Cancers, Vol. 12, Pages 2211: The Use of Artificial Intelligence in the Differentiation of Malignant and Benign Lung Nodules on Computed Tomograms Proven by Surgical Pathology Cancers doi: 10.3390/cancers12082211 Authors: Yung-Liang Wan Pei-Kwei Tsay Kuang-Tse Pan Nguyen Ngoc Trang Patricia Wanping Wu Pei-Ching Huang Wen-Yu Chuang Ching-Yang Wu ShihChung Benedict Lo The purpose of this work was to evaluate the performance of an existing commercially available...
Fri Aug 07, 2020 03:00
Cancers, Vol. 12, Pages 2212: Neoadjuvant Intraperitoneal Chemotherapy in Patients with Pseudomyxoma Peritonei—A Novel Treatment Approach Cancers doi: 10.3390/cancers12082212 Authors: Aruna Prabhu Andreas Brandl Satoshi Wakama Shouzou Sako Haruaki Ishibashi Akiyoshi Mizumoto Nobuyuki Takao Kousuke Noguchi Shunsuke Motoi Masumi Ichinose Yang Liu Yutaka Yonemura Neoadjuvant intravenous chemotherapy in patients with pseudomyxoma peritonei (PMP) has not shown...
Fri Aug 07, 2020 03:00
Cancers, Vol. 12, Pages 2213: Sigma 1 Receptor is Overexpressed in Hepatocellular Adenoma: Involvement of ERα and HNF1α Cancers doi: 10.3390/cancers12082213 Authors: Laure Villemain Sylvie Prigent Aurélie Abou-Lovergne Laura Pelletier Magali Chiral Marco Pontoglio Fabienne Foufelle Stefano Caruso Raphael Pineau Sandra Rebouissou Eric Chevet Jessica Zucman-Rossi Laurent Combettes Sigma receptor 1 (SigR1) is an endoplasmic reticulum resident integral...
Fri Aug 07, 2020 03:00
Cancers, Vol. 12, Pages 2208: Electroporation-Based Treatments in Urology Cancers doi: 10.3390/cancers12082208 Authors: Aleksander Kiełbik Wojciech Szlasa Jolanta Saczko Julita Kulbacka The observation that an application of a pulsed electric field (PEF) resulted in an increased permeability of the cell membrane has led to the discovery of the phenomenon called electroporation (EP). Depending on the parameters of the electric current and cell features, electroporation can be...
Fri Aug 07, 2020 03:00
Cancers, Vol. 12, Pages 2207: Pan-Cancer Analysis of Alternative Lengthening of Telomere Activity Cancers doi: 10.3390/cancers12082207 Authors: Ji-Yong Sung Hee-Woong Lim Je-Gun Joung Woong-Yang Park Alternative lengthening of telomeres (ALT) is a telomerase-independent mechanism that extends telomeres in cancer cells. It influences tumorigenesis and patient survival. Despite the clinical significance of ALT in tumors, the manner in which ALT is activated and influences prognostic...
Fri Aug 07, 2020 03:00
Cancers, Vol. 12, Pages 2209: Therapeutic Potential of Chemically Modified miR-489 in Triple-Negative Breast Cancers Cancers doi: 10.3390/cancers12082209 Authors: Young Hwa Soung Heesung Chung Cecilia Yan Andrew Fesler Hyungjin Kim Eok-Soo Oh Jingfang Ju Jun Chung Triple-negative breast cancers (TNBCs) lack ER, PR and her2 receptors that are targets of common breast cancer therapies with poor prognosis due to their high rates of metastasis and chemoresistance. Based...
Fri Aug 07, 2020 03:00
Cells, Vol. 9, Pages 1866: Insights into HP1a-Chromatin Interactions Cells doi: 10.3390/cells9081866 Authors: Silvia Meyer-Nava Victor E. Nieto-Caballero Mario Zurita Viviana Valadez-Graham Understanding the packaging of DNA into chromatin has become a crucial aspect in the study of gene regulatory mechanisms. Heterochromatin establishment and maintenance dynamics have emerged as some of the main features involved in genome stability, cellular development, and diseases. The...
Sun Aug 09, 2020 03:00
Cells, Vol. 9, Pages 1865: Characteristics and Possible Role of Bovine Sperm Head-to-Head Agglutination Cells doi: 10.3390/cells9081865 Authors: Kohei Umezu Shouhei Kurata Hironori Takamori Takashi Numabe Yuuki Hiradate Kenshiro Hara Kentaro Tanemura Although sperm head-to-head agglutination has been reported in many mammalian species, the biological significance of this unique sperm–sperm interaction remains largely unknown. Here, we aimed to examine the...
