Sprache Stimme Gehör 2020; 44: 44-45DOI: 10.1055/a-0916-4197© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Tue Mar 10, 2020 01:00
Sprache Stimme Gehör 2020; 44: 58-59DOI: 10.1055/a-0916-4080© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Tue Mar 10, 2020 01:00
Sprache Stimme Gehör 2020; 44: 1-1DOI: 10.1055/a-0916-4094© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Tue Mar 10, 2020 01:00
Journal of Neurotrauma, Volume 37, Issue 6, Page 899-903, March 15, 2020.
Fri Mar 06, 2020 10:00
Journal of Neurotrauma, Volume 37, Issue 6, Page 839-845, March 15, 2020.
Fri Mar 06, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Fri Mar 06, 2020 10:00
Journal of Neurotrauma, Volume 37, Issue 6, Page 846-859, March 15, 2020.
Fri Mar 06, 2020 10:00
Journal of Neurotrauma, Volume 37, Issue 6, Page 905-905, March 15, 2020.
Fri Mar 06, 2020 10:00
Journal of Neurotrauma, Volume 37, Issue 6, Page 860-867, March 15, 2020.
Fri Mar 06, 2020 10:00
Journal of Neurotrauma, Volume 37, Issue 6, Page 868-876, March 15, 2020.
Fri Mar 06, 2020 10:00
Journal of Neurotrauma, Volume 37, Issue 6, Page 906-906, March 15, 2020.
Fri Mar 06, 2020 10:00
Journal of Neurotrauma, Volume 37, Issue 6, Page 904-904, March 15, 2020.
Fri Mar 06, 2020 10:00
05:19
04:03
The patterns and outcomes of coevolution are expected to depend on intraspecific trait variation. Various evolutionary factors can change this variation in time. As a result, modeling coevolutionary processes solely in terms of mean trait values may not be sufficient; one may need to study the dynamics of the whole trait distribution. Here, we develop a theoretical framework for studying the effects of evolving intraspecific variation in two-species coevolutionary systems. In particular, we build...
Tue Mar 10, 2020 02:00
NCoR-1 and NCoR-2 are transcriptional corepressors encoded in vertebrates by two interrelated loci and play distinct, though overlapping, roles in development, differentiation, and homeostasis. In contrast NCoR is encoded by a single locus in cephalochordates, urochordates, hemichordates, and echinoderms, with vertebrate NCoR-1 and NCoR-2 thought to be the products of a gene duplication originating near the beginning of vertebrate evolution. The structures, molecular properties, and functions of...
Tue Mar 10, 2020 02:00
The polymorphism of Hydra microsatellite sequences provides strain-specific signatures [NEW RESULTS]
Hydra are freshwater polyps widely studied for their amazing regenerative capacity, adult stem cell populations, low senescence and value as ecotoxicological marker. Many wild-type strains of H. vulgaris have been collected worldwide and maintained effectively under laboratory conditions by asexual reproduction, while stable transgenic lines have been continuously produced since 2006. Efforts are now needed to ensure the genetic characterization of all these strains, which despite similar morphologies,...
Tue Mar 10, 2020 02:00
Caenorhabditis elegans nematodes produce and maintain imprints of attractive chemosensory cues to which they are exposed early in life. Early odor-exposure increases adult chemo-attraction to the same cues. Imprinting is transiently or stably inherited, depending on the number of exposed generations. We show here that the Alanine tRNA (UGC) plays a central role in regulating C. elegans chemo-attraction. Naive worms fed on tRNAAla (UGC) purified from odor-experienced worms, acquire odor-specific imprints....
Tue Mar 10, 2020 02:00
The rate of evolution differs between protein sites and changes with time. However, the link between these two phenomena remains poorly understood. Here, we design a phylogenetic approach for distinguishing pairs of amino acid sites that undergo coordinated evolution, i.e., such that substitutions at one site trigger subsequent substitutions at the other; and also pairs of sites that undergo discordant evolution, so that substitutions at one site impede subsequent substitutions at the other. We distinguish...
Mon Mar 09, 2020 02:00
Surgical Infections, Ahead of Print.
Fri Mar 06, 2020 10:00
Abstract Most primates are arboreal, and the current context of habitat fragmentation makes gap- and road-crossing behaviors more and more common. Great apes may try to avoid behaviors such as arboreal leaping because given their size such behaviors are risky. Here, we report impressive gap-crossing by wild bonobos (Pan paniscus) in the Democratic Republic of Congo, induced by human disturbance and habitat fragmentation. We quantify the basic mechanics of leaps and arboreal landing...
02:00
Abstract The study of intestinal parasite communities is an important aspect of conservation biology, disease ecology, and wildlife health. Researchers can use the presence of select micro- and macroparasites as an indicator of host health. Only two studies have sampled intestinal parasites in free-ranging Aotus monkeys despite their wide geographic distribution in Central and South America. We therefore conducted a survey of gastrointestinal parasites using 50 fecal samples from...
