Medicine by Alexandros G. Sfakianakis

Dietary Supplementation of L-Arginine and N-Carbamylglutamate Attenuated the Hepatic Inflammatory Response and Apoptosis in Suckling Lambs with Intrauterine Growth Retardation

L-arginine (Arg) is a semiessential amino acid with several physiological functions. N-Carbamylglutamate (NCG) can promote the synthesis of endogenous Arg in mammals. However, the roles of Arg or NCG on hepatic inflammation and apoptosis in suckling lambs suffering from intrauterine growth restriction (IUGR) are still unclear. The current work is aimed at examining the effects of dietary Arg and NCG on inflammatory and hepatocyte apoptosis in IUGR suckling lambs. On day 7 after birth, 48 newborn...

Mycobiome in the Gut: A Multiperspective Review

Sat Apr 04, 2020 14:35

Human gut is home to a diverse and complex microbial ecosystem encompassing bacteria, viruses, parasites, fungi, and other microorganisms that have an undisputable role in maintaining good health for the host. Studies on the interplay between microbiota in the gut and various human diseases remain the key focus among many researchers. Nevertheless, advances in sequencing technologies and computational biology have helped us to identify a diversity of fungal community that reside in the gut known...

Dexmedetomidine Protects against Ischemia and Reperfusion-Induced Kidney Injury in Rats

Sat Apr 04, 2020 14:05

Acute kidney injury (AKI), a clinical syndrome, is a sudden onset of kidney failure that severely affects the kidney tubules. One potential treatment is dexmedetomidine (DEX), a highly selective α2-adrenoreceptor agonist that is used as an anesthetic adjuvant. It also has anti-inflammatory, neuroprotective, and sympatholytic qualities. The aim of this study was to establish whether DEX also offers protection against ischemia and reperfusion- (I/R-) induced AKI in rats. An intraperitoneal injection...

European Archives of Oto-Rhino-Laryngology

Fri Apr 03, 2020 16:20

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Flavor education and training in olfactory dysfunction: a pilot study

Abstract Purpose Olfactory training is recommended in olfactory dysfunction (OD) showing promising results. OD patients frequently ask for training modifications in the hope of a better outcome. Also, a lack of knowledge of the flavor system is evident. This investigation sought to implement flavor education (FE) and encourage patients to experience flavors in terms of a flavor training (FT). ...

European Archives of Oto-Rhino-Laryngology

Sat Apr 04, 2020 03:00

Day-case thyroid lobectomy parameters at a tertiary referral head and neck centre: a sensitivity and cost analysis

Abstract Purpose Day-case thyroid surgery has been endorsed by the American Thyroid Association and the British Association of Day Surgery. Despite the many benefits of day surgery, day-case thyroid surgery is not widely practiced. We describe the use of sensitivity analysis modelling and cost analysis in determining and refining the patient cohort that safely meet the threshold for a new day-case thyroid lobectomy service at a tertiary...

European Archives of Oto-Rhino-Laryngology

Fri Apr 03, 2020 03:00

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Voice

Retest Reliability for Complete Airway Interruption Systems of Aerodynamic Measurement

Publication date: Available online 4 April 2020Source: Journal of VoiceAuthor(s): Jim R. Lamb, Sarah A. Schultz, Austin J. Scholp, Emily R. Wendel, Jack J. Jiang

Voice

Sat Apr 04, 2020 16:44

Early Management of Acute Unilateral Vocal Fold Paralysis: Update of the Literature

Publication date: Available online 3 April 2020Source: Journal of VoiceAuthor(s): Joana A.S. Marques, Adrien Marronnier, Frédéric Crampon, Aude Lagier, Jean-Paul Marie

Voice

Sat Apr 04, 2020 16:44

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Otolaryngology-Head and Neck Surgery

Editorial Board

Publication date: March 2020Source: Operative Techniques in Otolaryngology-Head and Neck Surgery, Volume 31, Issue 1Author(s):

Otolaryngology-Head and Neck Surgery

Sat Apr 04, 2020 16:32

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Prognostic significance of tumor poliovirus receptor and CTLA4 expression in patients with surgically resected non-small-cell lung cancer

Abstract Introduction Poliovirus receptor (PVR) is a tumor promoter and a regulatory checkpoint that enhances immunosuppression. We investigated PVR expression by applying immunohistochemistry (IHC) staining. A positive association existed between PVR expression and cytotoxic T lymphocyte-associated antigen 4 (CTLA4) expression in patients with surgically resected non-small-cell lung cancer (NSCLC). PVR expression is a prognosis predictor...

