Publication date: Available online 9 August 2020Source: American Journal of OtolaryngologyAuthor(s): Bulent Satar
Publication date: Available online 8 August 2020Source: American Journal of OtolaryngologyAuthor(s): Bassel Hallak, Stephan Graber, Salim Bouayed, Pedro S. Teiga
Publication date: Available online 8 August 2020Source: American Journal of OtolaryngologyAuthor(s): Kamil Gokce Tulaci, Erhan Arslan, Tugba Tulaci, Hasmet Yazici
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Publication date: June 2020Source: Auris Nasus Larynx, Volume 47, Issue 3Author(s):
Publication date: June 2020Source: Auris Nasus Larynx, Volume 47, Issue 3Author(s):
Publication date: June 2020Source: Auris Nasus Larynx, Volume 47, Issue 3Author(s):
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Abstract Non-inferiority randomized clinical trials are indicated when it is intended to prove that an experimental group is not inferior to a control group by more than a margin of non-inferiority. However, this type of study differs from traditional randomized clinical trials (superiority studies) because they have particularities that impact on the formulation of hypothesis to be tested, experimental design (non-inferiority margin determination, adapted sample size calculation, sensitivity of...
Abstract Clinical interventions in dental practice should be determined based on the best scientific evidence available. Well-designed randomized clinical trials (RCTs) provide important evidence supporting the efficacy of interventions and are usually considered as the best primary evidence. However, the strict criteria adopted by most RCTs reduce their external validity since some findings from these studies might not work under usual conditions. On the other hand, practice-based research (PBR)...
Abstract The impact of clinical trials on patient care depends on the outcomes that they evaluate. In Dentistry, many trials use outcomes that are important to clinicians, but not to the patients. Thus, the aim of the present manuscript is to present an overview of the limitations, challenges, and proposals on the use of clinically relevant outcomes (CRO) in dental trials. Clinically relevant outcomes are variables that directly measure how the patient feels, functions, or survives. Some CROs, such...
Abstract Clinical research needs to formulate a question, which must be answered by obeying ethical precepts with well-defined inclusion/exclusion criteria and approval of the study on platforms of ethical appreciation and clinical trial records. In comparing the results or clinically relevant outcomes should be prioritized in the study of techniques, products, inputs, drugs and therapies. However, it is not always possible to use long study drawings, with many participants, and with many costs,...
Abstract Recently, there has been greater interest in adopting a more holistic approach to healthcare. However, this trend should not limit itself merely to the notion that a human being lies behind the mouth being treated. Rather, it should embrace the understanding that this human can actively participate in and contribute to the treatment process. Patient Report Outcome Measures (PROMs) and Patient Report Experience Measures (PREMs) provide means for measuring data from the patient’s perspective,...
Abstract Economic evaluations in Dentistry have been increasing in recent years. They are a relevant contribution if an economic issue exists. Knowing if a new intervention is an efficient way of allocating available (and scarce) resources (the concept of opportunity costs), a well-designed economic evaluation may be helpful. One option is to conduct a trial-based economic analysis, which extracts a considerable board of information from a trial. This approach produces a more controlled result since...
Abstract The present manuscript discussed some relevant aspects related to private sponsored clinical trials in dentistry. For decades, the academy has been the major responsible for research in Brazil. Distant from the trade sector, academic research has not always provided clear benefits to society. A key aspect of making benefits clearer is the process of scientific knowledge transference to decision-makers, which is, in fact, the ground of evidence-based dentistry. Although private sponsoring...
Abstract Physicians and dentists usually make clinical decisions and recommendations without a clear understanding of the meaning of the numbers regarding the accuracy of diagnostic tests and the efficacy of treatments. This critical review aimed to identify problems in the communication of diagnostic test accuracy and treatment benefits and to suggest strategies to improve risk communication in these contexts. Most clinical decisions are taken under uncertainty. Health professionals cannot predict...