Tue Mar 10, 2020 02:00
Abstract Social and environmental disturbance occurs naturally, and species in bonded social groups should be resilient to it. Empirical evidence of social responses to disturbance in primates, however, remains limited. We constructed social networks using group-level scan samples (N = 299) to test the robustness of grooming networks in a captive group of 20 Sulawesi crested macaques (Macaca nigra) to two management interventions involving environmental and social disturbance....
Tue Mar 10, 2020 02:00
Abstract Purpose The objective of this phase IIa, open-label, single-centre, single-arm, two-stage clinical trial was to evaluate the safety and activity of 177-lutetium DOTATATE (LuDO) molecular radiotherapy in neuroblastoma. Methods Children with relapsed or refractory metastatic high-risk neuroblastoma were treated with up to four courses of LuDO....
02:00
Abstract Purpose The objective of this study is to investigate the hippocampal neurodegeneration and its associated aberrant functions in mild cognitive impairment (MCI) and Alzheimer’s disease (AD) patients using simultaneous PET/MRI. Methods Forty-two cognitively normal controls (NC), 38 MCI, and 22 AD patients were enrolled in this study. All subjects...
Tue Mar 10, 2020 02:00
Abstract Purpose Increased cardiac uptake (CU) on early-phase 99mTc-HMDP scintigraphy has demonstrated diagnostic and prognostic values in amyloid transthyretin (ATTR) cardiac amyloidosis (CA). Extracardiac uptake (ECU) has been poorly studied. We assessed the clinical value of ECU, in combination with CU, on 99mTc-HMDP scintigraphy using a novel Methodological Amyloidosis Diagnostic Index (MADI). ...
Tue Mar 10, 2020 02:00
Tue Mar 10, 2020 02:00
Tue Mar 10, 2020 02:00
Abstract Purpose 68Ga-PSMA-11-PET/CT is increasingly used in early-stage biochemical recurrence of prostate cancer to detect potential lesions for an individualized radiotherapy concept. However, subtle findings especially concerning small local recurrences can still be challenging to interpret and are prone to variability between different readers. Thus, we analyzed interobserver variability, detection rate, and lesion patterns systematically...
Tue Mar 10, 2020 02:00
British Journal of Cancer, Published online: 11 March 2020; doi:10.1038/s41416-020-0780-3An integrated analysis of lymphocytic reaction, tumour molecular characteristics and patient survival in colorectal cancer
02:00
British Journal of Cancer, Published online: 11 March 2020; doi:10.1038/s41416-020-0768-zNon-inferiority randomised phase 3 trial comparing two radiation schedules (single vs. five fractions) in malignant spinal cord compression
02:00
01:08
01:08
Dysregulation of DNA methylation is an established feature of breast cancers. DNA demethylating therapies like decitabine are proposed for the treatment of triple-negative breast cancers (TNBCs) and indicators of response need to be identified. For this purpose, we characterized the effects of decitabine in a panel of 10 breast cancer cell lines and observed a range of sensitivity to decitabine that was not subtype-specific. Knockdown of potential key effectors demonstrated the requirement of deoxycytidine...
Tue Mar 10, 2020 16:20
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and an agonistic antibody against the death-inducing TRAIL receptor 5, DR5, are thought to selectively induce tumor cell death and therefore, have gained attention as potential therapeutics currently under investigation in several clinical trials. However, some tumor cells are resistant to TRAIL/DR5-induced cell death, even though they express DR5. Previously, we reported that DR5 is transported into the nucleus by importin β1, and knockdown...
Tue Mar 10, 2020 16:20
Purpose: KRAS mutation is a negative predictive biomarker of anti-EGFR agents in patients with metastatic colorectal cancer (mCRC), and remains an elusive target. Pelareorep, a double-stranded RNA virus selectively replicates in KRAS mutated cells, and is synergistic with irinotecan. Patients and Methods: A dose escalation trial of FOLFIRI/bevacizumab (irinotecan (150-180 mg/m2) and pelareorep (1x1010 TCID50-3x1010 TCID50) was implemented in adult patients with oxaliplatin refractory/intolerant,...
Tue Mar 10, 2020 16:20
Fusarium verticillioides, which causes ear, kernel and stem rots, has been reported as the most prevalent species on maize worldwide. Kernel infection by F. verticillioides results in reduced seed yield and quality as well as fumonisin contamination, and may affect seedling traits like germination rate, entire plant seedling length and weight. Maize resistance to Fusarium is a quantitative and complex trait controlled by numerous genes with small effects. In the present work, a Genome Wide Association...
Tue Mar 10, 2020 23:23
Peripheral mechanisms underlying comorbid IBS‐like pain are qualitatively similar to stress‐induced pain during the transient phase of visceral hypersensitivity in female rats. Treating patients for IBS comorbid with other overlapping pain conditions might be similar to IBS in the absence of comorbid pain. Abstract Background Stress exacerbates many chronic pain syndromes including irritable bowel syndrome (IBS). Among these patient populations, many suffer from comorbid or chronic overlapping...
03:54
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου