IJMS, Vol. 21, Pages 4404: Platelet-Released Growth Factors and Platelet-Rich Fibrin Induce Expression of Factors Involved in Extracellular Matrix Organization in Human Keratinocytes 22.39 International Journal of Molecular Sciences doi: 10.3390/ijms21124404 Authors: Andreas Bayer Bernard Wijaya Lena Möbus Franziska Rademacher Meno Rodewald Mersedeh Tohidnezhad Thomas Pufe Daniel Drücke Regine Gläser Jürgen Harder Platelet-released growth factor (PRGF) is a...
Sat Jun 20, 2020 03:00
IJMS, Vol. 21, Pages 4405: Multifaceted Roles of Mitochondrial Components and Metabolites in Metabolic Diseases and Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21124405 Authors: Jean Nakhle Anne-Marie Rodriguez Marie-Luce Vignais Mitochondria are essential cellular components that ensure physiological metabolic functions. They provide energy in the form of adenosine triphosphate (ATP) through the electron transport chain (ETC). They also constitute a metabolic...
Sat Jun 20, 2020 03:00
IJMS, Vol. 21, Pages 4406: Downregulation of PPARα during Experimental Left Ventricular Hypertrophy Is Critically Dependent on Nox2 NADPH Oxidase Signalling International Journal of Molecular Sciences doi: 10.3390/ijms21124406 Authors: Harvey Robinson Edgar McMullan O’Neill Alderdice Amirkhah Dunne McDermott Grieve Pressure overload-induced left ventricular hypertrophy (LVH) is initially adaptive but ultimately promotes systolic dysfunction and chronic...
Sat Jun 20, 2020 03:00
IJMS, Vol. 21, Pages 4403: Investigating the Role of PPARβ/δ in Retinal Vascular Remodeling Using Pparβ/δ-Deficient Mice International Journal of Molecular Sciences doi: 10.3390/ijms21124403 Authors: Sze Yuan Ho Yuet Ping Kwan Beiying Qiu Alison Tan Hannah Louise Murray Veluchamy Amutha Barathi Nguan Soon Tan Chui Ming Gemmy Cheung Tien Yin Wong Walter Wahli Xiaomeng Wang Peroxisome proliferator-activated receptor (PPAR)β/δ is a member...
Sat Jun 20, 2020 03:00
IJMS, Vol. 21, Pages 4402: General and Target-Specific DExD/H RNA Helicases in Eukaryotic Translation Initiation International Journal of Molecular Sciences doi: 10.3390/ijms21124402 Authors: Leo Shen Jerry Pelletier DExD (DDX)- and DExH (DHX)-box RNA helicases, named after their Asp-Glu-x-Asp/His motifs, are integral to almost all RNA metabolic processes in eukaryotic cells. They play myriad roles in processes ranging from transcription and mRNA-protein complex remodeling, to RNA...
Sat Jun 20, 2020 03:00
IJMS, Vol. 21, Pages 4401: CG Demethylation Leads to Sequence Mutations in an Anther Culture of Barley Due to the Presence of Cu, Ag Ions in the Medium and Culture Time International Journal of Molecular Sciences doi: 10.3390/ijms21124401 Authors: Piotr T. Bednarek Renata Orłowska During plant tissue cultures the changes affecting regenerants have a broad range of genetic and epigenetic implications. These changes can be seen at the DNA methylation and sequence variation levels. In...
Sat Jun 20, 2020 03:00
IJMS, Vol. 21, Pages 4400: Semisynthetic Modification of Tau Protein with Di-Ubiquitin Chains for Aggregation Studies International Journal of Molecular Sciences doi: 10.3390/ijms21124400 Authors: Francesca Munari Carlo Giorgio Barracchia Francesca Parolini Roberto Tira Luigi Bubacco Michael Assfalg Mariapina D’Onofrio Ubiquitin, a protein modifier that regulates diverse essential cellular processes, is also a component of the protein inclusions characteristic of many...
