Related ArticlesPyoluteorin induces cell cycle arrest and apoptosis in human triple-negative breast cancer cells MDA-MB-231. J Pharm Pharmacol. 2020 Apr 04;: Authors: Ding T, Yang LJ, Zhang WD, Shen YH Abstract OBJECTIVES: To screen the cytotoxic activity of six secondary metabolites isolated from soil fungus Aspergillus niger. Importantly, to investigate the mechanism that pyoluteorin induced human triple-negative breast cancer MDA-MB-231 cells...
Sun Apr 05, 2020 14:46
Related ArticlesDual targeting of CDK4/6 and BCL2 pathways augments tumor response in estrogen receptor positive breast cancer. Clin Cancer Res. 2020 Apr 03;: Authors: Whittle JR, Vaillant F, Surgenor E, Policheni AN, Giner G, Capaldo BD, Chen HR, Liu HK, Dekkers JF, Sachs N, Clevers H, Fellowes A, Green T, Xu H, Fox SB, Herold MJ, Smyth GK, Gray DHD, Visvader JE, Lindeman GJ Abstract PURPOSE: Although cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors...
Sun Apr 05, 2020 13:47
Related ArticlesThe Immune Response Against Human Cytomegalovirus Links Cellular to Systemic Senescence. Cells. 2020 Mar 20;9(3): Authors: J Heath J, D Grant M Abstract Aging reflects long-term decline in physiological function and integrity. Changes arise at a variable pace governed by time-dependent and -independent mechanisms that are themselves complex, interdependent and variable. Molecular decay produces inferior cells that eventually dominate...
Sun Apr 05, 2020 13:47
Related ArticlesRole of uL3 in the Crosstalk between Nucleolar Stress and Autophagy in Colon Cancer Cells. Int J Mol Sci. 2020 Mar 20;21(6): Authors: Pecoraro A, Carotenuto P, Franco B, De Cegli R, Russo G, Russo A Abstract The nucleolus is the site of ribosome biogenesis and has been recently described as important sensor for a variety of cellular stressors. In the last two decades, it has been largely demonstrated that many chemotherapeutics act...
Sun Apr 05, 2020 13:47
Related ArticlesCD44s Induces miR-629-3p Expression in Association with Cisplatin Resistance in Head and Neck Cancer Cells. Cancers (Basel). 2020 Apr 01;12(4): Authors: Chikuda J, Otsuka K, Shimomura I, Ito K, Miyazaki H, Takahashi RU, Nagasaki M, Mukudai Y, Ochiya T, Shimane T, Shirota T, Yamamoto Y Abstract Cisplatin (cis-diamminedichloroplatinum II [CDDP] ) is a well-known chemotherapeutic drug that has been used for the treatment of various types...
Sun Apr 05, 2020 13:47
Related ArticlesAntiproliferative and Antimetastatic Effects of Praeruptorin C on Human Non-Small Cell Lung Cancer Through Inactivating ERK/CTSD Signalling Pathways. Molecules. 2020 Apr 01;25(7): Authors: Liu CM, Shen HT, Lin YA, Yu YL, Chen YS, Liu CJ, Hsieh YH Abstract Praeruptorin C (PC) reportedly has beneficial effects in terms of antiinflammation, antihypertension, and antiplatelet aggregation, and it potentially has anticancer activity. However,...
Sun Apr 05, 2020 13:47
Related ArticlesAdipose Tissue and FoxO1: Bridging Physiology and Mechanisms. Cells. 2020 Mar 31;9(4): Authors: Ioannilli L, Ciccarone F, Ciriolo MR Abstract Forkhead box O class proteins (FoxOs) are expressed nearly in all tissues and are involved in different functions such as energy metabolism, redox homeostasis, differentiation, and cell cycle arrest. The plasticity of FoxOs is demonstrated by post-translational modifications that determine diverse...
Sun Apr 05, 2020 13:47
Related ArticlesmiR-1285-3p Controls Colorectal Cancer Proliferation and Escape from Apoptosis through DAPK2. Int J Mol Sci. 2020 Mar 31;21(7): Authors: Villanova L, Barbini C, Piccolo C, Boe A, De Maria R, Fiori ME Abstract MicroRNAs are tiny but powerful regulators of gene expression at the post-transcriptional level. Aberrant expression of oncogenic and tumor-suppressor microRNAs has been recognized as a common feature of human cancers. Colorectal...
