Biology, Vol. 9, Pages 215: Expression Profile of SARS-CoV-2 Host Receptors in Human Pancreatic Islets Revealed Upregulation of ACE2 in Diabetic Donors Biology doi: 10.3390/biology9080215 Authors: Jalal Taneera Waseem El-Huneidi Mawieh Hamad Abdul Khader Mohammed Esraa Elaraby Mahmood Yaseen Hachim Cellular entry of SARS-CoV-2 is thought to occur through the binding of viral spike S1 protein to ACE2. The entry process involves priming of the S protein by TMPRSS2 and ADAM17,...
Fri Aug 07, 2020 03:00
Biology, Vol. 9, Pages 214: Enhanced Thermostability and Enzymatic Activity of Cel6A Variants from Thermobifida fusca by Empirical Domain Engineering (Short Title: Domain Engineering of Cel6A) Biology doi: 10.3390/biology9080214 Authors: Imran Ali Hafiz Muzzammel Rehman Muhammad Usman Mirza Muhammad Waheed Akhtar Rehana Asghar Muhammad Tariq Rashid Ahmed Fatima Tanveer Hina Khalid Huda Ahmed Alghamdi Matheus Froeyen Cellulases are a set of lignocellulolytic...
Fri Aug 07, 2020 03:00
Biology, Vol. 9, Pages 213: Non-Coding RNAs and Nucleosome Remodeling Complexes: An Intricate Regulatory Relationship Biology doi: 10.3390/biology9080213 Authors: Benjamin J. Patty Sarah J. Hainer Eukaryotic genomes are pervasively transcribed, producing both coding and non-coding RNAs (ncRNAs). ncRNAs are diverse and a critical family of biological molecules, yet much remains unknown regarding their functions and mechanisms of regulation. ATP-dependent nucleosome remodeling complexes,...
Fri Aug 07, 2020 03:00
Biomedicines, Vol. 8, Pages 279: Marijuana and Opioid Use during Pregnancy: Using Zebrafish to Gain Understanding of Congenital Anomalies Caused by Drug Exposure during Development Biomedicines doi: 10.3390/biomedicines8080279 Authors: Swapnalee Sarmah Marilia Ribeiro Sales Cadena Pabyton Gonçalves Cadena James A. Marrs Marijuana and opioid addictions have increased alarmingly in recent decades, especially in the United States, posing threats to society. When the drug user is...
Sat Aug 08, 2020 03:00
Biomedicines, Vol. 8, Pages 278: How Long Does a Neutrophil Live?—The Effect of 24 h Whole Blood Storage on Neutrophil Functions in Pigs Biomedicines doi: 10.3390/biomedicines8080278 Authors: Bonilla Fingerhut Alfonso-Castro Mergani Schwennen von Köckritz-Blickwede de Buhr Neutrophils are important effector cells of the innate immune system, traditionally regarded to have a short life span. The goal of this study was to evaluate the effect of the whole blood...
Sat Aug 08, 2020 03:00
Biomolecules, Vol. 10, Pages 1167: Targeting TLR4 with ApTOLL Improves Heart Function in Response to Coronary Ischemia Reperfusion in Pigs Undergoing Acute Myocardial Infarction Biomolecules doi: 10.3390/biom10081167 Authors: Rafael Ramirez-Carracedo Laura Tesoro Ignacio Hernandez Javier Diez-Mata David Piñeiro Macarena Hernandez-Jimenez Jose Luis Zamorano Carlos Zaragoza Toll-like receptor 4 (TLR4) contributes to the pathogenesis of coronary ischemia/reperfusion...
Sun Aug 09, 2020 03:00
Biomolecules, Vol. 10, Pages 1165: Fibrinogen Fucosylation as a Prognostic Marker of End-Stage Renal Disease in Patients on Peritoneal Dialysis Biomolecules doi: 10.3390/biom10081165 Authors: Marko Baralić Nikola Gligorijević Voin Brković Jaroslav Katrlík Lucia Pažitná Miloš Šunderić Goran Miljuš Ana Penezić Zorana Dobrijević Mirjana Laušević Olgica Nedić Dragana Robajac Glycosylation may strongly affect protein structure and functions. A high risk of...
Sun Aug 09, 2020 03:00
Biomolecules, Vol. 10, Pages 1166: Discovery of Sulfated Small Molecule Inhibitors of Matrix Metalloproteinase-8 Biomolecules doi: 10.3390/biom10081166 Authors: Shravan Morla Umesh R. Desai Elevated matrix metalloproteinase-8 (MMP-8) activity contributes to the etiology of many diseases, including atherosclerosis, pulmonary fibrosis, and sepsis. Yet, very few small molecule inhibitors of MMP-8 have been identified. We reasoned that the synthetic non-sugar mimetics of glycosaminoglycans...