Primary anatomical site as a prognostic factor for pleomorphic liposarcoma

Sat Apr 04, 2020 03:00

Abstract Background Pleomorphic liposarcomas (PLS) is an aggressive, high-grade subtype of soft tissue sarcoma representing < 15% of liposarcomas. It most commonly arises in the retroperitoneum and proximal upper extremities. Current prognostic factors are centered around staging, which accounts for the grade, size, and location of the tumor in relation to the superficial fascia. ...

Gender-specific differences in care-seeking behaviour among lung cancer patients: a systematic review

Sat Apr 04, 2020 03:00

Abstract Background In the literature, men are often described as unwilling to use healthcare services, whereas women as frequent users. We conducted a systematic literature review to examine the gender differences in healthcare utilisation of lung cancer patients. Our aim was to synthesise evidence to assess whether men and women utilise cancer diagnosis and treatments differently. ...

Fri Apr 03, 2020 03:00

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Dasatinib-induced chylothorax: report of a case and review of the literature

Summary Dasatinib is a tyrosine kinase inhibitor for the treatment of BCR-ABL-positive chronic myeloid leukaemia (CML) or Philadelphia chromosome-positive acute lymphoblastic leukaemia (ALL). Although fluid retention is a common adverse event associated with dasatinib, chylothorax is exceptionally rare. The pathological mechanism, clinical manifestation and management of dasatinib-induced chylothorax are completely unclear. A 71-year-old man treated with dasatinib for CML was...

A randomized, phase 2 study of deoxyuridine triphosphatase inhibitor, TAS-114, in combination with S-1 versus S-1 alone in patients with advanced non-small-cell lung cancer

Sat Apr 04, 2020 03:00

Summary Introduction TAS-114 is a potent inhibitor of deoxyuridine triphosphatase, which is a gatekeeper protein preventing uracil and 5-fluorouracil (5-FU) misincorporation into DNA. TAS-114 has been suggested to enhance the antitumor activity of 5-FU. This randomized, phase 2 study investigated TAS-114 plus S-1 (TAS-114/S-1) vs. S-1 in non-small-cell lung cancer (NSCLC) patients. Methods Patients with advanced NSCLC, previously treated with ≥ 2 regimens, were randomized 1:1...

Fri Apr 03, 2020 03:00

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Impact of sarcopenia on survival and late toxicity in head and neck cancer patients treated with radiotherapy

Publication date: June 2020Source: Radiotherapy and Oncology, Volume 147Author(s): Maria I. van Rijn-Dekker, Lisa van den Bosch, Johanna G.M. van den Hoek, Hendrik P. Bijl, Evert S.M. van Aken, Anouk van der Hoorn, Sjoukje F. Oosting, Gyorgy B. Halmos, Max J.H. Witjes, Hans P. van der Laan, Johannes A. Langendijk, Roel J.H.M. Steenbakkers

Cancer patients in covid-19 era: swimming against the tide

Sat Apr 04, 2020 16:06

Publication date: Available online 4 April 2020Source: Radiotherapy and OncologyAuthor(s): Gregucci Fabiana, Morena Caliandro, Alessia Surgo, Roberta Carbonara, Ilaria Bonaparte, Alba Fiorentino

In response to Park, et al

Sat Apr 04, 2020 16:06

Publication date: Available online 4 April 2020Source: Radiotherapy and OncologyAuthor(s): Judi N.A. van Diessen, Margriet H. Kwint, Jan-Jakob Sonke, José S.A. Belderbos

Regarding: van Diessen et al., “Safety and efficacy of reduced dose and margins to involved lymph node metastases in locally advanced non-small cell lung cancer (NSCLC) patients”

Sat Apr 04, 2020 16:06

Publication date: Available online 3 April 2020Source: Radiotherapy and OncologyAuthor(s): Jongmoo Park, Ji Woon Yea, Jae Won Park, Jaehyeon Park

International expert consensus statement regarding radiotherapy treatment options for rectal cancer during the COVID 19 pandemic

Fri Apr 03, 2020 17:44

Publication date: Available online 2 April 2020Source: Radiotherapy and OncologyAuthor(s): C.A.M. Marijnen, F.P. Peters, C. Rödel, K. Bujko, K. Haustermans, E. Fokas, R. Glynne-Jones, V. Valentini, K-L.G. Spindler, M.G. Guren, Philippe Maignon, F.A. Calvo, O. Pares, B. Glimelius, D. Sebag-Montefiore

An evaluation of hepatocellular carcinoma practice guidelines from a radiation oncology perspective

Fri Apr 03, 2020 17:44

Publication date: Available online 2 April 2020Source: Radiotherapy and OncologyAuthor(s): Chai Hong Rim, Jason Cheng, Wen-Yen Huang, Tomoki Kimura, Victor Lee, Zhao-Chong Zeng, Jinsil Seong

