Antibiotics, Vol. 9, Pages 148: Development of Staphylococcus Enzybiotics: The Ph28 Gene of Staphylococcus epidermidis Phage PH15 Is a Two-Domain Endolysin Antibiotics doi: 10.3390/antibiotics9040148 Authors: Muharram Abulhamd Aldawsari Alqarni Labrou Given the worldwide increase in antibiotic resistant bacteria, bacteriophage derived endolysins represent a very promising new alternative class of antibacterials in the fight against infectious diseases. Endolysins are...
Mon Mar 30, 2020 03:00
Antibiotics, Vol. 9, Pages 147: Essential Oils of Aromatic Plants with Antibacterial, Anti-Biofilm and Anti-Quorum Sensing Activities against Pathogenic Bacteria Antibiotics doi: 10.3390/antibiotics9040147 Authors: Marlon Cáceres William Hidalgo Elena Stashenko Rodrigo Torres Claudia Ortiz Both the ability of bacteria to form biofilms and communicate through quorum sensing allows them to develop different survival or virulence traits that lead to increased bacterial resistance...
Mon Mar 30, 2020 03:00
Antibiotics, Vol. 9, Pages 146: Peer-Education as a Tool to Educate on Antibiotics, Resistance and Use in 16–18-Year-Olds: A Feasibility Study Antibiotics doi: 10.3390/antibiotics9040146 Authors: Cliodna A. M. McNulty Rowshonara B. Syeda Carla L. Brown C. Verity Bennett Behnaz Schofield David G. Allison Neville Q. Verlander Nick Francis Peer education (PE) interventions may help improve knowledge and appropriate use of antibiotics in young adults. In this feasibility...
Mon Mar 30, 2020 03:00
Antioxidants, Vol. 9, Pages 289: Correction: Biswas, M.S. et al. Inactivation of Carbonyl-Detoxifying Enzymes by H2O2 Is a Trigger to Increase Carbonyl Load for Initiating Programmed Cell Death in Plants. Antioxidants 2020, 9, 141 Antioxidants doi: 10.3390/antiox9040289 Authors: Md. Sanaullah Biswas Ryota Terada Jun’ichi Mano The author wishes to make the following correction to this paper [...]
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Antioxidants, Vol. 9, Pages 288: Metabolic Flux Analysis of Catechin Biosynthesis Pathways Using Nanosensor Antioxidants doi: 10.3390/antiox9040288 Authors: Habiba Kausar Ghazala Ambrin Mohammad K. Okla Walid Soufan Abdullah A. Al-Ghamdi Altaf Ahmad (+)-Catechin is an important antioxidant of green tea (Camelia sinensis (L.) O. Kuntze). Catechin is known for its positive role in anticancerous activity, extracellular matrix degradation, cell death regulation, diabetes,...
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Arts, Vol. 9, Pages 45: Not Different Enough: Avoiding Representation as “Balkan” and the Constrained Appeal of Macedonian Ethno Music Arts doi: 10.3390/arts9020045 Authors: Dave Wilson Since the early 1990s, interest in various forms of traditional music among middle-class urban ethnic Macedonians has grown. Known by some as the “Ethno Renaissance”, this trend initially grew in the context of educational ensembles in Skopje and gained momentum due to the soundtrack...
Mon Mar 30, 2020 03:00
Atmosphere, Vol. 11, Pages 341: Density Correction of NRLMSISE-00 in the Middle Atmosphere (20–100 km) based on TIMED/SABER Density Data Atmosphere doi: 10.3390/atmos11040341 Authors: Xuan Cheng Junfeng Yang Cunying Xiao Xiong Hu This paper describes the density correction of the NRLMSISE-00 using more than 15 years (2002–2016) of TIMED/SABER satellite atmospheric density data from the middle atmosphere (20–100 km). A bias correction factor dataset is established...
Mon Mar 30, 2020 03:00
Atmosphere, Vol. 11, Pages 340: Chemical Composition of PM2.5 and its Impact on Inhalation Health Risk Evaluation in a City with Light Industry in Central China Atmosphere doi: 10.3390/atmos11040340 Authors: Wang Zhao Wang Yin Geng Niu Yang Yu Li A city with light industry in China was selected for the study of the chemical characteristics of PM2.5 and to assess its impact on inhalation health risks. During the period from May 2017 to February 2018, a...