Sun Aug 09, 2020 03:00
Biomolecules, Vol. 10, Pages 1164: Zinc Therapy in Early Alzheimer’s Disease: Safety and Potential Therapeutic Efficacy Biomolecules doi: 10.3390/biom10081164 Authors: Rosanna Squitti Amit Pal Mario Picozza Abofazl Avan Mariacarla Ventriglia Mauro C. Rongioletti Tjaard Hoogenraad Zinc therapy is normally utilized for treatment of Wilson disease (WD), an inherited condition that is characterized by increased levels of non-ceruloplasmin bound (‘free’)...
Sun Aug 09, 2020 03:00
Biomolecules, Vol. 10, Pages 1163: Triple Negative Breast Cancer and Breast Epithelial Cells Differentially Reprogram Glucose and Lipid Metabolism upon Treatment with Triterpenic Acids Biomolecules doi: 10.3390/biom10081163 Authors: Ângela R. Guerra Ana F. Paulino Maria M. Castro Helena Oliveira Maria F. Duarte Iola F. Duarte Plant-derived pentacyclic triterpenic acids (TAs) have gained increasing attention due to their multiple biological activities. Betulinic acid (BA)...
Sat Aug 08, 2020 03:00
Biomolecules, Vol. 10, Pages 1162: Mitochondrial Pyruvate Carrier Function in Health and Disease across the Lifespan Biomolecules doi: 10.3390/biom10081162 Authors: Jane L. Buchanan Eric B. Taylor As a nodal mediator of pyruvate metabolism, the mitochondrial pyruvate carrier (MPC) plays a pivotal role in many physiological and pathological processes across the human lifespan, from embryonic development to aging-associated neurodegeneration. Emerging research highlights the importance...
Sat Aug 08, 2020 03:00
Biomolecules, Vol. 10, Pages 1161: The CARF Protein MM_0565 Affects Transcription of the Casposon-Encoded cas1-solo Gene in Methanosarcina mazei Gö1 Biomolecules doi: 10.3390/biom10081161 Authors: Andrea Ulbricht Lisa Nickel Katrin Weidenbach Herman Vargas Gebauer Claudia Kießling Konrad U. Förstner Ruth A. Schmitz Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) loci are found in bacterial and archaeal genomes where they provide the molecular machinery...
Fri Aug 07, 2020 03:00
Biomolecules, Vol. 10, Pages 1160: Single and Combined Methods to Specifically or Bulk-Purify RNA–Protein Complexes Biomolecules doi: 10.3390/biom10081160 Authors: Roosje Van Ende Sam Balzarini Koen Geuten The ribonome interconnects the proteome and the transcriptome. Specific biology is situated at this interface, which can be studied in bulk using omics approaches or specifically by targeting an individual protein or RNA species. In this review, we focus on both RNA- and ribonucleoprotein-(RNP)...
Fri Aug 07, 2020 03:00
Biomolecules, Vol. 10, Pages 1159: Role of microRNA/Epithelial-to-Mesenchymal Transition Axis in the Metastasis of Bladder Cancer Biomolecules doi: 10.3390/biom10081159 Authors: Milad Ashrafizadeh Kiavash Hushmandi Mehrdad Hashemi Mohammad Esmaeil Akbari Peter Kubatka Mehdi Raei Lenka Koklesova Md Shahinozzaman Reza Mohammadinejad Masoud Najafi Gautam Sethi Alan Prem Kumar Ali Zarrabi Bladder cancer (BC) is the 11th most common diagnosed cancer, and...
Fri Aug 07, 2020 03:00
Biomolecules, Vol. 10, Pages 1158: Cellular Mechanisms of Melatonin: Insight from Neurodegenerative Diseases Biomolecules doi: 10.3390/biom10081158 Authors: Dongmei Chen Tao Zhang Tae Ho Lee Neurodegenerative diseases are the second most common cause of death and characterized by progressive impairments in movement or mental functioning in the central or peripheral nervous system. The prevention of neurodegenerative disorders has become an emerging public health challenge for our...
Fri Aug 07, 2020 03:00
Biosensors, Vol. 10, Pages 93: Ternary Fingerprints with Reference Odor for Fluctuation-Enhanced Sensing Biosensors doi: 10.3390/bios10080093 Authors: Xiaoyu Yu Laszlo B. Kish Jean-Luc Seguin Maria D. King An improved method for fluctuation-enhanced sensing (FES) is introduced. We enhanced the old binary fingerprinting method, where the fingerprint bit values were ±1, by introducing ternary fingerprint bits utilizing a reference odor. In the ternary method, the fingerprint...
