When the Large Hadron Collider resumes operations in 2021, several experiments will directly measure the motion of antihydrogen in free fall for the first time. Our current understanding of the universe is not yet fully prepared for the possibility that antimatter has negative gravitational mass. This paper proposes a model of cosmology, where the state of high energy density of the big bang is created by the collapse of an antineutrino star that has exceeded its Chandrasekhar limit. To allow the...
21h
The calculation and design of an ultralow-power Low Noise Amplifier (LNA) are proposed in this paper. The LNA operates from 5 GHz to 10 GHz, and forward body biasing technique is used to bring down power consumption of the circuit. The design revolves around precise calculations related to input impedance, output impedance, and the gain of the circuit. MATLAB and Advanced Design System (ADS) are utilized to design and simulate the LNA. In addition, TSMC 0.13 μm CMOS process is used in ADS. The LNA...
21h
A new approach to the optimal design of power inverters for on-grid photovoltaic systems that uses genetic algorithms (GA) is provided in this article. The nonlinear average model is adopted to model the conversion stage in order to accurately evaluate and quickly estimate the power losses of the power devices. The hysteresis current control that guarantees a quasi-sinusoidal output current is applied to generate the inverter control signals. The design of the solar inverter must meet three contradictory...
21h
In this study, a new magnetic field coupled deep cryogenic treatment (MDCT) is developed and its effect on wear resistance of AISI 4140 steel is investigated. Compared with wear resistance of untreatment (UT), wear resistance of MDCT increases by 29%. Wear resistance is inversely proportional to the friction coefficient. The treatment promotes the phase transformation and dislocation movement to generate more martensite in multidirectional distribution and optimized carbide. It enhances material...
21h
Mesenchymal stem cells (MSCs) and their secreted extracellular vesicles have been used effectively in different lung disease animal models and clinical trials. Their specific beneficial effects, the potential differences between MSCs derived from different organs, and interactions between MSC products and target cells still need to be studied further. Therefore, we investigated the effects of secreted products of human MSCs derived from the bone marrow and adipose tissue on human lung small airway...
21h
Among several variable selection methods, LASSO is the most desirable estimation procedure for handling regularization and variable selection simultaneously in the high-dimensional linear regression models when multicollinearity exists among the predictor variables. Since LASSO is unstable under high multicollinearity, the elastic-net (Enet) estimator has been used to overcome this issue. According to the literature, the estimation of regression parameters can be improved by adding prior information...
21h
The aim of this study is to generalize moving average by means of Choquet integral. First, by employing nonadditive measures with δ − λ rules, the calculation of the moving average for a series of fuzzy numbers can be transformed into Choquet integration of fuzzy-number-valued function under discrete case. Meanwhile, the Choquet integral of fuzzy number and Choquet integral of fuzzy number vector are defined. Finally, some properties are investigated by means of convolution formula of Choquet integral....
21h
Benign paroxysmal positional vertigo (BPPV) is the most prevalent form of peripheral vertigo and is common in posttraumatic patients. Sometimes, posttraumatic BPPV and subarachnoid hemorrhage (SAH) exist together. How to effectively recognize SAH especially concealed bleeding before maneuver treatment for BPPV is worth paying attention by every clinician. Presently described is a case that when there are some clinical symptoms cannot be completely explained by simple BPPV, the combination of CT and...
21h
This paper considers a class of semilinear fractional-order systems with Caputo derivative. New conditions ensuring asymptotic stability and stabilization of fractional systems with the fractional order between 0 and 2 are proposed. The analysis is based on a property of convolution and asymptotic properties of Mittag-Leffler functions. Some numerical examples are provided to illustrate the feasibility and validity of the proposed approach.
21h
Objectives. This research describes the prevalence and covariates associated with opioid-induced constipation (OIC) in an observational cohort study utilizing a national veteran cohort and integrated data from the Center for Medicare and Medicaid Services (CMS). Methods. A cohort of 152,904 veterans with encounters between 1 January 2008 and 30 November 2010, an exposure to opioids of 30 days or more, and no exposure in the prior year was developed to establish existing conditions and medications...
21h
As a pair of differential isomers, Kaji-ichigoside F1 and Rosamultin are both pentacyclic triterpenoids isolated from the subterranean root of Potentilla anserina L., a plant used in folk medicine in western China as antihypoxia and anti-inflammatory treatments. We demonstrated that Kaji-ichigoside F1 and Rosamultin effectively prevented hypoxia-induced apoptosis in vascular endothelial cells. We established a hypoxia model, using EA.hy926 cells, to further explore the mechanisms. Hypoxia promoted...
