Publication date: September 2020Source: Acta Histochemica, Volume 122, Issue 6Author(s):
Sat Aug 08, 2020 16:53
Publication date: Available online 8 August 2020Source: Annals of Diagnostic PathologyAuthor(s): Kristen C. Blanton, Allison M. Deal, Kathleen A. Kaiser-Rogers, Carey K. Anders, Siobhan M. O'Connor, Johann D. Hertel, Benjamin C. Calhoun
Sun Aug 09, 2020 19:30
Background The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) has established distinct diagnostic categories for reporting cytopathological findings, and each is associated with a defined risk of malignancy (ROM). However, the ROM is applied at the overall category level and is not specific for particular morphological entities within a category. Here, the diagnostic performance of the MSRSGC for pleomorphic adenoma (PA) and Warthin tumor (WT) is reported. Methods The pathology...
Fri Aug 07, 2020 19:40
Background Coronavirus disease 2019 is caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and represents the causative agent of a potentially fatal disease. The spread of the infection and the severe clinical disease have led to the widespread adoption of social distancing measures. Special attention and efforts to protect or reduce transmission have been applied at all social levels, including health care operators. Hence, this reports focuses on the description of a new protocol...
Fri Aug 07, 2020 17:16
Objective: To discuss how IRF9 affects the fibroblast-like synoviocytes (FLS) in TNF-induced rheumatoid arthritis (RA) via the SIRT-1/NF-κB signaling pathway. Methods: RA-FLS were isolated and divided into control, sh-IRF9, TNF, TNF + sh-Ctrl, TNF + sh-IRF9, TNF + sh-SIRT1, and TNF + sh-IRF9 + sh-SIRT1 groups. Biological features of FLS were evaluated by MTT, wound healing, and Transwell assays, respectively. Cell apoptosis and cycle were assessed flow cytometrically. Inflammatory cytokines were...
Fri Aug 07, 2020 10:01
Abstract Introduction This is the first study to evaluate the accuracy of bile duct brushings since the introduction of single operator cholangioscopy SpyGlass DS system in 2015. The primary aim of our study was to compare the accuracy of cytology brushings against biopsies obtained at endoscopic retrograde cholangiopancreatography (ERCP) and cholangioscopy. Method A retrospective search for bile duct brushing specimens was performed and the charts reviewed. The gold standard for definitive...
Sat Aug 08, 2020 17:36
Abstract Background Bronchoalveolar lavage (BAL), is a safe, minimally invasive procedure to sample the terminal airways and the lung parenchyma. Although frequently used, there is lack of contemporary literature regarding the diagnostic utility of BAL for various pulmonary diseases. This study was conducted to evaluate the utility of BAL in diagnosis of various pulmonary pathologies, both infectious and neoplastic. Methods This was a retrospective study performed over a period of 2 years....
Sat Aug 08, 2020 17:35
Abstract Background Adenoid cystic carcinoma (AdCC) is an uncommon malignancy of the salivary gland characterized by slow growth, increased risk of recurrence and poor prognosis. The annual incidence in the United States is approximately 1200 cases per year and rarely involves the body cavities. Case presentation We present a case of a 48‐year‐old male diagnosed with AdCC of the left submandibular gland. He received his last chemotherapy in 2006 and presented with pleural metastasis. After...
Sat Aug 08, 2020 17:34
Abstract Background Pathological nipple discharge (PND) is a relatively common symptom of breast cancer affecting the nipple. Mammary ductscopy (MD) allows direct visualization of the ductal lumen and collection of a cytological specimen using duct‐washing cytology (DWC). Herein, we clarified the diagnostic efficacy of DWC for the detection of breast cancers with PND, compared with fine‐needle aspiration cytology (FNAC). Methods We retrospectively examined 48 patients with PND who underwent...
Fri Aug 07, 2020 19:05
Abstract Background Toxoplasmosis causes serious and sometimes life‐threatening disease in immunocompromised patients like organ transplant recipients, immunodeficiency disorders or HIV‐infected individuals. The co‐occurrence of toxoplasmosis in a respiratory sample harboring tuberculosis (TB) may be missed especially in an area endemic for the latter infection. Case report A 10‐year‐old child presented with complaints of fever with loss of appetite and weight. Based on radiological and...
Fri Aug 07, 2020 18:55
Abstract Background Approximately 25% of thyroid nodule fine‐needle aspirates (FNAs) have cytology that is indeterminate for malignant disease. Accurate risk stratification of these FNAs with ancillary testing would reduce unnecessary thyroid surgery. Methods We evaluated the performance of an ancillary multiplatform test (MPTX) that has three diagnostic categories (negative, moderate, and positive). MPTX includes the combination of a mutation panel (ThyGeNEXT®) and a microRNA risk classifier...
