IJMS, Vol. 21, Pages 4369: ABCA1/ApoE/HDL Signaling Pathway Facilitates Myelination and Oligodendrogenesis after Stroke International Journal of Molecular Sciences doi: 10.3390/ijms21124369 Authors: Li Li Rongwen Li Alex Zacharek Fengjie Wang Julie Landschoot-Ward Michael Chopp Jieli Chen Xu Cui ATP-binding cassette transporter A1 (ABCA1) plays an important role in the regulation of apolipoprotein E (ApoE) and the biogenesis of high-density lipoprotein (HDL) cholesterol...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4367: Machine-Learned Association of Next-Generation Sequencing-Derived Variants in Thermosensitive Ion Channels Genes with Human Thermal Pain Sensitivity Phenotypes International Journal of Molecular Sciences doi: 10.3390/ijms21124367 Authors: Jörn Lötsch Dario Kringel Gerd Geisslinger Bruno G. Oertel Eduard Resch Sebastian Malkusch Genetic association studies have shown their usefulness in assessing the role of ion channels in human thermal pain...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4366: Femto- to Millisecond Time-Resolved Photodynamics of a Double-Functionalized Push–Pull Organic Linker: Potential Candidate for Optoelectronically Active MOFs International Journal of Molecular Sciences doi: 10.3390/ijms21124366 Authors: Mario Gutiérrez Lucie Duplouy-Armani Lorenzo Angiolini Mercedes Pintado-Sierra Félix Sánchez Abderrazzak Douhal The design of improved organic linkers for the further engineering of smarter metal–organic...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4368: Potential Application of Protamine for Antimicrobial Biomaterials in Bone Tissue Engineering International Journal of Molecular Sciences doi: 10.3390/ijms21124368 Authors: Michiyo Honda Morio Matsumoto Mamoru Aizawa Bacterial infection of biomaterials is a serious problem in the field of medical devices. It is urgently necessary to develop new biomaterials with bactericidal activity. Antimicrobial peptides and proteins (AMPs), alternative antibacterial...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4363: Dietary Regulation of Memory T Cells International Journal of Molecular Sciences doi: 10.3390/ijms21124363 Authors: Nicholas Collins Memory T cells are a fundamental component of immunological memory, providing rapid and potent host protection against secondary challenges. As such, memory T cells are key targets in the design of vaccination strategies and cancer immunotherapies, making it critical to understand the factors and mechanisms that regulate their...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4364: Optimization of a WGA-Free Molecular Tagging-Based NGS Protocol for CTCs Mutational Profiling International Journal of Molecular Sciences doi: 10.3390/ijms21124364 Authors: Giuseppa De Luca Barbara Cardinali Lucia Del Mastro Sonia Lastraioli Franca Carli Manlio Ferrarini George A. Calin Anna Garuti Carlotta Mazzitelli Simona Zupo Mariella Dono Molecular characterization of Circulating Tumor Cells (CTCs) is still challenging, despite...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4358: BRG1 Is Dispensable for Sertoli Cell Development and Functions in Mice International Journal of Molecular Sciences doi: 10.3390/ijms21124358 Authors: Shuai Wang Pengxiang Wang Dongli Liang Yuan Wang Sertoli cells are somatic supporting cells in spermatogenic niche and play critical roles in germ cell development, but it is yet to be understood how epigenetic modifiers regulate Sertoli cell development and contribution to spermatogenesis. BRG1 (Brahma...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4359: Nifedipine Exacerbates Lipogenesis in the Kidney via KIM-1, CD36, and SREBP Upregulation: Implications from an Animal Model for Human Study International Journal of Molecular Sciences doi: 10.3390/ijms21124359 Authors: Yen-Chung Lin Jhih-Cheng Wang Mai-Szu Wu Yuh-Feng Lin Chang-Rong Chen Chang-Yu Chen Kuan-Chou Chen Chiung-Chi Peng Dysregulation of fatty acid oxidation and accumulation of fatty acids can cause kidney injury. Nifedipine...