21h
Background.Exertional heat stroke is a life-threatening condition often complicated by multiorgan failure. We hereby present a case of a 25-year-old male presenting with syncope after a 10 km run in 28°C outside temperature who developed acute liver failure. Case Presentation. Initial temperature was found to be 41.1°C, and cooling measures were rapidly applied. He suffered from acute renal failure and rhabdomyolysis and proceeded to acute liver failure (ASAT 6100 U/l and ALAT 6561 U/l) due to hypoxic...
21h
Objectives. Essential thrombocythemia (ET) is one of the myeloproliferative neoplasms characterized by a sustained elevation of platelet numbers with a tendency for thrombosis and hemorrhage. The aim of this work is to establish the relation between calreticulin, factor V Leiden, prothrombin G20210A, and MTHFR mutations in ET patients and the thrombotic risk of these patients. Methods. This study was carried out on 120 ET patients and 40 apparently healthy individuals as a control group. Results....
21h
Topological index (numeric number) is a mathematical coding of the molecular graphs that predicts the physicochemical, biological, toxicological, and structural properties of the chemical compounds that are directly associated with the molecular graphs. The Zagreb connection indices are one of the TIs of the molecular graphs depending upon the connection number (degree of vertices at distance two) appeared in 1972 to compute the total electron energy of the alternant hydrocarbons. But after that,...
21h
Background. Diabetes is associated with chronic inflammation, and dendritic cells (DCs) have proinflammatory effect in diabetes. The anti-inflammatory effect of insulin on diabetes is not entirely clear. The study aims to examine insulin-induced effects on the inflammatory response in DCs. Methods. Twenty-one C57BL/6 mice were divided into 3 groups. Streptozotocin was injected into the diabetic mice model. The bone marrow-derived DCs (BMDCs) were obtained from C57BL/6 mice. CD83, CD86, and type II...
21h
For the preparation of orthopedic shoes, it is necessary to design boot-trees, where pathological abnormalities of club feet are taken into account as much as possible. For the normal functioning of the club foot, we have to develop such an internal shape of special-purpose footwear, which is comfortable for the patient. This paper describes the methods and issues of the 3D design for constructing the geometric shapes of the main cross sections of the orthopedic boot-tree. In the research process,...
21h
We compute the asymmetric and symmetric correlation functions of a four-point amplitude of a gauge field, a scalar field, and a closed string Ramond-Ramond (RR) for different nonvanishing BPS branes. All world volume, the Taylor and pull-back couplings, and their all-order corrections have also been explored. Due to various symmetry structures, different restricted BPS Bianchi identities have also been constructed. The prescription of exploring all the corrections of two closed string RR couplings...
21h
Objective. Diabetic kidney disease is one of the most common microvascular complications of diabetes mellitus. We aimed to analyze the association of thyroid parameters with kidney disorders, especially in euthyroid participants. Methods. The data were obtained from a cross-sectional study, the METAL study. Thyroid parameters, including thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), triiodothyronine (T3), thyroxin (T4), thyroid peroxidase antibody (TPOAb), and...
21h
A mathematical model is proposed to study the dynamics of the transmission of rabies, incorporating predation of dogs by humans. The model is shown to have a unique disease-free equilibrium which is globally asymptotically stable whenever . Local sensitivity analysis suggests that the disease can be controlled through reducing contact with infected dogs, increasing immunization of dogs, screening recruited dogs, culling of infected dogs, and use of dog meat as a delicacy.
21h
Background. The incidence of placenta accreta spectrum (PAS) disorders has risen over the last decades, and there has been a gradual shift towards expectant management. Conservative management of PAS is known to reduce major obstetric haemorrhage and salvage hysterectomy. There is a lack of consensus on the follow-up of patients undergoing conservative approaches. Here, we describe the follow-up of three patients with placenta percreta who were conservatively managed and review the literature for...
21h
Background. Type 1 diabetes is a chronic disease including hyperglycemia and accelerated atherosclerosis, with high risk of micro- and macrovascular complications. Circulating microvesicles (cMVs) are procoagulant cell fragments shed during activation/apoptosis and discussed to be markers of vascular dysfunction and hypercoagulability. Limited knowledge exists on hypercoagulability in young diabetics. We aimed to investigate cMVs over a five-year period in children/adolescents with type 1 diabetes...