Mon Mar 30, 2020 03:00
Atmosphere, Vol. 11, Pages 339: Modeling Land Suitability for Vitis vinifera in Michigan Using Advanced Geospatial Data and Methods Atmosphere doi: 10.3390/atmos11040339 Authors: Dan Wanyama Erin L. Bunting Robert Goodwin Nicholas Weil Paolo Sabbatini Jeffrey A. Andresen Michigan (MI) has a long history of diverse agricultural production. One of the most rapidly expanding and profitable agricultural crops, wine grapes (Vitis vinifera L.), has only been in cultivation across...
Mon Mar 30, 2020 03:00
Atmosphere, Vol. 11, Pages 338: Implicit Equal-Weights Variational Particle Smoother Atmosphere doi: 10.3390/atmos11040338 Authors: Pinqiang Wang Mengbin Zhu Yan Chen and Weimin Zhang Under the motivation of the great success of four-dimensional variational (4D-Var) data assimilation methods and the advantages of ensemble methods (e.g., Ensemble Kalman Filters and Particle Filters) in numerical weather prediction systems, we introduce the implicit equal-weights particle filter...
Mon Mar 30, 2020 03:00
Atmosphere, Vol. 11, Pages 336: Chemical Compositions and Source Analysis of PM2.5 during Autumn and Winter in a Heavily Polluted City in China Atmosphere doi: 10.3390/atmos11040336 Authors: Shasha Tian Yingying Liu Jing Wang Jian Wang Lujian Hou Bo Lv Xinhua Wang Xueyan Zhao Wen Yang Chunmei Geng Bin Han Zhipeng Bai As one of the biggest cities in North China, Jinan has been suffering heavy air pollution in recent decades. To better characterize the...
Mon Mar 30, 2020 03:00
Atmosphere, Vol. 11, Pages 337: A Portfolio Policy Package to Reduce Greenhouse Gas Emissions Atmosphere doi: 10.3390/atmos11040337 Authors: John Freebairn Arguments for a portfolio of price, regulation and subsidy policy interventions to reduce the production and consumption of greenhouse gas emissions are presented. The operation and effects of each intervention are described and compared. A combination of different sets of market failures across the many potential decision changes...
Mon Mar 30, 2020 03:00
Atmosphere, Vol. 11, Pages 335: Evaluating Temperature Measurements of the iMET-XQ, in the Field, under Varying Atmospheric Conditions Atmosphere doi: 10.3390/atmos11040335 Authors: Sytske K. Kimball Carlos J. Montalvo Madhuri S. Mulekar Temperature measurements of InterMET Inc. aluminum-coated iMET-XQ sensors were tested in an outdoor setting under a variety of solar radiation and wind speed conditions. Twelve unshielded sensors were mounted side-by-side on the tower of a South...
Mon Mar 30, 2020 03:00
Atmosphere, Vol. 11, Pages 334: Long-Term Characterization of Submicron Atmospheric Particles in an Urban Background Site in Southern Italy Atmosphere doi: 10.3390/atmos11040334 Authors: Adelaide Dinoi Marianna Conte Fabio M. Grasso Daniele Contini Continuous measurements of particle number size distributions in the size range from 10 nm to 800 nm were performed from 2015 to 2019 at the ECO Environmental-Climate Observatory of Lecce (Global Atmosphere Watch Programme/Aerosol,...
Mon Mar 30, 2020 03:00
Biology, Vol. 9, Pages 65: Osteoarthritis and Toll-Like Receptors: When Innate Immunity Meets Chondrocyte Apoptosis Biology doi: 10.3390/biology9040065 Authors: Goncalo Barreto Mikko Manninen Kari K. Eklund Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but accumulating evidence indicates that inflammation has a critical role in its pathogenesis. In particular, chondrocyte-mediated inflammatory responses triggered by the activation of innate immune...
Mon Mar 30, 2020 03:00
Biomolecules, Vol. 10, Pages 525: Characterization of a Novel Ginsenoside MT1 Produced by an Enzymatic Transrhamnosylation of Protopanaxatriol-Type Ginsenosides Re Biomolecules doi: 10.3390/biom10040525 Authors: Byeong-Min Jeon Jong-In Baek Min-Sung Kim Sun-Chang Kim Chang-hao Cui Background: Ginsenosides, triterpene saponins of Panax species, are considered the main active ingredients responsible for various pharmacological activities. Herein, a new protopanaxatriol-type...
