Publication date: Available online 4 April 2020Source: TalantaAuthor(s): Kaewta Danchana, Víctor Cerdà
Sun Apr 05, 2020 12:31
Publication date: Available online 3 April 2020Source: TalantaAuthor(s): Mohammad Reza Afshar Mogaddam, Mir Ali Farajzadeh, Ali Mohebbi, Mahboob Nemati
Sat Apr 04, 2020 16:56
Publication date: Available online 3 April 2020Source: TalantaAuthor(s): Isabel M. Perez de Vargas-Sansalvador, Miguel M. Erenas, Antonio Martínez-Olmos, Fatima Mirza-Montoro, Dermot Diamond, Luis Fermin Capitan-Vallvey
Sat Apr 04, 2020 16:56
Publication date: Available online 3 April 2020Source: TalantaAuthor(s): Lili Cui, Yongge Ma, Ming Li, Zhonglin Wei, Yanfu Huan, Qiang Fei, Hongmei Li, Lianyou Zheng
Sat Apr 04, 2020 16:56
Publication date: Available online 3 April 2020Source: TalantaAuthor(s): Polina Bogdanova, Aleksei Pochivalov, Christina Vakh, Andrey Bulatov
Sat Apr 04, 2020 16:56
Publication date: Available online 3 April 2020Source: TalantaAuthor(s): Shengrui Zhang, Qin Wang, Fangfang Wu, Jiajun Yang, Tianyi Cheng, Xiao-Feng Yang, Zheng Li, Hua Li
Sat Apr 04, 2020 16:56
Publication date: Available online 3 April 2020Source: TalantaAuthor(s): Quanzhi Yang, Yujie Wen, Jian Xu, Shijun Shao
Sat Apr 04, 2020 16:56
Publication date: Available online 3 April 2020Source: TalantaAuthor(s): Xing Huang, Zhaodong Nan
Sat Apr 04, 2020 16:56
Publication date: 15 August 2020Source: Talanta, Volume 216Author(s): Li Jun Gong, Yuan Fang Li, Hong Yan Zou, Cheng Zhi Huang
Sat Apr 04, 2020 16:56
Publication date: Available online 2 April 2020Source: TalantaAuthor(s): Ana P.R. Santana, Daniel F. Andrade, Taciana G.S. Guimarães, Clarice D.B. Amaral, Andrea Oliveira, Mario H. Gonzalez
Fri Apr 03, 2020 15:50
Abstract Whether sexual or viability selection drives the evolution of ornamental traits is often unclear because current function does not clarify evolutionary history, particularly when the ornamentation is a modified version of the functional traits. Here, using a phylogenetic comparative approach, we studied how deeply forked tails—a classic example of sexually selected traits that might also be a mechanical device for enhancing aerodynamic ability—evolved in two groups of aerial foragers,...
Sat Apr 04, 2020 11:15
Abstract Understanding how organisms adapt to complex environments is of special interest in the current era of rapidly changing climatic conditions (Parmesan et al., 1999; Parmesan, 2006). Widespread species have to cope with a variety of environmental conditions within their distribution ranges. Accordingly, selective pressures show spatial variation, which often results in geographic differences in fitness‐related traits (Kawecki & Ebert, 2004). Evidence for such local adaptation stems,...
Fri Apr 03, 2020 18:31
Abstract Extreme inbreeding is expected to reduce the incidence of hybridization, serving as a prezygotic barrier. Mangrove rivulus is a small killifish that reproduces predominantly by self‐fertilization, producing highly homozygous lines throughout its geographic range. The Bahamas and Caribbean are inhabited by two highly diverged phylogeographic lineages of mangrove rivulus, Kryptolebias marmoratus and a “Central clade” closely related to K. hermaphroditus from Brazil. The two lineages are...
Fri Apr 03, 2020 18:30
Publication date: Available online 5 April 2020Source: Clinical TherapeuticsAuthor(s): Ravi Jhaveri
Sun Apr 05, 2020 12:20
Publication date: Available online 4 April 2020Source: Clinical TherapeuticsAuthor(s): Hong Zhang, Jingrui Liu, Xiaoxue Zhu, Xiaojiao Li, Hong Chen, Min Wu, Cuiyun Li, Yanhua Ding
Sun Apr 05, 2020 12:20
Publication date: Available online 3 April 2020Source: Clinical TherapeuticsAuthor(s): Paul Dorinsky, Paolo DePetrillo, Kiernan DeAngelis, Roopa Trivedi, Patrick Darken, Michael Gillen
Sat Apr 04, 2020 22:25
Publication date: Available online 3 April 2020Source: Clinical TherapeuticsAuthor(s): Blake John Anderson, Mofei Liu, Xiangqin Cui, Melissa Stevens, Meredith Allison Arensman
Fri Apr 03, 2020 16:00
Key points Kv3.1 and Kv3.3 subunits are highly expressed in the auditory brainstem, with little or no mRNA for Kv3.2 or Kv3.4. Changes in Kv3 currents and action potential (AP) firing were analysed from wildtype, Kv3.1 and Kv3.3 knockout (KO) mice. Both Kv3.1 and Kv3.3 immunostaining was present and Western blots confirmed loss of subunit protein in the respective KO. MNTB AP repolarization utilized Kv3.1 and/or Kv3.3; while in the LSO Kv3.3 was essential. Voltage‐gated calcium currents...