Sun Aug 09, 2020 03:00
Brain Sciences, Vol. 10, Pages 536: Hopf Bifurcations in Complex Multiagent Activity: The Signature of Discrete to Rhythmic Behavioral Transitions Brain Sciences doi: 10.3390/brainsci10080536 Authors: Gaurav Patil Patrick Nalepka Rachel W. Kallen Michael J. Richardson Most human actions are composed of two fundamental movement types, discrete and rhythmic movements. These movement types, or primitives, are analogous to the two elemental behaviors of nonlinear dynamical systems,...
Sun Aug 09, 2020 03:00
Brain Sciences, Vol. 10, Pages 533: Subcortical T1-Rho MRI Abnormalities in Juvenile-Onset Huntington’s Disease Brain Sciences doi: 10.3390/brainsci10080533 Authors: Alexander V. Tereshchenko Jordan L. Schultz Ansley J. Kunnath Joel E. Bruss Eric A. Epping Vincent A. Magnotta Peg C. Nopoulos Huntington’s disease (HD) is a fatal neurodegenerative disease caused by the expansion of cytosine-adenine-guanine (CAG) repeats in the huntingtin gene. An increased CAG...
Sat Aug 08, 2020 03:00
Brain Sciences, Vol. 10, Pages 534: Localization of ZIP14 and ZIP8 in HIBCPP Cells Brain Sciences doi: 10.3390/brainsci10080534 Authors: Shannon E. Morgan Horst Schroten Hiroshi Ishikawa Ningning Zhao The blood–cerebrospinal fluid barrier (BCB) is important in maintaining brain manganese (Mn) homeostasis. This barrier consists of a single layer of epithelial cells, connected by tight junctions, that restrict the passage of nutrients to only allow molecules to be carried...
Sat Aug 08, 2020 03:00
Brain Sciences, Vol. 10, Pages 532: TLR Antagonism by Sparstolonin B Alters Microbial Signature and Modulates Gastrointestinal and Neuronal Inflammation in Gulf War Illness Preclinical Model Brain Sciences doi: 10.3390/brainsci10080532 Authors: Dipro Bose Ayan Mondal Punnag Saha Diana Kimono Sutapa Sarkar Ratanesh K. Seth Patricia Janulewicz Kimberly Sullivan Ronnie Horner Nancy Klimas Mitzi Nagarkatti Prakash Nagarkatti Saurabh Chatterjee The 1991...
Sat Aug 08, 2020 03:00
Brain Sciences, Vol. 10, Pages 535: Preliminary Evidence of the Role of Medial Prefrontal Cortex in Self-Enhancement: A Transcranial Magnetic Stimulation Study Brain Sciences doi: 10.3390/brainsci10080535 Authors: Birgitta Taylor-Lillquist Vivek Kanpa Maya Crawford Mehdi El Filali Julia Oakes Alex Jonasz Amanda Disney Julian Paul Keenan Humans employ a number of strategies to improve their position in their given social hierarchy. Overclaiming involves presenting...
Sat Aug 08, 2020 03:00
Brain Sciences, Vol. 10, Pages 531: Effects of Transcranial Electrical Stimulation on Human Auditory Processing and Behavior—A Review Brain Sciences doi: 10.3390/brainsci10080531 Authors: Yao Wang Limeng Shi Gaoyuan Dong Zuoying Zhang Ruijuan Chen Transcranial electrical stimulation (tES) can adjust the membrane potential by applying a weak current on the scalp to change the related nerve activity. In recent years, tES has proven its value in studying the neural processes...
Sat Aug 08, 2020 03:00
Brain Sciences, Vol. 10, Pages 530: Age-Related Changes in Attentional Refocusing during Simulated Driving Brain Sciences doi: 10.3390/brainsci10080530 Authors: Eleanor Huizeling Hongfang Wang Carol Holland Klaus Kessler We recently reported that refocusing attention between temporal and spatial tasks becomes more difficult with increasing age, which could impair daily activities such as driving (Callaghan et al., 2017). Here, we investigated the extent to which difficulties...
Fri Aug 07, 2020 03:00
Brain Sciences, Vol. 10, Pages 529: Sleepiness, Neuropsychological Skills, and Scholastic Learning in Children Brain Sciences doi: 10.3390/brainsci10080529 Authors: Luigi Macchitella Chiara Valeria Marinelli Fulvio Signore Enrico Ciavolino Paola Angelelli Excessive daytime sleepiness is a frequent condition among children and adolescents that may lead to several and significant daytime consequences, including impaired neurocognitive skills and scholastic performance. Here,...
