Related ArticlesQuantification of Early-Stage Myeloid-Derived Suppressor Cells in Cancer Requires Excluding Basophils. Cancer Immunol Res. 2020 Apr 01;: Authors: Khan ANH, Emmons TR, Wong JT, Alqassim E, Singel KL, Mark J, Smith BE, Tario JD, Eng KH, Moysich KB, Odunsi K, Abrams SI, Segal BH Abstract Myeloid derived suppressor cells (MDSCs) are a heterogeneous group of immature cells that accumulate in the peripheral blood and tumor microenvironment...
Fri Apr 03, 2020 15:02
Related ArticlesImpact of COVID-19 and Future Emerging Viruses on Hematopoietic Cell Transplantation and Other Cellular Therapies. Stem Cells Dev. 2020 Apr 01;: Authors: Broxmeyer HE, Parker GC Abstract COVID-19 where Co stand for corona, VI stands for virus, and D denotes disease and was in the recent past referred to as 2019 novel coronavirus or 2019-nCoV, has impacted numerous lives and businesses, and has led to a surreal emergency state within world...
Fri Apr 03, 2020 15:02
Related ArticlesA Phase II Study of Continuous Oral mTOR Inhibitor Everolimus for Recurrent, Radiographic-Progressive Neurofibromatosis Type 1-Associated Pediatric Low-Grade Glioma: A Neurofibromatosis Clinical Trials Consortium Study. Neuro Oncol. 2020 Apr 01;: Authors: Ullrich NJ, Prabhu SP, Reddy AT, Fisher MJ, Packer R, Goldman S, Robison NJ, Gutmann DH, Viskochil DH, Allen JC, Korf B, Cantor A, Cutter G, Thomas C, Perentesis JP, Mizuno T, Vinks AA, Manley PE, Chi...
Fri Apr 03, 2020 13:08
Related ArticlesAcute Myeloid Leukemia: A Review. R I Med J (2013). 2020 Apr 01;103(3):38-40 Authors: Pelcovits A, Niroula R Abstract Acute myeloid leukemia (AML) is a malignancy of the stem cell precursors of the myeloid lineage (red blood cells, platelets, and white blood cells other than B and T cells). Like other malignancies, it is due to genetic variations that lead to neoplastic changes and clonal proliferation. AML remains a rare malignancy,...
Fri Apr 03, 2020 13:08
Related ArticlesImmune Checkpoint Inhibitors in the Treatment of Gastrointestinal Malignancies: A Review of Current and Future Therapies. R I Med J (2013). 2020 Apr 01;103(3):33-37 Authors: Hsu A, Mendelson L, Almhanna K Abstract Gastrointestinal cancers are some of the most common malignancies worldwide. Traditional chemotherapy has been disappointing in improving overall survival in patients with unresectable or metastatic disease. The dawn of immunotherapy...
Fri Apr 03, 2020 13:08
Related ArticlesImmunotherapy in Glioblastoma: Current Shortcomings and Future Perspectives. Cancers (Basel). 2020 Mar 22;12(3): Authors: Weenink B, French PJ, Sillevis Smitt PAE, Debets R, Geurts M Abstract Glioblastomas are aggressive, fast-growing primary brain tumors. After standard-of-care treatment with radiation in combination with temozolomide, the overall prognosis of newly diagnosed patients remains poor, with a 2-year survival rate of less...
Fri Apr 03, 2020 13:08
Related ArticlesNon-Coding microRNAs as Novel Potential Tumor Markers in Testicular Cancer. Cancers (Basel). 2020 Mar 22;12(3): Authors: Regouc M, Belge G, Lorch A, Dieckmann KP, Pichler M Abstract Testicular cancer is an important disease with increasing incidence and a high burden of morbidity and mortality in young men worldwide. Histological examination of the testicular tissue after orchiectomy plays an important role alongside patient history,...
Fri Apr 03, 2020 13:08
Related ArticlesCombinatorial Therapies in Thyroid Cancer: An Overview of Preclinical and Clinical Progresses. Cells. 2020 Mar 30;9(4): Authors: Laetitia G, Sven S, Fabrice J Abstract Accounting for about 2% of cancers diagnosed worldwide, thyroid cancer has caused about 41,000 deaths in 2018. Despite significant progresses made in recent decades in the treatment of thyroid cancer, many resistances to current monotherapies are observed. In our complete...