Sat Jun 20, 2020 03:00
IJMS, Vol. 21, Pages 4397: Effect of SOX2 Repression on Corneal Endothelial Cells International Journal of Molecular Sciences doi: 10.3390/ijms21124397 Authors: Jin Sun Hwang Ho Chul Yi Young Joo Shin Purpose: Human corneal endothelial cells (hCECs) pump out water from the stroma and maintain the clarity of the cornea. The sex-determining region Y-box 2 (SOX2) participates in differentiation during the development of the anterior segment of the eye and is found in the periphery...
Sat Jun 20, 2020 03:00
IJMS, Vol. 21, Pages 4399: Characterization and Evaluation of Ternary Complexes of Ascorbic Acid with γ-Cyclodextrin and Poly(vinyl Alcohol) International Journal of Molecular Sciences doi: 10.3390/ijms21124399 Authors: Phennapha Saokham Kanokporn Burapapadh Pitsiree Praphanwittaya Thorsteinn Loftsson Ascorbic acid (AA) is a general antioxidant used in aqueous pharmaceutical formulations. However, in aqueous solutions, AA is unstable and easily oxidized when exposed to air,...
Sat Jun 20, 2020 03:00
IJMS, Vol. 21, Pages 4398: Percutaneous Ablation-Induced Immunomodulation in Hepatocellular Carcinoma International Journal of Molecular Sciences doi: 10.3390/ijms21124398 Authors: Lucile Dumolard Julien Ghelfi Gael Roth Thomas Decaens Zuzana Macek Jilkova Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related deaths worldwide and its incidence is rising. Percutaneous locoregional therapies, such as radiofrequency ablation and microwave ablation,...
Sat Jun 20, 2020 03:00
IJMS, Vol. 21, Pages 4396: Optimized qRT-PCR Approach for the Detection of Intra- and Extra-Cellular SARS-CoV-2 RNAs International Journal of Molecular Sciences doi: 10.3390/ijms21124396 Authors: Tuna Toptan Sebastian Hoehl Sandra Westhaus Denisa Bojkova Annemarie Berger Björn Rotter Klaus Hoffmeier Jindrich Cinatl Sandra Ciesek Marek Widera The novel coronavirus SARS-CoV-2 is the causative agent of the acute respiratory disease COVID-19, which has become a...
Sat Jun 20, 2020 03:00
IJMS, Vol. 21, Pages 4395: Silver Nano/Microparticles: Modification and Applications 2.0 International Journal of Molecular Sciences doi: 10.3390/ijms21124395 Authors: Xuan-Hung Pham Jaehi Kim Bong-Hyun Jun Currently, nano/microparticles are widely used in various fields [...]
Sat Jun 20, 2020 03:00
IJMS, Vol. 21, Pages 4394: Suppression of Nonsense Mutations by New Emerging Technologies International Journal of Molecular Sciences doi: 10.3390/ijms21124394 Authors: Pedro Morais Hironori Adachi Yi-Tao Yu Nonsense mutations often result from single nucleotide substitutions that change a sense codon (coding for an amino acid) to a nonsense or premature termination codon (PTC) within the coding region of a gene. The impact of nonsense mutations is two-fold: (1) the PTC-containing...
Sat Jun 20, 2020 03:00
IJMS, Vol. 21, Pages 4393: Pathophysiology of Peripheral Arterial Disease (PAD): A Review on Oxidative Disorders International Journal of Molecular Sciences doi: 10.3390/ijms21124393 Authors: Salvatore Santo Signorelli Elisa Marino Salvatore Scuto Domenico Di Raimondo Peripheral arterial disease (PAD) is an atherosclerotic disease that affects a wide range of the world’s population, reaching up to 200 million individuals worldwide. PAD particularly affects elderly...
Sat Jun 20, 2020 03:00
IJMS, Vol. 21, Pages 4391: Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS): Pathophysiology and Clinical Implications International Journal of Molecular Sciences doi: 10.3390/ijms21124391 Authors: Ana Maria Cabal-Herrera Nattaporn Tassanakijpanich Maria Jimena Salcedo-Arellano Randi J. Hagerman The fragile X-associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder seen in older premutation (55–200 CGG repeats) carriers of FMR1. The premutation...
