IJMS, Vol. 21, Pages 5684: Metabolism of Gallic Acid and Its Distributions in Tea (Camellia sinensis) Plants at the Tissue and Subcellular Levels International Journal of Molecular Sciences doi: 10.3390/ijms21165684 Authors: Xiaochen Zhou Lanting Zeng Yingjuan Chen Xuewen Wang Yinyin Liao Yangyang Xiao Xiumin Fu Ziyin Yang In tea (Camellia sinensis) plants, polyphenols are the representative metabolites and play important roles during their growth. Among tea polyphenols,...
Sat Aug 08, 2020 03:00
IJMS, Vol. 21, Pages 5687: Isoforsythiaside Attenuates Alzheimer’s Disease via Regulating Mitochondrial Function Through the PI3K/AKT Pathway International Journal of Molecular Sciences doi: 10.3390/ijms21165687 Authors: Chunyue Wang Jie Hao Xin Liu Chenliang Li Xuyang Yuan Robert J. Lee Tian Bai Di Wang Improving mitochondrial dysfunction and inhibiting apoptosis has always been regarded as a treatment strategy for Alzheimer’s disease (AD). Isoforsythiaside...
Sat Aug 08, 2020 03:00
IJMS, Vol. 21, Pages 5683: Complex III Inhibition-Induced Pulmonary Hypertension Affects the Mitochondrial Proteomic Landscape International Journal of Molecular Sciences doi: 10.3390/ijms21165683 Authors: Joel James Mathews Valuparampil Varghese Mikhail Vasilyev Paul R. Langlais Stevan P. Tofovic Olga Rafikova Ruslan Rafikov The mitochondria play a vital role in controlling cell metabolism and regulating crucial cellular outcomes. We previously demonstrated that chronic...
Sat Aug 08, 2020 03:00
IJMS, Vol. 21, Pages 5682: YRNAs and YRNA-Derived Fragments as New Players in Cancer Research and Their Potential Role in Diagnostics International Journal of Molecular Sciences doi: 10.3390/ijms21165682 Authors: Kacper Guglas Iga Kołodziejczak Tomasz Kolenda Magda Kopczyńska Anna Teresiak Joanna Sobocińska Renata Bliźniak Katarzyna Lamperska YRNAs are a type of short, noncoding RNAs. A total of four different transcripts can be distinguished, which are YRNA1, YRNA3,...
Sat Aug 08, 2020 03:00
IJMS, Vol. 21, Pages 5681: How the AHR Became Important in Intestinal Homeostasis—A Diurnal FICZ/AHR/CYP1A1 Feedback Controls Both Immunity and Immunopathology International Journal of Molecular Sciences doi: 10.3390/ijms21165681 Authors: Agneta Rannug Ever since the 1970s, when profound immunosuppression caused by exogenous dioxin-like compounds was first observed, the involvement of the aryl hydrocarbon receptor (AHR) in immunomodulation has been the focus of considerable research...
Sat Aug 08, 2020 03:00
IJMS, Vol. 21, Pages 5680: Contributions of Nitric Oxide to AHR-Ligand-Mediated Keratinocyte Differentiation International Journal of Molecular Sciences doi: 10.3390/ijms21165680 Authors: Carrie Hayes Sutter Haley M. Rainwater Thomas R. Sutter Activation of the aryl hydrocarbon receptor (AHR) in normal human epidermal keratinocytes (NHEKs) accelerates keratinocyte terminal differentiation through metabolic reprogramming and reactive oxygen species (ROS) production. Of the three...
Sat Aug 08, 2020 03:00
IJMS, Vol. 21, Pages 5679: Phenylpropanoids Are Connected to Cell Wall Fortification and Stress Tolerance in Avocado Somatic Embryogenesis International Journal of Molecular Sciences doi: 10.3390/ijms21165679 Authors: Carol A. Olivares-García Martín Mata-Rosas Carolina Peña-Montes Francisco Quiroz-Figueroa Aldo Segura-Cabrera Laura M. Shannon Victor M. Loyola-Vargas Juan L. Monribot-Villanueva Jose M. Elizalde-Contreras Enrique Ibarra-Laclette Mónica Ramirez-Vázquez...
Sat Aug 08, 2020 03:00
IJMS, Vol. 21, Pages 5677: The Role of the Liver-Specific microRNA, miRNA-122 in the HCV Replication Cycle International Journal of Molecular Sciences doi: 10.3390/ijms21165677 Authors: Rasika D. Kunden Juveriya Q. Khan Sarah Ghezelbash Joyce A. Wilson Hepatitis C virus (HCV) replication requires annealing of a liver specific microRNA, miR-122 to 2 sites on 5′ untranslated region (UTR). While, microRNAs downregulate gene expression by binding to the 3′ untranslated...
