Microorganisms, Vol. 8, Pages 1204: Does Biological Denitrification Inhibition (BDI) in the Field Induce an Increase in Plant Growth and Nutrition in Apium graveolens L. Grown for a Long Period? Microorganisms doi: 10.3390/microorganisms8081204 Authors: William Galland Florence Piola Céline Mathieu Lyna Bouladra Laurent Simon Feth el Zahar Haichar Intensive agriculture uses a lot of nitrogen fertilizers to increase crop productivity. These crops are in competition with...
Fri Aug 07, 2020 03:00
Microorganisms, Vol. 8, Pages 1205: Differential miRNA-Gene Expression in M Cells in Response to Crohn’s Disease-Associated AIEC Microorganisms doi: 10.3390/microorganisms8081205 Authors: Anaïs Larabi Laurène Salesse Charlotte Cordonnier Lucie Etienne-Mesmin Nicolas Barnich Guillaume Dalmasso Hang Thi Thu Nguyen Adherent-invasive Escherichia coli (AIEC), which abnormally colonize the ileal mucosa of Crohn’s disease (CD) patients, are able to invade intestinal epithelial...
Fri Aug 07, 2020 03:00
Microorganisms, Vol. 8, Pages 1203: Iron-Uptake Systems of Chicken-Associated Salmonella Serovars and Their Role in Colonizing the Avian Host Microorganisms doi: 10.3390/microorganisms8081203 Authors: Dinesh H. Wellawa Brenda Allan Aaron White Wolfgang Köster Iron is an essential micronutrient for most bacteria. Salmonella enterica strains, representing human and animal pathogens, have adopted several mechanisms to sequester iron from the environment depending on availability...
Fri Aug 07, 2020 03:00
Microorganisms, Vol. 8, Pages 1206: Antibiogram Signatures of Some Enterobacteria Recovered from Irrigation Water and Agricultural Soil in two District Municipalities of South Africa Microorganisms doi: 10.3390/microorganisms8081206 Authors: Chidozie Declan Iwu Erika M du Plessis Lise Korsten Nolonwabo Nontongana Anthony Ifeanyi Okoh This study was undertaken to evaluate the antibiogram fingerprints of some Enterobacteria recovered from irrigation water and agricultural soil...
Fri Aug 07, 2020 03:00
Microorganisms, Vol. 8, Pages 1202: Microbial Communities in Permafrost Soils of Larsemann Hills, Eastern Antarctica: Environmental Controls and Effect of Human Impact Microorganisms doi: 10.3390/microorganisms8081202 Authors: Ivan Alekseev Aleksei Zverev Evgeny Abakumov Although ice-free areas cover only about 0.1% of Antarctica and are characterized by harsh environmental conditions, these regions provide quite diverse conditions for the soil-forming process, having various physical...
Fri Aug 07, 2020 03:00
Microorganisms, Vol. 8, Pages 1201: Leishmania Immunity: Advancing Immunotherapy and Vaccine Development Microorganisms doi: 10.3390/microorganisms8081201 Authors: Nnamdi M. Ikeogu Gloria N. Akaluka Chidalu A. Edechi Enitan S. Salako Chukwunonso Onyilagha Aida F. Barazandeh Jude E. Uzonna Parasitic diseases still constitute a major global health problem affecting billions of people around the world. These diseases are capable of becoming chronic and result in high morbidity...
Fri Aug 07, 2020 03:00
Microorganisms, Vol. 8, Pages 1200: Marine Plastics from Norwegian West Coast Carry Potentially Virulent Fish Pathogens and Opportunistic Human Pathogens Harboring New Variants of Antibiotic Resistance Genes Microorganisms doi: 10.3390/microorganisms8081200 Authors: Vera Radisic Priyank S. Nimje André Marcel Bienfait Nachiket P. Marathe To our best knowledge this is the first study characterizing fish pathogens isolated from marine plastics from the West coast of Norway for...
Fri Aug 07, 2020 03:00
Molbank, Vol. 2020, Article M1151: Phenethyl Esters and Amide of Ferulic Acid, Hydroferulic Acid, Homovanillic Acid, and Vanillic Acid: Synthesis, Free Radicals Scavenging Activity, and Molecular Modeling as Potential Cholinesterases Inhibitors Molbank doi: 10.3390/M1151 Authors: Ayyoub Selka Fanta J. Ndongou Moutombi Marc Cormier Mohamed Touaibia As ferulic acid was reported to be involved in novel potential mechanisms associated with Alzheimer’s disease (AD) therapy,...