Fri Aug 07, 2020 18:53
Abstract A lymphoid‐rich stroma is a common finding in salivary gland tumors. Several reports documented this association with acinic cell carcinoma (ACC). However, cytologic studies reporting this phenomenon are rare and mainly confined to sporadic single case reports. We present the cytologic features of two cases of ACCs of the parotid gland displaying a lymphoid‐rich background and discuss the cytologic differential diagnoses of this uncommon ACC variant.
Thu Aug 06, 2020 16:35
Abstract Background The Paris System for reporting urinary cytology was introduced in 2013 and has a global impact. In our study, we assess the risk of malignancy (ROM) for each diagnostic category and our diagnostic accuracy in urinary cytology. Methods We have conducted a prospective study during 2019, including only new cases of urothelial neoplasms, all of them with subsequent histology. The risk of malignancy for each category was calculated and the diagnostic accuracy parameters were...
Thu Aug 06, 2020 16:32
Abstract Molecular testing has a potential to improve the management of patients with indeterminate thyroid nodules considered for surgery. This study examined the influence of molecular tests on the treatment of indeterminate nodules, particularly the differences between Western and Asian countries. Electronic databases including PubMed and Web of Science were searched for relevant articles from 2010 to March 2019. We computed meta-analysis of proportion and their 95% confidence...
Fri Aug 07, 2020 03:00
MicroCT data from cadaveric tibiae demonstrates that trabecular bone volume fraction at the site of the Segond fracture is significantly lower than other entheseal sites across the tibial plateau. This may equate to a region of local weakness which can predispose certain individuals to the avulsion injury following the application of excessive tibial internal rotation. Abstract In a series of human cadaveric experiments, Dr. Paul Segond first described the avulsion injury occurring at the anterolateral...
Sat Aug 08, 2020 22:09
The biopsy‐based diagnosis of autoimmune pancreatitis (AIP) is difficult but is becoming imperative for pathologists due to the increased amount of endoscopic ultrasound‐guided biopsy tissue. To cope with this challenge, we propose guidance for the biopsy diagnosis of type 1 AIP. This guidance is for pathologists and comprises three main parts. The first part includes basic issues on tissue acquisition, staining, and final diagnosis, and is intended for gastroenterologists as well. The second part...
Thu Aug 06, 2020 21:27
In the preceding article (part 1), we proposed the third type of microscopic colitis: colitis nucleomigrans (CN). Microscopically, the nuclei of surface‐lining columnar cells were migrated in chain to the middle part of the cells, and apoptotic nuclear debris was scattered in the cytoplasm beneath the nuclei. For ultrastructural analysis, buffered formalin‐fixed biopsy tissue of CN (n = 2) was dug out of paraffin blocks. After deparaffinization, tissue blocks were prepared with conventional sequences....
Thu Aug 06, 2020 14:05
Microscopic colitis (MC), encompassing collagenous colitis and lymphocytic colitis, is featured by chronic diarrhea, normal‐looking endoscopic findings and unique microscopic appearance. After reviewing biopsied nonspecific colitis, we propose the third type of MC: colitis nucleomigrans (CN). Histopathological criteria of CN included: (i) chained nuclear migration to the middle part of the surface‐lining columnar epithelium; (ii) apoptotic nuclear debris scattered below the nuclei; and (iii) mild/moderate...
Thu Aug 06, 2020 14:04
Publication date: Available online 8 August 2020Source: Pathology - Research and PracticeAuthor(s): Si-Hyong Jang, Ji-Hye Lee, Hyun Ju Lee, Hyundeuk Cho, Hyein Ahn, In Hag Song, Mee-Hye Oh
Sun Aug 09, 2020 16:15
Publication date: Available online 8 August 2020Source: Pathology - Research and PracticeAuthor(s): Xia Yang, Shi-Lu Chen, Cen-Shan Lin, Li-Li Liu, Chun-Hua Wang, Jing-ping Yun
Sun Aug 09, 2020 16:15
Abstract Hepatocellular carcinoma (HCC) is one of the leading causes of cancer‐related death worldwide. Lipogenesis has been considered as a critical player in HCC initiation and progression. However, the underlying mechanism is still not fully understood. Here, we identified Zinc fingers and homeobox 2 (ZHX2), an HCC‐associated tumor suppressor, as an important repressor of de novo lipogenesis. Ectopic expression of ZHX2 significantly inhibited de novo lipogenesis in HCC cells and decreased expression...
Sat Aug 08, 2020 12:04
Abstract The molecular and clinical characteristics of non‐ampullary duodenal adenomas and intramucosal adenocarcinomas are not fully understood because they are rare. To clarify these characteristics, we performed genetic and epigenetic analysis of cancer‐related genes in these lesions. One‐hundred seven non‐ampullary duodenal adenomas and intramucosal adenocarcinomas, including 100 small intestinal type tumors (90 adenomas and 10 intramucosal adenocarcinomas) and 7 gastric type tumors (2 pyloric...
Sat Aug 08, 2020 12:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου