Antibiotics, Vol. 9, Pages 116: Is Caretta Caretta a Carrier of Antibiotic Resistance in the Mediterranean Sea? Antibiotics doi: 10.3390/antibiotics9030116 Authors: Alduina Gambino Presentato Gentile Sucato Savoca Filippello Visconti Caracappa Vicari Arculeo Sea turtles can be considered a sentinel species for monitoring the health of marine ecosystems, acting, at the same time, as a carrier of microorganisms. Indeed, sea turtles can acquire the...
Tue Mar 10, 2020 02:00
Antioxidants, Vol. 9, Pages 226: NoxO1 Knockout Promotes Longevity in Mice Antioxidants doi: 10.3390/antiox9030226 Authors: Tim Schader Christina Reschke Manuela Spaeth Susanne Wienstroer Szeka Wong Katrin Schröder According to the free radical theory of aging, reactive oxygen species (ROS) have been proposed to be a major cause of aging for a long time. Meanwhile, it became clear that ROS have diverse functions in a healthy organism. They act as second messengers, and...
Tue Mar 10, 2020 02:00
Antioxidants, Vol. 9, Pages 227: Extracellular Redox Regulation of α7β Integrin-Mediated Cell Migration Is Signaled via a Dominant Thiol-Switch Antioxidants doi: 10.3390/antiox9030227 Authors: Lukas Bergerhausen Julius Grosche Juliane Meißner Christina Hecker Michele F. Caliandro Christoph Westerhausen Andrej Kamenac Maryam Rezaei Matthias Mörgelin Gereon Poschmann Dietmar Vestweber Eva-Maria Hanschmann Johannes A. Eble While adhering to extracellular...
Tue Mar 10, 2020 02:00
Antioxidants, Vol. 9, Pages 228: Dietary Compound Isoliquiritigenin, an Antioxidant from Licorice, Suppresses Triple-Negative Breast Tumor Growth via Apoptotic Death Program Activation in Cell and Xenograft Animal Models Antioxidants doi: 10.3390/antiox9030228 Authors: Po-Han Lin Yi-Fen Chiang Tzong-Ming Shieh Hsin-Yuan Chen Chun-Kuang Shih Tong-Hong Wang Kai-Lee Wang Tsui-Chin Huang Yong-Han Hong Sing-Chung Li Shih-Min Hsia Patients with triple-negative...
Tue Mar 10, 2020 02:00
Antioxidants, Vol. 9, Pages 225: An Update on Thiol Signaling: S-Nitrosothiols, Hydrogen Sulfide and a Putative Role for Thionitrous Acid Antioxidants doi: 10.3390/antiox9030225 Authors: Nadzeya Marozkina Benjamin Gaston Long considered vital to antioxidant defenses, thiol chemistry has more recently been recognized to be of fundamental importance to cell signaling. S-nitrosothiols—such as S-nitrosoglutathione (GSNO)—and hydrogen sulfide (H2S) are physiologic signaling...
Tue Mar 10, 2020 02:00
Arts, Vol. 9, Pages 36: Käthe Kollwitz: Memorialization as Anti-Militarist Weapon Arts doi: 10.3390/arts9010036 Authors: Ann Murray This essay explores Käthe Kollwitz’s antiwar graphic work in the context of the German, and later, international No More War movement from 1920 to 1925, where it played an important role in antimilitarist campaigns, exhibitions, and publications, both in Germany and internationally. Looking at Kollwitz’s production closely, we discover a deeply pragmatic...
Tue Mar 10, 2020 02:00
Arts, Vol. 9, Pages 37: The Artist as Soldier: Howard Cook’s Self-Portrait in a Foxhole Arts doi: 10.3390/arts9010037 Authors: Woodbury In the summer of 1943, Taos artist Howard Cook (1901–1980) traveled to the South Pacific to serve as a correspondent in the U.S. Army’s short-lived War Art Unit. During his assignment, Cook produced hundreds of sketches documenting the daily lives of Allied soldiers working there; yet, one group stands out for its subject matter:...
Tue Mar 10, 2020 02:00
Atmosphere, Vol. 11, Pages 274: Directional Extreme Value Models in Wave Energy Applications Atmosphere doi: 10.3390/atmos11030274 Authors: Karathanasi Soukissian Belibassakis A wide range of wave energy applications relies on the accurate estimation of extreme wave conditions, while some of them are frequently affected by directionality. For example, attenuators and terminators are the most common types of wave energy converters whose performance is highly influenced by their...
