Biomedicine & Pharmacotherapy

<em>Moringa oleifera</em> leaf extract enhances endothelial nitric oxide production leading to relaxation of resistance artery and lowering of arterial blood pressure

Publication date: October 2020Source: Biomedicine & Pharmacotherapy, Volume 130Author(s): Direk Aekthammarat, Panot Tangsucharit, Patchareewan Pannangpetch, Thanaporn Sriwantana, Nathawut Sibmooh

Biomedicine & Pharmacotherapy

Sun Aug 09, 2020 22:51

<em>Aster tataricus</em> attenuates asthma efficiently by simultaneously inhibiting tracheal ring contraction and inflammation

Publication date: October 2020Source: Biomedicine & Pharmacotherapy, Volume 130Author(s): Yijun Chen, Hao Wu, Yueting Li, Jie Liu, Zhixin Jia, Wenjuan Xu, Hongbin Xiao, Wei Wang

Biomedicine & Pharmacotherapy

Sun Aug 09, 2020 22:51

Prolonged caffeine intake decreases alveolar bone damage induced by binge-like ethanol consumption in adolescent female rats

Publication date: October 2020Source: Biomedicine & Pharmacotherapy, Volume 130Author(s): Cristiane Maia, Bruno Gonçalves Pinheiro, Carla Cristiane Soares da Silva, Rodrigo A. Cunha, Deiweson Souza-Monteiro, Maria Karolina Martins Ferreira, Tuany Rafaeli Schmidt, Gabriela de Souza Balbinot, Fabrício Mezzomo Collares, Manoela Domingues Martins, Rafael Rodrigues Lima

Biomedicine & Pharmacotherapy

Sun Aug 09, 2020 22:51

MicroRNAs in autoimmune liver diseases: from diagnosis to potential therapeutic targets

Publication date: October 2020Source: Biomedicine & Pharmacotherapy, Volume 130Author(s): Chen Huang, Xian Xing, Xinyu Xiang, Xiaoli Fan, Ruoting Men, Tinghong Ye, Li Yang

Biomedicine & Pharmacotherapy

Sun Aug 09, 2020 22:51

SIRT1 is a key regulatory target for the treatment of the endoplasmic reticulum stress-related organ damage

Publication date: October 2020Source: Biomedicine & Pharmacotherapy, Volume 130Author(s): Fuquan Wang, Shanglong Yao, Haifa Xia

Biomedicine & Pharmacotherapy

Sun Aug 09, 2020 22:51

Dysregulation of non-coding RNAs in Rheumatoid arthritis

Publication date: October 2020Source: Biomedicine & Pharmacotherapy, Volume 130Author(s): Mohammad Taheri, Reyhane Eghtedarian, Marcel E. Dinger, Soudeh Ghafouri-Fard

Biomedicine & Pharmacotherapy

Sun Aug 09, 2020 22:51

Acute metformin treatment provides cardioprotection via improved mitochondrial function in cardiac ischemia / reperfusion injury

Publication date: October 2020Source: Biomedicine & Pharmacotherapy, Volume 130Author(s): Siripong Palee, Louis Higgins, Tom Leech, Siriporn C. Chattipakorn, Nipon Chattipakorn

Biomedicine & Pharmacotherapy

Fri Aug 07, 2020 14:17

Pharmacokinetics and antiangiogenic studies of potassium koetjapate in rats

Publication date: October 2020Source: Biomedicine & Pharmacotherapy, Volume 130Author(s): Seyedeh F. Jafari, Fouad Saleih R. Al-Suede, Ashwaq H.S. Yehya, Mohamed B.K. Ahamed, Armaghan Shafaei, Muhammad Asif, Yasser M. Tabana, Amin M.S.A. Majid, Hussein M. Baharetha

Biomedicine & Pharmacotherapy

Fri Aug 07, 2020 14:17

Tanshinone IIA attenuates acetaminophen-induced hepatotoxicity through HOTAIR-Nrf2-MRP2/4 signaling pathway