Fri Apr 03, 2020 13:08
Related ArticlesCarcinoma in situ of the bladder: why is it underdetected? Curr Opin Urol. 2020 May;30(3):392-399 Authors: Subiela JD, Rodríguez Faba Ó, Guerrero-Ramos F, Aumatell J, Breda A, Palou J Abstract PURPOSE OF REVIEW: The standard diagnosis of carcinoma in situ (CIS) of the bladder, based on white light cystoscopy and urine cytology, is limited because CIS can vary from normal-appearing mucosa to a lesion indistinguishable from an inflammatory...
Fri Apr 03, 2020 13:08
Related ArticlesCD38 Antibody Daratumumab for the Treatment of Chronic Active Antibody-mediated Kidney Allograft Rejection. Transplantation. 2020 Mar 30;: Authors: Doberer K, Kläger J, Gualdoni GA, Mayer KA, Eskandary F, Farkash EA, Agis H, Reiter T, Reindl-Schwaighofer R, Wahrmann M, Cohen G, Haslacher H, Bond G, Simonitsch-Klupp I, Halloran PF, Böhmig GA Abstract BACKGROUND: Late antibody-mediated rejection (AMR) is a major cause of transplant failure....
Fri Apr 03, 2020 13:08
Related ArticlesDoxorubicin and Olaratumab Versus Doxorubicin, Ifosfamide, and Mesna for Treatment of Advanced Soft Tissue Sarcomas. Am J Clin Oncol. 2020 Mar 31;: Authors: Hammer KJ, Copeland VC, Loggers ET, Pollack SM, Wagner MJ, Cranmer LD Abstract OBJECTIVE: We compared the outcomes in soft tissue sarcoma (STS) treated with olaratumab and doxorubicin (OD) versus doxorubicin, ifosfamide, and mesna (AIM) to assess whether OD could supersede AIM in...
Fri Apr 03, 2020 13:08
Related ArticlesPatterns of Care for Stage II-III Rectosigmoid Cancers in the United States, 2004-2015. Am J Clin Oncol. 2020 Mar 31;: Authors: Sanford NN, Aguilera TA, Beg MS, Sanjeevaiah A, Hong TS, Wo JY, Folkert MR Abstract OBJECTIVES: Although current guidelines continue to recommend trimodality therapy for stage II to III rectal cancers, a lower incidence of local recurrence has been observed in patients with upper rectal tumors, including those...
Fri Apr 03, 2020 13:08
Related ArticlesInvasive Stratified Mucin-producing Carcinoma (ISMC) of the Cervix: A Study on Morphologic Diversity. Am J Surg Pathol. 2020 Mar 31;: Authors: Stolnicu S, Segura S, Parra-Herran C, Horn LC, Hoang L, Terinte C, Pesci A, Aviel-Ronen S, Kyokawa T, Alvarado-Cabrero I, Oliva E, Soslow RA, Park KJ Abstract Invasive stratified mucin-producing carcinoma (ISMC) is a recently described tumor with similar morphology to the stratified mucin-producing...
Fri Apr 03, 2020 13:08
Related ArticlesImmune escape and immunotherapy of acute myeloid leukemia. J Clin Invest. 2020 Apr 01;130(4):1552-1564 Authors: Vago L, Gojo I Abstract In spite of the recent approval of new promising targeted therapies, the clinical outcome of patients with acute myeloid leukemia (AML) remains suboptimal, prompting the search for additional and synergistic therapeutic rationales. It is increasingly evident that the bone marrow immune environment of...
Fri Apr 03, 2020 13:08
Related ArticlesDetermining the appropriate treatment for different EGFR mutations in non-small cell lung cancer patients. Expert Rev Respir Med. 2020 Apr 01;:1-12 Authors: Scodes S, Cappuzzo F Abstract Introduction: Epidermal growth factor receptor (EGFR) mutations occur in a significant fraction of non-small cell lung cancer (NSCLC) patients. Most common activating mutations are in-frame deletion in exon 19 and point mutation in exon 21. EGFR tyrosine...
Fri Apr 03, 2020 13:08
Related ArticlesBiologics, Immunotherapy, and Future Directions in the Treatment of Advanced Cholangiocarcinoma. Clin Colorectal Cancer. 2019 06;18(2):81-90 Authors: Saeed A, Park R, Al-Jumayli M, Al-Rajabi R, Sun W Abstract Gemcitabine plus cisplatin remains the standard first-line systemic therapy for advanced cholangiocarcinoma and offers a median survival of approximately 1 year. No standard regimens beyond the first line and no targeted or immunotherapy...