Sat Jun 20, 2020 03:00
IJMS, Vol. 21, Pages 4392: Drug Sequestration in Lysosomes as One of the Mechanisms of Chemoresistance of Cancer Cells and the Possibilities of Its Inhibition International Journal of Molecular Sciences doi: 10.3390/ijms21124392 Authors: Jan Hraběta Marie Belhajová Hana Šubrtová Miguel Angel Merlos Rodrigo Zbyněk Heger Tomáš Eckschlager Resistance to chemotherapeutics and targeted drugs is one of the main problems in successful cancer therapy. Various mechanisms have been...
Sat Jun 20, 2020 03:00
IJMS, Vol. 21, Pages 4389: Therapeutic Functions of Stem Cells from Oral Cavity: An Update International Journal of Molecular Sciences doi: 10.3390/ijms21124389 Authors: Yang Shin Seo Kim Adult stem cells have been developed as therapeutics for tissue regeneration and immune regulation due to their self-renewing, differentiating, and paracrine functions. Recently, a variety of adult stem cells from the oral cavity have been discovered, and these dental stem cells mostly...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4388: ESR Method in Monitoring of Nanoparticle Endocytosis in Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21124388 Authors: Ryszard Krzyminiewski Bernadeta Dobosz Bart Krist Grzegorz Schroeder Joanna Kurczewska Hans A.R. Bluyssen Magnetic nanoparticles are extensively studied for their use in diagnostics and medical therapy. The behavior of nanoparticles after adding them to cell culture is an essential factor (i.e., whether...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4387: The Influence of a Terminal Chlorine Substituent on the Kinetics and the Mechanism of the Solvolyses of n-Alkyl Chloroformates in Hydroxylic Solvents International Journal of Molecular Sciences doi: 10.3390/ijms21124387 Authors: Malcolm J. D’Souza Jeremy Wirick Osama Mahmoud Dennis N. Kevill Jin Burm Kyong A previous study of the effect of a 2-chloro substituent on the rates and the mechanisms of the solvolysis of ethyl chloroformate is extended...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4386: Proteome Analysis Reveals Syndecan 1 Regulates Porcine Sapelovirus Replication International Journal of Molecular Sciences doi: 10.3390/ijms21124386 Authors: Tingting Zhao Li Cui Xiangqian Yu Zhonghai Zhang Qi Chen Xiuguo Hua Porcine sapelovirus A (PSV) is a single stranded, positive-sense, non-enveloped RNA virus that causes enteritis, pneumonia, polioencephalomyelitis, and reproductive disorders in pigs. Research on PSV infection and interaction...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4384: Differentiation and Establishment of Dental Epithelial-Like Stem Cells Derived from Human ESCs and iPSCs International Journal of Molecular Sciences doi: 10.3390/ijms21124384 Authors: Gee-Hye Kim Jihye Yang Dae-Hyun Jeon Ji-Hye Kim Geun Young Chae Mi Jang Gene Lee Tooth development and regeneration occur through reciprocal interactions between epithelial and ectodermal mesenchymal stem cells. However, the current studies on tooth development...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4385: Validation of Enhancing Effects of Curcumin on Radiotherapy with F98/FGT Glioblastoma-Bearing Rat Model International Journal of Molecular Sciences doi: 10.3390/ijms21124385 Authors: Wei-Hsun Wang Chao-Yu Shen Yi-Chun Chien Wen-Shin Chang Chia-Wen Tsai Yi-Hsien Lin Jeng-Jong Hwang Glioblastoma, the most common and aggressive brain tumor with low survival rate, is difficult to be cured by neurosurgery or radiotherapy. Mounting evidence has...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4390: Antibiotics Act with vB_AbaP_AGC01 Phage against Acinetobacter baumannii in Human Heat-Inactivated Plasma Blood and Galleria mellonella Models International Journal of Molecular Sciences doi: 10.3390/ijms21124390 Authors: Bartłomiej Grygorcewicz Marta Roszak Piotr Golec Daria Śleboda-Taront Natalia Łubowska Martyna Górska Joanna Jursa-Kulesza Rafał Rakoczy Bartosz Wojciuk Barbara Dołęgowska Increasing multidrug resistance has led...