Publication date: October 2020Source: Biomedicine & Pharmacotherapy, Volume 130Author(s): Xiqian Zhang, Ting Wang, Yujie Yang, Ruina Li, Ya Chen, Rong Li, Xuehua Jiang, Ling Wang

Biomedicine & Pharmacotherapy

Fri Aug 07, 2020 14:17

Characterisation of endogenous Galectin-1 and -9 expression in monocyte and macrophage subsets under resting and inflammatory conditions

Publication date: October 2020Source: Biomedicine & Pharmacotherapy, Volume 130Author(s): Franziska Krautter, Carlota Recio, Mohammed T. Hussain, Danielle R. Lezama, Francesco Maione, Myriam Chimen, Asif J. Iqbal

Biomedicine & Pharmacotherapy

Fri Aug 07, 2020 14:17

Emerging role of non-coding RNAs in allergic disorders

Publication date: October 2020Source: Biomedicine & Pharmacotherapy, Volume 130Author(s): Soudeh Ghafouri-Fard, Hamed Shoorei, Mohammad Taheri, Marek Sanak

Biomedicine & Pharmacotherapy

Fri Aug 07, 2020 14:17

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 Brachytherapy

Paracervical Blocks Facilitate Timely Brachytherapy Amidst COVID-19

Publication date: Available online 7 August 2020Source: BrachytherapyAuthor(s): Daniel Brunnhoelzl, Alexander N. Hanania, Alfredo Echeverria, Jan Sunde, Connie Tran, Michelle Ludwig

Brachytherapy

Sat Aug 08, 2020 20:38

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 Clinical Therapeutics

Challenges and Opportunities for Clinical Pharmacogenetic Research Studies in Resource-Limited Settings: Conclusions From the Council for International Organizations of Medical Sciences–Ibero-American Network of Pharmacogenetics and Pharmacogenomics Meeting

Publication date: Available online 8 August 2020Source: Clinical TherapeuticsAuthor(s): Eva Peñas-LLedó, Enrique Terán, Marta Sosa-Macías, Carlos Galaviz-Hernández, Jose-Pedro Gil, Sujit Nair, Shyam Diwakar, Isabel Hernández, Julio Lara-Riegos, Ronald Ramírez-Roa, Ignacio Verde, Eduardo Tarazona-Santos, Juan Molina-Guarneros, Graciela Moya, Lembit Rägo, Adrián LLerena

Clinical Therapeutics

Sun Aug 09, 2020 15:43

The Unmet Medical Needs of Current Injectable Antidiabetic Therapies in China: Patient and Health Care Professional Perspectives

Publication date: Available online 8 August 2020Source: Clinical TherapeuticsAuthor(s): Taixiong Chen, Li Zhou, Ke Wang, Xiao Ma, Haiya Wu, Xin Liu, Jingyu Tong, Bojing Cai, Qiuhe Ji

Clinical Therapeutics

Sun Aug 09, 2020 15:43

Assessment of the Regulatory Dialogue Between Pharmaceutical Companies and the European Medicines Agency on the Choice of Noninferiority Margins

Publication date: Available online 8 August 2020Source: Clinical TherapeuticsAuthor(s): Turki A. Althunian, Anthonius de Boer, Aukje K. Mantel-Teeuwisse, Rolf H.H. Groenwold, Christine C. Gispen-de Wied, Hubert G.M. Leufkens, Olaf H. Klungel

Clinical Therapeutics

Sun Aug 09, 2020 15:43

Conversations With the Editors: Hepatitis C Virus—Where are We Now and Where Do We Go From Here?

Publication date: Available online 7 August 2020Source: Clinical TherapeuticsAuthor(s): Stacey Trooskin, Ravi Jhaveri

Clinical Therapeutics

Sat Aug 08, 2020 15:51

Dabigatran Reversal with Idarucizumab Preceding Thrombolysis in an Octogenarian Patient with Chronic Kidney Disease and Acute Stroke: a Case Report

Publication date: Available online 7 August 2020Source: Clinical TherapeuticsAuthor(s): Lina C. Laxamana, Christian Oliver C. Co, Jeryl Ritzi T. Yu, Christianne V. Mojica, Maria Adelaida M. Iboleon-Dy, Alyssa Mae C. Domingo, Karen Czarina S. Ilano, Ma Cristina Z. Macrohon-Valdez

Clinical Therapeutics

Sat Aug 08, 2020 15:51

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 Latest Results for Investigational New Drugs

A phase I study of intraperitoneal paclitaxel combined with gemcitabine plus nab-paclitaxel for pancreatic cancer with peritoneal metastasis

Summary Purpose. A phase I study of intraperitoneal paclitaxel (ip PTX) combined with gemcitabine (GEM) plus nab-paclitaxel (nab-PTX) (GnP) was conducted to determine the maximum tolerated dose (MTD) and the recommended dose (RD) in pancreatic cancer patients with peritoneal metastasis in first-line setting. Methods. Based on the 3 + 3 dose-escalation model, ip PTX, GEM and nab-PTX were administered at doses of 20 or 30 mg/m2, 800 or 1000 mg/m2 and 100 or 125 mg/m2 (level 1, 2...

Latest Results for Investigational New Drugs

Sat Aug 08, 2020 03:00

Dual-function chimeric antigen receptor T cells targeting c-Met and PD-1 exhibit potent anti-tumor efficacy in solid tumors

Summary Purpose Programmed cell death 1 (PD-1), which is upregulated under the continuous induction of the tumor microenvironment, causes chimeric antigen receptor (CAR)-T cell hypofunction via interaction with programmed death ligand 1 (PD-L1). This study aimed to construct CAR-T cells that are resistant to PD-1 inhibition to improve the effect of CAR-T cells in solid tumors. Methods We constructed a type of dual-function CAR-T cell that targets tumor-associated antigen c-Met...

Latest Results for Investigational New Drugs

Sat Aug 08, 2020 03:00

Analysis and identification of novel biomarkers involved in neuroblastoma via integrated bioinformatics

Summary Neuroblastoma (NB) is the most common extracranial solid tumor in children. Under various treatments, some patients still have a poor prognosis. Hence, it is necessary to find new valid targets for NB therapy. In this study, a comprehensive bioinformatic analysis was used to identify differentially expressed genes (DEGs) between NB and control cells, and to select hub genes associated with NB. GSE66586 and GSE78061 datasets were downloaded from the Gene Expression Omnibus...

Latest Results for Investigational New Drugs

Sat Aug 08, 2020 03:00

B7-H6 as an efficient target for T cell-induced cytotoxicity in haematologic malignant cells

Summary T cells play crucial roles in the antitumour immune response. However, their dysfunction leads to inefficient tumour eradication. New members of the B7 family have moved to the fore of cancer research because of their involvement in T cell-mediated immune escape and tumorigenesis. Recently, bispecific antibodies (Bi-Abs) have become attractive because of their ability to activate T cells to target tumours. In this study, we examined the expression of new B7 family members...

Latest Results for Investigational New Drugs

Fri Aug 07, 2020 03:00

Glioma progression is suppressed by Naringenin and APO2L combination therapy via the activation of apoptosis in vitro and in vivo

Summary Naringenin (NG) is a natural antioxidant flavonoid which is isolated from citrus fruits, and has been reported to inhibit colon cancer proliferation. However, the effects of NG treatment on glioma remain to be elucidated. The present study aimed to explore the effects of NG on glioma in vitro and in vivo. Also, the interactions between NG and APO2 ligand (APO2L; also known as tumor necrosis factor-related apoptosis-inducing ligand) were investigated in glioma. A synergistic...

