Related ArticlesGenetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency. Nat Commun. 2020 01 10;11(1):197 Authors: Araki R, Hoki Y, Suga T, Obara C, Sunayama M, Imadome K, Fujita M, Kamimura S, Nakamura M, Wakayama S, Nagy A, Wakayama T, Abe M Abstract A number of point mutations have been identified in reprogrammed pluripotent stem cells such as iPSCs and ntESCs. The molecular basis for these mutations has...
Fri Apr 03, 2020 13:48
Related ArticlesRecombinant expression and characterization of yeast Mrc1, a DNA replication checkpoint mediator. Prep Biochem Biotechnol. 2020;50(2):198-203 Authors: Li L, Zhang Z Abstract In Saccharomyces cerevisiae, Mrc1 (homolog of human Claspin and mediator of replication checkpoint) is not only a part of the replication machine, but also participates in the replication stress response when DNA replication is blocked by hydroxyurea. Since Mrc1...
Fri Apr 03, 2020 13:48
Related ArticlesUpregulated expression of eIF3C is associated with malignant behavior in renal cell carcinoma. Int J Oncol. 2019 Dec;55(6):1385-1395 Authors: Fan M, Wang K, Wei X, Yao H, Chen Z, He X Abstract Eukaryotic initiation factor 3c (eIF3C) is involved in the initiation of protein translation. Aberrant eIF3C expression has been reported in different types of human cancer. The present study aimed to assess the role of eIF3C in the malignant...
Fri Apr 03, 2020 13:48
Related ArticlesQuantitative analysis of T cell proteomes and environmental sensors during T cell differentiation. Nat Immunol. 2019 11;20(11):1542-1554 Authors: Howden AJM, Hukelmann JL, Brenes A, Spinelli L, Sinclair LV, Lamond AI, Cantrell DA Abstract Quantitative mass spectrometry reveals how CD4+ and CD8+ T cells restructure proteomes in response to antigen and mammalian target of rapamycin complex 1 (mTORC1). Analysis of copy numbers per cell...
Fri Apr 03, 2020 13:48
Related ArticlesNotch signaling inhibition induces G0/G1 arrest in murine Leydig cells. Andrologia. 2019 Nov;51(10):e13413 Authors: Lu E, Feng F, Wen W, Tong X, Li X, Xiao L, Li G, Wang J, Zhang C Abstract As a highly evolutionarily conserved signaling pathway, Notch widely participates in cell-fate decisions and the development of various tissues and organs. In male reproduction, research on the Notch signaling pathway has mainly concentrated on germ...
Fri Apr 03, 2020 13:48
Related ArticlesMechanisms underlying synergy between DNA topoisomerase I-targeted drugs and mTOR kinase inhibitors in NF1-associated malignant peripheral nerve sheath tumors. Oncogene. 2019 09;38(39):6585-6598 Authors: Ki DH, Oppel F, Durbin AD, Look AT Abstract Malignant peripheral nerve sheath tumors (MPNSTs) are soft-tissue sarcomas that frequently arise in patients with neurofibromatosis type 1 (NF1). Most of these tumors are unresectable at diagnosis...
Fri Apr 03, 2020 13:48
Related ArticlesReplication fork stalling elicits chromatin compaction for the stability of stalling replication forks. Proc Natl Acad Sci U S A. 2019 07 16;116(29):14563-14572 Authors: Feng G, Yuan Y, Li Z, Wang L, Zhang B, Luo J, Ji J, Kong D Abstract DNA replication forks in eukaryotic cells stall at a variety of replication barriers. Stalling forks require strict cellular regulations to prevent fork collapse. However, the mechanism underlying these...
Fri Apr 03, 2020 13:48
Related ArticlesLong noncoding RNA EMS connects c-Myc to cell cycle control and tumorigenesis. Proc Natl Acad Sci U S A. 2019 07 16;116(29):14620-14629 Authors: Wang C, Yang Y, Zhang G, Li J, Wu X, Ma X, Shan G, Mei Y Abstract Deregulated expression of c-Myc is an important molecular hallmark of cancer. The oncogenic function of c-Myc has been largely attributed to its intrinsic nature as a master transcription factor. Here, we report the long noncoding...
