One of the most feared complications after arthroplasty is infection due to its significant impact on patient morbidity. Infection may transfer to the joint at the time of surgery or be seeded, haematologically, to the prosthetic joint from another infection source. In this case, a 72-year-old female presented with symptoms of septic arthritis seven years after her original arthroplasty surgery. At presentation, she denied trauma and any comorbidity which would predispose her to infection. Culturing...
Tue Mar 10, 2020 12:05
A 27-year-old female patient initially presented with fever, myalgia, sore throat that progressed to multifocal pneumonia, and cerebral sinus venous thrombosis. A combination of upper respiratory symptoms with tooth infection, positive blood culture for Fusobacterium nucleatum, computed tomography (CT) chest finding of multifocal pneumonia, and magnetic resonance imaging (MRI) finding of internal jugular vein thrombosis (IJVT) and cerebral venous sinus thrombosis (CVST) suggested Lemierre syndrome....
Tue Mar 10, 2020 08:20
Publication date: 15 April 2020Source: Journal of Neuroscience Methods, Volume 336Author(s):
Tue Mar 10, 2020 22:59
Examining Brain Maturation during Adolescence Using Graph Laplacian Learning Based Fourier Transform
Publication date: Available online 10 March 2020Source: Journal of Neuroscience MethodsAuthor(s): Junqi Wang, Li Xiao, Tony W. Wilson, Julia M. Stephen, Vince D. Calhoun, Yu-Ping Wang
Tue Mar 10, 2020 22:59
Publication date: Available online 9 March 2020Source: Journal of Neuroscience MethodsAuthor(s): Farhad Qureshi, Jun Yan
Tue Mar 10, 2020 22:59
Abstract The paper discusses radical constructivism about episodic memory as developed by Kourken Michaelian under the name of “simulationism”, a view that equates episodic memory with mental time travel. An alternative, direct realist view is defended, which implies disjunctivism about the appearance of remembering. While admitting the importance of mental time travel as an underlying cognitive mechanism in episodic memory, as well as the prima facie reasonableness of the simulationist’s...
Tue Mar 10, 2020 02:00
Objective: The current study aims to investigate whether computer generated (CG) expressions of emotion evoke similar emotional appraisal processing in the lateral orbitofrontal cortex (lOFC) compared to real human expressions, as well as how speech cues would influence the processing. Methods: Functional near-infrared spectroscopy was used to measure the neural activations in the prefrontal cortex during emotion recognition task. Thirty normal participants were asked to view videos...
Mon Mar 09, 2020 02:00
Abstract Purpose Ligand-dependent corepressor (LCoR) and receptor-interacting protein 140 (RIP140/NRIP1) play an important role in the regulation of multiple oncogenic signaling pathways and the development of cancer. LCoR and RIP140 form a nuclear complex in breast cancer cells and are of prognostic value in further prostate and cervical cancer. The purpose of this study was to analyze the regulation of these proteins in the development...
Tue Mar 10, 2020 02:00
Abstract Background Microtubule-associated protein 1 light chain 3 (LC3), an autophagic gene, has been reported as a vital marker for many diseases and cancers. However, the role of LC3 in hepatocellular carcinoma (HCC) was not still investigated. Therefore, we conducted a meta-analysis to examine the association of LC3 with its clinicopathological and prognostic in HCC. ...
Tue Mar 10, 2020 02:00
The authors would like to correct figure, as the error was introduced in the preparation of this figure for publication. We sincerely apologize for having this error in the article, the authors have provided corrected version of figure here.
Tue Mar 10, 2020 02:00
Abstract Purpose Metformin has plausible direct and indirect anti-cancer properties against pancreatic adenocarcinoma cells. However, metformin may only be efficacious in patients with inoperable pancreatic ductal adenocarcinoma (PDAC) without liver metastases. Absorption may be decreased by gastrointestinal symptoms and proton pump inhibitors (PPIs). We aimed to justify and inform a future phase III trial of metformin versus placebo...
Tue Mar 10, 2020 02:00
The Association for Africanist Anthropology (AfAA) is pleased to announce the recipient of 2019 Elliott P. Skinner Book Award. Michael Lambek, Canada Research Chair in the Anthropology of Ethical Life at the University of Toronto Scarborough, received the book award for Island in the Stream: An Ethnographic History of Mayotte at the AfAA Business Meeting on Thursday evening, November 21 in Vancouver.. His book, published by the University of Toronto Press in 2018, is set in Mayotte, an island in...
Tue Mar 10, 2020 22:30
Abstract Aging is associated with many pathophysiological changes that could lead to the onset of degenerative disease. Some of the physiological changes that occur with aging include increased inflammation and decreased stem cell proliferation, leading to decreased capacity for tissue regeneration and loss of function. In previous studies, we and others have found nutraceutical intervention to ameliorate some of the deleterious effects associated with aging. In particular, we...
Tue Mar 10, 2020 02:00
Publication date: Available online 9 March 2020Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Luigi Canullo, Tullio Genova, Paolo Pesce, Yasushi Nakajima, Daichi Yonezawa, Federico Mussano
Tue Mar 10, 2020 22:00
In this protocol, we describe procedures to qualitatively and quantitatively analyze developmental phenotypes in mice associated with congenital heart defects.
Tue Mar 10, 2020 21:52
The seedling flood assay facilitates rapid screening of wild tomato accessions for the resistance to the Pseudomonas syringae bacterium. This assay, used in conjunction with the seedling bacterial growth assay, can assist in further characterizing the underlying resistance to the bacterium, and can be used to screen mapping populations to determine the genetic basis of resistance.
Tue Mar 10, 2020 20:51
Given that GPCRs are attractive druggable targets, GPCR ligand screening is thus indispensable for the identification of lead compounds and for deorphanization studies. Towards these efforts, we describe PRESTO-Tango, an open-source resource platform used for simultaneous profiling of transient β-arrestin2 recruitment at approximately 300 GPCRs using a TEV-based reporter assay.
Tue Mar 10, 2020 20:51
In vitro models of coronary angiogenesis can be utilized for the discovery of the cellular and molecular mechanisms of coronary angiogenesis. In vitro explant cultures of sinus venosus and endocardium tissues show robust growth in response to VEGF-A and display a similar pattern of COUP-TFII expression as in vivo.
Tue Mar 10, 2020 19:51
Imaging of bacterial cells is an emerging systems biology approach focused on defining static and dynamic processes that dictate the function of large macromolecular machines. Here, integration of quantitative live cell imaging and cryo-electron tomography is used to study Legionella pneumophila type IV secretion system architecture and functions.
Tue Mar 10, 2020 19:51
Although stool culture for Campylobacter is imprecise, it is still considered the gold standard for identification. Methods to determine the limit of detection and survival in transport media of C. jejuni in human stool are described and compared with a new immunoassay with better accuracy.
Tue Mar 10, 2020 18:50
We clone and analyze reporter genes generating circular RNAs. These reporter genes are larger than constructs to analyze linear splicing and contain Alu elements. To investigate the circular RNAs, the constructs are transfected into cells and resulting RNA is analyzed using RT-PCR after removal of linear RNA.
Tue Mar 10, 2020 18:50
Authors: Huan-Huan Zhou, Xin-Li Zheng, Tian-Ming Ma, Meng Qi, Jing-Guo Zhou, Hai-Ju Liu, Gang Lu and Wei Zhao.Parasite Vol. 27 , page 12Published online: 04/03/2020 Keywords: Enterocytozoon bieneusi ; Genotype ; ITS region ; Pigs.
Wed Mar 04, 2020 02:00
Publication date: Available online 10 March 2020Source: CortexAuthor(s): Claudio L. Ferre, Iryna Babik, George F. Michel
Tue Mar 10, 2020 21:14
Summary Cisplatin is a widely used chemotherapy for the treatment of certain solid tumors. Ototoxicity and subsequent permanent hearing loss remain a serious dose-limiting side effect associated with cisplatin treatment. To date, no therapies have been approved to prevent or treat cisplatin-induced hearing loss (CIHL). Sodium thiosulfate effectively inactivates cisplatin through covalent binding and may provide protection against cisplatin-induced ototoxicity. DB-020 is being...
Tue Mar 10, 2020 02:00
Summary Background Exon 19 deletion and L858R point mutation in exon 21 of the epidermal growth factor receptor (EGFR) are the most commonly encountered mutations in patients with non-small cell lung cancer (NSCLC) and predict better clinical outcomes following treatment with EGFR-tyrosine kinase inhibitors (TKIs). The inflammatory indicator neutrophil-to-lymphocyte ratio (NLR) in peripheral blood serves as a predictive factor for NSCLC patients treated with chemotherapy. Here,...
Tue Mar 10, 2020 02:00
Publication date: Available online 9 March 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Cong Liu, Ting Wu, Shengyu Wang, Wenwen Zhou, Yangxin Li, Xiaoli Chen, Wanyun Li, Zilan Huang, Tingting Li, Liu Yang, Peilan Xu, Junlin Liuzong, Jun Xie, Dong Yang, Jianghua Yan, Fanghong Luo
Tue Mar 10, 2020 20:01
Publication date: Available online 9 March 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Ismail Ozturk, Ayça Tunçel, Fatma Yurt, Zekeriya Biyiklioglu, Mine Ince, Kasim Ocakoglu
Tue Mar 10, 2020 20:01
Publication date: Available online 9 March 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Maryam Pourhajibagher, Hassan Mahmoudi, Loghman Rezaei-soufi, Mohammad Yousef Alikhani, Abbas Bahador
Tue Mar 10, 2020 20:01
In vitro evaluation of cytotoxic properties of 5-Aminolevulinic acid (5-ALA) on bladder cancer cells
Publication date: Available online 9 March 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Usama A. Fahmy, Omar Fahmy
Tue Mar 10, 2020 20:01
Publication date: Available online 9 March 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Kamil Bochynek, David Aebisher, Monika Gasiorek, Grzegorz Cieślar, Aleksandra Kawczyk-Krupka
Tue Mar 10, 2020 20:01
Publication date: Available online 9 March 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Fei Xu, Qinati Feyissa, Zina Ibrahim, Ying Li, Kevin L. Xu, Zihan Guo, Justen Ahmad, Jaroslav G. Vostal
Tue Mar 10, 2020 20:01
Publication date: Available online 9 March 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Fahim Vohra, Ishfaq A. Bukhari, Saeed A. Sheikh, Mustafa Naseem, Mudassir Hussain
Tue Mar 10, 2020 20:01
Publication date: Available online 10 March 2020Source: Journal of the American College of SurgeonsAuthor(s): Darrell A. Campbell
Tue Mar 10, 2020 19:40
Publication date: Available online 10 March 2020Source: Archives of Physical Medicine and RehabilitationAuthor(s): Stefanie Rewald, AF Ton Lenssen, Pieter J. Emans, Rob A. de Bie, Gerard van Breukelen, Ilse Mesters
Tue Mar 10, 2020 19:38
Publication date: Available online 9 March 2020Source: Brain Research BulletinAuthor(s): Xiaoyu Liu, Qing Ji, Fangfang Liu, Li Jin, Yuanhui Tan, Lidong Zhang, Jun Tang
Tue Mar 10, 2020 19:22
Abstract Subcutaneous mast cells (MCs) are vulnerable to mechanical stimulation from external environment. Thus, MCs immune function could be modulated by their mechanosensitivity. This property has been identified as the trigger mechanism of needling acupuncture, a traditional oriental therapy. Previously we have demonstrated release of adenosine triphosphate (ATP), a stress‐responsive signaling molecule, from mechanical‐perturbed MCs. The current work explores its underlying mechanisms. We...
Tue Mar 10, 2020 18:51
ObjectiveTo determine the number of latent body mass index (BMI) trajectories from 1994 to 2010 among working Canadians and their association with concurrent trajectories in work environment exposures.MethodsData of employed individuals from the longitudinal Canadian National Population Health Survey were used. Group-based trajectory modelling was used to determine the number of latent BMI trajectories and concurrent psychosocial work environment trajectories. A multinomial logistic regression of...
Tue Mar 10, 2020 18:00
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