Latest Results for Investigational New Drugs

Fri Aug 07, 2020 03:00

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 Radiotherapy and Oncology

Using stereotactic body radiation therapy to improve systemic treatment

Publication date: Available online 8 August 2020Source: Radiotherapy and OncologyAuthor(s): Daniel Moore Freitas Palhares, Gustavo dos Santos Fernandes

Radiotherapy and Oncology

Sat Aug 08, 2020 20:13

The danish head and neck cancer group (DAHANCA) 2020 radiotherapy guidelines

Publication date: Available online 8 August 2020Source: Radiotherapy and OncologyAuthor(s): Kenneth Jensen, Jeppe Friborg, Christian Rønn Hansen, Eva Samsøe, Jørgen Johansen, Maria Andersen, Bob Smulders, Elo Andersen, Martin Skovmos Nielsen, Jesper Grau Eriksen, Jørgen Breede Baltzer Petersen, Ulrik Vindelev Elstrøm, Anne Ivalu Holm, Mohammed Farhadi, Morten Hjartdal Morthorst, Peter Sandegaard Skyt, Jens Overgaard, Cai Grau

Radiotherapy and Oncology

Sat Aug 08, 2020 20:13

Online-adaptive versus robust IMPT for prostate cancer: how much can we gain?

Publication date: Available online 7 August 2020Source: Radiotherapy and OncologyAuthor(s): Thyrza Z. Jagt, Sebastiaan Breedveld, Rens van Haveren, Ben J.M. Heijmen, Mischa S. Hoogeman

Radiotherapy and Oncology

Sat Aug 08, 2020 20:13

National societies' needs as assessed by the ESTRO National Society Committee survey: a European perspective

Publication date: Available online 7 August 2020Source: Radiotherapy and OncologyAuthor(s): Cristina Garibaldi, Nuria Jornet, Li Tee Tan, Annette Boejen, Pierfrancesco Franco, Johan Bussink, Esther G.C. Troost, Bartosz Bak, Jean Emmanuel Bibault, Maia Dzhugashvili, Ludwig Van den Berghe, Lara Fizaine, Arta Leci, Umberto Ricardi, Barbara Alicja Jereczek-Fossa

Radiotherapy and Oncology

Fri Aug 07, 2020 15:21

Impact of non-adherence to radiotherapy on 1-year survival in cancer patients in catalonia, spain

Publication date: Available online 6 August 2020Source: Radiotherapy and OncologyAuthor(s): Josep M. Borras, Rebeca Font, Judit Solà, Miquel Macia, Victòria Tuset, Meritxell Arenas, Arantxa Eraso, Ramona Verges, Nuria Farré, Agustin Pedro, Meritxell Mollà, Manel Algara, Josep M. Solé, Moises Mira, Josep A. Espinàs

Radiotherapy and Oncology

Fri Aug 07, 2020 15:21

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 ScienceDirect Publication: International Immunopharmacology

Coronavirus Disease 2019 (COVID-19): Immunological Approaches and Emerging Pharmacologic Treatments

Publication date: Available online 8 August 2020Source: International ImmunopharmacologyAuthor(s): Pedram Goodarzi, Farzad Mahdavi, Rasoul Mirzaei, Hamze Hasanvand, Mohammad Sholeh, Farhad Zamani, Masodreza Sohrabi, Alireza Tabibzadeh, Ali Salimi Jeda, Mohammad Hadi Karbalaie Niya, Hossein Keyvani, Sajad Karampoor

ScienceDirect Publication: International Immunopharmacology

Sun Aug 09, 2020 14:49

Oxygen-ozone (O₂-O₃) immunoceutical therapy for patients with COVID-19. Preliminary evidence reported

Publication date: Available online 8 August 2020Source: International ImmunopharmacologyAuthor(s): Marianno Franzini, Luigi Valdenassi, Giovanni Ricevuti, Salvatore Chirumbolo, Markus Depfenhart, Dario Bertossi, Umberto Tirelli

ScienceDirect Publication: International Immunopharmacology

Sun Aug 09, 2020 14:49

A five-immune-related genes-based prognostic signature for colorectal cancer

Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): Lin Zhu, Haiying Wang, Zuofen Wang

ScienceDirect Publication: International Immunopharmacology

Sat Aug 08, 2020 13:51

A robust signature associated with patient prognosis and tumor immune microenvironment based on immune-related genes in lung squamous cell carcinoma

Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): Hao Zhou, Haijian Zhang, Muqi Shi, Jinjie Wang, Zhanghao Huang, Jiahai Shi

ScienceDirect Publication: International Immunopharmacology

Fri Aug 07, 2020 16:57

Emodin ameliorates ovalbumin-induced airway remodeling in mice by suppressing airway smooth muscle cells proliferation

Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): Yuanyuan Liu, Xin Li, Chao He, Ran Chen, Li Wei, Ling Meng, Caiqing Zhang

ScienceDirect Publication: International Immunopharmacology

Fri Aug 07, 2020 16:57

Clostridium butyricum modulates gut microbiota and reduces colitis associated colon cancer in mice

Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): Miao Liu, Wenjie Xie, Xinyue Wan, Tao Deng

ScienceDirect Publication: International Immunopharmacology

Fri Aug 07, 2020 16:57

Panax notoginseng saponin R1 modulates TNF-α/NF-κB signaling and attenuates allergic airway inflammation in asthma

Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): Kunjiao Xue, Lingying Ruan, Jie Hu, Zhou Fu, Daiyin Tian, Wenjing Zou

ScienceDirect Publication: International Immunopharmacology

Fri Aug 07, 2020 16:57

Identification and validation of an immune prognostic signature in colorectal cancer

Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): Mengting Li, Haizhou Wang, Wenjie Li, Yanan Peng, Fei Xu, Jian Shang, Shouquan Dong, Lupin Bu, Hao Wang, Wanhui Wei, Qian Hu, Lan Liu, Qiu Zhao

ScienceDirect Publication: International Immunopharmacology

Fri Aug 07, 2020 16:57

CSF-1R inhibition attenuates ischemia-induced renal injury and fibrosis by reducing Ly6C⁺ M2-like macrophage infiltration

Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): Xuan Deng, Qian Yang, Yuxi Wang, Cheng Zhou, Yi Guo, Zhizhi Hu, Wenhui Liao, Gang Xu, Rui Zeng

ScienceDirect Publication: International Immunopharmacology

Fri Aug 07, 2020 16:57

Colorectal cancer stem cell vaccine with high expression of MUC1 serves as a novel prophylactic vaccine for colorectal cancer

Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): Mei Guo, Biao Luo, Meng Pan, Miao Li, Hui Xu, Fengshu Zhao, Jun Dou

ScienceDirect Publication: International Immunopharmacology

Fri Aug 07, 2020 16:57

MiRNA-133a aggravates inflammatory responses in sepsis by targeting SIRT1

Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): Lei Chen, Wenfeng Xie, Lichun Wang, Xiaofei Zhang, Enhe Liu, Qiuye Kou

ScienceDirect Publication: International Immunopharmacology

Fri Aug 07, 2020 16:57

Melatonin suppresses Ti-particle-induced inflammatory osteolysis via activation of the Nrf2/Catalase signaling pathway

Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): Xu Zhu, Yazhong Zhang, Huilin Yang, Fan He, Jun Lin

ScienceDirect Publication: International Immunopharmacology

Fri Aug 07, 2020 16:57

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Thymosin α1 Therapy in Critically Ill Patients with COVID-19: a Multicenter Retrospective Cohort Study

Publication date: Available online 6 August 2020Source: International ImmunopharmacologyAuthor(s): Ming Wu, Jing-jing Ji, Li Zhong, Zi-yun Shao, Qi-feng Xie, Zhe-ying Liu, Cong-lin Wang, Lei Su, Yong-wen Feng, Zhi-feng Liu, Yong-ming Yao

ScienceDirect Publication: International Immunopharmacology

Fri Aug 07, 2020 16:57

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 ScienceDirect Publication: Journal of Bodywork and Movement Therapies

Association between Trigger Points in Hamstring, Posterior Leg, Foot Muscles And Plantar Fasciopathy: A Cross- Sectional Study

Publication date: Available online 7 August 2020Source: Journal of Bodywork and Movement TherapiesAuthor(s): Ravindra C. Thummar, S. Rajaseker, Ranjith Anumasa

ScienceDirect Publication: Journal of Bodywork and Movement Therapies

Sat Aug 08, 2020 20:07

Both the resistance training session and the static stretching after exercise does not affect the pectoralis major stiffness of well-trained men

Publication date: Available online 7 August 2020Source: Journal of Bodywork and Movement TherapiesAuthor(s): Liliam Fernandes de Oliveira, Hélio V. Cabral, Bruno Felipe Mendonça Leitão, Thiago Torres da Matta

ScienceDirect Publication: Journal of Bodywork and Movement Therapies

Sat Aug 08, 2020 20:07

Reliability of the Beighton Score and Impact of Generalized Joint Mobility and Resting Scapular Position on Median Neurodynamic Test 1

Publication date: Available online 7 August 2020Source: Journal of Bodywork and Movement TherapiesAuthor(s): Sean P. Riley, Jason K. Grimes, Kylie Calandra, Kelsey Foster, Melissa Peet, Matthew T. Walsh

ScienceDirect Publication: Journal of Bodywork and Movement Therapies

Sat Aug 08, 2020 20:07

The Effect of Visceral Manipulation on Diastasis Recti Abdominis (DRA): A Case Series

Publication date: Available online 6 August 2020Source: Journal of Bodywork and Movement TherapiesAuthor(s): Brandi Kirk, Teresa Elliott-Burke

ScienceDirect Publication: Journal of Bodywork and Movement Therapies

Fri Aug 07, 2020 14:26

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 ScienceDirect Publication: Photodiagnosis and Photodynamic Therapy

Phototoxicity in near-infrared photoimmunotherapy is influenced by the subcellular localization of antibody-IR700

Publication date: September 2020Source: Photodiagnosis and Photodynamic Therapy, Volume 31Author(s): Kohei Nakajima, Mikako Ogawa

ScienceDirect Publication: Photodiagnosis and Photodynamic Therapy

Sun Aug 09, 2020 14:57

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 Therapeutic Hypothermia and Temperature Management

Total Tau-Protein as Investigated by Cerebral Microdialysis Increases in Hypothermic Cardiac Arrest: A Pig Study

Therapeutic Hypothermia and Temperature Management, Ahead of Print.

Therapeutic Hypothermia and Temperature Management

Tue Aug 04, 2020 10:00

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 Tissue Engineering

Three-Dimensional Otic Neuronal Progenitor Spheroids Derived from Human Embryonic Stem Cells

Tissue Engineering Part A, Ahead of Print.

Tissue Engineering

Fri Aug 07, 2020 10:00

Combined Hydrogel and Mesenchymal Stem Cell Therapy for Moderate-Severity Disc Degeneration in Goats

Tissue Engineering Part A, Ahead of Print.

Tissue Engineering

Fri Aug 07, 2020 10:00

Call for TERMIS-AP 2020 Special Issue Papers: Revolutionizing Regenerative Research Strategies Towards Precision Medicine

Tissue Engineering Part A, Ahead of Print.

Tissue Engineering

Fri Aug 07, 2020 10:00

Coral-Derived Collagen Fibers for Engineering Aligned Tissues

Tissue Engineering Part A, Ahead of Print.

Tissue Engineering

Thu Aug 06, 2020 10:00

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