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Biomolecules, Vol. 10, Pages 524: Uncovering Prognosis-Related Genes and Pathways by Multi-Omics Analysis in Lung Cancer Biomolecules doi: 10.3390/biom10040524 Authors: Asada Kobayashi Joutard Tubaki Takahashi Takasawa Komatsu Kaneko Sese Hamamoto Lung cancer is one of the leading causes of death worldwide. Therefore, understanding the factors linked to patient survival is essential. Recently, multi-omics analysis has emerged, allowing for patient...
Mon Mar 30, 2020 03:00
Biomolecules, Vol. 10, Pages 523: Effects of Light Quality and Phytochrome Form on Melatonin Biosynthesis in Rice Biomolecules doi: 10.3390/biom10040523 Authors: Ok Jin Hwang Kiyoon Kang Kyoungwhan Back Light is an important factor influencing melatonin synthesis in response to cadmium treatment in rice. However, the effects of light quality on, and the involvement of phytochrome light receptors in, melatonin production have not been explored. In this study, we used light-emitting...
Mon Mar 30, 2020 03:00
Biomolecules, Vol. 10, Pages 522: Half Way to Hypusine—Structural Basis for Substrate Recognition by Human Deoxyhypusine Synthase Biomolecules doi: 10.3390/biom10040522 Authors: Wątor Wilk Grudnik Deoxyhypusine synthase (DHS) is a transferase enabling the formation of deoxyhypusine, which is the first, rate-limiting step of a unique post-translational modification: hypusination. DHS catalyses the transfer of a 4-aminobutyl moiety of polyamine spermidine to a specific lysine...
Mon Mar 30, 2020 03:00
Biomolecules, Vol. 10, Pages 521: Myo-Inositol Transporter SLC5A3 Associates with Degenerative Changes and Inflammation in Sporadic Inclusion Body Myositis Biomolecules doi: 10.3390/biom10040521 Authors: De Paepe Merckx Jarošová Cannizzaro De Bleecker Myo-inositol exerts many cellular functions, which include osmo-protection, membrane functioning, and secondary messaging. Its Na+/myo-inositol co-transporter SLC5A3 is expressed in muscle tissue and further accumulates...
Mon Mar 30, 2020 03:00
Biomolecules, Vol. 10, Pages 520: Temporal Dynamics of High-Density Lipoprotein Proteome in Diet-Controlled Subjects with Type 2 Diabetes Biomolecules doi: 10.3390/biom10040520 Authors: Karim G. Kheniser Abdullah Osme Chunki Kim Serguei Ilchenko Takhar Kasumov Sangeeta R. Kashyap We examined the effect of mild hyperglycemia on high-density lipoprotein (HDL) metabolism and kinetics in diet-controlled subjects with type 2 diabetes (T2D). 2H2O-labeling coupled with mass spectrometry...
Mon Mar 30, 2020 03:00
Biosensors, Vol. 10, Pages 31: Competitive HRP-Linked Colorimetric Aptasensor for the Detection of Fumonisin B1 in Food based on Dual Biotin-Streptavidin Interaction Biosensors doi: 10.3390/bios10040031 Authors: Zui Tao You Zhou Xiang Li Zhouping Wang Fumonisin B1 (FB1) is the most prevalent and toxic form among fumonisin homologues which are produced by fusarium species and it contaminates various types of food products, posing serious health hazards for humans and animals....
Mon Mar 30, 2020 03:00
Brain Sciences, Vol. 10, Pages 201: Chemosensory Event-Related Potentials and Power Spectrum could be A Possible Biomarker in 3M Syndrome Infants? Brain Sciences doi: 10.3390/brainsci10040201 Authors: Invitto Grasso Lofrumento Ciccarese Paladini Paladini Marulli Pascalis Polsinelli Placidi 3M syndrome is a rare disorder that involves the gene cullin-7 (CUL7). CUL7 modulates odour detection, conditions the olfactory response (OR) and plays a role in...