Fri Apr 03, 2020 13:48
Related ArticlesLetter comments on "Infraorbital groove correction by microfat injection after lower blepharoplasty". J Plast Reconstr Aesthet Surg. 2020 Mar 18;: Authors: Ho WT PMID: 32245737 [PubMed - as supplied by publisher]
Sun Apr 05, 2020 13:47
Related ArticlesOver-meshing 1:1 meshed skin graft. J Plast Reconstr Aesthet Surg. 2020 Mar 14;: Authors: Veija T, Koljonen V PMID: 32245736 [PubMed - as supplied by publisher]
Sun Apr 05, 2020 13:47
Related ArticlesSequencing in management of in-transit melanoma metastasis: Diphencyprone versus isolate limb infusion. J Plast Reconstr Aesthet Surg. 2020 Mar 17;: Authors: Lo MC, Garioch J, Moncrieff MD Abstract BACKGROUND: In-transit metastases (ITMs) in melanoma are associated with poor prognosis, however a significant proportion of these patients survive for extended periods without further disease progression. We routinely use locoregional treatment...
Sun Apr 05, 2020 13:47
Related ArticlesEditorial on the article "Risk of breast implant associated anaplastic large cell lymphoma in a cohort of 3546 women prospectively followed long term after reconstruction with macro-textured breast implants. J Plast Reconstr Aesthet Surg. 2020 Mar 17;: Authors: Mercer NSG PMID: 32245734 [PubMed - as supplied by publisher]
Sun Apr 05, 2020 13:47
Related ArticlesHow should indocyanine green dye angiography be assessed to best predict mastectomy skin flap necrosis? A systematic review. J Plast Reconstr Aesthet Surg. 2020 Feb 18;: Authors: Driessen C, Arnardóttir TH, Lorenzo AR, Mani MR Abstract INTRODUCTION: The incidence of skin flap necrosis after mastectomies is as high as 11-24%. Laser-assisted indocyanine green (ICG) angiography seems to be a promising technique to assess skin flap perfusion....
Sun Apr 05, 2020 13:47
Related ArticlesPredictors of oncologic outcome in patients with and without flap reconstruction after extremity and truncal soft tissue sarcomas. J Plast Reconstr Aesthet Surg. 2020 Mar 17;: Authors: Dadras M, Koepp P, Wallner C, Wagner JM, Sogorski A, Lehnhardt M, Harati K, Behr B Abstract BACKGROUND: Soft tissue sarcomas (STS) of the extremities or trunk often require plastic reconstructive transfer of vital tissue for wound closure after resection....
Sun Apr 05, 2020 13:47
Related ArticlesThe use of MolecuLight i:X device in acute hand trauma. J Plast Reconstr Aesthet Surg. 2020 Mar 16;: Authors: Chew BJW, Griffin M, Butler PE, Mosahebi A Abstract Early diagnosis of wound infections are crucial as they have been shown to increase patient morbidity and mortality. We evaluated the use of Moleculight i:X to identify infections in acute open wounds in hand trauma. Data were collected from patients who attended the hand trauma...
Sat Apr 04, 2020 15:57
Related ArticlesRefining our knowledge of macrovascular arteriovenous shunts (MAS): Anatomical and pathological studies. J Plast Reconstr Aesthet Surg. 2020 Feb 19;: Authors: Grinsell D, Rajkomar AKS, Rozen WM, Ramsey KWD Abstract BACKGROUND: The macrovascular arteriovenous shunt (MAS) connecting the deep inferior epigastric artery (DIEA) and superficial inferior epigastric vein (SIEV) in the abdominal wall has already been identified as an important...
Sat Apr 04, 2020 15:57
Related ArticlesPublication rates from BAPRAS meetings: where are we now? J Plast Reconstr Aesthet Surg. 2020 Mar 16;: Authors: Vinnicombe Z, Johal KS, Roblin P, Mohanna PN Abstract In the UK the BAPRAS (British Association of Plastic, Reconstructive and Aesthetic Surgeons) meetings have always represented the ideal platform for disseminating new information in the field of plastic surgery. Previous studies have suggested the publication rate for these...