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4361: Sialic Acid-Siglec Axis as Molecular Checkpoints Targeting of Immune System: Smart Players in Pathology and Conventional Therapy International Journal of Molecular Sciences doi: 10.3390/ijms21124361 Authors: Przemyslaw Wielgat Karol Rogowski Katarzyna Niemirowicz-Laskowska Halina Car The sialic acid-based molecular mimicry in pathogens and malignant cells is a regulatory mechanism that leads to cross-reactivity with host antigens resulting in suppression...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4357: Modeling the Effect of Composition on Formation of Aerosolized Nanoemulsion System Encapsulating Docetaxel and Curcumin Using D-Optimal Mixture Experimental Design International Journal of Molecular Sciences doi: 10.3390/ijms21124357 Authors: Azren Aida Asmawi Norazlinaliza Salim Emilia Abdulmalek Mohd Basyaruddin Abdul Rahman The synergistic anticancer effect of docetaxel (DTX) and curcumin (CCM) has emerged as an attractive therapeutic candidate...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4360: Characterisation of the Effect of the Spatial Organisation of Hemicellulases on the Hydrolysis of Plant Biomass Polymer International Journal of Molecular Sciences doi: 10.3390/ijms21124360 Authors: Thomas Enjalbert Marion De La Mare Pierre Roblin Louise Badruna Thierry Vernet Claire Dumon Cédric Y. Montanier Synergism between enzymes is of crucial importance in cell metabolism. This synergism occurs often through a spatial organisation favouring...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4362: NKG2A/CD94 Is a New Immune Receptor for HLA-G and Distinguishes Amino Acid Differences in the HLA-G Heavy Chain International Journal of Molecular Sciences doi: 10.3390/ijms21124362 Authors: Gia-Gia T. Hò Alexander A. Celik Trevor Huyton Wiebke Hiemisch Rainer Blasczyk Gwendolin S. Simper Christina Bade-Doeding Natural killer (NK) cell therapies are a tool to antagonize a dysfunctional immune system. NK cells recognize malignant cells, traffic...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4356: GLI1 and AXIN2 Are Distinctive Markers of Human Calvarial Mesenchymal Stromal Cells in Nonsyndromic Craniosynostosis International Journal of Molecular Sciences doi: 10.3390/ijms21124356 Authors: Lorena Di Pietro Marta Barba Chiara Prampolini Sabrina Ceccariglia Paolo Frassanito Alessia Vita Enrico Guadagni Davide Bonvissuto Luca Massimi Gianpiero Tamburrini Ornella Parolini Wanda Lattanzi All skeletal bones house osteogenic...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4354: Modeling Cardiac Disease Mechanisms Using Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Progress, Promises and Challenges International Journal of Molecular Sciences doi: 10.3390/ijms21124354 Authors: Elvira Immacolata Parrotta Valeria Lucchino Luana Scaramuzzino Stefania Scalise Giovanni Cuda Cardiovascular diseases (CVDs) are a class of disorders affecting the heart or blood vessels. Despite progress in clinical research and therapy, CVDs...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4355: Overview of Neurological Mechanism of Pain Profile Used for Animal “Pain-Like” Behavioral Study with Proposed Analgesic Pathways International Journal of Molecular Sciences doi: 10.3390/ijms21124355 Authors: Mun Fei Yam Yean Chun Loh Chuan Wei Oo Rusliza Basir Pain is the most common sensation installed in us naturally which plays a vital role in defending us against severe harm. This neurological mechanism pathway has been one of the most complex...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4353: Circulating Levels of Brain-Enriched MicroRNAs Correlate with Neuron Specific Enolase after Cardiac Arrest—A Substudy of the Target Temperature Management Trial International Journal of Molecular Sciences doi: 10.3390/ijms21124353 Authors: Francesca Maria Stefanizzi Niklas Nielsen Lu Zhang Josef Dankiewicz Pascal Stammet Patrik Gilje David Erlinge Christian Hassager Matthew P. Wise Michael Kuiper Hans Friberg Yvan Devaux Antonio...
Fri Jun 19, 2020 03:00
JCM, Vol. 9, Pages 1940: Genetic Variation in CCL18 Gene Influences CCL18 Expression and Correlates with Survival in Idiopathic Pulmonary Fibrosis: Part A Journal of Clinical Medicine doi: 10.3390/jcm9061940 Authors: Ivo A. Wiertz Sofia A. Moll Benjamin Seeliger Nicole P. Barlo Joanne J. van der Vis Nicoline M. Korthagen Ger T. Rijkers Henk J.T. Ruven Jan C. Grutters Antje Prasse Coline H.M. van Moorsel Idiopathic pulmonary fibrosis (IPF) is a progressive...