Mon Mar 30, 2020 03:00
Cancers, Vol. 12, Pages 832: Landscape and Future Perspectives of Immunotherapy in Neuroendocrine Neoplasia Cancers doi: 10.3390/cancers12040832 Authors: Maggio Manuzzi Lamberti Ricci Tober Campana Background: Neuroendocrine neoplasms are rare entities consisting of a heterogeneous group of tumors that can originate from neuroendocrine cells present in the whole body. Their different behavior, metastatic potential, and prognosis are highly variable, depending on...
Mon Mar 30, 2020 03:00
Cancers, Vol. 12, Pages 833: An Easy-To-Use Survival Score Compared to Existing Tools for Older Patients with Cerebral Metastases from Colorectal Cancer Cancers doi: 10.3390/cancers12040833 Authors: Dirk Rades Trang Nguyen Stefan Janssen Steven E. Schild An easy-to-use survival score was developed specifically for older patients with cerebral metastases from colorectal cancer, and was compared to existing tools regarding the accuracy of identifying patients who die in ≤6...
Mon Mar 30, 2020 03:00
Cancers, Vol. 12, Pages 831: Preclinical Study Using ABT263 to Increase Enzalutamide Sensitivity to Suppress Prostate Cancer Progression Via Targeting BCL2/ROS/USP26 Axis Through Altering ARv7 Protein Degradation Cancers doi: 10.3390/cancers12040831 Authors: Xu Sun Huang You Ye Chang : Background: The recently developed antiandrogen, Enzalutamide (Enz), has reformed the standard of care for castration resistant prostate cancer (CRPC) patients. However, Enz-resistance...
Mon Mar 30, 2020 03:00
Cancers, Vol. 12, Pages 828: BRCA1 Promoter Hypermethylation is Associated with Good Prognosis and Chemosensitivity in Triple-Negative Breast Cancer Cancers doi: 10.3390/cancers12040828 Authors: Jacot Lopez-Crapez Mollevi Boissière-Michot Simony-Lafontaine Ho-Pun-Cheung Chartron Theillet Lemoine Saffroy Lamy Guiu The aberrant hypermethylation of BRCA1 promoter CpG islands induces the decreased expression of BRCA1 (Breast Cancer 1) protein....
Mon Mar 30, 2020 03:00
Cancers, Vol. 12, Pages 829: Exploring the Role of Mutations in Fanconi Anemia Genes in Hereditary Cancer Patients Cancers doi: 10.3390/cancers12040829 Authors: Jesús del Valle Paula Rofes José Marcos Moreno-Cabrera Adriana López-Dóriga Sami Belhadj Gardenia Vargas-Parra Àlex Teulé Raquel Cuesta Xavier Muñoz Olga Campos Mónica Salinas Rafael de Cid Joan Brunet Sara González Gabriel Capellá Marta Pineda Lídia Feliubadaló Conxi Lázaro Fanconi...
Mon Mar 30, 2020 03:00
Cancers, Vol. 12, Pages 827: xCT Inhibition Increases Sensitivity to Vorinostat in a ROS-Dependent Manner Cancers doi: 10.3390/cancers12040827 Authors: Miyamoto Watanabe Boku Sukeno Morita Kondo Sakaguchi Taguchi Sakai As histone deacetylase inhibitors (HDACIs) have limited efficacy against solid tumors, we investigated whether and how oxidative stress is involved in sensitivity to HDACIs to develop a novel therapeutic option of HDACIs treatment. We...
Mon Mar 30, 2020 03:00
Cancers, Vol. 12, Pages 830: Optimal Body Mass Index Cut-off Point for Predicting Colorectal Cancer Survival in an Asian Population: A National Health Information Database Analysis Cancers doi: 10.3390/cancers12040830 Authors: Nan Song Dan Huang Doeun Jang Min Jung Kim Seung-Yong Jeong Aesun Shin Ji Won Park The optimal body mass index (BMI) range for predicting survival in Asian colorectal cancer patients is unknown. We established the most appropriate cut-off point...
Mon Mar 30, 2020 03:00
Cancers, Vol. 12, Pages 825: Pan-Cancer Analysis of Mitochondria Chaperone-Client Co-Expression Reveals Chaperone Functional Partitioning Cancers doi: 10.3390/cancers12040825 Authors: Geut Galai Hila Ben-David Liron Levin Martin F. Orth Thomas G. P. Grünewald Shai Pilosof Shimon Berstein Barak Rotblat Metabolic reprogramming is a hallmark of cancer. Such reprogramming entails the up-regulation of the expression of specific mitochondrial proteins, thus increasing...