Sat Apr 04, 2020 22:24
Key points Endurance‐type training with blood flow restriction (BFR) increases maximum oxygen uptake (V̇O2max) and exercise endurance of humans. However, the physiological mechanisms behind this phenomenon remain uncertain. Here, we show that BFR‐interval training reduces the peripheral resistance to oxygen transport during dynamic, submaximal exercise in recreationally‐trained men, mainly by increasing convective oxygen delivery to contracting muscles. Accordingly, BFR‐training increased...
Sat Apr 04, 2020 18:19
Sat Apr 04, 2020 17:18
Key points NMDA receptors (NMDARs) are key molecules for controlling neuronal plasticity, learning and memory processes. Their function is impaired during Alzheimer's disease (AD) but the exact consequence on synaptic function is not yet fully identified. An important hallmark of AD onset is represented by the neuronal accumulation of Amyloid Beta42 oligomers (Abeta42) that we have recently shown to be responsible for the increased intracellular Ca2+ concentration through Ryanodine Receptors...
Sat Apr 04, 2020 17:04
Sat Apr 04, 2020 16:59
Key points During maximal effort contractions, intense serotonin release via the raphe‐spinal pathway spills over from the somato‐dendritic compartment to activate inhibitory 5‐HT1A receptors on the axon initial segment of motoneurons to reduce motoneuronal output. We investigated whether the same mechanism of central fatigue is present for low‐intensity contractions, whereby weak serotonergic drive over an extended period may cause accumulation of serotonin and exacerbate central fatigue....
Fri Apr 03, 2020 22:03
The marriage of dynamic covalent chemistry (DCC) and coordination chemistry is a powerful tool for assembling complex architectures from simple building units. Recently, the synthesis of woven covalent organic frameworks (COFs) with topologically fascinating structures has been achieved using this approach. However, the scope is highly limited and there is a need to discover new pathways that can assemble covalently linked organic threads into crystalline frameworks. Here, we have identified branching...
Sat Apr 04, 2020 16:59
Although considerable effort in recent years has been devoted to the development of 2‐dimensional nanostructures, single layered chiral sheet structures using lateral assembly of discrete clusters remain elusive. Here, we report single‐layered chiral 2D sheet structures with dual chiral void spaces in which the discrete clusters of planar aromatic segments are arranged with in‐plane AB order in aqueous methanol solution. The chirality of the sheet is induced by the slipped‐cofacial stacks of rectangular...
Sat Apr 04, 2020 14:33
Comprehensive phenotypic profiling of heterogeneous circulating tumor cells (CTCs) at single‐cell resolution has great importance for cancer management. However, multiplex biomarker profiling of individual CTCs is greatly hampered by the limitations of current single‐cell protein assay techniques. Herein, a novel spectrally combined encoding (SCE) strategy was proposed for multiplex biomarker profiling of single CTCs using a multifunctional nanosphere‐mediated microfluidic platform. Different cellular...
Sat Apr 04, 2020 13:04
The contradiction between the rising demands of optical chirality sensing and the failure in chiral detection of cryptochiral compounds encourages us to find new methods for chirality amplification. Inspired by planar chirality and the host‒guest recognition of pillararenes, we establish a new concept for amplifying CD signals of cryptochiral molecules by pillararene host–guest complexation induced chirality amplification. The planar chirality of pillararenes is induced and stabilized in presence...
Fri Apr 03, 2020 21:34
Despite the success of natural killer (NK)‐based adoptive immunotherapy in hematological malignancies, targeting solid tumors still has only limited therapeutic efficacy. Herein, we propose an aptamer‐equipping strategy to generate specific, universal and permeable (Super) NK cells for enhanced immunotherapy in solid tumors. NK cells were chemically equipped with TLS11a aptamer targeting HepG2 cells and PDL1‐specific aptamer without genetic alteration. The dual aptamer‐equipped NK cells exhibited...