Sun Aug 09, 2020 03:00
Cells, Vol. 9, Pages 1864: S-Adenosylmethionine Treatment of Colorectal Cancer Cell Lines Alters DNA Methylation, DNA Repair and Tumor Progression-Related Gene Expression Cells doi: 10.3390/cells9081864 Authors: Sára Zsigrai Alexandra Kalmár Zsófia B. Nagy Barbara K. Barták Gábor Valcz Krisztina A. Szigeti Orsolya Galamb Titanilla Dankó Anna Sebestyén Gábor Barna Vanessza Szabó Orsolya Pipek Anna Medgyes-Horváth István Csabai Zsolt Tulassay Péter...
Sun Aug 09, 2020 03:00
Cells, Vol. 9, Pages 1863: Genomic Analysis of Localized High-Risk Prostate Cancer Circulating Tumor Cells at the Single-Cell Level Cells doi: 10.3390/cells9081863 Authors: Aline Rangel-Pozzo Songyan Liu Gabriel Wajnberg Xuemei Wang Rodney J. Ouellette Geoffrey G. Hicks Darrel Drachenberg Sabine Mai Accurate risk classification of men with localized high-risk prostate cancer directly affects treatment management decisions and patient outcomes. A wide range of risk...
Sat Aug 08, 2020 03:00
Cells, Vol. 9, Pages 1859: Targeting BC200/miR218-5p Signaling Axis for Overcoming Temozolomide Resistance and Suppressing Glioma Stemness Cells doi: 10.3390/cells9081859 Authors: Yu-Kai Su Jia Wei Lin Jing-Wen Shih Hao-Yu Chuang Iat-Hang Fong Chi-Tai Yeh Chien-Min Lin Background: Glioblastoma (GB) is one of the most common (~30%) and lethal cancers of the central nervous system. Although new therapies are emerging, chemoresistance to treatment is one of the major challenges...
Sat Aug 08, 2020 03:00
Cells, Vol. 9, Pages 1862: Robustness during Aging—Molecular Biological and Physiological Aspects Cells doi: 10.3390/cells9081862 Authors: Emanuel Barth Patricia Sieber Heiko Stark Stefan Schuster Understanding the process of aging is still an important challenge to enable healthy aging and to prevent age-related diseases. Most studies in age research investigate the decline in organ functionality and gene activity with age. The focus on decline can even be considered a paradigm...
Sat Aug 08, 2020 03:00
Cells, Vol. 9, Pages 1861: Clock Protein Bmal1 and Nrf2 Cooperatively Control Aging or Oxidative Response and Redox Homeostasis by Regulating Rhythmic Expression of Prdx6 Cells doi: 10.3390/cells9081861 Authors: Chhunchha Kubo Singh Many disorders of aging, including blinding-diseases, are associated with deficiency of brain and muscle arnt-like protein 1 (Bmal1) and, thereby, dysregulation of antioxidant-defense pathway. However, knowledge is limited regarding the role of Bmal1...
Sat Aug 08, 2020 03:00
Cells, Vol. 9, Pages 1860: Neuroprotective Effects of a Novel Inhibitor of c-Jun N-Terminal Kinase in the Rat Model of Transient Focal Cerebral Ischemia Cells doi: 10.3390/cells9081860 Authors: Mark B. Plotnikov Galina A. Chernysheva Vera I. Smolyakova Oleg I. Aliev Eugene S. Trofimova Eugene Y. Sherstoboev Anton N. Osipenko Andrei I. Khlebnikov Yana J. Anfinogenova Igor A. Schepetkin Dmitriy N. Atochin A novel specific inhibitor of c-Jun N-terminal kinase,...
Sat Aug 08, 2020 03:00
Cells, Vol. 9, Pages 1857: Role of Inflammasomes in HIV-1 and Drug Abuse Mediated Neuroinflammaging Cells doi: 10.3390/cells9081857 Authors: Susmita Sil Fang Niu Ernest T. Chivero Seema Singh Palsamy Periyasamy Shilpa Buch Despite the effectiveness of combined antiretroviral therapy (cART) in suppressing virus replication, chronic inflammation remains one of the cardinal features intersecting HIV-1, cART, drug abuse, and likely contributes to the accelerated neurocognitive...
Sat Aug 08, 2020 03:00
Cells, Vol. 9, Pages 1858: Tissue-Specific Impact of Autophagy Genes on the Ubiquitin–Proteasome System in C. elegans Cells doi: 10.3390/cells9081858 Authors: Sweta Jha Carina I. Holmberg The ubiquitin–proteasome system (UPS) and the autophagy–lysosomal pathway (ALP) are the two main eukaryotic intracellular proteolytic systems involved in maintaining proteostasis. Several studies have reported on the interplay between the UPS and ALP, however it remains largely...