Fri Apr 03, 2020 13:08
Related ArticlesParathyroid cancer: An update. Cancer Treat Rev. 2020 Mar 19;86:102012 Authors: Rodrigo JP, Hernandez-Prera JC, Randolph GW, Zafereo ME, Hartl DM, Silver CE, Suárez C, Owen RP, Bradford CR, Mäkitie AA, Shaha AR, Bishop JA, Rinaldo A, Ferlito A Abstract Parathyroid cancer (PC) is a rare malignant tumor which comprises 0.5-5% of patients with primary hyperparathyroidism (PHPT). Most of these cancers are sporadic, although it may also occur...
Sun Apr 05, 2020 14:38
Related ArticlesFibrous histiocytoma/Dermatofibroma in children (FH): the same as adults? Hum Pathol. 2020 Apr 01;: Authors: Berklite L, Ranganathan S, John I, Picarsic J, Santoro L, Alaggio R Abstract Fibrous histiocytoma (FH) or dermatofibroma are common cutaneous lesions mostly seen in adults and rare in the first two years of life. Two hundred sixty seven patients less than 18 years with a diagnosis of FH or dermatomyofibroma, a lesion with morphologic...
Sun Apr 05, 2020 14:38
Related ArticlesShould We Abandon Systematic Pelvic and Paraaortic Lymphadenectomy in Low-Grade Serous Ovarian Cancer? Ann Surg Oncol. 2020 Apr 03;: Authors: Simon V, Ngo C, Pujade-Lauraine E, Ferron G, Pomel C, Leblanc E, Nadeau C, Ray-Cocquard I, Lecuru F, Bonsang-Kitzis H Abstract BACKGROUND: Low-grade serous ovarian carcinoma (LGSOC) is a rare disease that accounts for 5% of all ovarian cancers and requires surgical complete debulking. To date, the...
Sun Apr 05, 2020 13:08
Related ArticlesA primary neuroendocrine tumor of the left ventricle presenting with diarrhea-an unusual experience and literature review. Diagn Pathol. 2020 Apr 03;15(1):32 Authors: Li C, Huang J, Yang X, Xia J, Xu G, Zheng H Abstract BACKGROUND: Neuroendocrine tumors (NETs) can secrete bioactive amines in the bloodstream, resulting in the carcinoid syndrome characterized by diarrhea and flushing. The frequency of occurrence of primary cardiac neuroendocrine...
Sun Apr 05, 2020 13:08
Related ArticlesConcurrent müllerianosis of the urinary bladder and the umbilicus presenting with umbilical bleeding: a rare case report and review of the literature. BMC Womens Health. 2020 Apr 03;20(1):66 Authors: Jhang S, Chen M, Chen LC Abstract BACKGROUND: Müllerianosis is a very rare neoplasm composed of two or three Müllerian derived tissues (endosalpinx, endometrium and endocervix). We report the first case of concurrent müllerianosis of the...
Sun Apr 05, 2020 13:08
Related ArticlesComprehensive genomic profiling aids in understanding the lesion origins of a patient with six synchronous invasive lung adenocarcinomas: a case study. BMC Pulm Med. 2020 Apr 03;20(1):80 Authors: Song Y, Jia Z, Wu P, Wang W, Ou Q, Bao H, Yu M, Wu X, Liu P, Liang N, Zhang S, Li S Abstract BACKGROUND: Synchronous multiple primary lung cancers (sMPLC) are rare forms of lung cancer, and their diagnosis remains as a significant challenge....
Sun Apr 05, 2020 13:08
Related ArticlesPrimary Neuroendocrine Neoplasms of the Breast: Case Series and Literature Review. Cancers (Basel). 2020 Mar 20;12(3): Authors: Özdirik B, Kayser A, Ullrich A, Savic LJ, Reiss M, Tacke F, Wiedenmann B, Jann H, Roderburg C Abstract Primary neuroendocrine carcinoma of the breast (NECB) as defined by the World Health Organization (WHO) in 2012 is a rare, but possibly under-diagnosed entity. It is heterogeneous as it entails a wide spectrum...