Sun Aug 09, 2020 03:00
Molecules, Vol. 25, Pages 3626: New Horizons in Chemical Functionalization of Endohedral Metallofullerenes Molecules doi: 10.3390/molecules25163626 Authors: Michio Yamada Michael T. H. Liu Shigeru Nagase Takeshi Akasaka This overview explains some new aspects of chemical functionalization of endohedral metallofullerenes (EMFs) that have been unveiled in recent years. After differences in chemical reactivity between EMFs and the corresponding empty fullerenes are discussed, cage-opening...
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Molecules, Vol. 25, Pages 3625: Rindera graeca (Boraginaceae) Phytochemical Profile and Biological Activities Molecules doi: 10.3390/molecules25163625 Authors: Ganos Aligiannis Chinou Naziris Chountoulesi Mroczek Graikou Rindera graeca is a Greek endemic plant of the Boraginaceae family which has never been studied before. Consequently, this study attempted to phytochemically examine the aerial parts of this species. Nine phenolic secondary metabolites were identified,...
Sun Aug 09, 2020 03:00
Molecules, Vol. 25, Pages 3624: The Role of β-Cyclodextrin in the Textile Industry—Review Molecules doi: 10.3390/molecules25163624 Authors: Fabricio Maestá Bezerra Manuel José Lis Helen Beraldo Firmino Joyce Gabriella Dias da Silva Rita de Cassia Siqueira Curto Valle José Alexandre Borges Valle Fabio Alexandre Pereira Scacchetti André Luiz Tessaro β-Cyclodextrin (β-CD) is an oligosaccharide composed of seven units of D-(+)-glucopyranose joined by...
Sun Aug 09, 2020 03:00
Molecules, Vol. 25, Pages 3622: Analyses of Skin Secretions of Vipera ammodytes (Linnaeus, 1758) (Reptilia: Serpentes), with Focus on the Complex Compounds and Their Possible Role in the Chemical Communication Molecules doi: 10.3390/molecules25163622 Authors: Kostadin Andonov Angel Dyugmedzhiev Simeon Lukanov Miroslav Slavchev Emiliya Vacheva Nikola Stanchev Georgi Popgeorgiev Deyan Duhalov Yurii V. Kornilev Daniela Nedeltcheva-Antonova Borislav Naumov Snakes...
Sun Aug 09, 2020 03:00
Molecules, Vol. 25, Pages 3623: Anthocyanins Isolated from Vitis coignetiae Pulliat Enhances Cisplatin Sensitivity in MCF-7 Human Breast Cancer Cells through Inhibition of Akt and NF-κB Activation Molecules doi: 10.3390/molecules25163623 Authors: Anjugam Paramanantham Min Jeong Kim Eun Joo Jung Hye Jung Kim Seong-Hwan Chang Jin-Myung Jung Soon Chan Hong Sung Chul Shin Gon Sup Kim Won Sup Lee Anthocyanins isolated from Vitis coignetiae Pulliat (Meoru in Korea)...
Sun Aug 09, 2020 03:00
Molecules, Vol. 25, Pages 3621: Base-Promoted Annulation of Amidoximes with Alkynes: Simple Access to 2,4-Disubstituted Imidazoles Molecules doi: 10.3390/molecules25163621 Authors: Hina Mehmood Muhammad Asif Iqbal Le Lu Ruimao Hua An efficient construction of imidazole ring by a Cs2CO3-promoted annulation of amidoximes with terminal alkynes in DMSO has been developed. This protocol provides a simple synthetic route with high atom-utilization for the synthesis of 2,4-disubstituted...
Sun Aug 09, 2020 03:00
Molecules, Vol. 25, Pages 3620: Natural Ingredient-Based Polymeric Nanoparticles for Cancer Treatment Molecules doi: 10.3390/molecules25163620 Authors: Ka Hong Wong Aiping Lu Xiaoyu Chen Zhijun Yang Cancer is a global health challenge. There are drawbacks to conventional chemotherapy such as poor bioavailability, development of drug resistance and severe side effects. Novel drug delivery system may be an alternative to optimize therapeutic effects. When such systems consist...
Sun Aug 09, 2020 03:00
Molecules, Vol. 25, Pages 3619: Naturally-Occurring Alkaloids of Plant Origin as Potential Antimicrobials against Antibiotic-Resistant Infections Molecules doi: 10.3390/molecules25163619 Authors: Bruno Casciaro Laura Mangiardi Floriana Cappiello Isabella Romeo Maria Rosa Loffredo Antonia Iazzetti Andrea Calcaterra Antonella Goggiamani Francesca Ghirga Maria Luisa Mangoni Bruno Botta Deborah Quaglio Antibiotic resistance is now considered a worldwide problem...