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Coronavirus disease 2019 (COVID-19) is a highly infectious respiratory illness caused by SARS-CoV-2. Not much is yet known about this new viral disease. In our early encounter with the COVID-19, before the pandemic and during the early days of dealing with this novel viral disease in our country, we saw some cases of anosmia in patients infected by SARS-CoV-2. In many cases, this chemosensitive dysfunction persisted after the negativization of the nasopharyngeal swab. We report effective treatment...
Maxillary sinus floor elevation (sinus lift) is a widely recognized dental-surgical approach for dental implant placement. However, for an otorhinolaryngological high-risk patient with severe anatomic-structural impairments of the maxillary sinus drainage pathway, surgical intervention is recommended before sinus lift to avoid postsinus lift maxillary sinusitis. Here, we show a case that postsinus lift maxillary sinusitis in such a high-risk patient was noninvasively prevented by the collaboration...
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AbstractIt is well established that early blindness results in enhancement of the remaining non-visual sensory modalities accompanied by functional and anatomical brain plasticity. While auditory and tactile functions have been largely investigated, the results regarding olfactory functions remained less explored and less consistent. In the present study, we investigated olfactory function in blind mice using three tests: the buried food test, the olfactory threshold test and the olfactory performance...
AbstractThe current prevalence of obesity has been linked to the consumption of highly palatable foods and may be mediated by a dysregulated or hyposensitive orosensory perception of dietary fat, thereby contributing to the susceptibility to develop obesity. The goal of the current study was to investigate the role of lingual taste input in obesity-prone (OP, Osborne-Mendel) and obesity-resistant (OR, S5B/Pl) rats on the consumption of a high fat diet (HFD). Density of fungiform papillae was assessed...
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Abstract Background The evaluation of voice quality with acoustic measurements is useful to objectify the diagnostic process. Particularly, breathiness was highly evaluated and the Acoustic Breathiness Index (ABI) might have promising features. Objective of review The goal of the present meta‐analysis is to quantify, from existing cross‐validation studies, the evidence for the diagnostic accuracy of ABI, including its sensitivity and specificity. Type of review Meta‐analysis Search...
Abstract Chronic cases of otitis externa, resistant to conventional treatments are notoriously difficult to treat, with resolution in these casesbeing challenging. Guidelines suggest the use of corticosteroid in chronic otitis externa, however, there is no specific advice on which corticosteroid to utilise. Our case‐series demonstrates the potential benefit of fluticasone propionate in patients who have previously failed a multitude of conventional management options. Despite the limitations...
Abstract Central skull base osteomyelitis has an infective pathology located in the deep‐seated regions of the skull base, close to critical neurovascular structures. The disease has significant morbidity and mortality risks associated with it especially if early specific management is not initiated. The diagnostic and therapeutic challenges are in identifying the causative organisms and administering specific antimicrobial therapy on a long‐term basis. The routine nasopharyngeal...
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Conditions: Gastric Adenocarcinoma; Esophageal Squamous Cell CarcinomaIntervention: Drug: Anlotinib Hydrochloride With NivolumabSponsor: Shanghai Zhongshan HospitalNot yet recruiting
Conditions: Esophageal Cancer; Lymph Node Metastases; Diagnoses DiseaseIntervention: Diagnostic Test: 99mTc-3PRGD2Sponsors: Fifth Affiliated Hospital, Sun Yat-Sen University; Peking UniversityRecruiting
Conditions: Clear Cell Renal Cell Cancer; Non-Small-Cell Lung Cancer; Triple Negative Breast Neoplasms; Squamous Cell Cancer of Head and Neck; Small Cell Lung Cancer; Gastric Cancer; Melanoma; Cervical Cancer; Advanced Solid TumoursInterventions: Drug: AZD8701; Biological: DurvalumabSponsor: AstraZenecaNot yet recruiting
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ABSTRACT Traction force microscopy (TFM) is a well‐established technique traditionally used by biophysicists to quantify the forces adherent biological cells exert on their microenvironment. As image processing software becomes increasingly user‐friendly, TFM is being adopted by broader audiences to quantify contractility of (myo)fibroblasts. While many technical reviews of TFM’s computational mechanics are available, this review focuses on practical experimental considerations for dermatology researchers...
ABSTRACT Advanced glycation end products (AGEs) interact with the membrane‐bound receptor for AGEs (RAGE), consequently amplifying the inflammatory response. Soluble receptor for AGE (sRAGE) and endogenous secretory RAGE (esRAGE) act as decoys for AGE and competitively sequester RAGE ligands, thereby serving a cytoprotective role. Our objective was to investigate AGE expression and their receptors in the serum and skin of patients with atopic dermatitis (AD). In this case‐control study, the levels...
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Abstract Background Patients with the heritable disease, Fanconi anemia (FA), have a 500‐fold risk of developing head and neck squamous cell carcinomas (HNSCC). However, the use of conventional cytotoxic agents including radiation therapy and cisplatin‐based chemotherapy is contraindicated in patients with FA due to underlying DNA repair defects. Methods/Results We present a young FA patient with recurrent HNSCC and high‐risk pathologic features treated with a therapeutic trial of chemoradiation....
Abstract Background Radiation for patients with head and neck cancer (HNC) is associated with painful mucositis that impacts the delivery of treatment and contributes to high symptom burden. Methods This was a prospective, randomized pilot trial. Eligible patients received primary or adjuvant chemoradiation. Patients were randomized to usual care vs usual care plus gabapentin titrated to drug tolerance during radiation. Patients completed a symptom survey at baseline and weekly during therapy....
Abstract The aim of this study is to evaluate the efficacy and long‐term outcome of a modification of the anterior‐posterior tongue rotation flap used for reconstruction of tongue following cancer ablation. From April 2016 to September 2017, 21 consecutive patients with tumor classification (T2), lymph node classification (N0) tongue cancer on the anterior and middle one‐third portion were selected for this study. A modification of the anterior‐posterior tongue rotation flap was selected for tongue...
Abstract Background Central neck scars following thyroidectomy can negatively impact patient quality of life. Transoral endoscopic thyroidectomy can reduce postoperative cosmetic burden. Methods Prospective cohort study of patients seen between June 2018 and January 2019. Scar cosmesis was determined using the validated Scar Cosmesis Assessment and Rating (SCAR) scale and a Visual Analog Scale (VAS) measuring color, contour, and irregularity. Results Eighty‐one patients (80% female,...
Abstract Concurrent chemo‐radiotherapy is the non‐surgical mainstay of treatment for locally advanced head and neck squamous cell carcinoma (HNSCC). The following aspects have emerged as fundamental components of the combined approach: first, intensity modulated radiotherapy (IMRT) is the minimum standard technical requirement, with level 1 evidence in support of its reduction of late treatment‐induced morbidity in comparison with 3D conformal radiotherapy. Second, cisplatin‐based chemotherapy is...
Abstract Background Patients requiring intensive upper airway reconstruction are anatomically restricted in terms of the respiratory support they can receive. While intraoperative extracorporeal membrane oxygenation (ECMO) has been effectively utilized, little has been shown regarding the utility of ECMO for long‐term support in these patients. Methods We demonstrate how a patient with tongue and hypopharyngeal squamous cell carcinoma that necessitated upper airway reconstruction was supported...
Abstract Microsurgical reconstruction for anterior maxillary defects presents a surgical challenge. The objective of this study was to ascertain the feasibility of a new series of intraoral surgical approach using deep circumflex iliac artery (DCIA) flap to achieve functional reconstruction for anterior maxillary defects. Two male patients with anterior maxillary defects (Brown Class IC) were treated in this study. Both patients underwent computer‐assisted maxillary reconstruction with a DCIA flap...
Abstract Recent modifications in the management of well‐differentiated thyroid cancer have resulted in significant alterations in clinical approach. Utilizing a series of preoperative and postoperative risk factors involving both the patient and the disease pathology, we offer the term “staged thyroidectomy” to help organize these risk factors for patients and the endocrine team to optimize management. This approach is intended to incorporate our latest nuanced understanding of certain endocrine...
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Abstract This study evaluates the prognostic impact of several factors in oropharyngeal squamous cell carcinoma (OPSCC), controlling for human papillomavirus (HPV)-associated tumors and stage (American Joint Committee on Cancer 8th edition). All patients in Southern California Permanente Medical Group diagnosed with OPSCC between 2006 and 2012 tested for p16 immunohistochemistry were included. Review of all pathology materials was combined with central p16 testing. Multivariable...
Abstract Primary angiosarcoma of salivary glands is a rare entity that most commonly arises in the parotid gland and affects adults and the elderly. Angiosarcoma of the parotid gland in a child is exceedingly rare and thus can be a diagnostic challenge. We present a case of angiosarcoma of the parotid gland in a 6-year-old female child with bilateral lung metastases. The patient underwent chemotherapy and showed a partial response. Awareness of this entity in salivary glands...
Abstract In 2015, Lewis et al. first described low-grade papillary Scheneiderian carcinoma (LGPSC) of the sinonasal tract. Their case resembled a sinonasal papilloma clinically and histopathologically; however, invasion and metastasis resulted in the death of the patient despite absence of malignant cytologic features. Additional reports established LGPSC as a distinct entity and characterized its immunohistochemical profile. Diffuse expression of low molecular weight cytokeratins,...
Abstract Clear cell odontogenic carcinoma (CCOC) is a rare and aggressive malignant epithelial neoplasm, which occurs most frequently in the mandible of elderly patients. Morphologically, CCOC shares similar characteristics with other clear cell tumors, especially hyalinizing clear cell carcinoma of the salivary glands (HCCC). Both CCOC and HCCC are known to harbor EWSR1 rearrangements, especially the EWSR1–ATF1 gene fusion, which indicates a possible link between the two lesions....
Abstract Juvenile mandibular chronic osteomyelitis (JMCO) is a rare, idiopathic disease of chronic bone inflammation without suppuration, sinus tract formation, or sequestration. As the name suggests, this condition predominately affects children. The few cases of JMCO reported in the literature describe different treatments, and thus a standard therapy protocol has not yet been established. The aim of this paper is to report a clinical case in a 9-year-old girl that was misdiagnosed...
Abstract Intravascular papillary endothelial hyperplasia (IPEH) is a benign, highly vascularized, endothelial growth that can be mischaracterized as a malignancy. While hundreds of IPEH cases are reported, only four occurred in the maxillary sinus. We present the case of a 28-year-old male who underwent surgical resection of IPEH of the right maxillary sinus. An additional consideration was the patient’s condition of univentricular tricuspid atresia which contributed to chronic...
Abstract Alveolar soft part sarcoma (ASPS) is a rare soft tissue tumor of unknown histogenesis generally characterized by the der(17)t(X;17)(p11.2;q25) translocation which results in the ASPSCR1-TFE3 gene fusion. Primary ASPS of the thyroid gland has not yet been reported. During oncology follow-up for breast cancer, a pulmonary nodule and thyroid gland mass were identified in a 71-year-old Korean male. Thyroid ultrasound showed a 5.7 cm left thyroid gland mass. After several...
Abstract To evaluate the prognostic significance of tumor infiltrating lymphocytes (TILs) and of CD8+ T-cell subsets in patients with surgically treated laryngeal squamous cell carcinoma (LSCC), LSCC from 283 patients were examined. TIL density was morphologically assessed on whole sections. CD8+ cell counts/mm2 were evaluated on multiple tissue microarray cores per tumor (median counts for high/low CD8+/mm2). TIL density and CD8+ counts weakly correlated with each other (Spearman’s...
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Zusammenfassung Die chirurgische Therapie, unabhängig vom Verfahren, besitzt trotz Fortschritte in der Strahlen- und Immuntherapie unverändert einen großen Stellenwert in der heutigen Behandlung von oropharyngealen Karzinomen. Der individuelle Behandlungsplan sollte in einer gemeinsamen Gesprächsführung mit dem Patienten und in einer interdisziplinären Tumorkonferenz, unter Berücksichtigung der Erreichbarkeit tumorfreier Resektionsgrenzen und einer angemessenen postoperativen Lebensqualität,...
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Related Articles Reply to letter to the editor "The role of fine-needle aspiration biopsy (FNAB) in the diagnostic management of parotid gland masses with emphasis on potential pitfalls". Eur Arch Otorhinolaryngol. 2020 Aug 07;: Authors: Dostalova L, Kalfert D, Jechova A, Koucky V, Novak S, Kuchar M, Zabrodsky M, Novakova Kodetova D, Ludvíkova M, Kholova I, Plzak J PMID: 32767168 [PubMed - as supplied by publisher]
Related Articles Is the spread of excitation width correlated to the speech recognition in cochlear implant users? Eur Arch Otorhinolaryngol. 2020 Aug 07;: Authors: da Silva JC, Goffi-Gomez MVS, Magalhães AT, Tsuji RK, Bento RF Abstract PURPOSE: To assess whether there is an interference of the spread of excitation (SOE) on speech recognition. METHODS: Retrospective cross-sectional study, approved by the institution's ethics committee...
Related Articles Caregivers' absence from work before and after tonsil surgery in children with sleep-disordered breathing. Eur Arch Otorhinolaryngol. 2020 Aug 07;: Authors: Gudmundsdottir J, Lindgren J, Thorpö M, Johansson H, Hellgren J, Gudnadottir G Abstract PURPOSE: Sleep-disordered breathing, SDB, in children is associated with morbidity that can result in caregivers having to stay at home from work. The aim of this study was to investigate...
Does the principle of homologous groups allow a reduction of allergens in the skin prick test panel?
Related Articles Does the principle of homologous groups allow a reduction of allergens in the skin prick test panel? Eur Arch Otorhinolaryngol. 2020 Aug 07;: Authors: Eder K, Markmann S, Gellrich D, Mann SL, Högerle C, Gröger M Abstract PURPOSE: Regulatory and economic conditions drive the application of the concept of homologous groups on therapeutic and diagnostic formulations. In this context, a possible reduction of allergens in the skin...
Related Articles Use of PerClot® in head and neck surgery: a Scottish centre experience. Eur Arch Otorhinolaryngol. 2020 Aug 06;: Authors: Rao K, Gomati A, Yeun Tong E, W Ah-See K, Shakeel M Abstract OBJECTIVE: PerClot® is a biocompatible, polysaccharide haemostatic system recommended for surgical procedures. It is an absorbable modified polymer that is non-pyrogenic and is derived from purified plant starch. Our goal was to evaluate the safety,...
Related Articles Who are good adult candidates for cartilage conduction hearing aids? Eur Arch Otorhinolaryngol. 2020 Aug 06;: Authors: Nishiyama T, Oishi N, Ogawa K Abstract PURPOSE: Cartilage conduction hearing aids (CC-HAs) are novel hearing aids using the third hearing pathway of cartilage conduction. We assessed the efficacy of CC-HAs in adult hearing-loss patients who had various anatomical conditions of their ear canal(s) and determined...
Related Articles Endoscope holder-assisted endoscopic coblation tonsillectomy. Eur Arch Otorhinolaryngol. 2020 Aug 05;: Authors: Parab SR, Khan MM Abstract BACKGROUND: Tonsillectomy is being performed either with a headlight, surgical loupe magnification or with microscopic aid. We report the technique of endoscope holder-assisted endoscopic tonsillectomy using coblation. Coblation tonsillectomy has the primary advantage of limited thermal damage...
Related Articles The bony obliteration tympanoplasty in cholesteatoma: safety, hygiene and hearing outcome: allograft versus autograft tympanic membrane reconstruction. Eur Arch Otorhinolaryngol. 2020 Aug 05;: Authors: van Waegeningh HF, van Dinther JJS, Vanspauwen R, Zarowski A, Offeciers E Abstract OBJECTIVE: To evaluate early results on hygiene, safety and functional outcome in a population undergoing a canal wall up technique with bony obliteration...
Related Articles Efficacy of Rhino-Protect ointment after endoscopic sinus surgery: a prospective, randomized, multicenter study. Eur Arch Otorhinolaryngol. 2020 Aug 05;: Authors: Cho KS, Kim SW, Kim JK, Kim CH Abstract OBJECTIVE: Blocking airflow into the sinonasal cavity after surgery may help to keep the cavity moist and thus decrease postoperative crusting. Here we investigated the efficacy of Rhino-Protect ointment following endoscopic...
Related Articles The Antwerp Vestibular Compensation Index (AVeCI): an index for vestibular compensation estimation, based on functional balance performance. Eur Arch Otorhinolaryngol. 2020 Aug 05;: Authors: Verbecque E, Wuyts FL, Vanspauwen R, Van Rompaey V, Van de Heyning P, Vereeck L Abstract PURPOSE: To create an index that is a measure of the amount of vestibular compensation and for which only functional balance performance is needed....
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J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1714108 Objectives Presently, there are no standards for reporting outcomes of endoscopic endonasal skull base reconstruction (ESBR). This is problematic as a lack of consistent reporting makes synthesizing findings in systematic reviews and meta-analysis challenging. Thus, the aim of this study was to systematically review and describe the patterns of reporting outcomes in ESBR as a foundation for developing reporting guidelines. ...
J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1714077Orbital surgery can result in damage to ocular and orbital structures, leading to a range of structural and visual sequelae, including corneal abrasions, globe malposition, diplopia, and blindness. Vision loss in particular is the most feared and devastating complication, occurs with an overall incidence of 0.84%, and can occur secondary to direct injury, optic nerve compression, or ischemic events. Different types of orbital surgery and surgical...
J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1713904The lateral orbitotomy approach (LOA) was first described by Kronlein in 1888 and has since been subject to many modifications and variations. When considering orbital approaches, the location of the pathology is often more important in decision making than the type of pathology. The LOA is best suited for access to intraconal and extraconal lesions lateral to the optic nerve. Pathologies treated via the LOA include primary orbital tumors, extraorbital...
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Malformations of the temporal bone present different challenges to the implantation of a transcutaneous active bone conduction device, such as Bonebridge (Med-el, Innsbruck, Austria). This study aims to descri...
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Background: Confirmation of permanent hearing loss in a newborn should be followed by a search for an underlying etiology because this may impact hearing loss management and counselling. Methods: Retrospective chart review of all newborns seen at a tertiary referral center after referral from newborn hearing screening over a 20-year period. The changes in the diagnostic protocol over the years are outlined and the most recent protocol includes targeted next-generation sequencing using...
Objective: Identify clinical screening tests to proficiently screen for patients with vestibular disorders. Study design: Retrospective case-control study. Setting: Tertiary referral center. Patients: 318 healthy individuals and 331 subjects with vestibular disorders. Interventions: All subjects performed Romberg and Jendrassic maneuver with eyes closed (ROMJec), standing on foam with eyes open (SOFeo) and eyes closed (SOFec), Tandem Romberg with eyes open...
Objective: Compare outcomes for patients who were seen via telemedicine visits after otology/neurotology surgical procedures with those who were seen in traditional office visits. Study Design: Retrospective case review. Setting: Tertiary care academic medical center. Patients: Inclusion criteria were patients who underwent otologic/neurotologic surgery and were seen in at least one telemedicine visit for postoperative care. Intervention (s): Telemedicine...
Background: For clinical confirmation of the diagnosis of hydropic ear disease (HED) (Menière) by MR imaging, two routes of contrast enhancement of the perilymphatic space are currently being used: intratympanic and intravenous. While unilateral intratympanic contrast application generally enables a higher perilymph signal intensity and image quality, the intravenous route allows for imaging of both inner ears simultaneously. It is conceivable that intratympanic contrast application to one ear...
Objective: Although it is commonly held that otosclerosis has become increasingly uncommon over recent decades, no population-based data exist to characterize this trend. Moreover, because most large epidemiologic databases within the United States primarily include cancer data, even the modern incidence of otosclerosis is unknown. The chief objective of the current work was to characterize the trend in the incidence of otosclerosis over 70 years using the unique resources of the Rochester Epidemiology...
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Publication date: Available online 7 August 2020Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): Remi Hervochon, Sarah Atallah, Sarah Levivien, Natacha Teissier, Bertrand Baujat, Frederic Tankere
Publication date: Available online 6 August 2020Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): I. Mosnier, E. Ferrary, K. Aubry, P. Bordure, A. Bozorg-Grayeli, O. Deguine, C. Eyermann, V. Franco-Vidal, B. Godey, N. Guevara, A. Karkas, N. Klopp, M. Labrousse, J.-P. Lebreton, Y. Lerosey, E. Lescanne, N. Loundon, R. Marianowski, F. Merklen, K. Mezouaghi
Publication date: Available online 6 August 2020Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): R. Jankowski
Publication date: Available online 6 August 2020Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): D. Garcia
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Publication date: Available online 9 August 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): A. Binet, O. El Ezzi, A. De Buys Roessingh
Publication date: Available online 9 August 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Hailey M. Umbaugh, Canice E. Crerand, Nicola M. Stock, Daniela V. Luquetti, Carrie L. Heike, Amelia F. Drake, Kristin J. Billaud Feragen, Alexis L. Johns
Publication date: Available online 8 August 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Ameen Biadsee, Or Dagan, Firas Kassem, Tom Ben-Dov, Yaniv Ebner
Publication date: Available online 8 August 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): J. Nicodemo, E. Hamersley, P. Baker, S. Reed
Publication date: Available online 8 August 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Gallus Roberto, Rizzo Davide, De Luca Laura Maria, Melis Andrea, Kilghren Caterina, Parente Paolo, Anzivino Roberta, Frezza Simonetta, Priolo Francesca, Bussu Francesco, Conti Guido
Publication date: Available online 8 August 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Michael D. Puricelli, Reza Rahbar, Gregory C. Allen, Karthik Balakrishnan, Matthew T. Brigger, Sam J. Daniel, Pierre Fayoux, Steven Goudy, Richard Hewitt, Wei-Chung Hsu, Jonathan B. Ida, Romaine Johnson, Nicolas Leboulanger, Scott M. Rickert, Soham Roy, John Russell, Michael Rutter, Douglas Sidell, Marlene Soma, Briac Thierry
Publication date: Available online 8 August 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Max Sallis Osborne, Anne Child-Hymas, Ann Louise McDermott
Publication date: Available online 8 August 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Sarah Lookabaugh, Margo McKenna, Sveta Karelsky, Michael Davis, Amanda Didas, Paul Allen, John Faria
Publication date: Available online 7 August 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Walaa Kamal Eldin Mohamed, Marc Arnoux, Thyago H.S. Cardoso, Abdullah Almutery, Abdelaziz Tlili
Publication date: Available online 7 August 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Mana Espahbodi, Samantha L. Kallenbach, Abigail A. Thorgerson, Chiang-Ching Huang, Sophie G. Shay, Michael E. McCormick, Robert H. Chun
Publication date: Available online 7 August 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Guoqiang Gao, Tao Fu, Wenhui Pang, Xiaoheng Zhang, Zuorong Qin, Ruifeng Ge, Aifeng Li
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Objective Liquid thickeners are commonly recommended in individuals with dysphagia and recurrent aspiration as a strategy for pneumonia prevention. The goal of this study was to examine the effects of small amounts of aspirated liquid thickener on the lungs. Study design Animal model. Prospective small animal clinical trial. Methods Adult Sprague Dawley rats (n = 19) were divided into two groups and underwent three intratracheal instillations of either xanthan gum‐based nectar‐thick...
Objectives To evaluate the rate of lymph node metastasis in parotid gland acinar cell carcinoma, to identified factors associated with increased risk of metastasis, and to evaluate the effect of nodal metastasis on survival. Methods This is a retrospective cohort study utilizing data from a large population‐based cancer database. Data were extracted from the Surveillance, Epidemiology, and End Results (SEER) 18 database. The study cohort included patients with parotid gland acinar cell carcinoma...
Objectives To evaluate and compare the oncological and functional outcomes of total laryngectomies (TL) performed as first line treatment or for salvage after failure of conservative approaches for treating advanced laryngeal carcinoma (LSCC). Study Design A retrospective cohort study. Methods A cohort of 217 patients who underwent TL was divided according to whether the procedure was for primary treatment of their LSCC (101 patients) or for recurrences after conservative surgery or...
Objectives/Hypothesis Eosinophilic and noneosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP and NECRSwNP) show distinguished clinical pathology, but their underlying mechanism remains unclear. We aimed to investigate the clinical, hematological, and histopathological changes in chronic rhinosinusitis with nasal polyps (CRSwNP) endotypes and its association with microbiota. Study Design A comparative cross‐sectional study. Methods A comparative study of 46 patients with CRSwNP...
We present a rare iatrogenic cholesteatoma of the neck in a ten year old male four years after tympanomastoidectomy, an entity that to our knowledge has not been published in the literature for over 30 years. Furthermore, we discuss the diagnostic uncertainty of typical magnetic resonance imaging protocols for pediatric neck lesions and the improved diagnostic specificity of diffusion weighted magnetic resonance imaging. En bloc surgical extirpation was performed. Laryngoscope , 2020
Objective Detection of fetal airway compromise through imaging raises the possible need for ex utero intrapartum treatment (EXIT) procedures. Despite EXIT procedures involving massive resource utilization and posing increased risk to the mother, decisions for EXIT are usually based on anecdotal experience. Our objectives were to analyze prenatal consultations with potential fetal airway obstruction for imaging and obstetric findings used to determine management strategy. Methods Retrospective...
Objectives/Hypothesis Little data exists regarding the relationship between socioeconomic and demographic factors and tracheostomy outcomes. The goal of this study was to determine associations between socioeconomic status (SES), demographic factors, and insurance status with hospital length of stay (LOS), intensive care unit (ICU) LOS, and mortality following tracheostomy. Study Design Retrospective cohort study. Methods A retrospective analysis of all patients who underwent tracheostomy...
The prevalence of residual epiphora following successful periocular surgery for facial nerve paralysis can be as high as 30% or more. The pathophysiology of residual epiphora is complex, but identification of the etiology is paramount because the therapeutic approach varies accordingly. Treatments range from medical management of systemic disease to botulinum toxin injections for conditions that arise from aberrant reinnervation to surgical procedures that bypass the lacrimal drainage system completely....
Objectives Familial non‐medullary thyroid cancer (FNMTC) is a distinct entity, increasingly diagnosed. By lacking an accurate genetic diagnostic test, its diagnosis is currently clinically based, with an ongoing debate over whether it has a more aggressive clinical behavior than sporadic non‐medullary thyroid cancer (SNMTC). We seek to compare in this study, the clinicopathological variables, and the outcome of FNMTC versus SNMTC patients. Methods We retrospectively searched a database of...
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