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JCM, Vol. 9, Pages 1939: Independent Predictive Ability of Procalcitonin of Acute Kidney Injury among Critically Ill Patients Journal of Clinical Medicine doi: 10.3390/jcm9061939 Authors: Ya-Ting Huang Min-Yu Lai Wei-Chih Kan Chih-Chung Shiao It is unclear whether serum procalcitonin (PCT) levels rise in patients with acute kidney injury (AKI), and it is also unclear whether the elevation of PCT levels in this setting is independent of the existence of infection and impaired...
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JCM, Vol. 9, Pages 1938: Benzodiazepines Reduce Relapse and Recurrence Rates in Patients with Psychotic Depression Journal of Clinical Medicine doi: 10.3390/jcm9061938 Authors: Hiroki Shiwaku Masako Fujita Hidehiko Takahashi The long-term use of benzodiazepines is not recommended for the treatment of major depressive disorder (MDD) due to the risk of adverse effects, including dependence, falls, dementia, mortality and the lack of evidence of effectiveness for symptoms other than...
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JCM, Vol. 9, Pages 1937: Benefits of High-Flow Nasal Cannula Therapy for Acute Pulmonary Edema in Patients with Heart Failure in the Emergency Department: A Prospective Multi-Center Randomized Controlled Trial Journal of Clinical Medicine doi: 10.3390/jcm9061937 Authors: Dong Ryul Ko Jinho Beom Hye Sun Lee Je Sung You Hyun Soo Chung Sung Phil Chung Heart failure patients with pulmonary edema presenting to the emergency department (ED) require an effective approach to deliver...
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JCM, Vol. 9, Pages 1936: Impulsivity, Emotional Dysregulation and Executive Function Deficits Could Be Associated with Alcohol and Drug Abuse in Eating Disorders Journal of Clinical Medicine doi: 10.3390/jcm9061936 Authors: María Lozano-Madrid Danielle Clark Bryan Roser Granero Isabel Sánchez Nadine Riesco Núria Mallorquí-Bagué Susana Jiménez-Murcia Janet Treasure Fernando Fernández-Aranda Background: Empirical data suggests a high comorbid occurrence of eating...
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JCM, Vol. 9, Pages 1935: Bioinformatics Approach for Identifying Novel Biomarkers and Their Signaling Pathways Involved in Interstitial Cystitis/Bladder Pain Syndrome with Hunner Lesion Journal of Clinical Medicine doi: 10.3390/jcm9061935 Authors: Subbroto Kumar Saha Tak-Il Jeon Soo Bin Jang Se Jong Kim Kyung Min Lim Yu Jin Choi Hyeong Gon Kim Aram Kim Ssang-Goo Cho The complexity of interstitial cystitis/bladder pain syndrome (IC/BPS) has led to considerable...
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JCM, Vol. 9, Pages 1934: Multimodal Imaging in the Management of Choroidal Neovascularization Secondary to Central Serous Chorioretinopathy Journal of Clinical Medicine doi: 10.3390/jcm9061934 Authors: Ahmed M. Hagag Shruti Chandra Hagar Khalid Ali Lamin Pearse A. Keane Andrew J. Lotery Sobha Sivaprasad The diagnosis and treatment of choroidal neovascularization (CNV) in eyes with chronic central serous chorioretinopathy (CSCR) can be challenging. The purpose of this...
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JCM, Vol. 9, Pages 1933: Survival Benefits Based on the Number of Lymph Nodes Removed during Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: Systematic Review and Meta-Analysis Journal of Clinical Medicine doi: 10.3390/jcm9061933 Authors: Min Soo Choo Sangjun Yoo Hyeong Dong Yuk Chang Wook Jeong Min Chul Cho Cheol Kwak Hyeon Jeong Hyeon Hoe Kim Ja Hyeon Ku The role of lymph node dissection (LND) is still controversial for upper tract urothelial...
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JCM, Vol. 9, Pages 1932: Dynamic Hyperglycemic Patterns Predict Adverse Outcomes in Patients with Acute Ischemic Stroke Undergoing Mechanical Thrombectomy Journal of Clinical Medicine doi: 10.3390/jcm9061932 Authors: Giovanni Merlino Carmelo Smeralda Massimo Sponza Gian Luigi Gigli Simone Lorenzut Alessandro Marini Andrea Surcinelli Sara Pez Alessandro Vit Vladimir Gavrilovic Mariarosaria Valente Background: Admission hyperglycemia impairs outcome in acute...
Sat Jun 20, 2020 03:00
JCM, Vol. 9, Pages 1931: Influence of Sociodemographic, Premorbid, and Injury-Related Factors on Post-Concussion Symptoms after Traumatic Brain Injury Journal of Clinical Medicine doi: 10.3390/jcm9061931 Authors: Marina Zeldovich Yi-Jhen Wu Anastasia Gorbunova Ana Mikolic Suzanne Polinder Anne Marie Plass Amra Covic Thomas Asendorf Nada Andelic Daphne C. Voormolen Nicole von von Steinbüchel Background: Post-concussion symptoms (PCS) are often reported as...
Fri Jun 19, 2020 03:00
JCM, Vol. 9, Pages 1929: The Effects of MELD-Based Liver Allocation on Patient Survival and Waiting List Mortality in a Country with a Low Donation Rate Journal of Clinical Medicine doi: 10.3390/jcm9061929 Authors: Paul V. Ritschl Leke Wiering Tomasz Dziodzio Maximilian Jara Jochen Kruppa Uwe Schoeneberg Nathanael Raschzok Frederike Butz Brigitta Globke Philippa Seika Max Maurer Matthias Biebl Wenzel Schöning Moritz Schmelzle Igor M. Sauer Frank...
Fri Jun 19, 2020 03:00
JCM, Vol. 9, Pages 1930: Genotypic and Phenotypic Resistance to Clarithromycin in Helicobacter pylori Strains Journal of Clinical Medicine doi: 10.3390/jcm9061930 Authors: Eun Jeong Gong Ji Yong Ahn Jung Mogg Kim Sun Mi Lee Hee Kyong Na Jeong Hoon Lee Kee Wook Jung Kee Don Choi Do Hoon Kim Ho June Song Gin Hyug Lee So Won Kim Hwoon-Yong Jung Background: The increasing prevalence of antimicrobial resistance, together with the lack of novel treatment...
Fri Jun 19, 2020 03:00
JCM, Vol. 9, Pages 1925: The Impact of Marijuana on the Cardiovascular System: A Review of the Most Common Cardiovascular Events Associated with Marijuana Use Journal of Clinical Medicine doi: 10.3390/jcm9061925 Authors: Zara Latif Nadish Garg With the expanded legalization of marijuana, its medical and recreational use have sharply increased over the past decade. A wide array of new forms of cannabis is available on the market today, and the potencies are ten times those of forms...
Fri Jun 19, 2020 03:00
JCM, Vol. 9, Pages 1927: Approach to Pulmonary Arteriovenous Malformations: A Comprehensive Update Journal of Clinical Medicine doi: 10.3390/jcm9061927 Authors: Shamaita Majumdar Justin P. McWilliams Pulmonary arteriovenous malformations (PAVMs) are abnormal direct vascular communications between pulmonary arteries and veins which create high-flow right-to-left shunts. They are most frequently congenital, usually in the setting of hereditary hemorrhagic telangiectasia (HHT). PAVMs...
Fri Jun 19, 2020 03:00
JCM, Vol. 9, Pages 1926: Number of Regularly Prescribed Drugs and Intrapatient Tacrolimus Trough Levels Variability in Stable Kidney Transplant Recipients Journal of Clinical Medicine doi: 10.3390/jcm9061926 Authors: Piotr Giza Rafał Ficek Tomasz Dwulit Jerzy Chudek Iwona Woźniak Andrzej Więcek Aureliusz Kolonko High intra-patient variability (IPV) of tacrolimus levels is associated with poor long-term outcome after transplantation. We aimed to evaluate whether the...
Fri Jun 19, 2020 03:00
JCM, Vol. 9, Pages 1924: Prospective Association of Air-Purifier Usage during Pregnancy with Infant Neurodevelopment: A Nationwide Longitudinal Study—Japan Environment and Children’s Study (JECS) Journal of Clinical Medicine doi: 10.3390/jcm9061924 Authors: Kenta Matsumura Kei Hamazaki Akiko Tsuchida Hidekuni Inadera The Japan Environment and Children’s Study (JECS) Group Fetal exposure to particulate matter (PM) is associated with infant developmental delay likely via neuroinflammation...