Sun Aug 09, 2020 03:00
Molecules, Vol. 25, Pages 3618: Toxicity Studies on Graphene-Based Nanomaterials in Aquatic Organisms: Current Understanding Molecules doi: 10.3390/molecules25163618 Authors: Nemi Malhotra Oliver B. Villaflores Gilbert Audira Petrus Siregar Jiann-Shing Lee Tzong-Rong Ger Chung-Der Hsiao Graphene and its oxide are nanomaterials considered currently to be very promising because of their great potential applications in various industries. The exceptional physiochemical...
Sun Aug 09, 2020 03:00
Molecules, Vol. 25, Pages 3616: 15N NMR Shifts of Eumelanin Building Blocks in Water: A Combined Quantum Mechanics/Statistical Mechanics Approach Molecules doi: 10.3390/molecules25163616 Authors: Leonardo Bruno Assis Oliveira Tertius L. Fonseca Benedito J. C. Cabral Theoretical results for the magnetic shielding of protonated and unprotonated nitrogens of eumelanin building blocks including monomers, dimers, and tetramers in gas phase and water are presented. The magnetic property...
Sun Aug 09, 2020 03:00
Molecules, Vol. 25, Pages 3617: Characterization of Anti-Inflammatory and Antioxidant Constituents from Scutellaria baicalensis Using LC-MS Coupled with a Bioassay Method Molecules doi: 10.3390/molecules25163617 Authors: Yoo Kyong Han Hyunwoo Kim Hyeji Shin Jiyeon Song Mi Kyeong Lee Byoungduck Park Ki Yong Lee An effective and previously demonstrated screening method for active constituents in natural products using LC-MS coupled with a bioassay was reported in our...
Sun Aug 09, 2020 03:00
Molecules, Vol. 25, Pages 3615: Construction of Zn(II) Linear Trinuclear Secondary Building Units from A Coordination Polymer Based on α-Acetamidocinnamic Acid and 4-Phenylpyridine Molecules doi: 10.3390/molecules25163615 Authors: Daniel Ejarque Teresa Calvet Mercè Font-Bardia Josefina Pons The synthesis and characterization of one coordination polymer and two trinuclear complexes are presented. The coordination polymer [Zn2(µ-O,O’-ACA)2(ACA)2(4-Phpy)2]n...
Sun Aug 09, 2020 03:00
Molecules, Vol. 25, Pages 3614: Effects of Storage Time and Temperature on Antioxidants in Juice from Momordica charantia L. and Momordica charantia L. var. abbreviata Ser. Molecules doi: 10.3390/molecules25163614 Authors: Yung-Sheng Lin Wen-Ying Huang Pang-Yen Ho Shiou-Yih Hu Ying-Yi Lin Cheng-You Chen Min-Yun Chang Shu-Ling Huang This study determined the antioxidant activities of juice from Momordica charantia L. (MC) and MC var. abbreviata Ser. (MCVAS) by analyzing...
Sun Aug 09, 2020 03:00
Molecules, Vol. 25, Pages 3613: The Cyclic Nitronate Route to Pharmaceutical Molecules: Synthesis of GSK’s Potent PDE4 Inhibitor as a Case Study Molecules doi: 10.3390/molecules25163613 Authors: Evgeny V. Pospelov Ivan S. Golovanov Sema L. Ioffe Alexey Yu. Sukhorukov An efficient asymmetric synthesis of GlaxoSmithKline’s potent PDE4 inhibitor was accomplished in eight steps from a catechol-derived nitroalkene. The key intermediate (3-acyloxymethyl-substituted 1,2-oxazine)...
Sat Aug 08, 2020 03:00
Molecules, Vol. 25, Pages 3611: Development and Validation of a TLC-Densitometry Method for Histamine Monitoring in Fish and Fishery Products Molecules doi: 10.3390/molecules25163611 Authors: Ayoub Kounnoun Adnane Louajri Francesco Cacciola Hafssa El Cadi Hajar Bougtaib Naoual Alahlah Aicha El Baaboua Mohamed El Maadoudi Histamine poisoning is a significant public health problem. Therefore, the monitoring of histamine content in fish and fishery products is considered...
Sat Aug 08, 2020 03:00
Molecules, Vol. 25, Pages 3610: Design and Synthesis of Novel Hybrid 8-Hydroxy Quinoline-Indole Derivatives as Inhibitors of Aβ Self-Aggregation and Metal Chelation-Induced Aβ Aggregation Molecules doi: 10.3390/molecules25163610 Authors: Suresh K. Bowroju Nirjal Mainali Srinivas Ayyadevara Narsimha R. Penthala Sesha Krishnamachari Samuel Kakraba Robert J. Shmookler Reis Peter A. Crooks A series of novel hybrid 8-hydroxyquinoline-indole derivatives (7a–7e, 12a–12b...
