The Motilis 3D‐Transit system allows ambulatory description of transit patterns throughout the gastrointestinal tract. Using the 3D‐transit system, we have established normative values for gastric motility patterns. Gastric emptying time was not associated with age, gender, BMI, or the minor differences in the composition of the meal given with the capsule. In contrast, the contraction frequency was affected by gender and age while position and rotation amplitudes were associated with gender, BMI,...
Tue Mar 10, 2020 18:07
Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT) is a rare and highly aggressive ovarian malignancy. In almost all cases, it is associated with somatic and often germline pathogenic variants in SMARCA4, which encodes for the SMARCA4 protein (BRG1), a subunit of the SWI/SNF chromatin remodeling complex. Approximately 20% of human cancers possess pathogenic variants in at least one SWI/SNF subunit. Because of their role in regulating many important cellular processes including transcriptional...
Tue Mar 10, 2020 15:36
Purpose: We hypothesized that autophagy inhibition would increase response to chemotherapy in the preoperative setting for patients with pancreatic adenocarcinoma. We performed a randomized controlled trial to assess the autophagy inhibitor hydroxychloroquine in combination with gemcitabine and nab-paclitaxel. Experimental Design: Participants with potentially resectable tumors were randomized to two cycles of nab-paclitaxel and gemcitabine (PG) alone or with hydroxychloroquine (PGH), followed by...
Tue Mar 10, 2020 15:36
Introduction: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) benefit advanced lung adenocarcinoma (ADC) patients harboring activating EGFR mutations. We aimed to identify biomarkers to monitor and predict the progression of patients receiving EGFR-TKIs via a comprehensive omic analysis. Methods: We applied quantitative proteomics to generate the TKI resistance-associated pleural effusion (PE) proteome from ADC patients with or without EGFR-TKI resistance. Candidates were...
Tue Mar 10, 2020 15:36
Purpose: To determine the impact of basal-like and classical subtypes in advanced PDAC and to explore GATA6 expression as a surrogate biomarker. Experimental design: Within the COMPASS trial patients proceeding to chemotherapy for advanced PDAC undergo tumour biopsy for RNA sequencing. Overall response rate (ORR) and overall survival (OS) were stratified by subtypes and according to chemotherapy received. Correlation of GATA6 with the subtypes using gene expression profiling, in situ hybridization...
Tue Mar 10, 2020 15:36
Purpose: Oncogenic mutations in NRAS promote tumorigenesis. Although novel anti-NRAS inhibitors are urgently needed for the treatment of cancer, the protein is generally considered "undruggable" and no effective therapies have yet reached the clinic. STK19 kinase was recently reported to be a novel activator of NRAS and a potential therapeutic target for NRAS-mutant melanomas. Here, we describe a new pharmacological inhibitor of STK19 kinase for the treatment of NRAS-mutant cancers. Experimental...
Tue Mar 10, 2020 15:36
Purpose: We evaluated the association between molecular subtypes of advanced gastric cancer (AGC) and the efficacy of standard chemotherapy or immune checkpoint inhibitors. Experimental Design: Patients with AGC who received systemic chemotherapy from October 2015 to July 2018 with available molecular features were analyzed. We investigated the efficacy of standard first- (fluoropyrimidine + platinum ± trastuzumab) and second-line (taxanes ± ramucirumab) chemotherapy, and subsequent anti-PD-1 therapy...
Tue Mar 10, 2020 15:36
Purpose: Bruton's tyrosine kinase (BTK) inhibition alone leads to incomplete responses in chronic lymphocytic leukemia (CLL). Combination therapy may reduce activation of escape pathways and deepen responses. This open-label, phase 1b, sequential dose-escalation and dose-expansion study evaluated the safety, tolerability, pharmacokinetics, and preliminary efficacy of the selective BTK inhibitor tirabrutinib (TIRA) alone, in combination with the phosphoinositide-3-kinase delta (PI3K) inhibitor idelalisib...
Tue Mar 10, 2020 15:36
Abstract OBJECTIVE Cancer diagnosis in adolescents and young adults (AYA) coincides with the developmental initiation of substance use and emergence of affective disturbance. We examined substance use behaviors and risk‐stratified associations with mental and physical health, as well as objective indicators of tobacco and cannabis use and concordance with self‐report and medical records. METHODS AYAs were 15‐39 years at cancer diagnosis and ≥ 18 years and ≥ 6 months post‐diagnosis...
02:50
Abstract Background To investigate the relationships between self‐reported and objectively measured cognitive function prior to systemic therapy and subsequent well‐being outcomes over 24 months in older breast cancer survivors. Methods Data were from 397 women aged 60‐98 diagnosed with non‐metastatic breast cancer in the Thinking and Living with Cancer Study recruited from 2010‐2016. Cognitive function was measured at baseline (following surgery, prior to systemic therapy) using...
02:50
Abstract Objective The relationship between physical activity (PA) and quality of life (QOL) relative to active treatment for prostate cancer (PCa) has been well‐studied; however, little is known about this relationship during active surveillance (AS). Moreover, whether PA is associated with better emotional well‐being (EWB) in men with low‐risk PCa requires further investigation. Accordingly, we examined the association between self‐reported PA and the average change in QOL and EWB over time...
02:50
Abstract Objective Specific personality traits are associated with differential use of various coping strategies. Few studies have examined the relationship between personality and coping in oncology patients undergoing chemotherapy. We therefore examined the relationship between previously identified personality profiles (ie, Distressed [14.3% of total sample], Normative [53.8%], Resilient [31.9%]) and measures of coping and adjustment. Methods Patients (n = 1248) undergoing chemotherapy...
02:50
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04969
Tue Mar 10, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05763
Tue Mar 10, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05661
Tue Mar 10, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05384
Tue Mar 10, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05050
Tue Mar 10, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00021
Tue Mar 10, 2020 06:00
Abstract Purpose The change in sleep patterns across the duration of pregnancy is an item of interest. The aim of this study is to provide data on pregnant women’s quality of sleep (QoS) and quality of life (QoL) to determine appropriate times to screen for potential problems. Methods This is a multicenter, prospective, longitudinal observational study....
Tue Mar 10, 2020 02:00
Limited prospective data about the activity of immune checkpoint inhibitors (ICIs) are available for elderly patients. The aim of our analysis was to determine the relative efficacy of ICIs versus available standard therapies [standard of care (SOC)] in subgroups defined by patients’ age. Searching the MEDLINE/PubMed, Cochrane Library, and American Society of Clinical Oncology (ASCO) Meeting abstracts randomized clinical trials were identified. Data extraction was conduced according to the Preferred...
02:26
Ipilimumab and nivolumab are immune checkpoint inhibitors used in the treatment of metastatic melanoma. The authors report the case of a 62-year-old white male individual with metastatic choroidal melanoma who had commenced adjuvant systemic treatment with combination checkpoint inhibitor therapy of intravenous ipilimumab (anti-cytotoxic T-lymphocyte antigen-4) and nivolumab (anti-programmed cell death-1) at 3-week cycle intervals. On day 4 after the second cycle, he developed an acute widespread...
02:26
Adoptive cell therapy with ex vivo expanded tumor infiltrating lymphocytes or gene engineering T cells expressing chimeric antigen receptors (CAR) is a promising treatment for cancer patients. This production utilizes T-cell activation and transduction with activation beads and RetroNectin, respectively. However, the high cost of production is an obstacle for the broad clinical application of novel immunotherapeutic cell products. To facilitate production we refined our approach by using artificial...
02:26
Summary: Nivolumab is an anti-programmed death-1 inhibitor used in the treatment of cancer. Nivolumab has recently been approved as an adjuvant treatment for patients with stage IIIB, IIIC, and completely resected stage IV melanoma in the Netherlands. Despite the promising results of nivolumab, there is a wide variation in toxic side effects. A nivolumab-induced bilateral vocal cord paralysis (BVCP) was not reported. In this case, we present a nivolumab-induced BVCP. A 75-year-old man received...
02:26
Diaphragmatic dysfunction is a rare cause of dyspnea that can lead to hypercapnic respiratory failure. A variety of causes of diaphragmatic dysfunction have been identified, including myopathies and neuropathies, the latter of which can be further subdivided into infectious, idiopathic, demyelinating, malignant, and iatrogenic etiologies. Now, in the era of immune checkpoint inhibitors (ICIs), case reports of immune-mediated phrenic nerve palsies have been described. This diagnosis can be challenging...
02:26
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01306
Tue Mar 10, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01475
Tue Mar 10, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b13729
Tue Mar 10, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b13157
Tue Mar 10, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01133
Tue Mar 10, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02441
Tue Mar 10, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00901
Tue Mar 10, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b13484
Tue Mar 10, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b11061
Tue Mar 10, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02326
Tue Mar 10, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00062
Tue Mar 10, 2020 06:00
Tue Mar 10, 2020 02:00
Background. In China, the incidence of cancer has significantly decreased over the last two decades. In contrast, the incidence of gastric carcinoma (GC) has risen in young patients. Methods. We reevaluated the histopathological results of 4,353 endoscopic gastroscopies from the Department of Pathology at No 1 Hospital of Liangshan. The ethnic groups Han and Yi were almost equally distributed in this cohort. Over a five-year period, 1407 GC were diagnosed. Results. In 171 of these cases (12%), the...
Tue Mar 10, 2020 13:20
Background. Metal artisans have been using lead and mercury in their settings for centuries. Exposure to these toxic heavy metals causes adverse health effects. We assessed the occupational exposure of metal artisans and their high-risk household contacts at Thimphu, Bhutan. Methods. A cross-sectional study in which 134 metal artisan center employees and 48 high-risk household contacts were tested for blood lead and mercury levels. Sociodemographic data, occupational exposure risk factors, and clinical...
Tue Mar 10, 2020 08:50
A review by biologists finds that plant domestication has often had a negative effect on plant microbiomes, making domesticated plants more dependent on fertilizer and other soil amendments than their wild relatives. To make crops more productive and sustainable, the authors recommend reintroduction of genes from the wild relatives of commercial crops that restore domesticated plants' ability to interact with beneficial soil microbes.
Tue Mar 10, 2020 22:47
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