Biomolecules, Vol. 10, Pages 933: Seminal Plasma Modulates miRNA Expression by Sow Genital Tract Lining Explants Biomolecules doi: 10.3390/biom10060933 Authors: Isabel Barranco Lorena Padilla Cristina A. Martinez Manuel Alvarez-Rodriguez Inmaculada Parrilla Xiomara Lucas Graça Ferreira-Dias Marc Yeste Heriberto Rodriguez-Martinez Jordi Roca The seminal plasma (SP) modulates the female reproductive immune environment after mating, and microRNAs (miRNAs) could...
Fri Jun 19, 2020 03:00
Biomolecules, Vol. 10, Pages 932: Anti-Inflammatory and Chondroprotective Effects of Vanillic Acid and Epimedin C in Human Osteoarthritic Chondrocytes Biomolecules doi: 10.3390/biom10060932 Authors: Reihane Ziadlou Andrea Barbero Ivan Martin Xinluan Wang Ling Qin Mauro Alini Sibylle Grad In osteoarthritis (OA), inhibition of excessively expressed pro-inflammatory cytokines in the OA joint and increasing the anabolism for cartilage regeneration are necessary. In this...
Fri Jun 19, 2020 03:00
Biomolecules, Vol. 10, Pages 931: Deep Learning of Cancer Stem Cell Morphology Using Conditional Generative Adversarial Networks Biomolecules doi: 10.3390/biom10060931 Authors: Saori Aida Junpei Okugawa Serena Fujisaka Tomonari Kasai Hiroyuki Kameda Tomoyasu Sugiyama Deep-learning workflows of microscopic image analysis are sufficient for handling the contextual variations because they employ biological samples and have numerous tasks. The use of well-defined annotated...
Fri Jun 19, 2020 03:00
Brain Sciences, Vol. 10, Pages 396: Multiscale Computation and Dynamic Attention in Biological and Artificial Intelligence Brain Sciences doi: 10.3390/brainsci10060396 Authors: Ryan Paul Badman Thomas Trenholm Hills Rei Akaishi Biological and artificial intelligence (AI) are often defined by their capacity to achieve a hierarchy of short-term and long-term goals that require incorporating information over time and space at both local and global scales. More advanced forms of this...
Sat Jun 20, 2020 03:00
Brain Sciences, Vol. 10, Pages 395: Neurochemical Correlates of Brain Atrophy in Fibromyalgia Syndrome: A Magnetic Resonance Spectroscopy and Cortical Thickness Study Brain Sciences doi: 10.3390/brainsci10060395 Authors: Paola Feraco Salvatore Nigro Luca Passamonti Alessandro Grecucci Maria Eugenia Caligiuri Cesare Gagliardo Antonella Bacci (1) Background: Recently, a series of clinical neuroimaging studies on fibromyalgia (FM) have shown a reduction in cortical volume...
Sat Jun 20, 2020 03:00
Brain Sciences, Vol. 10, Pages 394: Cholinergic System and NGF Receptors: Insights from the Brain of the Short-Lived Fish Nothobranchius furzeri Brain Sciences doi: 10.3390/brainsci10060394 Authors: Paolo de Girolamo Adele Leggieri Antonio Palladino Carla Lucini Chiara Attanasio Livia D’Angelo Nerve growth factor (NGF) receptors are evolutionary conserved molecules, and in mammals are considered necessary for ensuring the survival of cholinergic neurons. The age-dependent...
Sat Jun 20, 2020 03:00
Brain Sciences, Vol. 10, Pages 393: Theory of Mind Deficits and Neurophysiological Operations in Autism Spectrum Disorders: A Review Brain Sciences doi: 10.3390/brainsci10060393 Authors: Maria Andreou Vasileia Skrimpa Theory of Mind (ToM) is a multifaceted skill set which encompasses a variety of cognitive and neurobiological aspects. ToM deficits have long been regarded as one of the most disabling features in individuals with Autism Spectrum Disorder. One of the theories that attempts...
Sat Jun 20, 2020 03:00
Brain Sciences, Vol. 10, Pages 392: A Novel Connectome-Based Electrophysiological Study of Subjective Cognitive Decline Related to Alzheimer’s Disease by Using Resting-State High-Density EEG EGI GES 300 Brain Sciences doi: 10.3390/brainsci10060392 Authors: Ioulietta Lazarou Kostas Georgiadis Spiros Nikolopoulos Vangelis P. Oikonomou Anthoula Tsolaki Ioannis Kompatsiaris Magda Tsolaki Dimitris Kugiumtzis Aim: To investigate for the first time the brain network in...
Fri Jun 19, 2020 03:00
Brain Sciences, Vol. 10, Pages 390: Lacking Pace but Not Precision: Age-Related Information Processing Changes in Response to a Dynamic Attentional Control Task Brain Sciences doi: 10.3390/brainsci10060390 Authors: Anna Torrens-Burton Claire J. Hanley Rodger Wood Nasreen Basoudan Jade Eloise Norris Emma Richards Andrea Tales Age-related decline in information processing can have a substantial impact on activities such as driving. However, the assessment of these changes...
Fri Jun 19, 2020 03:00
Brain Sciences, Vol. 10, Pages 391: Reward Responsiveness in the Adolescent Brain Cognitive Development (ABCD) Study: African Americans’ Diminished Returns of Parental Education Brain Sciences doi: 10.3390/brainsci10060391 Authors: Shervin Assari Shanika Boyce Golnoush Akhlaghipour Mohsen Bazargan Cleopatra H. Caldwell (1) Background: Reward responsiveness (RR) is a risk factor for high-risk behaviors such as aggressive behaviors and early sexual initiation, which are all...
Fri Jun 19, 2020 03:00
Brain Sciences, Vol. 10, Pages 388: Effect of Mental Fatigue on Postural Sway in Healthy Older Adults and Stroke Populations Brain Sciences doi: 10.3390/brainsci10060388 Authors: Gonzalo Varas-Diaz Lakshmi Kannan Tanvi Bhatt The aim of this study was to examine the effect of mental fatigue on postural sway under different sensory conditions in healthy older adults and in persons with chronic stroke (PwCS). Thirty healthy older adults (> 60 years old), randomly separated...
Fri Jun 19, 2020 03:00
Brain Sciences, Vol. 10, Pages 389: Functional Aspects of Hypothalamic Asymmetry Brain Sciences doi: 10.3390/brainsci10060389 Authors: David Sandor Kiss Istvan Toth Gergely Jocsak Zoltan Barany Tibor Bartha Laszlo V. Frenyo Tamas L. Horvath Attila Zsarnovszky Anatomically, the brain is a symmetric structure. However, growing evidence suggests that certain higher brain functions are regulated by only one of the otherwise duplicated (and symmetric) brain halves. Hemispheric...
Fri Jun 19, 2020 03:00
Brain Sciences, Vol. 10, Pages 387: Behavioral and Cognitive Electrophysiological Differences in the Executive Functions of Taiwanese Basketball Players as a Function of Playing Position Brain Sciences doi: 10.3390/brainsci10060387 Authors: Yi-Kang Chiu Chien-Yu Pan Fu-Chen Chen Yu-Ting Tseng Chia-Liang Tsai The effect of the predominant playing position of elite basketball players on executive functions using both behavioral and electrophysiological measurements was investigated...
Fri Jun 19, 2020 03:00
Cancers, Vol. 12, Pages 1641: Fluoropyrimidine Modulation of the Anti-Tumor Immune Response―Prospects for Improved Colorectal Cancer Treatment Cancers doi: 10.3390/cancers12061641 Authors: William H. Gmeiner Chemotherapy modulates the anti-tumor immune response and outcomes depend on the balance of favorable and unfavorable effects of drugs on anti-tumor immunity. 5-Florouracil (5-FU) is widely used in adjuvant chemotherapy regimens to treat colorectal cancer (CRC) and provides a survival...
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Cancers, Vol. 12, Pages 1642: The Liver Microbiome Is Implicated in Cancer Prognosis and Modulated by Alcohol and Hepatitis B Cancers doi: 10.3390/cancers12061642 Authors: Jaideep Chakladar Lindsay M. Wong Selena Z. Kuo Wei Tse Li Michael Andrew Yu Eric Y. Chang Xiao Qi Wang Weg M. Ongkeko Hepatocellular carcinoma (HCC) is one of the deadliest cancers in the world. Previous studies have identified the importance of alcohol and hepatitis B (HBV) infection on HCC carcinogenesis,...
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Cancers, Vol. 12, Pages 1643: Myoferlin Is a Yet Unknown Interactor of the Mitochondrial Dynamics’ Machinery in Pancreas Cancer Cells Cancers doi: 10.3390/cancers12061643 Authors: Sandy Anania Raphaël Peiffer Gilles Rademaker Alexandre Hego Marc Thiry Louise Deldicque Marc Francaux Naïma Maloujahmoum Ferman Agirman Akeila Bellahcène Vincent Castronovo Olivier Peulen Pancreas ductal adenocarcinoma is one of the deadliest cancers where surgery remains the...