Sat Aug 08, 2020 03:00
Molecules, Vol. 25, Pages 3609: Involvement of Differentially Expressed microRNAs in the PEGylated Liposome Encapsulated 188Rhenium-Mediated Suppression of Orthotopic Hypopharyngeal Tumor Molecules doi: 10.3390/molecules25163609 Authors: Bing-Ze Lin Shen-Ying Wan Min-Ying Lin Chih-Hsien Chang Ting-Wen Chen Muh-Hwa Yang Yi-Jang Lee Hypopharyngeal cancer (HPC) accounts for the lowest survival rate among all types of head and neck cancers (HNSCC). However, the therapeutic...
Sat Aug 08, 2020 03:00
Molecules, Vol. 25, Pages 3612: A DFT Study on FeI/FeII/FeIII Mechanism of the Cross-Coupling between Haloalkane and Aryl Grignard Reagent Catalyzed by Iron-SciOPP Complexes Molecules doi: 10.3390/molecules25163612 Authors: Sharma Nakamura To explore plausible reaction pathways of the cross-coupling reaction between a haloalkane and an aryl metal reagent catalyzed by an iron–phosphine complex, we examine the reaction of FeBrPh(SciOPP) 1 and bromocycloheptane employing...
Sat Aug 08, 2020 03:00
Molecules, Vol. 25, Pages 3608: Cannabidiol Determination on Peripheral Capillary Blood Using a Microsampling Method and Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry with On-Line Sample Preparation Molecules doi: 10.3390/molecules25163608 Authors: Federica Pigliasco Sebastiano Barco Sara Dubois Francesca Marchese Pasquale Striano Tommaso Lomonaco Francesca Mattioli Gino Tripodi Giuliana Cangemi The aim of this work is to evaluate volumetric...
Sat Aug 08, 2020 03:00
Molecules, Vol. 25, Pages 3607: Zeaxanthin and Lutein: Photoprotectors, Anti-Inflammatories, and Brain Food Molecules doi: 10.3390/molecules25163607 Authors: Barbara Demmig-Adams Marina López-Pozo Jared J. Stewart William W. Adams This review compares and contrasts the role of carotenoids across the taxa of life—with a focus on the xanthophyll zeaxanthin (and its structural isomer lutein) in plants and humans. Xanthophylls’ multiple protective roles are summarized,...
Sat Aug 08, 2020 03:00
Molecules, Vol. 25, Pages 3605: Comparative Proteomic Analysis of Dipsacus asperoides Roots from Different Habitats in China Molecules doi: 10.3390/molecules25163605 Authors: Haijun Jin Hua Yu Haixia Wang Jia Zhang Dipsacus asperoides is a kind of Chinese herbal medicine with beneficial health properties. To date, the quality of D. asperoides from different habitats has shown significant differences. However, the molecular differences in D. asperoides from different habitats...
Sat Aug 08, 2020 03:00
Molecules, Vol. 25, Pages 3606: Effects of Secretome from Fat Tissues on Ion Currents of Cardiomyocyte Modulated by Sodium-Glucose Transporter 2 Inhibitor Molecules doi: 10.3390/molecules25163606 Authors: Shih-Jie Jhuo I-Hsin Liu Wei-Chung Tsai Te-Wu Chou Yi-Hsiung Lin Bin-Nan Wu Kun-Tai Lee Wen-Ter Lai Sodium-glucose transporter 2 (SGLT2) inhibitors were shown to decrease mortality from cardiovascular diseases in the EMPA-REG trial. However, the effects of empagliflozin...
Sat Aug 08, 2020 03:00
Molecules, Vol. 25, Pages 3604: Safety Evaluation of an Alpha-Emitter Bismuth-213 Labeled Antibody to (1→3)-β-Glucan in Healthy Dogs as a Prelude for a Trial in Companion Dogs with Invasive Fungal Infections Molecules doi: 10.3390/molecules25163604 Authors: Muath Helal Kevin J. H. Allen Hilary Burgess Rubin Jiao Mackenzie E. Malo Matthew Hutcheson Ekaterina Dadachova Elisabeth Snead Background: With the limited options available for therapy to treat invasive fungal...