Sun Apr 05, 2020 13:08
Related ArticlesGastrointestinal Stromal Tumours (GIST) in Young Adult (18-40 Years) Patients: A Report from the Dutch GIST Registry. Cancers (Basel). 2020 Mar 20;12(3): Authors: IJzerman NS, Drabbe C, den Hollander D, Mohammadi M, van Boven H, Desar IME, Gelderblom H, Grünhagen DJ, Reyners AKL, van Noesel MM, Mathijssen RHJ, Steeghs N, van der Graaf WTA Abstract Gastrointestinal stromal tumour (GIST) is a disease of older adults and is dominated by...
Sun Apr 05, 2020 13:08
Related ArticlesOptimization of rVAR2-Based Isolation of Cancer Cells in Blood for Building a Robust Assay for Clinical Detection of Circulating Tumor Cells. Int J Mol Sci. 2020 Mar 31;21(7): Authors: Sand NT, Petersen TB, Bang-Christensen SR, Ahrens TD, Løppke C, Jørgensen AM, Gustavsson T, Choudhary S, Theander TG, Salanti A, Agerbæk MØ Abstract Early detection and monitoring of cancer progression is key to successful treatment. Therefore, much research...
Sun Apr 05, 2020 13:08
Related ArticlesSAMHD1 Functions and Human Diseases. Viruses. 2020 Mar 31;12(4): Authors: Coggins SA, Mahboubi B, Schinazi RF, Kim B Abstract Deoxynucleoside triphosphate (dNTP) molecules are essential for the replication and maintenance of genomic information in both cells and a variety of viral pathogens. While the process of dNTP biosynthesis by cellular enzymes, such as ribonucleotide reductase (RNR) and thymidine kinase (TK), has been extensively...
Sun Apr 05, 2020 13:08
Related ArticlesPituitary adenomas in the setting of multiple endocrine neoplasia type 1: a single-institution experience. J Neurosurg. 2020 Apr 03;:1-7 Authors: Cohen-Cohen S, Brown DA, Himes BT, Wheeler LP, Ruff MW, Major BT, Singh Ospina NM, Atkinson JLD, Meyer FB, Bancos I, Young WF, Van Gompel JJ Abstract OBJECTIVE: Multiple endocrine neoplasia type 1 (MEN1) is a rare, autosomal-dominant tumor disorder characterized by the development of pituitary...
Sat Apr 04, 2020 14:31
Related ArticlesScute myeloid leukemia with inv(3)(q21q26.2)/t(3;3)(q21;q26.2). study of 61 patients treated with intensive protocols. Eur J Haematol. 2020 Apr 03;: Authors: Sitges M, Boluda B, Garrido A, Morgades M, Granada I, Barragan E, Arnan M, Serrano J, Tormo M, Miguel Bergua J, Colorado M, Salamero O, Esteve J, Benavente C, Pérez-Encinas M, Coll R, Martí-Tutusaus JM, Brunet S, Sierra J, Ángel Sanz M, Montesinos P, Ribera JM, Vives S, PETHEMA, CETLAM cooperative...
Sat Apr 04, 2020 14:31
Related ArticlesTriple Collision Tumor Comprising Merkel Cell Carcinoma with an Unusual Immunophenotype, Squamous Cell Carcinoma In-Situ, and Basal Cell Carcinoma. J Cutan Pathol. 2020 Apr 03;: Authors: Hobbs MM, Geers TE, Brown TS, Malone JC Abstract Merkel cell carcinoma (MCC) is a rare, aggressive primary cutaneous neuroendocrine cancer which almost always exhibits the cytokeratin (CK)20+/thyroid transcription factor (TTF)-1- immunophenotype. MCC...
Sat Apr 04, 2020 14:31
Related ArticlesRacial/ethnic disparities in ovarian cancer research. Adv Cancer Res. 2020;146:1-21 Authors: Peres LC, Schildkraut JM Abstract Ovarian cancer is one of the most fatal cancers diagnosed in women in the United States (U.S.). Data from national databases, including the Surveillance Epidemiology and End Results (SEER) program, show racial/ethnic differences in risk and survival of epithelial ovarian cancer with higher incidence among white...
Sat Apr 04, 2020 14:31
Related ArticlesRare Gynecologic Tumors: Coming of Age. Gynecol Oncol. 2020 Apr;157(1):1-2 Authors: Gershenson DM, Okamoto A, Ray-Coquard I PMID: 32241340 [PubMed - in process]
Sat Apr 04, 2020 14:31
Related ArticlesClinical characteristics and outcomes of SDHB-related pheochromocytoma and paraganglioma in children and adolescents. J Cancer Res Clin Oncol. 2020 Apr;146(4):1051-1063 Authors: Jochmanova I, Abcede AMT, Guerrero RJS, Malong CLP, Wesley R, Huynh T, Gonzales MK, Wolf KI, Jha A, Knue M, Prodanov T, Nilubol N, Mercado-Asis LB, Stratakis CA, Pacak K Abstract PURPOSE: Pheochromocytomas/paragangliomas (PHEOs/PGLs) are rare in children with...
Sat Apr 04, 2020 13:29
Related ArticlesMuscle involvement in myasthenia gravis: Expanding the clinical spectrum of Myasthenia-Myositis association from a large cohort of patients. Autoimmun Rev. 2020 Apr;19(4):102498 Authors: Garibaldi M, Fionda L, Vanoli F, Leonardi L, Loreti S, Bucci E, Di Pasquale A, Morino S, Vizzaccaro E, Merlonghi G, Ceccanti M, Lucchini M, Mirabella M, Andreetta F, Pennisi EM, Petrucci A, Salvetti M, Antonini G Abstract Myastenia-Inflammatory Myopathy...
Sat Apr 04, 2020 13:29
Related ArticlesVerrucous venous malformation. Dermatol Online J. 2019 Dec 15;25(12): Authors: Leavens J, Worswick S, Kim GH Abstract Verrucous venous malformation, also known as verrucous hemangioma, is a superficial vascular malformation with a variable degree of hyperkeratosis that is composed of capillaries and veins in the dermis and sometimes subcutaneous tissue. We describe a 53-year-old man who presented with a large hyperkeratotic plaque of...
Sat Apr 04, 2020 13:29
Related ArticlesHow to bridge the gap? European medical plants used for treating oral mucositis: on the search for evidence. J Cancer Res Clin Oncol. 2020 Apr;146(4):985-1001 Authors: Buentzel J, Bauer C, Buentzel J Abstract PURPOSE: Oral mucositis is a common, painful side effect of cancer treatment-be it locoregional (e.g. irradiation) or systemic (e. g. chemotherapy). Phytotherapy is often used by patients to alleviate symptoms. However, knowledge...
Sat Apr 04, 2020 13:29
Related ArticlesDisseminated Cryptococcosis revealed by transverse myelitis in Immunocompetent patient: a case report and review of the literature. BMC Neurol. 2020 Jan 10;20(1):13 Authors: Qu F, Qu Z, Lv Y, Song B, Wu B Abstract BACKGROUND: Transverse myelitis (TM) is due to inflammatory spinal cord injury with bilateral neurologic involvement, which is sensory, motor, or autonomic in nature. It may be associated with autoimmune disease, vaccination,...
Sat Apr 04, 2020 13:29
Related ArticlesUnique molecular features and clinical outcomes in young patients with non-small cell lung cancer harboring ALK fusion genes. J Cancer Res Clin Oncol. 2020 Apr;146(4):935-944 Authors: Tian P, Liu Y, Zeng H, Tang Y, Lizaso A, Ye J, Shao L, Li Y Abstract PURPOSE: This study aimed to determine the molecular features and clinical outcomes of young patients with non-small cell lung cancer (NSCLC) harboring ALK fusion genes. METHODS:...
Sat Apr 04, 2020 13:29
Related ArticlesSudden bilateral vision loss due to third ventricular cavernous angioma with intratumoral hemorrhage - case report. BMC Ophthalmol. 2019 Dec 16;19(1):259 Authors: Ishijima K, Shinmei Y, Nozaki M, Yamaguchi S, Chin S, Ishida S Abstract BACKGROUND: We report a rare case of sudden bilateral vision loss due to third ventricular cavernous angioma with intratumoral hemorrhage. CASE PRESENTATION: A 45-year-old woman presented decreased...
Sat Apr 04, 2020 13:29
Related ArticlesToxicities associated with checkpoint inhibitors-an overview. Rheumatology (Oxford). 2019 12 01;58(Suppl 7):vii7-vii16 Authors: Spiers L, Coupe N, Payne M Abstract Immunotherapy has an increasing role in the management of cancer, both in metastatic disease and as an adjuvant therapy. However, sensitization of the immune system with checkpoint inhibitors comes with a unique side effect profile. Full appreciation of this can take some...
Sat Apr 04, 2020 13:29
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