Tue Mar 10, 2020 02:00
Atmosphere, Vol. 11, Pages 275: Dust Deposition on the Gulf of California Caused by Santa Ana Winds Atmosphere doi: 10.3390/atmos11030275 Authors: Álvarez Carbajal Pineda-Martínez Tuxpan Flores Numerical simulations revealed a profound interaction between the severe dust storm of 2007 caused by Santa Ana winds and the Gulf of California. The weather research and forecasting model coupled with a chemistry module (WRF-CHEM) and the hybrid single-particle Lagrangian integrated...
Tue Mar 10, 2020 02:00
Atmosphere, Vol. 11, Pages 273: Characteristics, Secondary Formation and Regional Contributions of PM2.5 Pollution in Jinan during Winter Atmosphere doi: 10.3390/atmos11030273 Authors: Yingying Liu Jing Wang Xueyan Zhao Jian Wang Xinhua Wang Lujian Hou Wen Yang Bin Han Zhipeng Bai Air pollution is an increasing threat to human health in China. In this study, daily PM10 and PM2.5 samples were collected simultaneously at the Jinan Environmental Monitoring Station...
Tue Mar 10, 2020 02:00
Behavioral Sciences, Vol. 10, Pages 67: Self-Regulation and Psychological Well-Being in Early Adolescence: A Two-Wave Longitudinal Study Behavioral Sciences doi: 10.3390/bs10030067 Authors: Tatiana Fomina Angelika Burmistrova-Savenkova Varvara Morosanova This paper addresses the question of whether self-regulation capacities are a significant psychological resource of schoolchildren’s psychological well-being. The study contributes to the search of significant predictors...
Tue Mar 10, 2020 02:00
Biomedicines, Vol. 8, Pages 56: Characterization of Osteoarthritis in a Medial Meniscectomy-Induced Animal Model Using Contrast-Enhanced X-ray Microtomography Biomedicines doi: 10.3390/biomedicines8030056 Authors: Takehito Sugasawa Tomoaki Kuji Kai Aoki Koki Yanazawa Akiko Takenouchi Makoto Watanabe Yoshiya Tome Yoshinori Takeuchi Yuichi Aita Naoya Yahagi Yasuhiro Shishikura Seiko Ono Yasuko Yoshida Yasushi Kawakami Kazuhiro Takekoshi The aim...
Tue Mar 10, 2020 02:00
Biomedicines, Vol. 8, Pages 57: The Biological Role of Apurinic/Apyrimidinic Endonuclease1/Redox Factor-1 as a Therapeutic Target for Vascular Inflammation and as a Serologic Biomarker Biomedicines doi: 10.3390/biomedicines8030057 Authors: Yu Ran Lee Hee Kyoung Joo Byeong Hwa Jeon Endothelial dysfunction promotes vascular inflammation by inducing the production of reactive oxygen species and adhesion molecules. Vascular inflammation plays a key role in the pathogenesis of vascular...
Tue Mar 10, 2020 02:00
Biomolecules, Vol. 10, Pages 432: Interactions between Muscle and Bone—Where Physics Meets Biology Biomolecules doi: 10.3390/biom10030432 Authors: Herrmann Engelke Ebert Müller-Deubert Rudert Ziouti Jundt Felsenberg Jakob Muscle and bone interact via physical forces and secreted osteokines and myokines. Physical forces are generated through gravity, locomotion, exercise, and external devices. Cells sense mechanical strain via adhesion molecules and translate...
Tue Mar 10, 2020 02:00
Biomolecules, Vol. 10, Pages 431: Rings, Hexagons, Hetals, and Dipolar Moment Sink-Sources: The Fanciful Behavior of Water around Cyclodextrin Complexes Biomolecules doi: 10.3390/biom10030431 Authors: Pablo F. Garrido Martín Calvelo Rebeca Garcia-Fandiño Ángel Piñeiro The basket-like geometry of cyclodextrins (CDs), with a cavity able to host hydrophobic groups, makes these molecules well suited for a large number of fundamental and industrial applications. Most of the established...
Tue Mar 10, 2020 02:00
Biomolecules, Vol. 10, Pages 428: Salient Features of Monomeric Alpha-Synuclein Revealed by NMR Spectroscopy Biomolecules doi: 10.3390/biom10030428 Authors: Do-Hyoung Kim Jongchan Lee K. H. Mok Jung Ho Lee Kyou-Hoon Han Elucidating the structural details of proteins is highly valuable and important for the proper understanding of protein function. In the case of intrinsically disordered proteins (IDPs), however, obtaining the structural details is quite challenging, as the...