Mon Mar 30, 2020 03:00
Cancers, Vol. 12, Pages 826: Cardiovascular Toxicity of Tyrosine Kinase Inhibitors Used in Chronic Myeloid Leukemia: An Analysis of the FDA Adverse Event Reporting System Database (FAERS) Cancers doi: 10.3390/cancers12040826 Authors: Santa Cirmi Asmae El Abd Louis Letinier Michele Navarra Francesco Salvo Tyrosine kinase inhibitors (TKIs), the treatment of choice for chronic myeloid leukemia (CML), can be associated to cardiovascular (CV) adverse events (AEs). A case/non-case...
Mon Mar 30, 2020 03:00
Cells, Vol. 9, Pages 835: Rho GTPase Regulators and Effectors in Autism Spectrum Disorders: Animal Models and Insights for Therapeutics Cells doi: 10.3390/cells9040835 Authors: Daji Guo Xiaoman Yang Lei Shi The Rho family GTPases are small G proteins that act as molecular switches shuttling between active and inactive forms. Rho GTPases are regulated by two classes of regulatory proteins, guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Rho GTPases...
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Cells, Vol. 9, Pages 834: Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex Cells doi: 10.3390/cells9040834 Authors: Minor Hollinger McNees Jung Jain Hyser Bissig Slagle The hepatitis B virus (HBV) regulatory HBx protein is required for infection, and its binding to cellular damaged DNA binding protein 1 (DDB1) is critical for this function. DDB1 is an adaptor protein for...
Mon Mar 30, 2020 03:00
Cells, Vol. 9, Pages 832: Cholangiocarcinoma Disease Modelling Through Patients Derived Organoids Cells doi: 10.3390/cells9040832 Authors: Amato Rae Prete Braconi Cancer organoids are 3D phenotypic cultures that can be established from resected or biopsy tumour samples and can be grown as mini tumours in the dish. Flourishing evidence supports the feasibility of patient derived organoids (PDO) from a number of solid tumours. Evidence for cholangiocarcinoma (CCA) PDO is still...
Mon Mar 30, 2020 03:00
Cells, Vol. 9, Pages 833: Sex-Specific Regulation of miR-29b in the Myocardium Under Pressure Overload Is Associated with Differential Molecular, Structural and Functional Remodeling Patterns in Mice and Patients with Aortic Stenosis Cells doi: 10.3390/cells9040833 Authors: García Salido-Medina Gil Merino Gómez Villar González-Vílchez Hurlé Nistal Pressure overload in patients with aortic stenosis (AS) induces an adverse remodeling of the left ventricle...
Mon Mar 30, 2020 03:00
Cells, Vol. 9, Pages 830: Combinatorial Therapies in Thyroid Cancer: An Overview of Preclinical and Clinical Progresses Cells doi: 10.3390/cells9040830 Authors: Laetitia Sven Fabrice Accounting for about 2% of cancers diagnosed worldwide, thyroid cancer has caused about 41,000 deaths in 2018. Despite significant progresses made in recent decades in the treatment of thyroid cancer, many resistances to current monotherapies are observed. In our complete review, we report all treatments...
Mon Mar 30, 2020 03:00
Cells, Vol. 9, Pages 831: Mitophagy in the Pathogenesis of Liver Diseases Cells doi: 10.3390/cells9040831 Authors: Ke Autophagy is a catabolic process involving vacuolar sequestration of intracellular components and their targeting to lysosomes for degradation, thus supporting nutrient recycling and energy regeneration. Accumulating evidence indicates that in addition to being a bulk, nonselective degradation mechanism, autophagy may selectively eliminate damaged mitochondria to promote...
Mon Mar 30, 2020 03:00
Cells, Vol. 9, Pages 829: Vγ9Vδ2 T Cells: Can We Re-Purpose a Potent Anti-Infection Mechanism for Cancer Therapy? Cells doi: 10.3390/cells9040829 Authors: Künkele Wesch Oberg Aichinger Supper Baumann Cancer therapies based on in vivo stimulation, or on adoptive T cell transfer of Vγ9Vδ2 T cells, have been tested in the past decades but have failed to provide consistent clinical efficacy. New, promising concepts such as γδ Chimeric...
Mon Mar 30, 2020 03:00
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