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Cancers, Vol. 12, Pages 1640: Melanoma Brain Metastases in the Era of Target Therapies: An Overview Cancers doi: 10.3390/cancers12061640 Authors: Paolo Becco Susanna Gallo Stefano Poletto Mirko Pio Manlio Frascione Luca Crotto Alessandro Zaccagna Luca Paruzzo Daniela Caravelli Fabrizio Carnevale-Schianca Massimo Aglietta Malignant melanoma is the third most common type of tumor that causes brain metastases. Patients with cerebral involvement have a dismal prognosis...
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Cancers, Vol. 12, Pages 1639: Results of a Phase I-II Study on Laser Therapy for Vaginal Side Effects after Radiotherapy for Cancer of Uterine Cervix or Endometrium Cancers doi: 10.3390/cancers12061639 Authors: Anna Myriam Perrone Marco Tesei Martina Ferioli Francesca De Terlizzi Anna Nunzia Della Gatta Safia Boussedra Giulia Dondi Andrea Galuppi Alessio Giuseppe Morganti Pierandrea De Iaco Women who have previously received radiotherapy (RT) for gynecologic...
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Cancers, Vol. 12, Pages 1638: Primary Tumor Location Is a Prognostic Factor for Intrahepatic Progression-Free Survival in Patients with Colorectal Liver Metastases Undergoing Portal Vein Embolization as Preparation for Major Hepatic Surgery Cancers doi: 10.3390/cancers12061638 Authors: Hitpass Heise Schulze-Hagen Pedersoli Ulmer Amygdalos Isfort Neumann Kuhl Bruners Zimmermann The aim of this study was to identify prognostic factors affecting...
Sat Jun 20, 2020 03:00
Cancers, Vol. 12, Pages 1636: Pro-Oxidant Enzymes, Redox Balance and Oxidative Damage to Proteins, Lipids and DNA in Colorectal Cancer Tissue. Is Oxidative Stress Dependent on Tumour Budding and Inflammatory Infiltration? Cancers doi: 10.3390/cancers12061636 Authors: Justyna Zińczuk Mateusz Maciejczyk Konrad Zaręba Anna Pryczynicz Violetta Dymicka-Piekarska Joanna Kamińska Olga Koper-Lenkiewicz Joanna Matowicka-Karna Bogusław Kędra Anna Zalewska Katarzyna Guzińska-Ustymowicz...
Sat Jun 20, 2020 03:00
Cancers, Vol. 12, Pages 1637: Bromodomain-Containing Protein BRD4 Is Hyperphosphorylated in Mitosis Cancers doi: 10.3390/cancers12061637 Authors: Ranran Wang June F. Yang Flora Ho Erle S. Robertson Jianxin You The epigenetic reader BRD4 binds acetylated histones and plays a central role in controlling cellular gene transcription and proliferation. Dysregulation of BRD4′s activity has been implicated in the pathogenesis of a wide variety of cancers. While blocking...
Sat Jun 20, 2020 03:00
Cancers, Vol. 12, Pages 1635: Circulating miRNAs in Small Extracellular Vesicles Secreted by a Human Melanoma Xenograft in Mouse Brains Cancers doi: 10.3390/cancers12061635 Authors: Loredana Guglielmi Marta Nardella Carla Musa Ingrid Cifola Manuela Porru Beatrice Cardinali Ilaria Iannetti Chiara Di Pietro Giulia Bolasco Valentina Palmieri Laura Vilardo Nicolò Panini Fabrizio Bonaventura Massimiliano Papi Ferdinando Scavizzi Marcello Raspa Carlo...
Fri Jun 19, 2020 03:00
Cancers, Vol. 12, Pages 1634: Oral Manifestations and Complications in Childhood Acute Myeloid Leukemia Cancers doi: 10.3390/cancers12061634 Authors: Francisco Cammarata-Scalisi Katia Girardi Luisa Strocchio Pietro Merli Annelyse Garret Bernardin Angela Galeotti Fabio Magliarditi Alessandro Inserra Michele Callea Acute myeloid leukemia (AML) is a heterogeneous group of diseases, whose classification is based on lineage-commitment and genetics. Although rare in...
Fri Jun 19, 2020 03:00
Cancers, Vol. 12, Pages 1632: EMT-Associated Heterogeneity in Circulating Tumor Cells: Sticky Friends on the Road to Metastasis Cancers doi: 10.3390/cancers12061632 Authors: Genna Vanwynsberghe Villard Pottier Ancel Polette Gilles Epithelial–mesenchymal transitions (EMTs) generate hybrid phenotypes with an enhanced ability to adapt to diverse microenvironments encountered during the metastatic spread. Accordingly, EMTs play a crucial role in the biology...