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4383: Kallikrein-Related Peptidase 14 Activates Zymogens of Membrane Type Matrix Metalloproteinases (MT-MMPs)—A CleavEx Based Analysis International Journal of Molecular Sciences doi: 10.3390/ijms21124383 Authors: Katherine Falkowski Ewa Bielecka Ida B. Thøgersen Oliwia Bocheńska Karolina Płaza Magdalena Kalińska Laura Sąsiadek Małgorzata Magoch Aleksandra Pęcak Magdalena Wiśniewska Natalia Gruba Magdalena Wysocka Anna Wojtysiak Magdalena...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4382: Molecular and Functional Phenotypes of Human Bone Marrow-Derived Mesenchymal Stromal Cells Depend on Harvesting Techniques International Journal of Molecular Sciences doi: 10.3390/ijms21124382 Authors: Sebastian Walter Thomas Randau Cäcilia Hilgers El-Mustapha Haddouti Werner Masson Sascha Gravius Christof Burger Dieter Wirtz Frank Schildberg Mesenchymal stromal cells (MSC) harvested in different tissues from the same donor exhibit different...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4380: Benchmarking Data Sets from PubChem BioAssay Data: Current Scenario and Room for Improvement International Journal of Molecular Sciences doi: 10.3390/ijms21124380 Authors: Viet-Khoa Tran-Nguyen Didier Rognan Developing realistic data sets for evaluating virtual screening methods is a task that has been tackled by the cheminformatics community for many years. Numerous artificially constructed data collections were developed, such as DUD, DUD-E, or DEKOIS....
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4377: Anti-Cancer Effects of CKD-581, a Potent Histone Deacetylase Inhibitor against Diffuse Large B-Cell Lymphoma International Journal of Molecular Sciences doi: 10.3390/ijms21124377 Authors: Soo Jin Kim U Ji Kim Hae Yong Yoo Yong June Choi Keon Wook Kang Double-hit lymphoma (DHL) and double-expressor lymphoma (DEL) are aggressive forms of lymphoma that require better treatments to improve patient outcomes. CKD-581 is a new histone deacetylase (HDAC)...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4379: OsJAZ13 Negatively Regulates Jasmonate Signaling and Activates Hypersensitive Cell Death Response in Rice International Journal of Molecular Sciences doi: 10.3390/ijms21124379 Authors: Xiujing Feng Lei Zhang Xiaoli Wei Yun Zhou Yan Dai Zhen Zhu Jasmonate ZIM-domain (JAZ) proteins belong to the subgroup of TIFY family and act as key regulators of jasmonate (JA) responses in plants. To date, only a few JAZ proteins have been characterized in rice....
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4381: Preimplantation Genetic Testing: Where We are Today International Journal of Molecular Sciences doi: 10.3390/ijms21124381 Authors: Ermanno Greco Katarzyna Litwicka Maria Giulia Minasi Elisabetta Cursio Pier Francesco Greco Paolo Barillari Background: Preimplantation genetic testing (PGT) is widely used today in in-vitro fertilization (IVF) centers over the world for selecting euploid embryos for transfer and to improve clinical outcomes in terms...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4376: Metabolomics Analysis Reveals Tissue-Specific Metabolite Compositions in Leaf Blade and Traps of Carnivorous Nepenthes Plants International Journal of Molecular Sciences doi: 10.3390/ijms21124376 Authors: Alberto Dávila-Lara Carlos E. Rodríguez-López Sarah E. O'Connor Axel Mithöfer Nepenthes is a genus of carnivorous plants that evolved a pitfall trap, the pitcher, to catch and digest insect prey to obtain additional nutrients. Each pitcher is part...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4371: ApoE4 Astrocytes Secrete Basement Membranes Rich in Fibronectin and Poor in Laminin Compared to ApoE3 Astrocytes International Journal of Molecular Sciences doi: 10.3390/ijms21124371 Authors: Abby Keable Ronan O’Neill Matthew MacGregor Sharp Maureen Gatherer Ho Ming Yuen David Annandale Johnston Roy Oliver Weller Roxana Octavia Carare The accumulation of amyloid-β (Aβ) in the walls of capillaries and arteries as cerebral...