Sat Apr 04, 2020 15:57
Related ArticlesTactics for effective contemporary hand surgery journal clubs. J Plast Reconstr Aesthet Surg. 2020 Mar 14;: Authors: Duggan E, Forsyth M, Ryan D PMID: 32241742 [PubMed - as supplied by publisher]
Sat Apr 04, 2020 15:57
Related ArticlesLetter of response to the comment in "Modification of jumping man flap". J Plast Reconstr Aesthet Surg. 2020 Mar 14;: Authors: Diver AJ PMID: 32241741 [PubMed - as supplied by publisher]
Sat Apr 04, 2020 15:57
Related ArticlesQuality issues identified in systematic reviews on early laser intervention to reduce scar formation in wound healing. J Plast Reconstr Aesthet Surg. 2020 Mar 14;: Authors: Peinemann F, Behrouz-Pirnia A PMID: 32241740 [PubMed - as supplied by publisher]
Sat Apr 04, 2020 15:57
Related ArticlesFreestyle superficial femoral artery perforator (SFAp) free flap combined with a free periosteal medial condyle flap in Gustillo IIb fracture: Overkill or ideal treatment? J Plast Reconstr Aesthet Surg. 2020 Mar 17;: Authors: di Summa PG, Sapino G, Higgins GC, Guillier D PMID: 32241739 [PubMed - as supplied by publisher]
Sat Apr 04, 2020 15:57
Related ArticlesA standardized patient education class as a vehicle to improving shared decision-making and increasing access to breast reconstruction. J Plast Reconstr Aesthet Surg. 2020 Feb 18;: Authors: Henn D, Momeni A Abstract BACKGROUND: Shared decision-making is a key component of patient-centered care and has been shown to improve patient satisfaction and quality of life. Herein, we study the impact of a standardized patient education class for...
Sat Apr 04, 2020 15:57
Related ArticlesLetter comments on published article "Modification of jumping man flap". J Plast Reconstr Aesthet Surg. 2020 Mar 17;: Authors: Eiben II, Gilbert PM PMID: 32241737 [PubMed - as supplied by publisher]
Sat Apr 04, 2020 15:57
Related ArticlesImproving plastic surgery resident education and quality of care with outcomes feedback using the surgery report card: An initial experience. J Plast Reconstr Aesthet Surg. 2020 Feb 24;: Authors: Halani SH, Cho MJ, Garibay M, Nevin J, Zhang AY Abstract BACKGROUND: The practice of tracking and analyzing surgical outcomes is essential to becoming better surgeons. However, this feedback system is largely absent in residency training programs....
Sat Apr 04, 2020 15:57
Related ArticlesEvaluation of nasal pathologies accompanying rhinoplasty cases at otorhinolaryngology and plastic, reconstructive, & aesthetic surgery clinics. J Plast Reconstr Aesthet Surg. 2020 Feb 18;: Authors: Hanege FM, Celik S, Gunduz AY, Aksan T Abstract BACKGROUND AND OBJECTIVES: Rhinoplasty is a frequently performed surgical procedure. Besides an aesthetically successful outcome, determination of additional nasal pathologies and making a...
Sat Apr 04, 2020 15:57
Related ArticlesMinimally invasive cortical bone collector: A new tool in rhinoplasty. J Plast Reconstr Aesthet Surg. 2020 Feb 20;: Authors: Sert G, Bitik O, Vargel I PMID: 32238307 [PubMed - as supplied by publisher]
Fri Apr 03, 2020 14:21
Related ArticlesRobotic versus conventional nipple sparing mastectomy and immediate gel implant breast reconstruction in the management of breast cancer- A case control comparison study with analysis of clinical outcome, medical cost, and patient-reported cosmetic results. J Plast Reconstr Aesthet Surg. 2020 Feb 18;: Authors: Lai HW, Chen ST, Mok CW, Lin YJ, Wu HK, Lin SL, Chen DR, Kuo SJ Abstract BACKGROUND: Robotic nipple sparing mastectomy (R-NSM),...
Fri Apr 03, 2020 14:21
Related ArticlesQuality of life after total laryngectomy: impact of different vocal rehabilitation methods in a middle income country. Health Qual Life Outcomes. 2020 Apr 03;18(1):92 Authors: Souza FGR, Santos IC, Bergmann A, Thuler LCS, Freitas AS, Freitas EQ, Dias FL Abstract INTRODUCTION: The impact of advanced laryngeal cancer and its extensive surgical treatments cause significant morbidity for these patients. Total laryngectomy impacts essential...
Sun Apr 05, 2020 13:44
Related ArticlesCommunication and swallowing changes, everyday impacts and access to speech-language pathology services for people with Parkinson's disease: An Australian survey. Int J Speech Lang Pathol. 2020 Apr 03;:1-13 Authors: Swales M, Theodoros D, Hill AJ, Russell T Abstract Purpose: To investigate people with Parkinson's disease (PwPD): 1) self-reported communication and swallowing difficulties due to Parkinson's disease (PD), 2) participation...
Sun Apr 05, 2020 13:44
Related ArticlesThe most problematic symptoms of prion disease - an analysis of carer experiences. Int Psychogeriatr. 2019 08;31(8):1181-1190 Authors: Ford L, Rudge P, Robinson K, Collinge J, Gorham M, Mead S Abstract OBJECTIVES: Prion diseases are rare dementias that most commonly occur sporadically, but can be inherited or acquired, and for which there is no cure. We sought to understand which prion disease symptoms are most problematic for carers,...
