New Findings What is the central question of this study? This study aims to explore the functions of lncRNA OIP5‐AS1 in rheumatoid arthritis inflammation and development and molecule mechanism. What is the main finding and its importance? LncRNA OIP5‐AS1 mitigates rheumatoid arthritis progression through the ceRNA network involving miR‐448/PON1 axis and through the inactivation of the TLR3/NF‐κB signaling pathway. This study may offer new ideas for molecule‐based control for rheumatoid...
Fri Aug 07, 2020 20:26
New Findings What is the central question of this study? How do peripheral muscle tissue oxygenation and physical conditioning levels of children and adolescents with cystic fibrosis compare to demographically matched controls? What is the main finding and is its importance? Children and adolescents with cystic fibrosis consumed more oxygen, more quickly and exhibited slower recovery, demonstrating that there may have been deficiencies in oxygen supply related to both oxygen uptake...
Fri Aug 07, 2020 20:25
Abstract Sjögren’s syndrome (SS) is a chronic autoimmune disease targeting salivary and lacrimal glands. C-X-C motif chemokine ligand 10 (CXCL10) expression is upregulated in lip salivary glands (LSGs) of primary SS (pSS) patients, and CXCL10 involved in SS pathogenesis via immune-cell accumulation. Moreover, interferon (IFN)-γ enhances CXCL10 production via the Janus kinase (JAK)/signal transducer and activator of transcription (STAT)...
Sun Aug 09, 2020 03:00
Abstract Type D personality has been consistently associated with adverse cardiovascular health with atypical cardiovascular reactions to psychological stress one potential underlying mechanism. As Type D individuals have been noted to report lower social support and greater perceptions of negativity in social interactions, this study examined if the association between Type D personality and cardiovascular reactivity was mediated by these social relationships. A sample of 195 undergraduate students...
Fri Aug 07, 2020 14:53
Abstract ‘Inter‐hemispheric inhibition’ is used frequently to describe the action of one hemisphere in suppressing or impeding processing in its counterpart. It is widely believed that this is required in order to prevent a bilateral cerebrum giving rise to simultaneous and potentially competing outputs. It is argued here that a fundamental role of inter‐hemispheric inhibition is to support contrast enhancing and integrative functions by co‐opting the capacities of the two cerebral hemispheres....
Sat Aug 08, 2020 16:53
Key points The carotid chemoreceptor mediates the ventilatory and muscle sympathetic nerve activity (MSNA) responses to hypoxia and contributes to tonic sympathetic and respiratory drives. It is often presumed that both excitatory and inhibitory tests of chemoreflex function show congruence in the end‐organ responses. We measured ventilatory and neurocirculatory (MSNA, blood pressure, and heart rate) responses to chemoreflex inhibition elicited by transient hyperoxia and to chemoreflex excitation...
Fri Aug 07, 2020 21:59
Key points S100A4 is expressed in many tissues including smooth muscle, but its physiologic function is unknown. S100A4 regulates the motility of metastatic cancer cells by binding to non‐muscle myosin II. Contractile stimulation causes the polymerization of NM myosin in airway smooth muscle, which is necessary for tension development. NM myosin regulates the assembly of adhesion junction signalling complexes (adhesomes) that catalyze actin polymerization. In airway smooth muscle, ACh stimulated...
Fri Aug 07, 2020 16:46
Key points A fall in oxygen supply releases a remedial response that is otherwise prevented when the oxygen supply is sufficient; for example, the remedial function of HIF‐1α is released when oxygen levels fall. Concept: the physiological responses initiated when oxygen supply is compromised operate in a fail‐safe manner. This concept is applied to two cases: the control of cerebral blood flow, and the detection of hypoxia by the carotid body. The fail‐safe oxygen supply concept was tested with...
Thu Aug 06, 2020 13:44
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