Cancers, Vol. 12, Pages 638: c-MYC Expression Is a Possible Keystone in the Colorectal Cancer Resistance to EGFR Inhibitors Cancers doi: 10.3390/cancers12030638 Authors: Antonia Strippoli Alessandra Cocomazzi Michele Basso Tonia Cenci Riccardo Ricci Francesco Pierconti Alessandra Cassano Vincenzo Fiorentino Carlo Barone Emilio Bria Lucia Ricci-Vitiani Giampaolo Tortora Luigi Maria Larocca Maurizio Martini Alterations in the transcriptional...
Tue Mar 10, 2020 02:00
Cancers, Vol. 12, Pages 645: Hippo/YAP Signaling Pathway: A Promising Therapeutic Target in Bone Paediatric Cancers? Cancers doi: 10.3390/cancers12030645 Authors: Sarah Morice Geoffroy Danieau Françoise Rédini Bénédicte Brounais-Le-Royer Franck Verrecchia Osteosarcoma and Ewing sarcoma are the most prevalent bone pediatric tumors. Despite intensive basic and medical research studies to discover new therapeutics and to improve current treatments, almost 40% of osteosarcoma...
Tue Mar 10, 2020 02:00
Cancers, Vol. 12, Pages 646: The Interplay between Antiviral Signalling and Carcinogenesis in Human Papillomavirus Infections Cancers doi: 10.3390/cancers12030646 Authors: Ferreira Ramalho Marques Ribeiro Human papillomaviruses (HPV) are the causative agents of the most common sexually transmitted infection worldwide. While infection is generally asymptomatic and can be cleared by the host immune system, when persistence occurs, HPV can become a risk factor for malignant...
Tue Mar 10, 2020 02:00
Cancers, Vol. 12, Pages 639: Recovery of Adrenal Insufficiency Is Frequent After Adjuvant Mitotane Therapy in Patients with Adrenocortical Carcinoma Cancers doi: 10.3390/cancers12030639 Authors: Jonathan Poirier Nadia Gagnon Massimo Terzolo Soraya Puglisi Nada El Ghorayeb Anna Calabrese André Lacroix Isabelle Bourdeau Mitotane is a steroidogenesis inhibitor and adrenolytic drug used for treatment of adrenocortical cancer (ACC). Mitotane therapy causes...
Tue Mar 10, 2020 02:00
Cancers, Vol. 12, Pages 644: High Specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG Positive Ewing Sarcoma Cancers doi: 10.3390/cancers12030644 Authors: Orth Hölting Dallmayer Wehweck Paul Musa Baldauf Surdez Delattre Knott Romero-Pérez Kasan Cidre-Aranaz Gerke Ohmura Li Marchetto Henssen Özen Sugita Hasegawa Kanaseki Bertram Dirksen Hartmann Kirchner ...
Tue Mar 10, 2020 02:00
Cancers, Vol. 12, Pages 642: Precision Medicine Management of Chronic Lymphocytic Leukemia Cancers doi: 10.3390/cancers12030642 Authors: Riccardo Moia Andrea Patriarca Mattia Schipani Valentina Ferri Chiara Favini Sruthi Sagiraju Wael Al Essa Gianluca Gaidano Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in western countries, with an incidence of approximately 5.1/100,000 new cases per year. Some patients may never require treatment,...
Tue Mar 10, 2020 02:00
Cancers, Vol. 12, Pages 643: Molecular Heterogeneity and Cellular Diversity: Implications for Precision Treatment in Medulloblastoma Cancers doi: 10.3390/cancers12030643 Authors: Han Zou Brad Poore Alberto Broniscer Ian F. Pollack Baoli Hu Medulloblastoma, the most common pediatric malignant brain tumor, continues to have a high rate of morbidity and mortality in childhood. Recent advances in cancer genomics, single-cell sequencing, and sophisticated tumor models...
Tue Mar 10, 2020 02:00
Cancers, Vol. 12, Pages 640: Proton Pump Inhibitors Reduce Pancreatic Adenocarcinoma Progression by Selectively Targeting H+, K+-ATPases in Pancreatic Cancer and Stellate Cells Cancers doi: 10.3390/cancers12030640 Authors: Marco Tozzi Christiane E. Sørensen Lara Magni Nynne M. Christensen Rayhana Bouazzi Caroline M. Buch Matteo Stefanini Claudia Duranti Annarosa Arcangeli Ivana Novak Pancreatic duct cells are equipped with acid/base transporters...