Sat Aug 08, 2020 03:00
Cells, Vol. 9, Pages 1856: Interplay of Structural Disorder and Short Binding Elements in the Cellular Chaperone Function of Plant Dehydrin ERD14 Cells doi: 10.3390/cells9081856 Authors: Nikoletta Murvai Lajos Kalmar Bianka Szalaine Agoston Beata Szabo Agnes Tantos Gyorgy Csikos András Micsonai József Kardos Didier Vertommen Phuong N. Nguyen Nevena Hristozova Andras Lang Denes Kovacs Laszlo Buday Kyou-Hoon Han Andras Perczel Peter Tompa Details...
Fri Aug 07, 2020 03:00
Cells, Vol. 9, Pages 1852: Mesenchymal Stem/Stromal Cells for Rheumatoid Arthritis Treatment: An Update on Clinical Applications Cells doi: 10.3390/cells9081852 Authors: Mercedes Lopez-Santalla Raquel Fernandez-Perez Marina I Garin Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects the lining of the synovial joints leading to stiffness, pain, inflammation, loss of mobility, and erosion of joints. Its pathogenesis is related to aberrant immune responses...
Fri Aug 07, 2020 03:00
Cells, Vol. 9, Pages 1851: Tristetraprolin Posttranscriptionally Downregulates TRAIL Death Receptors
Cells, Vol. 9, Pages 1851: Tristetraprolin Posttranscriptionally Downregulates TRAIL Death Receptors Cells doi: 10.3390/cells9081851 Authors: Won Hyeok Lee Myung Woul Han Song Hee Kim Daseul Seong Jae Hee An Hyo Won Chang Sang Yoon Kim Seong Who Kim Jong Cheol Lee Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) has attracted attention as a potential candidate for cancer therapy. However, many primary cancers are resistant to TRAIL, even when...
Fri Aug 07, 2020 03:00
Cells, Vol. 9, Pages 1854: Homeoprotein Msx1-PIASy Interaction Inhibits Angiogenesis Cells doi: 10.3390/cells9081854 Authors: Myung Jin Son Seung Bae Rho Kwangbae Kim Mijung Oh Chaeyeon Son Sang Yong Song Kyoungsook Park Previously, we demonstrated that the homeoprotein Msx1 interaction with p53 inhibited tumor growth by inducing apoptosis. However, Msx1 can exert its tumor suppressive effect through the inhibition of angiogenesis since growth of the tumor relies on...
Fri Aug 07, 2020 03:00
Cells, Vol. 9, Pages 1853: The Chromatin Response to Double-Strand DNA Breaks and Their Repair Cells doi: 10.3390/cells9081853 Authors: Radoslav Aleksandrov Rossitsa Hristova Stoyno Stoynov Anastas Gospodinov Cellular DNA is constantly being damaged by numerous internal and external mutagenic factors. Probably the most severe type of insults DNA could suffer are the double-strand DNA breaks (DSBs). They sever both DNA strands and compromise genomic stability, causing deleterious...
Fri Aug 07, 2020 03:00
Cells, Vol. 9, Pages 1850: DNA Methylation as a Therapeutic Target for Bladder Cancer Cells doi: 10.3390/cells9081850 Authors: Sandra P. Nunes Rui Henrique Carmen Jerónimo Jesús M. Paramio Bladder cancer (BC) is the tenth most frequent cancer worldwide and is associated with high mortality when diagnosed in its most aggressive form, which is not reverted by the current treatment options. Thus, the development of new therapeutic strategies, either alternative or complementary...
Fri Aug 07, 2020 03:00
Cells, Vol. 9, Pages 1855: Diverse Roles of Annexin A6 in Triple-Negative Breast Cancer Diagnosis, Prognosis and EGFR-Targeted Therapies Cells doi: 10.3390/cells9081855 Authors: Olga Y. Korolkova Sarrah E. Widatalla Stephen D. Williams Diva S. Whalen Heather K. Beasley Josiah Ochieng Thomas Grewal Amos M. Sakwe The calcium (Ca2+)-dependent membrane-binding Annexin A6 (AnxA6), is a multifunctional, predominantly intracellular scaffolding protein, now known to play...