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4378: Discovery of Isoplumbagin as a Novel NQO1 Substrate and Anti-Cancer Quinone International Journal of Molecular Sciences doi: 10.3390/ijms21124378 Authors: Yen-Chi Tsao Yu-Jung Chang Chun-Hsien Wang Linyi Chen Isoplumbagin (5-hydroxy-3-methyl-1,4-naphthoquinone), a naturally occurring quinone from Lawsonia inermis and Plumbago europaea, has been reported to have anti-inflammatory and antimicrobial activity. Inflammation has long been implicated in cancer...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4365: Biological Functions and Therapeutic Potential of Lipocalin 2 in Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21124365 Authors: Ginette S. Santiago-Sánchez Valentina Pita-Grisanti Blanca Quiñones-Díaz Kristyn Gumpper Zobeida Cruz-Monserrate Pablo E. Vivas-Mejía Lipocalin-2 (LCN2) is a secreted glycoprotein linked to several physiological roles, including transporting hydrophobic ligands across cell membranes, modulating...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4374: SSADH Variants Increase Susceptibility of U87 Cells to Mitochondrial Pro-Oxidant Insult International Journal of Molecular Sciences doi: 10.3390/ijms21124374 Authors: Giovanna Menduti Alessandra Vitaliti Concetta Rosa Capo Daniele Lettieri-Barbato Katia Aquilano Patrizia Malaspina Luisa Rossi Succinate semialdehyde dehydrogenase (SSADH) is a mitochondrial enzyme, encoded by ALDH5A1, mainly involved in γ-aminobutyric acid (GABA) catabolism...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4375: Prediction of the Secretome and the Surfaceome: A Strategy to Decipher the Crosstalk between Adipose Tissue and Muscle during Fetal Growth International Journal of Molecular Sciences doi: 10.3390/ijms21124375 Authors: Muriel Bonnet Nicolas Kaspric Kimberly Vonnahme Didier Viala Christophe Chambon Brigitte Picard Crosstalk between adipose and muscular tissues is hypothesized to regulate the number of muscular and adipose cells during fetal growth,...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4373: Phosphodiesterase SMPDL3B Gene Expression as Independent Outcome Prediction Marker in Localized Prostate Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21124373 Authors: Frank Waldbillig Katja Nitschke Abdallah Abdelhadi Jost von Hardenberg Philipp Nuhn Malin Nientiedt Cleo-Aron Weis Maurice Stephan Michel Philipp Erben Thomas Stefan Worst Current outcome prediction markers for localized prostate cancer (PCa)...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4370: MicroRNA and ROS Crosstalk in Cardiac and Pulmonary Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21124370 Authors: Montserrat Climent Giacomo Viggiani Ya-Wen Chen Gerald Coulis Alessandra Castaldi Reactive oxygen species (ROS) affect many cellular functions and the proper redox balance between ROS and antioxidants contributes substantially to the physiological welfare of the cell. During pathological conditions, an altered...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4372: S(+)-(2E)-N-(2-Hydroxypropyl)-3-Phenylprop-2-Enamide (KM-568): A Novel Cinnamamide Derivative with Anticonvulsant Activity in Animal Models of Seizures and Epilepsy International Journal of Molecular Sciences doi: 10.3390/ijms21124372 Authors: Agnieszka Gunia-Krzyżak Ewa Żesławska Karolina Słoczyńska Dorota Żelaszczyk Aleksandra Sowa Paulina Koczurkiewicz-Adamczyk Justyna Popiół Wojciech Nitek Elżbieta Pękala Henryk Marona Epilepsy...
Fri Jun 19, 2020 03:00
IJMS, Vol. 21, Pages 4369: ABCA1/ApoE/HDL Signaling Pathway Facilitates Myelination and Oligodendrogenesis after Stroke International Journal of Molecular Sciences doi: 10.3390/ijms21124369 Authors: Li Li Rongwen Li Alex Zacharek Fengjie Wang Julie Landschoot-Ward Michael Chopp Jieli Chen Xu Cui ATP-binding cassette transporter A1 (ABCA1) plays an important role in the regulation of apolipoprotein E (ApoE) and the biogenesis of high-density lipoprotein (HDL) cholesterol...
Fri Jun 19, 2020 03:00
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