Tue Mar 10, 2020 02:00
Cancers, Vol. 12, Pages 641: Inflammatory Mechanisms of HCC Development Cancers doi: 10.3390/cancers12030641 Authors: Maria Grazia Refolo Caterina Messa Vito Guerra Brian Irving Carr Rosalba D’Alessandro HCC (hepatocellular carcinoma) is the second leading cause of cancer deaths worldwide, with several etiologic causes, mostly inflammation-associated. Different inflammatory responses in the liver can be triggered by different etiological agents. The inflammatory...
Tue Mar 10, 2020 02:00
Cancers, Vol. 12, Pages 647: Latest Insights into Marek’s Disease Virus Pathogenesis and Tumorigenesis Cancers doi: 10.3390/cancers12030647 Authors: Luca D. Bertzbach Andelé M. Conradie Yu You Benedikt B. Kaufer Marek’s disease virus (MDV) infects chickens and causes one of the most frequent cancers in animals. Over 100 years of research on this oncogenic alphaherpesvirus has led to a profound understanding of virus-induced tumor development. Live-attenuated...
Tue Mar 10, 2020 02:00
Cancers, Vol. 12, Pages 636: Crosstalk between HER2 and PD-1/PD-L1 in Breast Cancer: From Clinical Applications to Mathematical Models Cancers doi: 10.3390/cancers12030636 Authors: Regina Padmanabhan Hadeel Shafeeq Kheraldine Nader Meskin Semir Vranic Ala-Eddin Al Moustafa Breast cancer is one of the major causes of mortality in women worldwide. The most aggressive breast cancer subtypes are human epidermal growth factor receptor-positive (HER2+) and triple-negative...
Tue Mar 10, 2020 02:00
Cancers, Vol. 12, Pages 637: Functional Classification of TP53 Mutations in Acute Myeloid Leukemia Cancers doi: 10.3390/cancers12030637 Authors: Sayantanee Dutta Gudrun Pregartner Frank G. Rücker Ellen Heitzer Armin Zebisch Lars Bullinger Andrea Berghold Konstanze Döhner Heinz Sill Mutations of the TP53 gene occur in a subset of patients with acute myeloid leukemia (AML) and confer an exceedingly adverse prognosis. However, whether different types...
Tue Mar 10, 2020 02:00
Zusammenfassung Hintergrund Die Erlernung komplexer psychomotorisches Handlungsabläufe erfordert eine erhöhte Anzahl an Trainingseinheiten zur genauen und sicheren Ausführung. Hierfür stehen im derzeitigen studentischen Curriculum nur sehr wenige Lehreinheiten zur Verfügung. Ziel Ziel der vorliegenden Arbeit war die Erfassung der Lernkurve für psychomotorische...
Mon Mar 09, 2020 02:00
Kontinuierliches intraoperatives Neuromonitoring (cIONM) in der Kopf-Hals-Chirurgie – eine Übersicht
Zusammenfassung Obwohl die Geschichte des intraoperativen Neuromonitorings (IONM) bereits in das 19. Jahrhundert zurückdatiert werden kann, hat sich diese Methode bis vor Kurzem nicht von der reinen Differenzierung des Nervs weiterentwickelt. Erst das kontinuierliche IONM (cIONM) ermöglichte die durchgehende Analyse der Reizamplituden und -latenzen, welche mittlerweile ebenfalls in die Software gängiger Monitoringsysteme integriert wurde. Zielsetzung des cIONM ist ein Real-Time-Monitoring...
Tue Mar 10, 2020 02:00
Zusammenfassung Hintergrund Augenbewegungen gehören zu den komplexesten motorischen Leistungen des zentralen Nervensystems (ZNS). Störungen der Okulomotorik und Nystagmen kommen bei zentralen und peripher-vestibulären Erkrankungen vor. Die systematische klinische Untersuchung gestattet häufig eine topodiagnostische Einordnung der Läsion. Ziel der Arbeit In...
