JCM, Vol. 9, Pages 1917: COVID-19: The Potential Treatment of Pulmonary Fibrosis Associated with SARS-CoV-2 Infection Journal of Clinical Medicine doi: 10.3390/jcm9061917 Authors: Kacper Lechowicz Sylwester Drożdżal Filip Machaj Jakub Rosik Bartosz Szostak Małgorzata Zegan-Barańska Jowita Biernawska Wojciech Dabrowski Iwona Rotter Katarzyna Kotfis In December 2019, a novel coronavirus, SARS-CoV-2, appeared, causing a wide range of symptoms, mainly respiratory...
Fri Jun 19, 2020 03:00
JCM, Vol. 9, Pages 1916: Distinctive Pathophysiology Underlying Constipation in Parkinson’s Disease: Implications for Cognitive Inefficiency Journal of Clinical Medicine doi: 10.3390/jcm9061916 Authors: Rosalind M. Tucker Suzanne Ryan Bu’ Hussain Hayee Ingvar Bjarnason Aisha D. Augustin Chianna Umamahesan David Taylor Clive Weller Sylvia M Dobbs R John Dobbs André Charlett Depression is associated with constipation within and outside Parkinson’s...
Fri Jun 19, 2020 03:00
JFMK, Vol. 5, Pages 44: Alterations in Adiponectin, Leptin, Resistin, Testosterone, and Cortisol across Eleven Weeks of Training among Division One Collegiate Throwers: A Preliminary Study Journal of Functional Morphology and Kinesiology doi: 10.3390/jfmk5020044 Authors: W. Guy Hornsby G. Gregory Haff Dylan G. Suarez Michael W. Ramsey N. Travis Triplett Justin P. Hardee Margaret E. Stone Michael H. Stone Cytokine and hormone concentrations can be linked to the manipulation...
Fri Jun 19, 2020 03:00
J. Imaging, Vol. 6, Pages 52: Explainable Deep Learning Models in Medical Image Analysis Journal of Imaging doi: 10.3390/jimaging6060052 Authors: Amitojdeep Singh Sourya Sengupta Vasudevan Lakshminarayanan Deep learning methods have been very effective for a variety of medical diagnostic tasks and have even outperformed human experts on some of those. However, the black-box nature of the algorithms has restricted their clinical use. Recent explainability studies aim to show the...
Sat Jun 20, 2020 03:00
J. Imaging, Vol. 6, Pages 51: Classification Models for Skin Tumor Detection Using Texture Analysis in Medical Images Journal of Imaging doi: 10.3390/jimaging6060051 Authors: Marcos A. M. Almeida Iury A. X. Santos Medical images have made a great contribution to early diagnosis. In this study, a new strategy is presented for analyzing medical images of skin with melanoma and nevus to model, classify and identify lesions on the skin. Machine learning applied to the data generated by...
Fri Jun 19, 2020 03:00
JPM, Vol. 10, Pages 53: rs622342 in SLC22A1, CYP2C9*2 and CYP2C9*3 and Glycemic Response in Individuals with Type 2 Diabetes Mellitus Receiving Metformin/Sulfonylurea Combination Therapy: 6-Month Follow-Up Study Journal of Personalized Medicine doi: 10.3390/jpm10020053 Authors: Khaled Naja Ali Salami Said El Shamieh Rajaa Fakhoury Background and Objective: Since the treatment outcome with oral anti-diabetics differs between individuals, the objective of this study is to evaluate...
Sat Jun 20, 2020 03:00
JPM, Vol. 10, Pages 52: Correlation between F18-FDG PET/CT Imaging and BRAF V600E Genetic Mutation for the Early Assessment of Treatment Response in Papillary Thyroid Cancers Journal of Personalized Medicine doi: 10.3390/jpm10020052 Authors: Andra Piciu Maria-Iulia Larg Doina Piciu In thyroid neoplastic pathology, the BRAF V600E mutation is shown to be involved in the oncogenesis of papillary thyroid cancer and its subtypes. The purpose of this study is to evaluate the correlation...
Fri Jun 19, 2020 03:00
Life, Vol. 10, Pages 89: Mass Spectrometry: A Rosetta Stone to Learn How Fungi Interact and Talk Life doi: 10.3390/life10060089 Authors: Erika Calla-Quispe Hammerly Lino Fuentes-Rivera Pablo Ramírez Carlos Martel Alfredo J. Ibañez Fungi are a highly diverse group of heterotrophic organisms that play an important role in diverse ecological interactions, many of which are chemically mediated. Fungi have a very versatile metabolism, which allows them to synthesize a large number...