Fri Aug 07, 2020 03:00
IJMS, Vol. 21, Pages 5678: Sarcopenia in Autoimmune and Rheumatic Diseases: A Comprehensive Review International Journal of Molecular Sciences doi: 10.3390/ijms21165678 Authors: Hyo Jin An Kalthoum Tizaoui Salvatore Terrazzino Sarah Cargnin Keum Hwa Lee Seoung Wan Nam Jae Seok Kim Jae Won Yang Jun Young Lee Lee Smith Ai Koyanagi Louis Jacob Han Li Jae Il Shin Andreas Kronbichler Sarcopenia refers to a decrease in skeletal muscle mass and function....
Fri Aug 07, 2020 03:00
IJMS, Vol. 21, Pages 5676: Role of Excitatory Amino Acid Carrier 1 (EAAC1) in Neuronal Death and Neurogenesis After Ischemic Stroke International Journal of Molecular Sciences doi: 10.3390/ijms21165676 Authors: Minwoo Lee Dong Gyun Ko Dae Ki Hong Man-Sup Lim Bo Young Choi Sang Won Suh Although there have been substantial advances in knowledge regarding the mechanisms of neuron death after stroke, effective therapeutic measures for stroke are still insufficient. Excitatory...
Fri Aug 07, 2020 03:00
IJMS, Vol. 21, Pages 5674: Development and Evaluation of Novel and Highly Sensitive Single-Tube Nested Real-Time RT-PCR Assays for SARS-CoV-2 Detection International Journal of Molecular Sciences doi: 10.3390/ijms21165674 Authors: Cyril Chik-Yan Yip Siddharth Sridhar Kit-Hang Leung Anthony Chin-Ki Ng Kwok-Hung Chan Jasper Fuk-Woo Chan Owen Tak-Yin Tsang Ivan Fan-Ngai Hung Vincent Chi-Chung Cheng Kwok-Yung Yuen Kelvin Kai-Wang To Sensitive molecular assays...
Fri Aug 07, 2020 03:00
IJMS, Vol. 21, Pages 5675: Small Non-Coding RNAome of Ageing Chondrocytes International Journal of Molecular Sciences doi: 10.3390/ijms21165675 Authors: Panagiotis Balaskas Jonathan A. Green Tariq M. Haqqi Philip Dyer Yalda A. Kharaz Yongxiang Fang Xuan Liu Tim J.M. Welting Mandy J. Peffers Ageing is a leading risk factor predisposing cartilage to osteoarthritis. However, little research has been conducted on the effect of ageing on the expression of small non-coding...
Fri Aug 07, 2020 03:00
IJMS, Vol. 21, Pages 5673: Changes in Novel AKI Biomarkers after Exercise. A Systematic Review International Journal of Molecular Sciences doi: 10.3390/ijms21165673 Authors: Wojciech Wołyniec Wojciech Ratkowski Joanna Renke Marcin Renke More than 100 substances have been identified as biomarkers of acute kidney injury. These markers can help to diagnose acute kidney injury (AKI) in its early phase, when the creatinine level is not increased. The two markers most frequently studied...
Fri Aug 07, 2020 03:00
IJMS, Vol. 21, Pages 5671: Dual Substrate Specificity of the Rutinosidase from Aspergillus niger and the Role of Its Substrate Tunnel International Journal of Molecular Sciences doi: 10.3390/ijms21165671 Authors: Katerina Brodsky Michal Kutý Helena Pelantová Josef Cvačka Martin Rebroš Michael Kotik Ivana Kutá Smatanová Vladimír Křen Pavla Bojarová Rutinosidases (α-l-rhamnopyranosyl-(1-6)-β-d-glucopyranosidases, EC 3.2.1.168, CAZy GH5) are diglycosidases...
Fri Aug 07, 2020 03:00
IJMS, Vol. 21, Pages 5670: Evolution of Urothelial Bladder Cancer in the Context of Molecular Classifications International Journal of Molecular Sciences doi: 10.3390/ijms21165670 Authors: Martina Minoli Mirjam Kiener George N. Thalmann Marianna Kruithof-de Julio Roland Seiler Bladder cancer is a heterogeneous disease that is not depicted by current classification systems. It was originally classified into non-muscle invasive and muscle invasive. However, clinically and genetically...