Tue Mar 10, 2020 02:00
Biomolecules, Vol. 10, Pages 430: Codon Harmonization of a Kir3.1-KirBac1.3 Chimera for Structural Study Optimization Biomolecules doi: 10.3390/biom10030430 Authors: van Aalst Yekefallah Mehta Eason Wylie The expression of functional, folded, and isotopically enriched membrane proteins is an enduring bottleneck for nuclear magnetic resonance (NMR) studies. Indeed, historically, protein yield optimization has been insufficient to allow NMR analysis of many complex Eukaryotic...
Tue Mar 10, 2020 02:00
Biomolecules, Vol. 10, Pages 429: Cortisol Directly Stimulates Spermatogonial Differentiation, Meiosis, and Spermiogenesis in Zebrafish (Danio rerio) Testicular Explants Biomolecules doi: 10.3390/biom10030429 Authors: Aldo Tovo-Neto Emanuel R. M. Martinez Aline G. Melo Lucas B. Doretto Arno J. Butzge Maira S. Rodrigues Rafael T. Nakajima Hamid R. Habibi Rafael H. Nóbrega Cortisol is the major endocrine factor mediating the inhibitory effects of stress on vertebrate...
Tue Mar 10, 2020 02:00
Brain Sciences, Vol. 10, Pages 158: Quantified EEG for the Characterization of Epileptic Seizures versus Periodic Activity in Critically Ill Patients Brain Sciences doi: 10.3390/brainsci10030158 Authors: Vega-Zelaya Martín Abad Pastor Epileptic seizures (ES) are frequent in critically ill patients and their detection and treatment are mandatory. However, sometimes it is quite difficult to discriminate between ES and non-epileptic bursts of periodic activity (BPA). Our aim was...
Tue Mar 10, 2020 02:00
Cancers, Vol. 12, Pages 638: c-MYC Expression Is a Possible Keystone in the Colorectal Cancer Resistance to EGFR Inhibitors Cancers doi: 10.3390/cancers12030638 Authors: Antonia Strippoli Alessandra Cocomazzi Michele Basso Tonia Cenci Riccardo Ricci Francesco Pierconti Alessandra Cassano Vincenzo Fiorentino Carlo Barone Emilio Bria Lucia Ricci-Vitiani Giampaolo Tortora Luigi Maria Larocca Maurizio Martini Alterations in the transcriptional factor...
Tue Mar 10, 2020 02:00
Cancers, Vol. 12, Pages 645: Hippo/YAP Signaling Pathway: A Promising Therapeutic Target in Bone Paediatric Cancers? Cancers doi: 10.3390/cancers12030645 Authors: Sarah Morice Geoffroy Danieau Françoise Rédini Bénédicte Brounais-Le-Royer Franck Verrecchia Osteosarcoma and Ewing sarcoma are the most prevalent bone pediatric tumors. Despite intensive basic and medical research studies to discover new therapeutics and to improve current treatments, almost 40% of osteosarcoma...
Tue Mar 10, 2020 02:00
Cancers, Vol. 12, Pages 646: The Interplay between Antiviral Signalling and Carcinogenesis in Human Papillomavirus Infections Cancers doi: 10.3390/cancers12030646 Authors: Ferreira Ramalho Marques Ribeiro Human papillomaviruses (HPV) are the causative agents of the most common sexually transmitted infection worldwide. While infection is generally asymptomatic and can be cleared by the host immune system, when persistence occurs, HPV can become a risk factor for malignant...
Tue Mar 10, 2020 02:00
Cancers, Vol. 12, Pages 644: High Specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG Positive Ewing Sarcoma Cancers doi: 10.3390/cancers12030644 Authors: Orth Hölting Dallmayer Wehweck Paul Musa Baldauf Surdez Delattre Knott Romero-Pérez Kasan Cidre-Aranaz Gerke Ohmura Li Marchetto Henssen Özen Sugita Hasegawa Kanaseki Bertram Dirksen Hartmann Kirchner Grünewald Ewing sarcoma...