Fri Aug 07, 2020 03:00
Brain Sciences, Vol. 10, Pages 528: Evaluation of Cerebral Microvascular Regulatory Mechanisms with Transcranial Doppler in Fabry Disease Brain Sciences doi: 10.3390/brainsci10080528 Authors: Pedro Castro Mariana Gutierres Gilberto Pereira Susana Ferreira João Paulo Oliveira Elsa Azevedo Background: Fabry disease (FD) causes cerebrovascular disease (CVD) even if asymptomatic, and this is why it is important to identify non-invasive methods to monitor the disease. We evaluated...
Fri Aug 07, 2020 03:00
Cancers, Vol. 12, Pages 2225: Risk of Cancer in Family Members of Patients with Lynch-Like Syndrome Cancers doi: 10.3390/cancers12082225 Authors: María Dolores Picó Ana Beatriz Sánchez-Heras Adela Castillejo Mar Giner-Calabuig Miren Alustiza Ariadna Sánchez Leticia Moreira María Pellise Antoni Castells Gemma Llort Carmen Yagüe Teresa Ramon y Cajal Alexandra Gisbert-Beamud Joaquin Cubiella Laura Rivas Maite Herraiz Catalina Garau Inmaculada...
Sun Aug 09, 2020 03:00
Cancers, Vol. 12, Pages 2226: Understanding the Role of Innate Immune Cells and Identifying Genes in Breast Cancer Microenvironment Cancers doi: 10.3390/cancers12082226 Authors: Israa Shihab Bariaa A. Khalil Noha Mousaad Elemam Ibrahim Y. Hachim Mahmood Yaseen Hachim Rifat A. Hamoudi Azzam A. Maghazachi The innate immune system is the first line of defense against invading pathogens and has a major role in clearing transformed cells, besides its essential role in activating...
Sun Aug 09, 2020 03:00
Cancers, Vol. 12, Pages 2224: TERT Promoter Mutation as an Independent Prognostic Marker for Poor Prognosis MAPK Inhibitors-Treated Melanoma Cancers doi: 10.3390/cancers12082224 Authors: Pauline Blateau Etienne Coyaud Estelle Laurent Benoit Béganton Vincent Ducros Géraldine Chauchard Julie A. Vendrell Jérôme Solassol Although the development of mitogen-activated protein kinase (MAPK) inhibitors has greatly improved the prognosis of BRAFV600 cutaneous melanomas, the...
Sun Aug 09, 2020 03:00
Cancers, Vol. 12, Pages 2223: Antibody-Drug Conjugates: A Promising Novel Therapy for the Treatment of Ovarian Cancer Cancers doi: 10.3390/cancers12082223 Authors: Aranzazu Manzano Alberto Ocaña Antibody-drug conjugates (ADCs) represent a novel and promising therapeutic strategy for the treatment of cancer patients. ADCs target antigens highly expressed on the membrane surface of tumor cells to selectively deliver a cytotoxic drug. Ovarian tumors differentially express tumor-specific...
Sun Aug 09, 2020 03:00
Cancers, Vol. 12, Pages 2222: Modeling the Diversity of Epithelial Ovarian Cancer through Ten Novel Well Characterized Cell Lines Covering Multiple Subtypes of the Disease Cancers doi: 10.3390/cancers12082222 Authors: Alexandre Sauriol Kayla Simeone Lise Portelance Liliane Meunier Kim Leclerc-Desaulniers Manon de Ladurantaye Meriem Chergui Jennifer Kendall-Dupont Kurosh Rahimi Euridice Carmona Diane M. Provencher Anne-Marie Mes-Masson Cancer cell lines...
Sat Aug 08, 2020 03:00
Cancers, Vol. 12, Pages 2218: Autocrine Signaling of NRP1 Ligand Galectin-1 Elicits Resistance to BRAF-Targeted Therapy in Melanoma Cells Cancers doi: 10.3390/cancers12082218 Authors: Sabrina Rizzolio Simona Corso Silvia Giordano Luca Tamagnone Melanoma cells addicted to mutated BRAF oncogene activity can be targeted by specific kinase inhibitors until they develop resistance to therapy. We observed that the expression of Galectin-1 (Gal-1), a soluble ligand of Neuropilin-1...