Fri Aug 07, 2020 03:00
IJMS, Vol. 21, Pages 5672: Inhibition of Rab27a and Rab27b Has Opposite Effects on the Regulation of Hair Cycle and Hair Growth International Journal of Molecular Sciences doi: 10.3390/ijms21165672 Authors: Kyung-Eun Ku Nahyun Choi Jong-Hyuk Sung Rab27a/b are known to play an important role in the transport of melanosomes, with their knockout causing silvery gray hair. However, the relationship between Rab27a/b and hair growth is not well known. To evaluate the role of Rab27a/b...
Fri Aug 07, 2020 03:00
IJMS, Vol. 21, Pages 5668: The CBL–CIPK Pathway in Plant Response to Stress Signals International Journal of Molecular Sciences doi: 10.3390/ijms21165668 Authors: Xiao Ma Quan-Hui Li Ya-Nan Yu Yi-Ming Qiao Saeed ul Haq Zhen-Hui Gong Plants need to cope with multitudes of stimuli throughout their lifecycles in their complex environments. Calcium acts as a ubiquitous secondary messenger in response to numerous stresses and developmental processes in plants. The major Ca2+...
Fri Aug 07, 2020 03:00
IJMS, Vol. 21, Pages 5669: Antitumor Efficacy of the Herbal Recipe Benja Amarit against Highly Invasive Cholangiocarcinoma by Inducing Apoptosis both In Vitro and In Vivo International Journal of Molecular Sciences doi: 10.3390/ijms21165669 Authors: Rittibet Yapasert Nirush Lertprasertsuk Subhawat Subhawa Juthathip Poofery Bungorn Sripanidkulchai Ratana Banjerdpongchai Thailand is the country with highest incidence and prevalence of cholangiocarcinoma (CCA) in the world....
Fri Aug 07, 2020 03:00
IJMS, Vol. 21, Pages 5665: A Revolution toward Gene-Editing Technology and Its Application to Crop Improvement International Journal of Molecular Sciences doi: 10.3390/ijms21165665 Authors: Sunny Ahmar Sumbul Saeed Muhammad Hafeez Ullah Khan Shahid Ullah Khan Freddy Mora-Poblete Muhammad Kamran Aroosha Faheem Ambreen Maqsood Muhammad Rauf Saba Saleem Woo-Jong Hong Ki-Hong Jung Genome editing is a relevant, versatile, and preferred tool for crop improvement,...
Fri Aug 07, 2020 03:00
IJMS, Vol. 21, Pages 5667: MiR-93/miR-375: Diagnostic Potential, Aggressiveness Correlation and Common Target Genes in Prostate Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21165667 Authors: Ewa Ciszkowicz Paweł Porzycki Małgorzata Semik Ewa Kaznowska Mirosław Tyrka Dysregulation of miRNAs has a fundamental role in the initiation, development and progression of prostate cancer (PCa). The potential of miRNA in gene therapy and diagnostic applications...
Fri Aug 07, 2020 03:00
IJMS, Vol. 21, Pages 5666: A Practical Review of NMR Lineshapes for Spin-1/2 and Quadrupolar Nuclei in Disordered Materials International Journal of Molecular Sciences doi: 10.3390/ijms21165666 Authors: Kuizhi Chen NMR is a powerful spectroscopic method that can provide information on the structural disorder in solids, complementing scattering and diffraction techniques. The structural disorder in solids can generate a dispersion of local magnetic and electric fields, resulting in a...
Fri Aug 07, 2020 03:00
IJMS, Vol. 21, Pages 5662: IGF2BP2 Polymorphisms Are Associated with Clinical Characteristics and Development of Oral Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21165662 Authors: Chia-Hsuan Chou Chien-Yuan Chang Hsueh-Ju Lu Min-Chien Hsin Mu-Kuan Chen Hsien-Cheng Huang Chia-Ming Yeh Chiao-Wen Lin Shun-Fa Yang Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is associated with insulin resistance, lipid metabolism, and tumorigenesis....
Fri Aug 07, 2020 03:00
IJMS, Vol. 21, Pages 5663: Metabolic Dysregulation in Idiopathic Pulmonary Fibrosis International Journal of Molecular Sciences doi: 10.3390/ijms21165663 Authors: Elena Bargagli Rosa Metella Refini Miriana d'Alessandro Laura Bergantini Paolo Cameli Lorenza Vantaggiato Luca Bini Claudia Landi Idiopathic pulmonary fibrosis (IPF) is a fibroproliferative disorder limited to the lung. New findings, starting from our proteomics studies on IPF, suggest that systemic involvement...
