Crosstalk between Dental Pulp Stem Cells and Endothelial Cells Augments Angiogenic Factor Expression

Abstract Objectives We aimed to investigate whether the mesenchymal stem cell‐endothelial cell crosstalk enhances angiogenic factor expression via nuclear factor kappa B (NF‐κB) dependent mechanisms. Materials and Methods Human dermal microvascular endothelial cells (HDMECs) and stem cells from human exfoliated deciduous teeth (SHEDs) were co‐cultured for 96 h, in the presence of NF‐κB decoy oligodeoxynucleotides (ODN) or scramble (control). Vascular endothelial cell growth factor...

Oral Diseases

Sun Apr 05, 2020 14:15

Topical pilocarpine for xerostomia in patients with head and neck cancer treated with radiotherapy

Abstract Objective To evaluate a pilocarpine spray as a treatment for xerostomia in patients treated with radiotherapy (RT) for head and neck cancer (HNC). Methods This was a placebo‐controlled, double‐blind, crossover clinical trial of patients complaining of dry mouth after RT for HNC. Forty patients were randomly assigned to either placebo or pilocarpine (1.54%) spray and instructed to use 3 times a day for three months. After one‐month washout period, patients were crossed over...

Oral Diseases

Sun Apr 05, 2020 11:14

Submandibular gland excision: from external surgery to robotic intraoral and extraoral approaches

Abstract Submandibular gland excision is generally performed through a trans‐cervical approach, a safe procedure that, however, carries few neurological, functional and aesthethic drawbacks. Intraoral approach to the submandibular gland has been described many years ago but it has been newly proposed in recent years thanks to endoscope‐assisted and robot‐assisted surgical procedures. The main purpose of intraoral approaches is to avoid cosmetic sequelae and to reduce the risk of marginal nerve...

Oral Diseases

Sat Apr 04, 2020 11:27

Does autoimmune thyroid disorder act as a predisposing factor in the development of oral lichen planus?

Abstract Some studies (including two of our own [Hirota et al., 2011; Hirota et al., 2013]) – have demonstrated that thyroid disorders (mainly hypothyroidism) are more prevalent in those with oral lichen planus (OLP) than in the general population (i.e., control group). However, another independent study (Compilato et al., 2011) did not find a significant prevalence of OLP in patients with hypothyroidism compared with that of control subjects from the general population.

Oral Diseases

Sat Apr 04, 2020 11:27