Tue Mar 10, 2020 02:00
Cancers, Vol. 12, Pages 642: Precision Medicine Management of Chronic Lymphocytic Leukemia Cancers doi: 10.3390/cancers12030642 Authors: Riccardo Moia Andrea Patriarca Mattia Schipani Valentina Ferri Chiara Favini Sruthi Sagiraju Wael Al Essa Gianluca Gaidano Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in western countries, with an incidence of approximately 5.1/100,000 new cases per year. Some patients may never require treatment, whereas...
Tue Mar 10, 2020 02:00
Cancers, Vol. 12, Pages 647: Latest Insights into Marek’s Disease Virus Pathogenesis and Tumorigenesis Cancers doi: 10.3390/cancers12030647 Authors: Luca D. Bertzbach Andelé M. Conradie Yu You Benedikt B. Kaufer Marek’s disease virus (MDV) infects chickens and causes one of the most frequent cancers in animals. Over 100 years of research on this oncogenic alphaherpesvirus has led to a profound understanding of virus-induced tumor development. Live-attenuated vaccines...
Tue Mar 10, 2020 02:00
Cancers, Vol. 12, Pages 640: Proton Pump Inhibitors Reduce Pancreatic Adenocarcinoma Progression by Selectively Targeting H+, K+-ATPases in Pancreatic Cancer and Stellate Cells Cancers doi: 10.3390/cancers12030640 Authors: Marco Tozzi Christiane E. Sørensen Lara Magni Nynne M. Christensen Rayhana Bouazzi Caroline M. Buch Matteo Stefanini Claudia Duranti Annarosa Arcangeli Ivana Novak Pancreatic duct cells are equipped with acid/base transporters important for...
Tue Mar 10, 2020 02:00
Cancers, Vol. 12, Pages 643: Molecular Heterogeneity and Cellular Diversity: Implications for Precision Treatment in Medulloblastoma Cancers doi: 10.3390/cancers12030643 Authors: Han Zou Brad Poore Alberto Broniscer Ian F. Pollack Baoli Hu Medulloblastoma, the most common pediatric malignant brain tumor, continues to have a high rate of morbidity and mortality in childhood. Recent advances in cancer genomics, single-cell sequencing, and sophisticated tumor models have revolutionized...
Tue Mar 10, 2020 02:00
Cancers, Vol. 12, Pages 641: Inflammatory Mechanisms of HCC Development Cancers doi: 10.3390/cancers12030641 Authors: Maria Grazia Refolo Caterina Messa Vito Guerra Brian Irving Carr Rosalba D’Alessandro HCC (hepatocellular carcinoma) is the second leading cause of cancer deaths worldwide, with several etiologic causes, mostly inflammation-associated. Different inflammatory responses in the liver can be triggered by different etiological agents. The inflammatory process can...
Tue Mar 10, 2020 02:00
Cancers, Vol. 12, Pages 639: Recovery of Adrenal Insufficiency Is Frequent After Adjuvant Mitotane Therapy in Patients with Adrenocortical Carcinoma Cancers doi: 10.3390/cancers12030639 Authors: Jonathan Poirier Nadia Gagnon Massimo Terzolo Soraya Puglisi Nada El Ghorayeb Anna Calabrese André Lacroix Isabelle Bourdeau Mitotane is a steroidogenesis inhibitor and adrenolytic drug used for treatment of adrenocortical cancer (ACC). Mitotane therapy causes adrenal insufficiency...
Tue Mar 10, 2020 02:00
Cancers, Vol. 12, Pages 636: Crosstalk between HER2 and PD-1/PD-L1 in Breast Cancer: From Clinical Applications to Mathematical Models Cancers doi: 10.3390/cancers12030636 Authors: Regina Padmanabhan Hadeel Shafeeq Kheraldine Nader Meskin Semir Vranic Ala-Eddin Al Moustafa Breast cancer is one of the major causes of mortality in women worldwide. The most aggressive breast cancer subtypes are human epidermal growth factor receptor-positive (HER2+) and triple-negative breast...
Tue Mar 10, 2020 02:00
Cancers, Vol. 12, Pages 637: Functional Classification of TP53 Mutations in Acute Myeloid Leukemia Cancers doi: 10.3390/cancers12030637 Authors: Sayantanee Dutta Gudrun Pregartner Frank G. Rücker Ellen Heitzer Armin Zebisch Lars Bullinger Andrea Berghold Konstanze Döhner Heinz Sill Mutations of the TP53 gene occur in a subset of patients with acute myeloid leukemia (AML) and confer an exceedingly adverse prognosis. However, whether different types of TP53 mutations...
Tue Mar 10, 2020 02:00
Cells, Vol. 9, Pages 681: Glioblastoma Multiforme Stem Cell Cycle Arrest by Alkylaminophenol Through the Modulation of EGFR and CSC Signaling Pathways Cells doi: 10.3390/cells9030681 Authors: Doan Musa Murugesan Sipilä Candeias Emmert-Streib Ruusuvuori Granberg Yli-Harja Kandhavelu Cancer stem cells (CSCs), a small subpopulation of cells existing in the tumor microenvironment promoting cell proliferation and growth. Targeting the stemness of the CSC...
Tue Mar 10, 2020 02:00
Cells, Vol. 9, Pages 679: Noble Metals and Soft Bio-Inspired Nanoparticles in Retinal Diseases Treatment: A Perspective Cells doi: 10.3390/cells9030679 Authors: De Matteis Rizzello We are witnessing an exponential increase in the use of different nanomaterials in a plethora of biomedical fields. We are all aware of how nanoparticles (NPs) have influenced and revolutionized the way we supply drugs or how to use them as therapeutic agents thanks to their tunable physico-chemical properties....
Tue Mar 10, 2020 02:00
Cells, Vol. 9, Pages 680: Exosomes from Human Adipose Tissue-Derived Mesenchymal Stem Cells Promote Epidermal Barrier Repair by Inducing de Novo Synthesis of Ceramides in Atopic Dermatitis Cells doi: 10.3390/cells9030680 Authors: Shin Ha Kim Crumrine Meyer Wakefield Lee Kim Kim Kim Lee Kwon Park Lee Lim Park Elias Park Yi Cho Atopic dermatitis (AD) is a multifactorial, heterogeneous disease associated with epidermal...
Tue Mar 10, 2020 02:00
Cells, Vol. 9, Pages 676: Loss of Cx43 in Murine Sertoli Cells Leads to Altered Prepubertal Sertoli Cell Maturation and Impairment of the Mitosis-Meiosis Switch Cells doi: 10.3390/cells9030676 Authors: Hilbold Distl Hoedemaker Wilkening Behr Rajkovic Langeheine Rode Jung Metzger Brehm Male factor infertility is a problem in today’s society but many underlying causes are still unknown. The generation of a conditional Sertoli cell (SC)-specific...
Tue Mar 10, 2020 02:00
Cells, Vol. 9, Pages 671: Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases Cells doi: 10.3390/cells9030671 Authors: Song An Zou Senescent cells are generally characterized by permanent cell cycle arrest, metabolic alteration and activation, and apoptotic resistance in multiple organs due to various stressors. Excessive accumulation of senescent cells in numerous tissues leads to multiple chronic diseases, tissue dysfunction, age-related diseases and...
Tue Mar 10, 2020 02:00
Cells, Vol. 9, Pages 675: Exosomes Could Offer New Options to Combat the Long-Term Complications Inflicted by Gestational Diabetes Mellitus Cells doi: 10.3390/cells9030675 Authors: Floriano Willis Catapano Lima Reis Barbosa Rudge Emanueli Gestational diabetes Mellitus (GDM) is a complex clinical condition that promotes pelvic floor myopathy, thus predisposing sufferers to urinary incontinence (UI). GDM usually regresses after birth. Nonetheless, a GDM history...
Tue Mar 10, 2020 02:00
Cells, Vol. 9, Pages 672: Yeast as a Model to Understand Actin-Mediated Cellular Functions in Mammals—Illustrated with Four Actin Cytoskeleton Proteins Cells doi: 10.3390/cells9030672 Authors: Akram Ahmed Mack Kaur Silva Castilho Friant Sattlegger Munn The budding yeast Saccharomyces cerevisiae has an actin cytoskeleton that comprises a set of protein components analogous to those found in the actin cytoskeletons of higher eukaryotes. Furthermore, the...
Tue Mar 10, 2020 02:00
Cells, Vol. 9, Pages 673: Cyclin-Dependent Kinase 18 Controls Trafficking of Aquaporin-2 and Its Abundance through Ubiquitin Ligase STUB1, Which Functions as an AKAP Cells doi: 10.3390/cells9030673 Authors: Dema Faust Lazarow Wippich Neuenschwander Zühlke Geelhaar Pallien Hallscheidt Eichhorst Wiesner Černecká Popp Mertins Dittmar von Kries Klussmann Arginine-vasopressin (AVP) facilitates water reabsorption in renal collecting...
Tue Mar 10, 2020 02:00
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