Fri Aug 07, 2020 03:00
Chemosensors, Vol. 8, Pages 67: Sputtered SnO2/ZnO Heterostructures for Improved NO2 Gas Sensing Properties Chemosensors doi: 10.3390/chemosensors8030067 Authors: Bharat Sharma Ashutosh Sharma Monika Joshi Jae-ha Myung A highly sensitive and selective NO2 gas sensor dependent on SnO2/ZnO heterostructures was fabricated using a sputtering process. The SnO2/ZnO heterostructure thin film samples were characterized by field emission scanning electron microscopy (FESEM), X-ray diffraction...
Fri Aug 07, 2020 03:00
Chemosensors, Vol. 8, Pages 66: Anti-Biofouling Strategies for Long-Term Continuous Use of Implantable Biosensors Chemosensors doi: 10.3390/chemosensors8030066 Authors: Jian Xu Hyowon Lee The growing trend for personalized medicine calls for more reliable implantable biosensors that are capable of continuously monitoring target analytes for extended periods (i.e., >30 d). While promising biosensors for various applications are constantly being developed in the laboratories...
Fri Aug 07, 2020 03:00
Children, Vol. 7, Pages 94: Robotic Stereotactic Assistance (ROSA) for Pediatric Epilepsy: A Single-Center Experience of 23 Consecutive Cases Children doi: 10.3390/children7080094 Authors: Jonathon H. Nelson Samantha L. Brackett Chima O. Oluigbo Srijaya K. Reddy Robotic assisted neurosurgery has become increasingly utilized for its high degree of precision and minimally invasive approach. Robotic stereotactic assistance (ROSA®) for neurosurgery has been infrequently...
Fri Aug 07, 2020 03:00
Climate, Vol. 8, Pages 92: Greening and Browning Trends of Vegetation in India and Their Responses to Climatic and Non-Climatic Drivers Climate doi: 10.3390/cli8080092 Authors: Bikash Ranjan Parida Arvind Chandra Pandey N.R. Patel It is imperative to know the spatial distribution of vegetation trends in India and its responses to both climatic and non-climatic drivers because many ecoregions are vulnerable to global climate change. Here we employed the NDVI3g satellite data over...
Sun Aug 09, 2020 03:00
Climate, Vol. 8, Pages 91: SI: Air Pollution and Plant Ecosystems Climate doi: 10.3390/cli8080091 Authors: Evgenios Agathokleous Elisa Carrari Pierre Sicard Air pollution continues to be a serious issue for plant health and terrestrial ecosystems. In this issue of climate, some papers relevant to air pollution and its potential impacts on plant health and terrestrial ecosystems are collated. The papers provide some new insights and offer the opportunity to further advance the current...
Sun Aug 09, 2020 03:00
Dentistry Journal, Vol. 8, Pages 89: Potential Advantages of Peroxoborates and Their Ester Adducts Over Hydrogen Peroxide as Therapeutic Agents in Oral Healthcare Products: Chemical/Biochemical Reactivity Considerations In Vitro, Ex Vivo And In Vivo Dentistry Journal doi: 10.3390/dj8030089 Authors: Martin Grootveld Edward Lynch Georgina Page Wyman Chan Benita Percival Eugenia Anagnostaki Valina Mylona Sonia Bordin-Aykroyd Kerry L. Grootveld Peroxides present in...
Fri Aug 07, 2020 03:00
Diagnostics, Vol. 10, Pages 576: Evaluation of Nuclear Cataract with Smartphone-Attachable Slit-Lamp Device Diagnostics doi: 10.3390/diagnostics10080576 Authors: Hiroyuki Yazu Eisuke Shimizu Sho Okuyama Takuya Katahira Naohiko Aketa Ryota Yokoiwa Yasunori Sato Yoko Ogawa Hiroshi Fujishima Background: Visual impairments and age-related eye diseases need to be detected and treated in a timely manner. However, this is often hampered by lack of appropriate medical...
Sun Aug 09, 2020 03:00
Diagnostics, Vol. 10, Pages 578: Evaluation of MicroRNAs as Non-Invasive Diagnostic Markers in Urinary Cells from Patients with Suspected Prostate Cancer Diagnostics doi: 10.3390/diagnostics10080578 Authors: Angelika Borkowetz Andrea Lohse-Fischer Jana Scholze Ulrike Lotzkat Christian Thomas Manfred P. Wirth Susanne Fuessel Kati Erdmann Currently used tumor markers for early diagnosis of prostate cancer (PCa) are often lacking sufficient specificity and sensitivity....
Sun Aug 09, 2020 03:00
Diagnostics, Vol. 10, Pages 575: Preliminary Post-Mortem COVID-19 Evidence of Endothelial Injury and Factor VIII Hyperexpression Diagnostics doi: 10.3390/diagnostics10080575 Authors: Luigi Cipolloni Francesco Sessa Giuseppe Bertozzi Benedetta Baldari Santina Cantatore Roberto Testi Stefano D’Errico Giulio Di Mizio Alessio Asmundo Sergio Castorina Monica Salerno Cristoforo Pomara (1) Background: The current outbreak of COVID-19 infection is an ongoing...