Sun Apr 05, 2020 13:47
Related ArticlesPolyphyllosides A-F, six new spirostanol saponins from the stems and leaves of Paris polyphylla var. chinensis. Bioorg Chem. 2020 Mar 24;99:103788 Authors: Qin XJ, Zhang LJ, Zhang Y, Ni W, Yang XZ, Yu Q, Yan H, An LK, Liu HY Abstract The first phytochemical investigation on the steroidal saponins from the stems and leaves of Paris polyohylla var. chinensis led to the discovery and characterization of six new spirostanol saponins,...
Sat Apr 04, 2020 14:48
Related ArticlesThe effect of polysaccharides from Cibotium barometz on enhancing temozolomide-induced glutathione exhausted in human glioblastoma U87 cells, as revealed by 1H NMR metabolomics analysis. Int J Biol Macromol. 2020 Mar 31;: Authors: Shi Y, Wang X, Wang N, Li FF, You YL, Wang SQ Abstract Glioblastoma (GBM) is the most malignant central nervous system tumor, with poor prognosis. Temozolomide (TMZ) has been used as a first-line drug for...
Sat Apr 04, 2020 14:48
Related ArticlesROS-Mediated Selective Killing Effect of Black Phosphorus: Mechanistic Understanding and its Guidance for Safe Biomedical Applications. Nano Lett. 2020 Apr 03;: Authors: Kong N, Ji X, Wang J, Sun X, Chen G, Fan T, Liang W, Zhang H, Xie A, Farokhzad OC, Tao W Abstract Black phosphorus (BP)-based nanomaterials have distinguished advantages and potential applications in various biomedical fields. However, their biological effects in...
Sat Apr 04, 2020 14:48
Related ArticlesFish Lipid against Prostate Cancer (PC-3) through Apoptosis and Cell Cycle Arrest. Nutr Cancer. 2020 Apr 03;:1-7 Authors: Gupta P, Serajuddin M Abstract Anti-proliferative and apoptotic activities of different concentrations (10-50 μg/ml) of total lipid of the freshwater fish, Labeo rohita against human prostate cancer cells (PC3) were assessed using cells viability analysis by MTT assay, intracellular ROS generation and nuclear condensation....
Sat Apr 04, 2020 14:48
Related ArticlesExosome-transmitted lncRNA UFC1 promotes non-small-cell lung cancer progression by EZH2-mediated epigenetic silencing of PTEN expression. Cell Death Dis. 2020 Apr 02;11(4):215 Authors: Zang X, Gu J, Zhang J, Shi H, Hou S, Xu X, Chen Y, Zhang Y, Mao F, Qian H, Zhu T, Xu W, Zhang X Abstract Long non-coding RNAs (LncRNAs) have been suggested as important regulators of cancer development and progression in non-small cell lung cancer (NSCLC)....
Sat Apr 04, 2020 14:48
Related ArticlesThe tumor suppressor NOR1 suppresses cell growth, invasiveness, and tumorigenicity in glioma. Neoplasma. 2020 Mar 30;: Authors: Cai J, Liu C, Yi M, Tan Y, Chen S, Ren N, Cheng H, Li X, Xiong W, Li G, Wu M, Wang W, Xiang B Abstract Oxidored-nitro domain-containing protein 1 (NOR1) is a tumor suppressor downregulated in various human cancers, including nasopharyngeal carcinoma (NPC), lung cancer, and testicular cancer. NOR1 protein...
Sat Apr 04, 2020 14:48
Related ArticlesTop1 and Top2 promote replication fork arrest at a programmed pause site. Genes Dev. 2020 01 01;34(1-2):1-3 Authors: Larcher MV, Pasero P Abstract Programmed fork pausing is a complex process allowing cells to arrest replication forks at specific loci in a polar manner. Studies in budding yeast and other model organisms indicate that such replication fork barriers do not act as roadblocks passively impeding fork progression but rather...
Sat Apr 04, 2020 13:48
Related ArticlesToxicity assessment of the herbicide acetochlor in the human liver carcinoma (HepG2) cell line. Chemosphere. 2020 Mar;243:125345 Authors: Huang T, Huang Y, Huang Y, Yang Y, Zhao Y, Martyniuk CJ Abstract Acetochlor is a high-volume herbicide used on a global scale and toxicity assessments are needed to define its potential for adverse effects in wildlife and humans. This study was conducted to determine the effects of acetochlor on human...
Sat Apr 04, 2020 13:48
Related ArticlesCRL4 ubiquitin ligase stimulates Fanconi anemia pathway-induced single-stranded DNA-RPA signaling. BMC Cancer. 2019 Nov 05;19(1):1042 Authors: Codilupi T, Taube D, Naegeli H Abstract BACKGROUND: DNA-crosslinking agents like cisplatin and mitomycin C (MMC) are indispensible for the treatment of many solid malignancies. These anticancer drugs generate DNA interstrand crosslinks (ICLs) that cause cell death by blocking replication forks....
Sat Apr 04, 2020 13:48
Related ArticlesRFC2, a direct target of miR-744, modulates the cell cycle and promotes the proliferation of CRC cells. J Cell Physiol. 2020 Apr 02;: Authors: Hu T, Shen H, Li J, Yang P, Gu Q, Fu Z Abstract Colorectal cancer (CRC) is a common digestive tract malignancy, which is characterized by high mortality, morbidity, and poor prognosis. Replication factor C subunit 2 (RFC2), one RFC family member, was reported to be related to various malignancies...
Fri Apr 03, 2020 14:49
Related ArticlesPreliminary study on radiosensitivity to carbon ions in human breast cancer. J Radiat Res. 2020 Apr 02;: Authors: Zhang Q, Kong Y, Yang Z, Liu Y, Liu R, Geng Y, Luo H, Zhang H, Li H, Feng S, Wang X Abstract The aim of the study was to investigate the various effects of high linear energy transfer (LET) carbon ion (12C6+) and low LET X-ray radiation on MDA-MB-231 and MCF-7 human breast cancer cells and to explore the underlying mechanisms...
Fri Apr 03, 2020 14:49
Related ArticlesHS‑146, a novel phosphoinositide 3‑kinase α inhibitor, induces the apoptosis and inhibits the metastatic ability of human breast cancer cells. Int J Oncol. 2020 Mar 19;: Authors: Kim OH, Lee JH, Mah S, Park SY, Hong S, Hong SS Abstract The phosphoinositide 3‑kinase (PI3K) signaling pathway plays an important role in human cancer as it regulates critical cellular functions, such as survival, proliferation and metabolism. In the present...
Fri Apr 03, 2020 13:48
Related Articles17‑AAG synergizes with Belinostat to exhibit a negative effect on the proliferation and invasion of MDA‑MB‑231 breast cancer cells. Oncol Rep. 2020 Mar 26;: Authors: Zuo Y, Xu H, Chen Z, Xiong F, Zhang B, Chen K, Jiang H, Luo C, Zhang H Abstract Breast cancer is one of the most common malignancies that threaten the health of women. Although there are a few chemotherapies for the clinical treatment of breast cancer, these therapies...
Fri Apr 03, 2020 13:48
Related ArticlesCDK5 inhibition in vitro and in vivo induces cell death in myeloma and overcomes the obstacle of bortezomib resistance. Int J Mol Med. 2020 Mar 26;: Authors: Tang H, Xu L, Cen X, Yang L, Feng J, Li G, Zhu H, Gao S, Yu Y, Zhao Y, Tian Z, Hou L, Yu S, Gao G Abstract The emergence of new drugs is a major feature of the treatment history of multiple myeloma (MM), which also reflects the current incurability of MM. As a unique member of...
Fri Apr 03, 2020 13:48
Related ArticlesCD44 inhibition attenuates EGFR signaling and enhances cisplatin sensitivity in human EGFR wild‑type non‑small‑cell lung cancer cells. Int J Mol Med. 2020 Apr 01;: Authors: Yin J, Zhang H, Wu X, Zhang Y, Li J, Shen J, Zhao Y, Xiao Z, Lu L, Huang C, Zhang Z, Du F, Wu Y, Kaboli PJ, Cho CH, Yuan D, Li M Abstract Cluster of differentiation 44 (CD44) as a transmembrane glycoprotein is found to be expressed in non‑small cell lung cancer...
Fri Apr 03, 2020 13:48
Related ArticlesAndrographolide induces apoptosis in human osteosarcoma cells via the ROS/JNK pathway. Int J Oncol. 2020 Mar 30;: Authors: Wang S, Li H, Chen S, Wang Z, Yao Y, Chen T, Ye Z, Lin P Abstract Osteosarcoma is the most common primary malignant tumor of the bone and the long‑term survival of patients with this disease has remained unsatisfactory over the past several decades. Andrographolide, a traditional drug used in Chinese medicine,...
Fri Apr 03, 2020 13:48
Related ArticlesTriptolide interrupts rRNA synthesis and induces the RPL23‑MDM2‑p53 pathway to repress lung cancer cells. Oncol Rep. 2020 Mar 30;: Authors: Wang J, Zhang ZQ, Li FQ, Chen JN, Gong X, Cao BB, Wang W Abstract Lung cancer has one of the highest mortalities of any cancer worldwide. Triptolide (TP) is a promising tumor suppressor extracted from the Chinese herb Tripterygium wilfordii. Our previous proteomics analysis revealed that TP significantly...
Fri Apr 03, 2020 13:48
Related ArticlesUpregulated NTF4 in colorectal cancer promotes tumor development via regulating autophagy. Int J Oncol. 2020 Mar 26;: Authors: Yang Z, Chen Y, Wei X, Wu D, Min Z, Quan Y Abstract Autophagy plays a key role in colorectal cancer (CRC) development and reduces the sensitivity of CRC cells to treatment. The present study reported a novel tumor‑suppressive role for autophagy, which was demonstrated to be regulated through the novel oncogene...
Fri Apr 03, 2020 13:48
Related ArticlesEnhanced selectivity, cellular uptake, and in vitro activity of an intrinsically fluorescent copper-tirapazamine nanocomplex for hypoxia targeted therapy in prostate cancer. Biomater Sci. 2020 Apr 01;: Authors: Silva VL, Kaassis A, Dehsorkhi A, Koffi CR, Severic M, Abdelhamid M, Nyimanu D, Morris CJ, Al-Jamal WT Abstract In the present work, a copper-tirapazamine (TPZ) nanocomplex [Cu(TPZ)2] was synthesized for selective hypoxia-targeted...
Fri Apr 03, 2020 13:48
Related ArticlesERβ and NFκB-Modulators of Zearalenone-Induced Oxidative Stress in Human Prostate Cancer Cells. Toxins (Basel). 2020 Mar 22;12(3): Authors: Kowalska K, Habrowska-Górczyńska DE, Domińska K, Urbanek KA, Piastowska-Ciesielska AW Abstract Nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) is commonly expressed in prostate cancer (PCa) cells and is associated with increased proliferation, metastases and androgen independence....
Fri Apr 03, 2020 13:48
Related ArticlesEffective Cellular Transport of Ortho-Halogenated Sulfonamide Derivatives of Metformin Is Related to Improved Antiproliferative Activity and Apoptosis Induction in MCF-7 Cells. Int J Mol Sci. 2020 Mar 30;21(7): Authors: Markowicz-Piasecka M, Komeil I, Huttunen J, Sikora J, Huttunen KM Abstract Metformin is a substrate for plasma membrane monoamine transporters (PMAT) and organic cation transporters (OCTs); therefore, the expression...
Fri Apr 03, 2020 13:48
Related ArticlesNorhierridin B, a New Hierridin B-Based Hydroquinone with Improved Antiproliferative Activity. Molecules. 2020 Mar 30;25(7): Authors: Brandão P, Moreira J, Almeida J, Nazareth N, Sampaio-Dias IE, Vasconcelos V, Martins R, Leão P, Pinto M, Saraíva L, Cidade H Abstract Hierridin B (6), a methylated hydroquinone isolated from the marine picocyanobacterium Cyanobium sp. LEGE 06113, moderately inhibited the growth of colon adenocarcinoma...
Fri Apr 03, 2020 13:48
Related ArticlesCurcumin and Colorectal Cancer: From Basic to Clinical Evidences. Int J Mol Sci. 2020 Mar 29;21(7): Authors: Pricci M, Girardi B, Giorgio F, Losurdo G, Ierardi E, Di Leo A Abstract Curcumin diffuses through cell membranes into the endoplasmic reticulum, mitochondria, and nucleus, where it exerts actions, as an antioxidant property. Therefore, its use has been advocated for chemopreventive, antimetastatic, and anti-angiogenic purposes....
Fri Apr 03, 2020 13:48
Related ArticlesKnockdown of CARD14 Inhibits Cell Proliferation and Migration in Breast Cancer Cells. Anticancer Res. 2020 Apr;40(4):1953-1962 Authors: Lim JY, Kim SW, Kim B, Park SJ Abstract BACKGROUND/AIM: Caspase recruitment domain family, member 14 (CARD14) is a member of the CARD family of proteins, which play an important role in immune and inflammatory response, and cell survival and proliferation. Here, we identified the role of CARD14 in...
Fri Apr 03, 2020 13:48
Related ArticlesEffect of Methylsulfonylmethane on Proliferation and Apoptosis of A549 Lung Cancer Cells Through G2/M Cell-cycle Arrest and Intrinsic Cell Death Pathway. Anticancer Res. 2020 Apr;40(4):1905-1913 Authors: Kim DH, Sp N, Kang DY, Jo ES, Rugamba A, Jang KJ, Yang YM Abstract BACKGROUND/AIM: Methylsulfonylmethane (MSM) is a natural organic compound that displays anti-inflammatory as well as antioxidant properties. MSM reportedly has potential...
Fri Apr 03, 2020 13:48
Related ArticlesAQ-4, a deuterium-containing molecule, acts as a microtubule-targeting agent for cancer treatment. Eur J Pharmacol. 2020 Mar 29;:173093 Authors: Lin BY, Liu WL, Huang H, Hu YG, Gong S, Meng YH, Yan J, Lu YZ, Chen HL Abstract The important physiological function of microtubules makes them an indispensable and clinically effective target of anti-tumor agents. Herein, we sought to design, synthesize, and evaluate a novel 4-anilinoquinazoline...
Fri Apr 03, 2020 13:48
Related ArticlesNutlin-Induced Apoptosis Is Specified by a Translation Program Regulated by PCBP2 and DHX30. Cell Rep. 2020 Mar 31;30(13):4355-4369.e6 Authors: Rizzotto D, Zaccara S, Rossi A, Galbraith MD, Andrysik Z, Pandey A, Sullivan KD, Quattrone A, Espinosa JM, Dassi E, Inga A Abstract Activation of p53 by the small molecule Nutlin can result in a combination of cell cycle arrest and apoptosis. The relative strength of these events is difficult...
Fri Apr 03, 2020 13:48
Related ArticlesIrradiation-induced senescence of bone marrow mesenchymal stem cells aggravates osteogenic differentiation dysfunction via paracrine signaling. Am J Physiol Cell Physiol. 2020 Apr 01;: Authors: Bai J, Wang Y, Wang J, Zhai J, He F, Zhu G Abstract The role of cellular senescence induced by radiation in bone loss has attracted much attention. As one of the common complications of anti-cancer radiotherapy, irradiation-induced bone deterioration...
Fri Apr 03, 2020 13:48
Related ArticlesKnockdown of lncRNA OGFRP1 Inhibits Proliferation and Invasion of JEG-3 Cells Via AKT/mTOR Pathway. Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820905823 Authors: Meng Q, Xue H Abstract Increasing evidence indicates the pivotal role of long noncoding RNAs in a variety of cancers, but there is limited focus on the link between long noncoding RNAs and gestational choriocarcinoma. This study aimed to examine the role of long noncoding...
Fri Apr 03, 2020 13:48
Related ArticlesConstruction of lncRNA regulatory networks reveal the key lncRNAs associated with Pituitary adenomas progression. Math Biosci Eng. 2020 Jan 06;17(3):2138-2149 Authors: Xue YH, Ge YQ Abstract Pituitary adenomas (PA) is one of the most frequent types of intracranial neoplasms. Long noncoding RNAs (lncRNAs) played important roles in the progression of human cancers, including PA. However, the roles of lncRNAs in PA remained to be further...
Fri Apr 03, 2020 13:48
Related ArticlesGenetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency. Nat Commun. 2020 01 10;11(1):197 Authors: Araki R, Hoki Y, Suga T, Obara C, Sunayama M, Imadome K, Fujita M, Kamimura S, Nakamura M, Wakayama S, Nagy A, Wakayama T, Abe M Abstract A number of point mutations have been identified in reprogrammed pluripotent stem cells such as iPSCs and ntESCs. The molecular basis for these mutations has...
Fri Apr 03, 2020 13:48
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