Sat Apr 04, 2020 13:16
Related ArticlesCompartmental Surgery for Oral Tongue Cancer: Objective and Subjective Functional Evaluation. Laryngoscope. 2020 Apr 02;: Authors: Grammatica A, Piazza C, Montalto N, Del Bon F, Frittoli B, Mazza M, Paderno A, Lancini D, Fior M, Deganello A, Lombardi D, Nicolai P Abstract OBJECTIVE: To assess functional outcomes in patients treated by compartmental tongue surgery (CTS) and reconstruction for advanced oral tongue/floor-of-mouth cancer....
Fri Apr 03, 2020 14:55
Related Articles[Dental malocclusion in children: warning signs]. Rev Prat. 2019 Dec;69(10):1109-1112 Authors: Desbarats C, Chekroun M, Abdelqader S Abstract DENTAL MALOCCLUSION IN CHILDREN: WARNING SIGNS. Dental malocclusions are common, and can be dental, skeletal and/or functional. Detecting these pathologies earlier is a signal to remove these causing factors, and act in favor of an harmonious growth of the jaws and the face. The dental alert signs...
Fri Apr 03, 2020 14:55
Related ArticlesEffect of Expiratory Muscle Strength Training on Swallowing and Cough Functions in Patients With Neurological Diseases: A Meta-analysis. Am J Phys Med Rehabil. 2019 12;98(12):1060-1066 Authors: Wang Z, Wang Z, Fang Q, Li H, Zhang L, Liu X Abstract OBJECTIVE: The aim of this review was to evaluate and summarize the results of published studies exploring the effects of expiratory muscle strength training on swallowing and cough functions...
Fri Apr 03, 2020 14:55
Related ArticlesKv3.1 and Kv3.3 subunits differentially contribute to Kv3 channels and action potential repolarization in principal neurons of the auditory brainstem. J Physiol. 2020 Apr 04;: Authors: Choudhury N, Linley D, Richardson A, Anderson M, Robinson SW, Marra V, Ciampani V, Walter SM, Kopp-Scheinpflug C, Steinert JR, Forsythe ID Abstract KEY POINTS: Kv3.1 and Kv3.3 subunits are highly expressed in the auditory brainstem, with little or no mRNA...
Sun Apr 05, 2020 15:28
Related ArticlesNew insights into the complexity of arterial baroreflex control of muscle sympathetic outflow in humans. J Physiol. 2020 Apr 04;: Authors: Incognito AV, Millar PJ PMID: 32246770 [PubMed - as supplied by publisher]
Sun Apr 05, 2020 15:28
Related ArticlesAbeta42 oligomers up-regulate the excitatory synapses by potentiating presynaptic release while impairing postsynaptic NMDA receptors. J Physiol. 2020 Apr 04;: Authors: Marcantoni A, Cerullo MS, Buxeda P, Tomagra G, Giustetto M, Chiantia G, Carabelli V, Carbone E Abstract KEY POINTS: NMDA receptors (NMDARs) are key molecules for controlling neuronal plasticity, learning and memory processes. Their function is impaired during Alzheimer's...
Sun Apr 05, 2020 15:28
Related ArticlesTraining with blood flow restriction increases femoral artery diameter and thigh oxygen delivery during knee-extensor exercise in recreationally trained men. J Physiol. 2020 Apr 04;: Authors: Christiansen D, Eibye K, Hostrup M, Bangsbo J Abstract KEY POINTS: Endurance-type training with blood flow restriction (BFR) increases maximum oxygen uptake (V̇O2max) and exercise endurance of humans. However, the physiological mechanisms behind...
Sun Apr 05, 2020 15:28
Related ArticlesOne and one is not always two: hypo- and hyper-additive effects of the chemoreflex during exercise. J Physiol. 2020 Apr 04;: Authors: Sheel AW, Peters CM PMID: 32246766 [PubMed - as supplied by publisher]
Sun Apr 05, 2020 15:28
Related ArticlesEnhanced serotonin availability amplifies fatigue perception and modulates the TMS-induced silent period during sustained low-intensity elbow flexions. J Physiol. 2020 Apr 03;: Authors: Thorstensen JR, Taylor JL, Tucker MG, Kavanagh JJ Abstract KEY POINTS: During maximal effort contractions, intense serotonin release via the raphe-spinal pathway spills over from the somato-dendritic compartment to activate inhibitory 5-HT1A receptors...
Sat Apr 04, 2020 15:46
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