretroviral therapy for human immunodeficiency virus type 1 (HIV-1) infection provides durable viral suppression, which is associated with improved immunologic function and extended survival. Current guideline-recommended first-line regimens require lifelong daily oral therapy that…
Wed Mar 04, 2020 02:00
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