Fri Apr 03, 2020 20:05
In layered hybrid perovskites like (BA) 2 PbI 4 (BA = C 4 H 9 NH 3 ), electrons and holes are considered to be confined in atomically thin two dimensional (2D) Pb‐I inorganic layers. These inorganic layers are electronically isolated from each other in the third dimension by the insulating organic layers. Our experimental findings suggest the presence of electronic interaction between the inorganic layers in some parts of the single crystals. The extent of this interaction is reversibly...
Fri Apr 03, 2020 20:03
Certain hydrolases preferentially catalyze acyl transfer over hydrolysis in an aqueous environment. However, molecular and structural reasons for this phenomenon are still unclear. Here we provide evidence that acyltransferase activity in esterases highly correlates with the hydrophobicity of the substrate‐binding pocket. A hydrophobicity scoring system developed in this work allows accurate prediction of promiscuous acyltransferase activity solely from the amino acid sequence of the cap domain....
Fri Apr 03, 2020 19:30
Asymmetric palladaelectro‐catalyzed C–H olefinations were achieved through the synergistic cooperation with transient directing groups. The electrochemical, atroposelective C–H activations were realized with high position‐, diastereo‐, and enantio‐control under mild reaction conditions to obtain highly enantiomerically‐enriched biaryls and fluorinated N–C axially chiral scaffolds. Our strategy provided expedient access to, among others, novel chiral BINOLs, dicarboxylic acids and helicenes of value...
Fri Apr 03, 2020 19:20
The attempts towards enzyme mimics to design simple, stable and efficient non‐protein systems for achieving the performance of natural enzymes, especially attractive to realize highly specific cancer diagnosis and treatment, have become an emerging field in recent years. The features of enzyme mimics highlight the pivotal importance of active site components and also the supported network environment for integrating and stabilizing them. Herein, the metal cross‐linked polymeric nanogels (MPGs) system...
Fri Apr 03, 2020 19:05
Electrochemical N2 reduction reactions (NRR) and N2 oxidation reaction (NOR), using H2O and N2, represent a sustainable approach to N2 fixation and arouse widespread attention. To date, due to the chemical inertness of nitrogen, emerging electrocatalysts for the electrochemical NRR and NOR at room temperature and atmospheric pressure remain largely under explored. Herein, a new‐type Fe–SnO2 was rationally designed as a Janus electrocatalyst for achieving highly efficient NRR and NOR catalysis. A...
Fri Apr 03, 2020 19:05
Two Co II 4 L 4 tetrahedral cages prepared from similar building blocks showed contrasting host‐guest properties. One cage did not bind guests, whereas the second encapsulated a series of anions, due to electronic and geometric effects. When the building blocks of both cages were present during self‐assembly, a library of five CoIILAxLB4‐x cages was formed in a statistical ratio in the absence of guests. Upon incorporation of anions able to interact preferentially with some library members,...
Fri Apr 03, 2020 19:00
Steroidal C7β alcohols and their respective esters have shown significant promise as neuroprotective and anti‐inflammatory agents to treat chronic neuronal damage like stroke, brain trauma and cerebral ischemia. Since position C7 is spatially far away from any functional groups that could direct C–H activation, these transformations are not readily possible using modern synthetic organic techniques. We report P450‐BM3 mutants that catalyze the oxidative hydroxylation of six different steroids with...
Fri Apr 03, 2020 18:29
The first aromatic C–H silylation between arylphosphines and hydrosilanes enabled by ruthenium complex has been developed. The excellent ortho‐selectivity was resulted from a four‐membered metallacyclic intermediate involving phosphorus chelation. The developed system could be extended to benzylic C–H silylation of arylphosphines. Diverse silylated arylphosphines are produced, which exhibit broad functional group compatibility. Further functionalization of the products under mild conditions renders...
Fri Apr 03, 2020 18:29
Self‐assembly of d8 metal polypyridine systems is a well‐established approach for the creation of 1D organometallic assemblies but there are still challenges for the large scale construction of nanostructured patterns from these building blocks. We describe here the use of high‐throughput nanoimprint lithography (NIL) to direct the self‐assembly of the heterobimetallic complexes [4′‐ferrocenyl‐(2,2′:6′,2′′‐terpyridine)M(OAc)]+(OAc)‐ (M = Pd or Pt; OAc = acetate). Uniform nanorods are fabricated from...
Fri Apr 03, 2020 18:01
Elimination of pulmonary Pseudomonas aeruginosa (PA) infections is challenging to accomplish with antibiotic therapies, mainly due to formidable resistance mechanisms. Quorum sensing inhibitors (QSIs) interfering with biofilm formation can thus complement antibiotics. For simultaneous and improved delivery of both actives to the infection sites, self‐assembling nanoparticles of a newly synthesized Squalenyl Hydrogen Sulfate (called SqNPs) were prepared. These nanocarriers allowed for remarkably high...
Fri Apr 03, 2020 17:54
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