Fri Aug 07, 2020 03:00
IJMS, Vol. 21, Pages 5664: Functional Aspects of Seminal Plasma in Bird Reproduction International Journal of Molecular Sciences doi: 10.3390/ijms21165664 Authors: Julian Santiago-Moreno Elisabeth Blesbois This review provides an updated overview of the seminal plasma composition, and the role of metabolic and protein components on the sperm function of avian species. In addition, the implication of seminal plasma on assisted reproductive techniques of birds was discussed. The semen...
Fri Aug 07, 2020 03:00
IJMS, Vol. 21, Pages 5661: Orchestration of Intracellular Circuits by G Protein-Coupled Receptor 39 for Hepatitis B Virus Proliferation International Journal of Molecular Sciences doi: 10.3390/ijms21165661 Authors: Kaku Goto Hironori Nishitsuji Masaya Sugiyama Nao Nishida Masashi Mizokami Kunitada Shimotohno Hepatitis B virus (HBV), a highly persistent pathogen causing hepatocellular carcinoma (HCC), takes full advantage of host machinery, presenting therapeutic targets....
Fri Aug 07, 2020 03:00
JCM, Vol. 9, Pages 2578: Antithrombotic PreTreatment and Invasive Strategies in Patients with Non-ST-Segment Elevation Acute Coronary Syndrome Journal of Clinical Medicine doi: 10.3390/jcm9082578 Authors: Cyril Camaro Peter Damman In the current era, the antithrombotic treatment of patients with non-ST segment elevation acute coronary syndrome (NSTE-ACS) includes standard aspirin, and one of the potent P2Y12 inhibitors ticagrelor or prasugrel. The optimal timing of ticagrelor has...
Sun Aug 09, 2020 03:00
JCM, Vol. 9, Pages 2577: Gene Therapy in Rare Respiratory Diseases: What Have We Learned So Far? Journal of Clinical Medicine doi: 10.3390/jcm9082577 Authors: Lucía Bañuls Daniel Pellicer Silvia Castillo María Mercedes Navarro-García María Magallón Cruz González Francisco Dasí Gene therapy is an alternative therapy in many respiratory diseases with genetic origin and currently without curative treatment. After five decades of progress, many different vectors and gene...
Sat Aug 08, 2020 03:00
JCM, Vol. 9, Pages 2574: Molecular Mechanisms of AKI in the Elderly: From Animal Models to Therapeutic Intervention Journal of Clinical Medicine doi: 10.3390/jcm9082574 Authors: Barbara Infante Rossana Franzin Desirèe Madio Martina Calvaruso Annamaria Maiorano Fabio Sangregorio Giuseppe Stefano Netti Elena Ranieri Loreto Gesualdo Giuseppe Castellano Giovanni Stallone Acute kidney injury (AKI), a critical syndrome characterized by a sudden reduction of renal...
Sat Aug 08, 2020 03:00
JCM, Vol. 9, Pages 2575: Abnormal Microvascular Architecture, Fibrosis, and Pericyte Characteristics in the Calf Muscle of Peripheral Artery Disease Patients with Claudication and Critical Limb Ischemia Journal of Clinical Medicine doi: 10.3390/jcm9082575 Authors: Constance J. Mietus Timothy J. Lackner Petros S. Karvelis Gregory T. Willcockson Christina M. Shields Nicholas G. Lambert Panagiotis Koutakis Matthew A. Fuglestad Hernan Hernandez Gleb R. Haynatzki Julian...
Sat Aug 08, 2020 03:00
JCM, Vol. 9, Pages 2576: Limited Mandibular Movements as a Consequence of Unilateral or Asymmetrical Temporomandibular Joint Involvement in Juvenile Idiopathic Arthritis Patients Journal of Clinical Medicine doi: 10.3390/jcm9082576 Authors: Tamara Pawlaczyk-Kamieńska Tomasz Kulczyk Elżbieta Pawlaczyk-Wróblewska Maria Borysewicz-Lewicka Marek Niedziela This study aimed to assess the asymmetry of the lower face and motor dysfunction of the masticatory system resulting from...
Sat Aug 08, 2020 03:00
JCM, Vol. 9, Pages 2572: Screening Services in a Community Pharmacy in Poznan (Poland) to Increase Early Detection of Hypertension Journal of Clinical Medicine doi: 10.3390/jcm9082572 Authors: Magdalena Waszyk-Nowaczyk Weronika Guzenda Beata Plewka Michał Michalak Magdalena Cerbin-Koczorowska Łukasz Stryczyński Michał Byliniak Anna Ratka Background: Community pharmacies in many countries around the world provide healthcare services for patients. Pharmacists trained...
Sat Aug 08, 2020 03:00
JCM, Vol. 9, Pages 2571: A Novel Clinical Perspective on New Masses after Lead Extraction (Ghosts) by Means of Intracardiac Echocardiography Journal of Clinical Medicine doi: 10.3390/jcm9082571 Authors: Carlo Caiati Giovanni Luzzi Paolo Pollice Stefano Favale Mario Erminio Lepera Background: A lead-reactive fibrous capsule (FC) identified by ultrasounds as an atrial or ventricular lead thickness of more than 1 mm above the vendor-declared lead diameter (TL) and its local...
Sat Aug 08, 2020 03:00
JCM, Vol. 9, Pages 2573: MicroRNA-222 Regulates Melanoma Plasticity Journal of Clinical Medicine doi: 10.3390/jcm9082573 Authors: Maria Chiara Lionetti Filippo Cola Oleksandr Chepizhko Maria Rita Fumagalli Francesc Font-Clos Roberto Ravasio Saverio Minucci Paola Canzano Marina Camera Guido Tiana Stefano Zapperi Caterina A. M. La Porta Melanoma is one of the most aggressive and highly resistant tumors. Cell plasticity in melanoma is one of the main culprits...
Sat Aug 08, 2020 03:00
JCM, Vol. 9, Pages 2570: Promises of Fibroblast Growth Factor Receptor–Directed Therapy in Tailored Cancer Treatment Journal of Clinical Medicine doi: 10.3390/jcm9082570 Authors: Sharmila Fagoonee Rinaldo Pellicano Cancer, one of the deadliest and undefeatable diseases, involves the deregulated growth of cells with the conferment of a high potential to metastasize [...]
Sat Aug 08, 2020 03:00
JCM, Vol. 9, Pages 2569: The Impact of Spinopelvic Mobility on Arthroplasty: Implications for Hip and Spine Surgeons Journal of Clinical Medicine doi: 10.3390/jcm9082569 Authors: Henryk Haffer Dominik Adl Amini Carsten Perka Matthias Pumberger Spinopelvic mobility represents the complex interaction of hip, pelvis, and spine. Understanding this interaction is relevant for both arthroplasty and spine surgeons, as a predicted increasing number of patients will suffer from hip and...
Sat Aug 08, 2020 03:00
JCM, Vol. 9, Pages 2568: Modified Split-Scan Computed Tomography (CT) Diagnostics of Severely Injured Patients: First Results from a Level I Trauma Center Using a Dedicated Head-and-Neck CT-Angiogram for the Detection of Cervical Artery Dissections Journal of Clinical Medicine doi: 10.3390/jcm9082568 Authors: Daniel Popp Claudius Thiedemann Wolf Bäumler Antonio Ernstberger Volker Alt Andreas Schicho Introduction: Traumatic cervical artery dissections are associated with...
Sat Aug 08, 2020 03:00
JCM, Vol. 9, Pages 2564: Maternal-Autoantibody-Related (MAR) Autism: Identifying Neuronal Antigens and Approaching Prospects for Intervention Journal of Clinical Medicine doi: 10.3390/jcm9082564 Authors: Katya Marks Angela Vincent Ester Coutinho Recent studies indicate the existence of a maternal-autoantibody-related subtype of autism spectrum disorder (ASD). To date, a large number of studies have focused on describing patterns of brain-reactive serum antibodies in maternal-autoantibody-related...
Fri Aug 07, 2020 03:00
JCM, Vol. 9, Pages 2566: Methylphenidate in Autism Spectrum Disorder: A Long-Term Follow up Naturalistic Study Journal of Clinical Medicine doi: 10.3390/jcm9082566 Authors: Ventura de Giambattista Spagnoletta Trerotoli Cavone Di Gioia Margari Autism spectrum disorder (ASD) often co-occurs with attention deficit/hyperactivity disorder (ADHD). Although methylphenidate (MPH) efficacy and safety are well-demonstrated for ADHD, evidences are scant in the context of...
Fri Aug 07, 2020 03:00
JCM, Vol. 9, Pages 2565: Evolving Technologies in Gastrointestinal Microbiome Era and Their Potential Clinical Applications Journal of Clinical Medicine doi: 10.3390/jcm9082565 Authors: Abraham Ajayi Tolulope Jolaiya Stella Smith The human gastrointestinal microbiota (GIM) is a complex and diverse ecosystem that consists of community of fungi, viruses, protists and majorly bacteria. The association of several human illnesses, such as inflammatory bowel disease, allergy, metabolic...
Fri Aug 07, 2020 03:00
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