Fri Jun 19, 2020 03:00
Cancers, Vol. 12, Pages 1631: Small Molecule Inhibitors Targeting Gαi2 Protein Attenuate Migration of Cancer Cells Cancers doi: 10.3390/cancers12061631 Authors: Silvia Caggia Subhasish Tapadar Bocheng Wu Smrruthi V. Venugopal Autumn S. Garrett Aditi Kumar Janae S. Stiffend John S. Davis Adegboyega K. Oyelere Shafiq A. Khan Heterotrimeric G-proteins are ubiquitously expressed in several cancers, and they transduce signals from activated G-protein coupled receptors....
Fri Jun 19, 2020 03:00
Cancers, Vol. 12, Pages 1633: Metabolic Landscape of a Genetically Engineered Mouse Model of IDH1 Mutant Glioma Cancers doi: 10.3390/cancers12061633 Authors: Victor Ruiz-Rodado Tomohiro Seki Tyrone Dowdy Adrian Lita Meili Zhang Sue Han Chunzhang Yang Murali K. Cherukuri Mark R. Gilbert Mioara Larion Understanding the metabolic reprogramming of aggressive brain tumors has potential applications for therapeutics as well as imaging biomarkers. However, little...
Fri Jun 19, 2020 03:00
Cancers, Vol. 12, Pages 1630: A Small-Molecule Tankyrase Inhibitor Reduces Glioma Stem Cell Proliferation and Sphere Formation Cancers doi: 10.3390/cancers12061630 Authors: Kirsten Strømme Kierulf-Vieira Cecilie Jonsgar Sandberg Jo Waaler Kaja Lund Erlend Skaga Birthe Mikkelsen Saberniak Ioannis Panagopoulos Petter Brandal Stefan Krauss Iver Arne Langmoen Einar Osland Vik-Mo Evidence suggests that the growth and therapeutic resistance of glioblastoma (GBM)...
Fri Jun 19, 2020 03:00
Cancers, Vol. 12, Pages 1628: The Modified Phenanthridine PJ34 Unveils an Exclusive Cell-Death Mechanism in Human Cancer Cells Cancers doi: 10.3390/cancers12061628 Authors: Malka Cohen-Armon This overview summarizes recent data disclosing the efficacy of the PARP inhibitor PJ34 in exclusive eradication of a variety of human cancer cells without impairing healthy proliferating cells. Its cytotoxic activity in cancer cells is attributed to the insertion of specific un-repairable anomalies...
Fri Jun 19, 2020 03:00
Cancers, Vol. 12, Pages 1629: Identification of a Blood-Based Protein Biomarker Panel for Lung Cancer Detection Cancers doi: 10.3390/cancers12061629 Authors: Victoria El-Khoury Anna Schritz Sang-Yoon Kim Antoine Lesur Katriina Sertamo François Bernardin Konstantinos Petritis Patrick Pirrotte Cheryl Selinsky Jeffrey R. Whiteaker Haizhen Zhang Jacob J. Kennedy Chenwei Lin Lik Wee Lee Ping Yan Nhan L. Tran Landon J. Inge Khaled Chalabi Georges...
Fri Jun 19, 2020 03:00
Cancers, Vol. 12, Pages 1625: Hot Spot TERT Promoter Mutations Are Rare in Sporadic Pancreatic Neuroendocrine Neoplasms and Associated with Telomere Length and Epigenetic Expression Patterns Cancers doi: 10.3390/cancers12061625 Authors: Alexandra Posch Sarah Hofer-Zeni Eckhard Klieser Florian Primavesi Elisabeth Naderlinger Anita Brandstetter Martin Filipits Romana Urbas Stefan Swiercynski Tarkan Jäger Paul Winkelmann Tobias Kiesslich Lingeng Lu Daniel...
Fri Jun 19, 2020 03:00
Cancers, Vol. 12, Pages 1626: Molecular Interplay between Dormant Bone Marrow-Resident Cells (BMRCs) and CTCs in Breast Cancer Cancers doi: 10.3390/cancers12061626 Authors: Debasish Boral Haowen N. Liu S. Ray Kenney Dario Marchetti Despite widespread knowledge that bone marrow-resident breast cancer cells (BMRCs) affect tumor progression, signaling mechanisms of BMRCs implicated in maintaining long-term dormancy have not been characterized. To overcome these hurdles, we developed...