Tue Mar 10, 2020 02:00
Abstract The underlying mechanisms of aggressive pituitary neuroendocrine tumors (pitNETs) are still unclear. The p16 protein, encoded by the CDKN2A tumor suppressor gene on chromosome 9p21, is commonly reported to be lost in numerous types of cancer. For this reason, this study examined to examine the status of homozygous deletion of CDKN2A in high-risk pitNETs. Thirty-eight high-risk pitNETs (30 male, 8 female) were analyzed for CDKN2A deletion by fluorescent in situ hybridization...
Mon Mar 09, 2020 02:00
CAR T cell-based therapies have shown promising results in hematological malignancies. Results of CAR T cell projects in solid tumors have been less impressive, and factors including lack of targetable antigen...
Tue Mar 10, 2020 02:00
Abstract Holter recordings are widely used to detect cardiac events that occur transiently, such as ischemic events. Much effort has been made to detect early ischemia, thus preventing myocardial infarction. However, after detection, classification of ischemia has still not been fully solved. The main difficulty relies on the false positives produced because of non-ischemic events, such as changes in the heart rate, the intraventricular conduction or the cardiac electrical axis....
Mon Mar 09, 2020 02:00
Publication date: Available online 9 March 2020Source: Seminars in OncologyAuthor(s): Tarek Assi, Elie Rassy, Hussein Nassereddine, Fadi Farhat, Fadi El Karak, Joseph Kattan, Marwan Ghosn
Tue Mar 10, 2020 15:59
Publication date: Available online 9 March 2020Source: Clinical NeurophysiologyAuthor(s): Gregor Omejec, Simon Podnar
Tue Mar 10, 2020 15:58
Abstract Purpose To investigate the dosimetric influence of daily interfractional (inter) setup errors and intrafractional (intra) target motion on the planning target volume (PTV) and the possibility of an offline adaptive radiotherapy (ART) method to correct larger patient positioning uncertainties in image-guided radiotherapy for prostate cancer (PCa). Materials and...
Tue Mar 10, 2020 02:00
Two novel glycoside hydrolases were cloned from the genomic DNA of alklinphilic bacterium Cellulomonas bogoriensis 69B4T and functionally expressed in Escherichia coli. The two enzymes shared less than 73% of ide...
Tue Mar 10, 2020 02:00
Insulin has captured researchers’ attention worldwide. There is a rapid global rise in the number of diabetic patients, which increases the demand for insulin. Current methods of insulin production are expensi...
Tue Mar 10, 2020 02:00
Publication date: Available online 10 March 2020Source: Practical Radiation OncologyAuthor(s): Mark A. Ritter, Patrick A. Kupelian, Daniel G. Petereit, Colleen A. Lawton, Nick Anger, Heather Geye, Richard J. Chappell, Jeffrey D. Forman
Tue Mar 10, 2020 15:49
Abstract Introduction Despite aggressive treatment with chemoradiotherapy and maximum surgical resection, survival in patients with glioblastoma (GBM) remains poor. Ongoing efforts are aiming to prolong the lifespan of these patients; however, disparities exist in reported survival values with lack of clear evidence that objectively examines GBM survival trends. We aim to describe the current status and advances in the survival of patients...
Mon Mar 09, 2020 02:00
Abstract Purpose Given the rarity in the population with adult thalamic gliomas (ATGs), comprehensive characteristics, treatments and survival outcome are not well characterized. This study was conducted to investigate the comprehensive characteristic and treatment of ATGs and identify the prognostic factors associated with overall survival (OS). Methods ...
Tue Mar 10, 2020 02:00
Abstract Objective The aim of this analysis is to evaluate the relative weight of different epidemiological risk factors on the development of different breast cancer subtypes (i.e. luminal, Her2+ overexpressed or triple negative). Methods De-identified datasets of female participants recruited within the Prostate, Lung, Colorectal, and Ovarian (PLCO)...
Tue Mar 10, 2020 02:00
Publication date: Available online 10 March 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Adam Klocperk, Susanne Unger, David Friedmann, Maximilian Seidl, Katharina Zoldan, Jens Pfeiffer, Oliver Hausmann, Vladimir Benes, Geoffroy Andrieux, Tobias Boettler, Anna Sediva, Bertram Bengsch, Klaus Warnatz
Tue Mar 10, 2020 15:40
Publication date: Available online 10 March 2020Source: Seminars in Ultrasound, CT and MRIAuthor(s): Sheng-Che Hung
Tue Mar 10, 2020 15:38
Abstract Wilms tumor is the most common pediatric renal malignancy. Several genetic loci have been shown to be associated with its formation. Genetic or epigenetic aberrations at WT1 and WT2 loci have been implicated in the etiology of the majority of sporadic Wilms tumors. In our previous study, most Wilms tumors tested negative for both constitutional mutations and somatic mutations in the WT1 gene. Thus, WT2 may play an important role in these tumors. In the present study,...
Tue Mar 10, 2020 02:00
Publication date: Available online 9 March 2020Source: Sleep MedicineAuthor(s): Giuseppe Lanza
Tue Mar 10, 2020 15:30
Visual imprinting is a learning process whereby young animals come to prefer a visual stimulus after exposure to it (training). The intermediate medial mesopallium in the domestic chick forebrain is critical for visual imprinting and contributes to molecular regulation of memory formation. Criteria used to infer that a change following training is learning-related have been formulated and published. Cognin (protein disulphide isomerase) is one of several identified plasma membrane and mitochondrial...
Tue Mar 10, 2020 15:27
Objective: Cervical spondylotic myelopathy is regarded as a chronic, special incomplete spinal cord injury, so the sensory components transmitted to thalamus decreased after distal spinal cord injury, which lead the disturbance of thalamus-cortex circuits, which might explain the alterations of clinical function of cervical spondylotic myelopathy patients. However, for lack of effective methods to evaluate the disturbance circuits and how the relative mechanism adapt to the recovery of cervical...
Tue Mar 10, 2020 15:27
Objective During muscle fatigue, acute changes in the interaction between the sensorimotor cortex and peripheral neurons have been widely studied. However, it is still unclear about the effect of antagonist muscle prefatigue on corticomuscular coupling and central modulation. The purpose of this study was to investigate the changes in the magnitude of electroencephalogram-electromyography (EEG-EMG) coherence and phase synchronization index (PSI) induced by antagonistic muscle prefatigue. Methods...
Tue Mar 10, 2020 15:27
The neurophysiological basis of spontaneous low-frequency brain activity has become a major theme in the study of neural function in both humans and animal models. In such studies, the anesthesia model was generally adopted. However, the effects of anesthesia on spontaneous activity remain unclear. In this work, we explored the characteristics of cerebral spontaneous low-frequency activities at different depths of anesthesia in mice. Using Fourier transformation and the multitaper analysis methods,...
Tue Mar 10, 2020 15:27
Onset delay of current antidepressants is always the most significant limitation for the treatment of depression. More attention has been given to the glutamate acid system for developing fast-onset antidepressants. Xenon, acting as a well-known N-methyl-D-aspartate receptors antagonist, has been widely used clinically as anesthetics and was reported to exert antidepressant-like effects in rats under normal condition. The robust and rapid-acting antidepressant- and anxiolytic-like activities of xenon...
Tue Mar 10, 2020 15:27
Recent study has demonstrated that high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) have the same effect to alleviate β-amyloid pathology in the hippocampus of APPswe/PS1dE9 (APP/PS1) mice. Activation of nucleotide binding and oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is pivotal and has been demonstrated to accelerate β-amyloid accumulation. The present study aimed to examine whether the exercise-induced β-amyloid...
Tue Mar 10, 2020 15:27
Long non-coding (lncRNA) cancer susceptibility candidate (CASC7) plays a tumor-suppressive role in several malignancies. In this study, the role of CASC7 in neuroblastoma was investigated for the first time. We observed the downregulation of CASC7 in neuroblastoma tissues compared to non-cancer tissues of neuroblastoma patients. Across neuroblastoma tissues, CASC7 was inversely correlated with microRNA-10a (miR-10a) but positively correlated with phosphatase and tensin homolog mRNA. In neuroblastoma...
Tue Mar 10, 2020 15:27
Surface texture can be perceived not only from tactile, but also from auditory and visual sensory cues. In our previous psychophysical study, we demonstrated that humans can recognize surface stickiness using only one kind of sensory modality without any difficulty. However, the brain regions that would be activated by non-corresponding sensory cues, for example, auditory and visual cues, remain unknown. In this human functional MRI study, we explored brain regions associated with surface stickiness...
Tue Mar 10, 2020 15:27
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