Sat Aug 08, 2020 03:00
Cancers, Vol. 12, Pages 2221: Identification and Validation of an Aspergillus nidulans Secondary Metabolite Derivative as an Inhibitor of the Musashi-RNA Interaction Cancers doi: 10.3390/cancers12082221 Authors: Lan Lan Jiajun Liu Minli Xing Amber R. Smith Jinan Wang Xiaoqing Wu Carl Appelman Ke Li Anuradha Roy Ragul Gowthaman John Karanicolas Amber D. Somoza Clay C. C. Wang Yinglong Miao Roberto De Guzman Berl R. Oakley Kristi L. Neufeld Liang...
Sat Aug 08, 2020 03:00
Cancers, Vol. 12, Pages 2220: Does the Use of Proton Pump Inhibitors Increase the Risk of Pancreatic Cancer? A Systematic Review and Meta-Analysis of Epidemiologic Studies Cancers doi: 10.3390/cancers12082220 Authors: Hee-Eun Hong A-Sol Kim Mi-Rae Kim Hae-Jin Ko Min Kyu Jung Background: One of the most frequently used medications for treating gastrointestinal disorders is proton pump inhibitor (PPI), which reportedly has potential adverse effects. Although the relationship...
Sat Aug 08, 2020 03:00
Cancers, Vol. 12, Pages 2217: Donor-Site Morbidity after Fibula Transplantation in Head and Neck Tumor Patients: A Split-Leg Retrospective Study with Focus on Leg Stability and Quality of Life Cancers doi: 10.3390/cancers12082217 Authors: Sameh Attia Jonas Diefenbach Daniel Schmermund Sebastian Böttger Jörn Pons-Kühnemann Christine Scheibelhut Christian Heiss Hans-Peter Howaldt The free fibula flap has been one of the most important microvascular grafts for orofacial...
Sat Aug 08, 2020 03:00
Cancers, Vol. 12, Pages 2219: Genetic and Epigenetic Regulation of the Smoothened Gene (SMO) in Cancer Cells Cancers doi: 10.3390/cancers12082219 Authors: Hong Lou Hongchuan Li Andrew R. Huehn Nadya I. Tarasova Bahara Saleh Stephen K. Anderson Michael Dean (1) Background: The hedgehog (HH) signaling pathway is a key regulator of embryonic patterning, tissue regeneration, stem cell renewal, and cancer growth. The smoothened (SMO) protein regulates the HH signaling pathway...
Sat Aug 08, 2020 03:00
Cancers, Vol. 12, Pages 2216: Splicing Anomalies in Myeloproliferative Neoplasms: Paving the Way for New Therapeutic Venues Cancers doi: 10.3390/cancers12082216 Authors: Marie Hautin Clélia Mornet Aurélie Chauveau Delphine Bernard Laurent Corcos Eric Lippert Since the discovery of spliceosome mutations in myeloid malignancies, abnormal pre-mRNA splicing, which has been well studied in various cancers, has attracted novel interest in hematology. However, despite the common...
Fri Aug 07, 2020 03:00
Cancers, Vol. 12, Pages 2214: Renal Cell Tumors: Uncovering the Biomarker Potential of ncRNAs Cancers doi: 10.3390/cancers12082214 Authors: Gonçalo Outeiro-Pinho Daniela Barros-Silva Margareta P. Correia Rui Henrique Carmen Jerónimo Renal cell tumors (RCT) remain as one of the most common and lethal urological tumors worldwide. Discrimination between (1) benign and malignant disease, (2) indolent and aggressive tumors, and (3) patient responsiveness to a specific therapy...
Fri Aug 07, 2020 03:00
Cancers, Vol. 12, Pages 2215: Role of Chemokines in the Biology of Cholangiocarcinoma Cancers doi: 10.3390/cancers12082215 Authors: Alessandra Caligiuri Mirella Pastore Giulia Lori Chiara Raggi Giovanni Di Maira Fabio Marra Alessandra Gentilini Cholangiocarcinoma (CCA), a heterogeneous tumor with poor prognosis, can arise at any level in the biliary tree. It may derive from epithelial cells in the biliary tracts and peribiliary glands and possibly from progenitor...
Fri Aug 07, 2020 03:00
Cancers, Vol. 12, Pages 2210: Human FBXL8 Is a Novel E3 Ligase Which Promotes BRCA Metastasis by Stimulating Pro-Tumorigenic Cytokines and Inhibiting Tumor Suppressors Cancers doi: 10.3390/cancers12082210 Authors: Shu-Chun Chang Wayne Hsu Emily Chia-Yu Su Chin-Sheng Hung Jeak Ling Ding The initiation and progression of breast cancer (BRCA) is associated with inflammation and immune-overactivation, which is critically modulated by the E3 ubiquitin ligase. However, the underlying...
Fri Aug 07, 2020 03:00
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