Sat Aug 08, 2020 03:00
Molecules, Vol. 25, Pages 3603: Recent Advances in the Chemistry of Metal Carbamates Molecules doi: 10.3390/molecules25163603 Authors: Giulio Bresciani Lorenzo Biancalana Guido Pampaloni Fabio Marchetti Following a related review dating back to 2003, the present review discusses in detail the various synthetic, structural and reactivity aspects of metal species containing one or more carbamato ligands, representing a large family of compounds across all the periodic table. A...
Fri Aug 07, 2020 03:00
Molecules, Vol. 25, Pages 3599: Synthesis and Initial Evaluation of a Novel Fluorophore for Selective FMDV 3C Protease Detection Molecules doi: 10.3390/molecules25163599 Authors: Samerah Malik Alex Sinclair Ali Ryan Adam Le Gresley The development and evaluation of a Boc-AL(Boc)Q(Trt)-AMC fluorophore to detect 3C Protease, produced by Foot and Mouth Disease Virus (FMDV) is reported, with a view to a potential use as a rapid screen for FMDV infected livestock The peptide-linked...
Fri Aug 07, 2020 03:00
Molecules, Vol. 25, Pages 3601: High Efficacy of Ozonated Oils on the Removal of Biofilms Produced by Methicillin-Resistant Staphylococcus aureus (MRSA) from Infected Diabetic Foot Ulcers Molecules doi: 10.3390/molecules25163601 Authors: Vanessa Silva Cecília Peirone Joana S. Amaral Rosa Capita Carlos Alonso-Calleja José A. Marques-Magallanes Ângela Martins Águeda Carvalho Luís Maltez José Eduardo Pereira José Luís Capelo Gilberto Igrejas Patrícia Poeta...
Fri Aug 07, 2020 03:00
Molecules, Vol. 25, Pages 3600: Pro-Oxidant Activity of an ALS-Linked SOD1 Mutant in Zn-Deficient Form Molecules doi: 10.3390/molecules25163600 Authors: Chise Nagao Kunisato Kuroi Taiyu Wakabayashi Takakazu Nakabayashi Cu, Zn superoxide dismutase (SOD1) is a representative antioxidant enzyme that catalyzes dismutation of reactive oxygen species in cells. However, (E,E)-SOD1 mutants in which both copper and zinc ions were deleted exhibit pro-oxidant activity, contrary to their...
Fri Aug 07, 2020 03:00
Molecules, Vol. 25, Pages 3602: Neuroprotective Effects of Cryptotanshinone in a Direct Reprogramming Model of Parkinson’s Disease Molecules doi: 10.3390/molecules25163602 Authors: Joo-Eun Lee Hyuna Sim Hee Min Yoo Minhyung Lee Aruem Baek Young-Joo Jeon Kang-Sik Seo Mi-Young Son Joo Seog Yoon Janghwan Kim Parkinson’s disease (PD) is a well-known age-related neurodegenerative disease. Considering the vital importance of disease modeling based on reprogramming...
Fri Aug 07, 2020 03:00
Molecules, Vol. 25, Pages 3594: Toxicity Assessment of SiO2 and TiO2 in Normal Colon Cells, In Vivo and in Human Colon Organoids Molecules doi: 10.3390/molecules25163594 Authors: Sung Bum Park Won Hoon Jung Ki Young Kim Byumseok Koh We conducted systemic assessments on the toxicity of silicon dioxide (SiO2) and titanium dioxide (TiO2) nanoparticles using different forms of normal colon cells (CCD-18Co), in vivo and in human colon organoids. The in vivo acute oral toxicity data...
Fri Aug 07, 2020 03:00
Molecules, Vol. 25, Pages 3597: Kinetics of the Lattice Response to Hydrogen Absorption in Thin Pd and CoPd Films Molecules doi: 10.3390/molecules25163597 Authors: Sudhansu Sekhar Das Gregory Kopnov Alexander Gerber Hydrogen can penetrate reversibly a number of metals, occupy the interstitial sites and cause large expansion of the crystal lattice. The question discussed here is whether the kinetics of the structural response matches hydrogen absorption. We show that thin Pd and...
Fri Aug 07, 2020 03:00
Molecules, Vol. 25, Pages 3596: Anticancer and Antiviral Properties of Cardiac Glycosides: A Review to Explore the Mechanism of Actions Molecules doi: 10.3390/molecules25163596 Authors: Dhanasekhar Reddy Ranjith Kumavath Debmalya Barh Vasco Azevedo Preetam Ghosh Cardiac glycosides (CGs) have a long history of treating cardiac diseases. However, recent reports have suggested that CGs also possess anticancer and antiviral activities. The primary mechanism of action of these...
Fri Aug 07, 2020 03:00
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