Sun Aug 09, 2020 03:00
Diagnostics, Vol. 10, Pages 577: Melanoma Diagnosis Using Deep Learning and Fuzzy Logic Diagnostics doi: 10.3390/diagnostics10080577 Authors: Shubhendu Banerjee Sumit Kumar Singh Avishek Chakraborty Atanu Das Rajib Bag Melanoma or malignant melanoma is a type of skin cancer that develops when melanocyte cells, damaged by excessive exposure to harmful UV radiations, start to grow out of control. Though less common than some other kinds of skin cancers, it is more dangerous...
Sun Aug 09, 2020 03:00
Diagnostics, Vol. 10, Pages 572: Screening Strategy of Pancreatic Cancer in Patients with Diabetes Mellitus Diagnostics doi: 10.3390/diagnostics10080572 Authors: Suguru Mizuno Yousuke Nakai Kazunaga Ishigaki Kei Saito Hiroki Oyama Tsuyoshi Hamada Yukari Suzuki Akiyuki Inokuma Sachiko Kanai Kensaku Noguchi Tatsuya Sato Ryunosuke Hakuta Tomotaka Saito Naminatsu Takahara Hirofumi Kogure Hiroyuki Isayama Kazuhiko Koike The incidence of pancreatic...
Sat Aug 08, 2020 03:00
Diagnostics, Vol. 10, Pages 573: Ki67 and PR in Patients Treated with CDK4/6 Inhibitors: A Real-World Experience Diagnostics doi: 10.3390/diagnostics10080573 Authors: Palleschi Maltoni Ravaioli Vagheggini Mannozzi Fanini Pirini Tumedei Barzotti Cecconetto Sarti Manunta Possanzini Fedeli Curcio Altini De Giorgi Rocca Bravaccini : CDK4/6 inhibitors (CDK4/6i) are recommended in patients with estrogen receptor (ER)-positive,...
Sat Aug 08, 2020 03:00
Diagnostics, Vol. 10, Pages 574: Low Myostatin Serum Levels Are Associated with Poor Outcome in Critically Ill Patients Diagnostics doi: 10.3390/diagnostics10080574 Authors: Theresa H. Wirtz Sven H. Loosen Lukas Buendgens Berkan Kurt Samira Abu Abu Jhaisha Philipp Hohlstein Jonathan F. Brozat Ralf Weiskirchen Tom Luedde Frank Tacke Christian Trautwein Christoph Roderburg Alexander Koch Background: Growth differentiation factor 8, GDF-8 (Myostatin),...
Sat Aug 08, 2020 03:00
Diagnostics, Vol. 10, Pages 571: Regional Mapping of Brain Glutamate Distributions Using Glutamate-Weighted Chemical Exchange Saturation Transfer Imaging Diagnostics doi: 10.3390/diagnostics10080571 Authors: Do-Wan Lee Chul-Woong Woo Dong-Cheol Woo Jeong Kon Kim Kyung Won Kim Dong-Hoon Lee Purpose: To investigate glutamate signal distributions in multiple brain regions of a healthy rat brain using glutamate-weighted chemical exchange saturation transfer (GluCEST) imaging....
Sat Aug 08, 2020 03:00
Diagnostics, Vol. 10, Pages 570: Cystic Fibrosis-Screening Positive Inconclusive Diagnosis: Newborn Screening and Long-Term Follow-Up Permits to Early Identify Patients with CFTR-Related Disorders Diagnostics doi: 10.3390/diagnostics10080570 Authors: Alice Castaldo Chiara Cimbalo Raimondo J. Castaldo Marcella D’Antonio Manuela Scorza Laura Salvadori Angela Sepe Valeria Raia Antonella Tosco Background: Newborn screening (NBS) early-identifies cystic fibrosis (CF),...
Sat Aug 08, 2020 03:00
Diagnostics, Vol. 10, Pages 569: Validation of Copy Number Variants Detection from Pregnant Plasma Using Low-Pass Whole-Genome Sequencing in Noninvasive Prenatal Testing-Like Settings Diagnostics doi: 10.3390/diagnostics10080569 Authors: Michaela Hyblova Maria Harsanyova Diana Nikulenkov-Grochova Jitka Kadlecova Marcel Kucharik Jaroslav Budis Gabriel Minarik Detection of copy number variants as an integral part of noninvasive prenatal testing is increasingly used in...
Sat Aug 08, 2020 03:00
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