Sat Jun 20, 2020 03:00
Life, Vol. 10, Pages 88: Representational Difference Analysis of Transcripts Involved in Jervine Biosynthesis Life doi: 10.3390/life10060088 Authors: Magdalena Szeliga Joanna Ciura Mirosław Tyrka Veratrum-type steroidal alkaloids (VSA) are the major bioactive ingredients that strongly determine the pharmacological activities of Veratrum nigrum. Biosynthesis of VSA at the molecular and genetic levels is not well understood. Next-generation sequencing of representational difference...
Fri Jun 19, 2020 03:00
Medicina, Vol. 56, Pages 304: Cervical-Vaginal Mucin in Fertility Assessment: CA125 as a Predictor of the Fertile Phase of the Normal Menstrual Cycle Medicina doi: 10.3390/medicina56060304 Authors: Trindade Usala : To evaluate the cervical-vaginal mucin, CA125, as a measure of fertility and possible method for natural family planning (NFP). Cervical-vaginal fluid (CVF) swab samples have been previously used to measure CA125, ‘Qvaginal CA125 levels’, as a function...
Sat Jun 20, 2020 03:00
Medicina, Vol. 56, Pages 303: Right Ventricle Mechanics and Function during Stress in Patients with Asymptomatic Primary Moderate to Severe Mitral Regurgitation and Preserved Left Ventricular Ejection Fraction Medicina doi: 10.3390/medicina56060303 Authors: Rūta Žvirblytė Ieva Merkytė Eglė Tamulėnaitė Agnė Saniukaitė Vaida Mizarienė Eglė Ereminienė Jolanta Justina Vaškelytė Background and objectives. Mitral regurgitation (MR) is usually dynamic and increasing with exertion....
Sat Jun 20, 2020 03:00
Medicina, Vol. 56, Pages 302: Risk Factors and Management of Osteoporosis Post-Transplant Medicina doi: 10.3390/medicina56060302 Authors: Karthik Kovvuru Swetha Rani Kanduri Pradeep Vaitla Rachana Marathi Shiva Gosi Desiree F. Garcia Garcia Anton Franco H. Cabeza Cabeza Rivera Vishnu Garla Bone and mineral disorders are common after organ transplantation. Osteoporosis post transplantation is associated with increased morbidity and mortality. Pathogenesis of bone...
Fri Jun 19, 2020 03:00
Medicina, Vol. 56, Pages 301: Can the Computed Tomographic Aspect of Porto-Systemic Circulation in Cirrhotic Patients be Associated with the Presence of Variceal Hemorrhage? Medicina doi: 10.3390/medicina56060301 Authors: Cosmin Caraiani Bianca Petresc Anamaria Pop Magda Rotaru Lidia Ciobanu Horia Ștefănescu Background and objectives: Variceal bleeding is a serious complication caused by portal hypertension, frequently encountered among cirrhotic patients. The purpose...
Fri Jun 19, 2020 03:00
Membranes, Vol. 10, Pages 127: Assessment of the Performance of Electrodialysis in the Removal of the Most Potent Odor-Active Compounds of Herring Milt Hydrolysate: Focus on Ion-Exchange Membrane Fouling and Water Dissociation as Limiting Process Conditions Membranes doi: 10.3390/membranes10060127 Authors: Sarah Todeschini Véronique Perreault Charles Goulet Mélanie Bouchard Pascal Dubé Yvan Boutin Laurent Bazinet Herring milt hydrolysate (HMH), like many fish products,...
Sat Jun 20, 2020 03:00
Metabolites, Vol. 10, Pages 259: A Systematic Review of Metabolomic and Lipidomic Candidates for Biomarkers in Radiation Injury Metabolites doi: 10.3390/metabo10060259 Authors: Vicente Vujaskovic Jackson A large-scale nuclear event has the ability to inflict mass casualties requiring point-of-care and laboratory-based diagnostic and prognostic biomarkers to inform victim triage and appropriate medical intervention. Extensive progress has been made to develop post-exposure point-of-care...
Sat Jun 20, 2020 03:00
Metabolites, Vol. 10, Pages 258: Microbial Metabolite Urolithin B Inhibits Recombinant Human Monoamine Oxidase A Enzyme Metabolites doi: 10.3390/metabo10060258 Authors: Rajbir Singh Sandeep Chandrashekharappa Praveen Kumar Vemula Bodduluri Haribabu Venkatakrishna Rao Jala Urolithins are gut microbial metabolites derived from ellagitannins (ET) and ellagic acid (EA), and shown to exhibit anticancer, anti-inflammatory, anti-microbial, anti-glycative and anti-oxidant activities....
Fri Jun 19, 2020 03:00
Metabolites, Vol. 10, Pages 257: Tumor Tissue-Specific Biomarkers of Colorectal Cancer by Anatomic Location and Stage Metabolites doi: 10.3390/metabo10060257 Authors: Yuping Cai Nicholas J. W. Rattray Qian Zhang Varvara Mironova Alvaro Santos-Neto Engjel Muca Ana K. Rosen Vollmar Kuo-Shun Hsu Zahra Rattray Justin R. Cross Yawei Zhang Philip B. Paty Sajid A. Khan Caroline H. Johnson The progress in the discovery and validation of metabolite biomarkers...
Fri Jun 19, 2020 03:00
MPs, Vol. 3, Pages 44: Creating Custom Neural Circuits on Multiple Electrode Arrays Utilizing Optical Tweezers for Precise Nerve Cell Placement Methods and Protocols doi: 10.3390/mps3020044 Authors: Frank H. Kung Ellen Townes-Anderson Precise creation, maintenance, and monitoring of neuronal circuits would facilitate the investigation of subjects such as neuronal development or synaptic plasticity, or assist in the development of neuronal prosthetics. Here we present a method to precisely...
Sat Jun 20, 2020 03:00
Microorganisms, Vol. 8, Pages 933: Environmental Factors, More Than Spatial Distance, Explain Community Structure of Soil Ammonia-Oxidizers in Wetlands on the Qinghai–Tibetan Plateau Microorganisms doi: 10.3390/microorganisms8060933 Authors: Wen Zhou Xiaoliang Jiang Jian Ouyang Bei Lu Wenzhi Liu Guihua Liu In wetland ecosystems, ammonia oxidation highly depends on the activity of ammonia-oxidizing archaea (AOA) and ammonia-oxidizing bacteria (AOB), which are, therefore,...
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Microorganisms, Vol. 8, Pages 932: A Unique Isolation of a Lytic Bacteriophage Infected Bacillus anthracis Isolate from Pafuri, South Africa Microorganisms doi: 10.3390/microorganisms8060932 Authors: Hassim Lekota van Dyk Dekker van Heerden Bacillus anthracis is a soil-borne, Gram-positive endospore-forming bacterium and the causative agent of anthrax. It is enzootic in Pafuri, Kruger National Park in South Africa. The bacterium is amplified in a wild ungulate host,...
Sat Jun 20, 2020 03:00
Microorganisms, Vol. 8, Pages 931: Genetic Diversity of Pseudomonas syringae pv. actinidiae: Seasonal and Spatial Population Dynamics Microorganisms doi: 10.3390/microorganisms8060931 Authors: Daniela Figueira Eva Garcia Aitana Ares Igor Tiago António Veríssimo Joana Costa Pseudomonassyringae pv. actinidiae (Psa) is a gram-negative bacterium responsible for the bacterial canker in Actinidia chinensis var. deliciosa and A. chinensis var. chinensis, a quarantine organism...
Sat Jun 20, 2020 03:00
Microorganisms, Vol. 8, Pages 927: Frequency of Toxoplasma gondii and Risk Factors Associated with the Infection in Stray Dogs and Cats of Panama Microorganisms doi: 10.3390/microorganisms8060927 Authors: Lorena Fábrega Carlos M. Restrepo Alicia Torres Diorene Smith Patricia Chan Dimas Pérez Alberto Cumbrera Zuleima Caballero Caballero E. Stray animals such as dogs and cats have an important role in maintaining the transmission cycles and dissemination of Toxoplasma...
Fri Jun 19, 2020 03:00
Microorganisms, Vol. 8, Pages 929: Isolation and Characterization of a New Endophytic Actinobacterium Streptomyces californicus Strain ADR1 as a Promising Source of Anti-Bacterial, Anti-Biofilm and Antioxidant Metabolites Microorganisms doi: 10.3390/microorganisms8060929 Authors: Radha Singh Ashok K. Dubey In view of the fast depleting armamentarium of drugs against significant pathogens, like methicillin-resistant Staphylococcus aureus (MRSA) and others due to rapidly emerging drug-resistance,...
Fri Jun 19, 2020 03:00
Microorganisms, Vol. 8, Pages 928: Comparative Genomics of Beggiatoa leptomitoformis Strains D-401 and D-402T with Contrasting Physiology but Extremely High Level of Genomic Identity Microorganisms doi: 10.3390/microorganisms8060928 Authors: Tatyana S. Rudenko Sergey V. Tarlachkov Nikolay D. Shatskiy Margarita Yu. Grabovich Representatives of filamentous colorless sulfur-oxidizing bacteria often dominate in sulfide biotopes, preventing the diffusion of toxic sulfide into the...
Fri Jun 19, 2020 03:00
Microorganisms, Vol. 8, Pages 930: Removal Ability and Resistance to Cinnamic and Vanillic Acids by Fungi Microorganisms doi: 10.3390/microorganisms8060930 Authors: Barbara Speranza Francesca Cibelli Antonietta Baiano Antonia Carlucci Maria Luisa Raimondo Daniela Campaniello Ilaria Viggiani Antonio Bevilacqua Maria Rosaria Rosaria Corbo Twelve fungal strains were assayed to investigate their resistance to cinnamic and vanillic acids and their ability to remove...
Fri Jun 19, 2020 03:00
Microorganisms, Vol. 8, Pages 926: Isolation and Characterization of Two Bacteriophages and Their Preventive Effects against Pathogenic Vibrio coralliilyticus Causing Mortality of Pacific Oyster (Crassostrea gigas) Larvae Microorganisms doi: 10.3390/microorganisms8060926 Authors: Hyoun Joong Kim Sib Sankar Giri Sang Guen Kim Sang Wha Kim Jun Kwon Sung Bin Lee Se Chang Park Vibrio coralliilyticus is one of the major pathogens causing mass mortality in marine bivalve...
Fri Jun 19, 2020 03:00
Molecules, Vol. 25, Pages 2862: Antiparasitic Constituents of Beilschmiedia louisii and Beilschmiedia obscura and Some Semisynthetic Derivatives (Lauraceae) Molecules doi: 10.3390/molecules25122862 Authors: Christine C. Waleguele Brice M. Mba’ning Angelbert F. Awantu Jean J. K. Bankeu Yannick S. F. Fongang Augustin S. Ngouela Etienne Tsamo Norbert Sewald Bruno N. Lenta Rui W. M. Krause The MeOH/CH2Cl2 (1:1) extracts of the roots and leaves of Beilschmiedia...
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Molecules, Vol. 25, Pages 2861: Antibody-Drug Conjugates and Targeted Treatment Strategies for Hepatocellular Carcinoma: A Drug-Delivery Perspective Molecules doi: 10.3390/molecules25122861 Authors: David Dahlgren Hans Lennernäs Increased understanding of cancer biology, pharmacology and drug delivery has provided a new framework for drug discovery and product development that relies on the unique expression of specific macromolecules (i.e., antigens) on the surface of tumour cells....
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Molecules, Vol. 25, Pages 2857: The Similarities between Human Mitochondria and Bacteria in the Context of Structure, Genome, and Base Excision Repair System Molecules doi: 10.3390/molecules25122857 Authors: Karolina Boguszewska Michał Szewczuk Julia Kaźmierczak-Barańska Bolesław T. Karwowski Mitochondria emerged from bacterial ancestors during endosymbiosis and are crucial for cellular processes such as energy production and homeostasis, stress responses, cell survival, and...
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Molecules, Vol. 25, Pages 2859: Pomegranate Peel as Suitable Source of High-Added Value Bioactives: Tailored Functionalized Meat Products Molecules doi: 10.3390/molecules25122859 Authors: Patricia Gullón Gonzalo Astray Beatriz Gullón Igor Tomasevic José M. Lorenzo In the last few years, the consumer’s concern with the relationship between health and diet has led to the search of foods with functional properties beyond the nutritional. In this framework, the consumption...
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Molecules, Vol. 25, Pages 2858: Hydromethanolic Extracts from Adansonia digitata L. Edible Parts Positively Modulate Pathophysiological Mechanisms Related to the Metabolic Syndrome Molecules doi: 10.3390/molecules25122858 Authors: Stefania Cicolari Marco Dacrema Arold Jorel Tsetegho Sokeng Jianbo Xiao Achille Parfait Atchan Nwakiban Carmen Di Giovanni Cristina Santarcangelo Paolo Magni Maria Daglia Metabolic syndrome includes a cluster of risk factors for many...
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Molecules, Vol. 25, Pages 2860: Evaluation of the Anticancer Activities of Novel Transition Metal Complexes with Berenil and Nitroimidazole Molecules doi: 10.3390/molecules25122860 Authors: Robert Czarnomysy Dominika Radomska Anna Muszyńska Justyna Magdalena Hermanowicz Izabela Prokop Anna Bielawska Krzysztof Bielawski Novel transition metal complexes (Au, Pd, Pt) with berenil and 2-(1-methyl-5-nitroimidazol-2-yl)ethanol were obtained through two-step synthesis. The...
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Molecules, Vol. 25, Pages 2856: Treatment with a New Barbituric Acid Derivative Exerts Antiproliferative and Antimigratory Effects against Sorafenib Resistance in Hepatocellular Carcinoma Molecules doi: 10.3390/molecules25122856 Authors: Yi-Jen Liao Shih-Ming Hsu Chia-Ying Chien Yuan-Hsi Wang Ming-Hua Hsu Fat-Moon Suk Hepatocellular carcinoma (HCC) is a common cause of cancer death worldwide. Sorafenib, a multikinase inhibitor, is the first-line drug approved by the Food...
Sat Jun 20, 2020 03:00
Molecules, Vol. 25, Pages 2855: Unsymmetrically-Substituted 5,12-dihydrodibenzo[b,f][1,4]diazocine-6,11-dione Scaffold—A Useful Tool for Bioactive Molecules Design Molecules doi: 10.3390/molecules25122855 Authors: Bieszczad Garbicz Trzybiński Dudek Woźniak Grzesiuk Mieczkowski Unsymmetrically N-substituted and N,N’-disubstituted 5,12-dihydrodibenzo [b,f][1,4]diazocine-6,11-diones were synthesized in the new protocol. The desired modifications of the...
Sat Jun 20, 2020 03:00
Molecules, Vol. 25, Pages 2854: Flavonoids in Decorticated Sorghum Grains Exert Antioxidant, Antidiabetic and Antiobesity Activities Molecules doi: 10.3390/molecules25122854 Authors: Fred Kwame Ofosu Fazle Elahi Eric Banan-Mwine Daliri Su-Jung Yeon Hun Ju Ham Joong-Hark Kim Sang-Ik Han Deog-Hwan Oh Eight new genotypes of brown sorghum grain were decorticated and assessed for their antioxidant, antidiabetic and antiobesity activities in vitro. The DPPH and ABTS radical...
Sat Jun 20, 2020 03:00
Molecules, Vol. 25, Pages 2853: Epigallocatechin-3-Gallate (EGCG), an Active Compound of Green Tea Attenuates Acute Lung Injury Regulating Macrophage Polarization and Krüpple-Like-Factor 4 (KLF4) Expression Molecules doi: 10.3390/molecules25122853 Authors: Saleh A. Almatroodi Ahmad Almatroudi Mohammed A. Alsahli Mohammad A. Aljasir Mansoor Ali Syed Arshad Husain Rahmani Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are serious clinical complications...
Sat Jun 20, 2020 03:00
Molecules, Vol. 25, Pages 2852: Assessment of Raman Spectroscopy for Reducing Unnecessary Biopsies for Melanoma Screening Molecules doi: 10.3390/molecules25122852 Authors: Yao Zhang Austin J. Moy Xu Feng Hieu T. M. Nguyen Katherine R. Sebastian Jason S. Reichenberg Claus O. Wilke Mia K. Markey James W. Tunnell A key challenge in melanoma diagnosis is the large number of unnecessary biopsies on benign nevi, which requires significant amounts of time and money....
Sat Jun 20, 2020 03:00
Molecules, Vol. 25, Pages 2851: Identification of Selected Antibiotic Resistance Genes in Two Different Wastewater Treatment Plant Systems in Poland: A Preliminary Study Molecules doi: 10.3390/molecules25122851 Authors: Magdalena Pazda Magda Rybicka Stefan Stolte Krzysztof Piotr Bielawski Piotr Stepnowski Jolanta Kumirska Daniel Wolecki Ewa Mulkiewicz Antibiotic resistance is a growing problem worldwide. The emergence and rapid spread of antibiotic resistance determinants...
Sat Jun 20, 2020 03:00
Molecules, Vol. 25, Pages 2850: Antimicrobial Peptides as Anticancer Agents: Functional Properties and Biological Activities Molecules doi: 10.3390/molecules25122850 Authors: Anna Lucia Tornesello Antonella Borrelli Luigi Buonaguro Franco Maria Buonaguro Maria Lina Tornesello Antimicrobial peptides (AMPs), or host defense peptides, are small cationic or amphipathic molecules produced by prokaryotic and eukaryotic organisms that play a key role in the innate immune defense...
Fri Jun 19, 2020 03:00
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