Fri Jun 19, 2020 03:00
JCM, Vol. 9, Pages 1928: Angiopoietins, Vascular Endothelial Growth Factors and Secretory Phospholipase A2 in Ischemic and Non-Ischemic Heart Failure Journal of Clinical Medicine doi: 10.3390/jcm9061928 Authors: Gilda Varricchi Stefania Loffredo Leonardo Bencivenga Anne Lise Ferrara Giuseppina Gambino Nicola Ferrara Amato de Paulis Gianni Marone Giuseppe Rengo Heart failure (HF) is a growing public health burden, with high prevalence and mortality rates. In contrast...
Fri Jun 19, 2020 03:00
JCM, Vol. 9, Pages 1923: The Effect of Cellular Coenzyme Q10 Deficiency on Lysosomal Acidification Journal of Clinical Medicine doi: 10.3390/jcm9061923 Authors: Robert A. Heaton Simon Heales Khalid Rahman Darren W. Sexton Iain Hargreaves Coenzyme Q10 (CoQ10) deficiency currently represents the only treatable mitochondrial disorder, however, little is known about how it may affect other organelles. The lysosome has been found to have a large concentration of CoQ10 localised...
Fri Jun 19, 2020 03:00
JCM, Vol. 9, Pages 1921: Ursodeoxycholic Acid Halts Pathological Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy Journal of Clinical Medicine doi: 10.3390/jcm9061921 Authors: Menaka C. Thounaojam Ravirajsinh N. Jadeja Shubhra Rajpurohit Diana R. Gutsaeva Brian K. Stansfield Pamela M. Martin Manuela Bartoli Retinopathy of prematurity (ROP) is the leading cause of blindness in infants. We have investigated the efficacy of the secondary bile acid ursodeoxycholic...
Fri Jun 19, 2020 03:00
JCM, Vol. 9, Pages 1922: Adherence to Anti-Viral Treatment for Chronic Hepatitis B Journal of Clinical Medicine doi: 10.3390/jcm9061922 Authors: Naim Abu-Freha Muhammad Abu Tailakh Alexander Fich Nasreen Abu Bader Yonat Shemer-Avni Farhan Alsana Nava Gasper Heba Abu-Kaf Ohad Etzion Adherence to treatment of chronic Hepatitis B Virus (HBV) is an important issue and can affect the complication rate. Nucleos(t)ide analogue as oral treatments are used for patients...
Fri Jun 19, 2020 03:00
JCM, Vol. 9, Pages 1920: Evaluation of Physiological Parameters of Intestinal Sulfate-Reducing Bacteria Isolated from Patients Suffering from IBD and Healthy People Journal of Clinical Medicine doi: 10.3390/jcm9061920 Authors: Ivan Kushkevych Jorge Castro Sangrador Dani Dordević Monika Rozehnalová Martin Černý Roman Fafula Monika Vítězová Simon K.-M. R. Rittmann Background: Inflammatory bowel diseases (IBDs) are multifactorial illnesses of the intestine, to which...
Fri Jun 19, 2020 03:00
JCM, Vol. 9, Pages 1919: Immunoadsorption for Treatment of Patients with Suspected Alzheimer Dementia and Agonistic Autoantibodies against Alpha1a-Adrenoceptor—Rationale and Design of the IMAD Pilot Study Journal of Clinical Medicine doi: 10.3390/jcm9061919 Authors: Sylvia Stracke Sandra Lange Sarah Bornmann Holger Kock Lara Schulze Johanna Klinger-König Susanne Böhm Antje Vogelgesang Felix von Podewils Agnes Föel Stefan Gross Katrin Wenzel Gerd Wallukat...
Fri Jun 19, 2020 03:00
JCM, Vol. 9, Pages 1918: The Role of MET Inhibitor Therapies in the Treatment of Advanced Non-Small Cell Lung Cancer Journal of Clinical Medicine doi: 10.3390/jcm9061918 Authors: Ramon Andrade De Mello Nathália Moisés Neves Giovanna Araújo Amaral Estela Gudin Lippo Pedro Castelo-Branco Daniel Humberto Pozza Carla Chizuru Tajima Georgios Antoniou Introduction: Non-small cell lung cancer (NSCLC) is the second most common cancer globally. The mesenchymal-epithelial...
Fri Jun 19, 2020 03:00
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