Fri Jun 19, 2020 03:00
Cancers, Vol. 12, Pages 1624: Exploring the Therapeutic Potential of Membrane Transport Proteins: Focus on Cancer and Chemoresistance Cancers doi: 10.3390/cancers12061624 Authors: Shekoufeh Almasi Yassine El Hiani Improving the therapeutic efficacy of conventional anticancer drugs represents the best hope for cancer treatment. However, the shortage of druggable targets and the increasing development of anticancer drug resistance remain significant problems. Recently, membrane transport...
Fri Jun 19, 2020 03:00
Cancers, Vol. 12, Pages 1627: Molecular and Genomic Profiling of Lung Cancer in the Era of Precision Medicine: A Position Paper from the Italian Association of Thoracic Oncology (AIOT) Cancers doi: 10.3390/cancers12061627 Authors: Nicola Normanno Massimo Barberis Filippo De Marinis Cesare Gridelli on the behalf of the AIOT Expert Panel The identification of the optimal cancer treatment has become progressively more intricate for non-small-cell lung cancer (NSCLC) patients...
Fri Jun 19, 2020 03:00
Cells, Vol. 9, Pages 1510: Statistical Mechanics of Non-Muscle Myosin IIA in Human Bone Marrow-Derived Mesenchymal Stromal Cells Seeded in a Collagen Scaffold: A Thermodynamic Near-Equilibrium Linear System Modified by the Tripeptide Arg-Gly-Asp (RGD) Cells doi: 10.3390/cells9061510 Authors: Yves Lecarpentier Vincent Kindler Xénophon Krokidis Marie-Luce Bochaton-Piallat Victor Claes Jean-Louis Hébert Alexandre Vallée Olivier Schussler Mesenchymal stromal cells (MSCs)...
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Cells, Vol. 9, Pages 1509: The Anti-Inflammatory and Pain-Relieving Effects of AR170, an Adenosine A3 Receptor Agonist, in a Rat Model of Colitis Cells doi: 10.3390/cells9061509 Authors: Luca Antonioli Elena Lucarini Catia Lambertucci Matteo Fornai Carolina Pellegrini Laura Benvenuti Lorenzo Di Cesare Mannelli Andrea Spinaci Gabriella Marucci Corrado Blandizzi Carla Ghelardini Rosaria Volpini Diego Dal Ben The pharmacological activation of A3 receptors...
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Cells, Vol. 9, Pages 1511: Mechanistic Involvement of Long Non-Coding RNAs in Oncotherapeutics Resistance in Triple-Negative Breast Cancer Cells doi: 10.3390/cells9061511 Authors: Samarth Kansara Vijay Pandey Peter E. Lobie Gautam Sethi Manoj Garg Amit Kumar Pandey Triple-negative breast cancer (TNBC) is one of the most lethal forms of breast cancer (BC), with a significant disease burden worldwide. Chemoresistance and lack of targeted therapeutics are major hindrances...
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Cells, Vol. 9, Pages 1505: Ferroptosis and Cancer: Mitochondria Meet the “Iron Maiden” Cell Death Cells doi: 10.3390/cells9061505 Authors: Anna Martina Battaglia Roberta Chirillo Ilenia Aversa Alessandro Sacco Francesco Costanzo Flavia Biamonte Ferroptosis is a new type of oxidative regulated cell death (RCD) driven by iron-dependent lipid peroxidation. As major sites of iron utilization and master regulators of oxidative metabolism, mitochondria are the main source of...
Sat Jun 20, 2020 03:00
Cells, Vol. 9, Pages 1507: Role of 2-Arachidonoyl-Glycerol and CB1 Receptors in Orexin-A-Mediated Prevention of Oxygen–Glucose Deprivation-Induced Neuronal Injury Cells doi: 10.3390/cells9061507 Authors: Letizia Palomba Andrea Motta Roberta Imperatore Fabiana Piscitelli Raffaele Capasso Federica Mastroiacovo Giuseppe Battaglia Valeria Bruno Luigia Cristino Vincenzo Di Marzo Orexin-A (OX-A) protects the brain against oxidative stress-mediated ischemic injury....
Sat Jun 20, 2020 03:00
Cells, Vol. 9, Pages 1508: Higher Mast Cell Accumulation in Human Adipose Tissues Defines Clinically Favorable Obesity Sub-Phenotypes Cells doi: 10.3390/cells9061508 Authors: Nir Goldstein Yarden Kezerle Yftach Gepner Yulia Haim Tal Pecht Roi Gazit Vera Polischuk Idit F. Liberty Boris Kirshtein Ruthy Shaco-Levy Matthias Blüher Assaf Rudich The identification of human obesity sub-types may improve the clinical management of patients with obesity and uncover...
Sat Jun 20, 2020 03:00
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