Fri Apr 03, 2020 17:44

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Use of Surgical Risk Preoperative Assessment System (SURPAS) and Patient Satisfaction during Informed Consent for Surgery

Publication date: Available online 3 April 2020Source: Journal of the American College of SurgeonsAuthor(s): Brett M. Wiesen, Michael R. Bronsert, Davis M. Aasen, Abhinav B. Singh, Anne Lambert-Kerzner, William G. Henderson, Karl E. Hammermeister, Robert A. Meguid

Improved Mortality in Necrotizing Pancreatitis with a Multidisciplinary Minimally Invasive Step Up Approach: Comparison to a Modern Open Necrosectomy Cohort

Sat Apr 04, 2020 16:00

Publication date: Available online 3 April 2020Source: Journal of the American College of SurgeonsAuthor(s): Casey M. Luckhurst, Majed El Hechi, Ahmed E. Elsharkawy, Ahmed I. Eid, Lydia R. Maurer, Haytham M. Kaafarani, Ashraf Thabet, David G. Forcione, Carlos Fernandez-Del Castillo, Keith D. Lillemoe, Peter J. Fagenholz

Residency and Fellowship Program Accreditation: Effects of the Novel Coronavirus (COVID-19) Pandemic

Sat Apr 04, 2020 16:00

Publication date: Available online 3 April 2020Source: Journal of the American College of SurgeonsAuthor(s): John R. Potts

Eliminating Opiate Prescriptions in Children after Non-Perforated Appendectomy

Sat Apr 04, 2020 16:00

Publication date: Available online 3 April 2020Source: Journal of the American College of SurgeonsAuthor(s): Bethany J. Farr, Lee Ranstrom, David P. Mooney

Precautions for Operating Room Team Members during the COVID-19 Pandemic

Sat Apr 04, 2020 16:00

Publication date: Available online 2 April 2020Source: Journal of the American College of SurgeonsAuthor(s): Joseph D. Forrester, Aussama K. Nassar, Paul M. Maggio, Mary T. Hawn

Fri Apr 03, 2020 15:38

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A peer evaluation training results in high-quality feedback, as measured over time in nutritional sciences graduate students.

Related ArticlesA peer evaluation training results in high-quality feedback, as measured over time in nutritional sciences graduate students. Adv Physiol Educ. 2020 Jun 01;44(2):203-209 Authors: Anderson OS, El Habbal N, Bridges D Abstract Peer evaluation skills are not typically taught to students, yet they are expected to provide high-quality feedback to their peers. Gameful learning, a pedagogy supporting student-driven learning, can further reinforce...

Approaches used for teaching anatomy and physiology in the university pre-professional program at King Saud bin Abdulaziz University for Health Sciences.

Sat Apr 04, 2020 15:43

Related ArticlesApproaches used for teaching anatomy and physiology in the university pre-professional program at King Saud bin Abdulaziz University for Health Sciences. Adv Physiol Educ. 2020 Jun 01;44(2):188-191 Authors: Memon I, Alkushi A, Shewar DE, Anjum I, Feroz Z Abstract Many medical schools offer pre-professional programs to undergraduate students. The main purpose of the university pre-professional program (UPPP) is to equip students with the...

The Old West analogy for acid-base buffering.

Sat Apr 04, 2020 15:43

Related ArticlesThe Old West analogy for acid-base buffering. Adv Physiol Educ. 2020 Jun 01;44(2):210-211 Authors: Bobulescu IA PMID: 32243219 [PubMed - as supplied by publisher]

Development of low-cost cardiac and skeletal muscle laboratory activities to teach physiology concepts and the scientific method.

Sat Apr 04, 2020 15:43

Related ArticlesDevelopment of low-cost cardiac and skeletal muscle laboratory activities to teach physiology concepts and the scientific method. Adv Physiol Educ. 2020 Jun 01;44(2):181-187 Authors: Judge JL, Cazares VA, Thompson Z, Skidmore LA Abstract Anatomy and Physiology courses taught at community colleges tend to focus laboratory hours primarily on anatomy as opposed to physiology. However, research demonstrates that, when instructors utilize...

Inquiry in oral communication: adapting oral examinations for teaching introductory physiology students to evaluate scientific research studies.

Sat Apr 04, 2020 15:43

Related ArticlesInquiry in oral communication: adapting oral examinations for teaching introductory physiology students to evaluate scientific research studies. Adv Physiol Educ. 2020 Jun 01;44(2):192-202 Authors: St James AR, Campbell D Abstract Generating an increasingly skilled and numerous workforces of science, technology, engineering, and mathematics (STEM) professionals is a national priority. Central to this goal is improving the ability of STEM...