21h
Abstract Purpose Deciding whether patients with a cytologically indeterminate thyroid nodule should be referred for surgery or for active surveillance is an important challenge for clinicians. The aim of this study was to evaluate the performance of a novel dual-component molecular assay as an ancillary molecular method for resolving indeterminate thyroid nodule cytology. ...
9h
We thank van Delft et al.[1] for their letter to the Editor related to our published European consensus-based interdisciplinary guidelines on the diagnosis and treatment of basal cell carcinoma (BCC) [2]. They comment on the extensive safety margins for conventional (2D) surgical excision of high-risk BCCs and the proposed frequent follow-up of patients with a history of BCC.
9h
Abstract Objective To study the effects of Prunella vulgaris polysaccharide (PVP) on human breast carcinoma-associated fibroblasts (CAFs). Methods Cell viability was detected by 3-[4,5-dimethylthiazol-2-yl]-2,5-(3-carboxymethoxyphenyl)-2-4-sulfophenyl)-2H-tetrazolium (MTS) assay. Wound healing experiment and transwell migration assay...
9h
Abstract Objective To establish a novel cardiocentesis method for withdrawing venous blood from the right atrium, and to improve an acute blood stasis rat model using an ice bath and epinephrine hydrochloride (Epi) while considering the 3Rs (reduction, refinement, and replacement) of humane animal experimentation. Methods An acute blood...
9h
Abstract Identifying individuals at the earliest disease stage becomes crucial as we aim to develop disease-modifying treatments for neurodegenerative disorders. Prodromal diagnostic criteria were recently developed for Parkinson’s disease (PD) and are forthcoming for dementia with Lewy bodies (DLB). The latest 2008 version of diagnostic criteria for multiple system atrophy (MSA) have improved diagnostic accuracy in early disease stages compared to previous criteria, but we do...
10h
Abstract Glyphosate (N-[phosphonomethyl]-glycine) is the most widely used herbicide worldwide. Due to health concerns about glyphosate exposure, its continued use is controversially discussed. Biomonitoring is an important tool in safety evaluation and this study aimed to determine exposure to glyphosate and its metabolite AMPA, in association with food consumption data, in participants of the cross-sectional KarMeN study (Germany). Glyphosate and AMPA levels were measured in...
10h
Abstract The genus Loxosceles comprises 140 species widely distributed around the world. These spiders are nocturnal, sedentary and remarkably nonaggressive, although they cause accidents in humans with wide degrees of severity, generating signs and symptoms that define the clinical condition known as loxoscelism. Its local signs and symptoms were first reported in 1872, and over the years, a large medical literature has been accumulated; unfortunately, it is not always trustworthy....
1d
Abstract Salivary gland carcinomas (SGCs) are rare and can be subdivided into distinct entities, some of which confer a poor prognosis. As targets for effective systemic therapy are warranted, some studies investigated the role of immune-checkpoint proteins PD-L1 and CTLA-4 in SGC. Our study depicts the expression of lymphocyte activation gene 3 (LAG3) in a test cohort and a larger validation cohort, totaling 139 SGCs. LAG3 is expressed on tumor-infiltrating lymphocytes (TILs),...
10h
Abstract Purpose To examine physical activity (PA) patterns from pre- to post-diagnosis, and compare these changes to women without breast cancer. To determine pre-diagnosis predictors of PA change, post-diagnosis, in breast cancer survivors (BCS). Methods Data were from 2314 Study of Women’s Health Across the Nation (SWAN) participants, average age of 46.4 ± 2.7 years...
10h
Abstract The inter-arterial watershed zone in neonates is a geographic area without discernible anatomic boundaries and difficult to demarcate and usually not featured in atlases. Schematics currently used to depict the areas are not based on any prior anatomic mapping, compared to adults. Magnetic resonance imaging (MRI) of neonates in the acute to subacute phase with suspected hypoxic-ischaemic injury (HII) can demonstrate signal abnormality and restricted...
11h
Abstract The 2019 European Congress of Radiology program, “Women in Focus: Be Inspired,” offered insights from successful women and men for overcoming a number of everyday work and personal life challenges. With regard to balancing career and personal life and achieving well-being, the advice of female and male radiology leaders on the front lines, throughout the world, shares common themes. This paper highlights and expands on points of advice and encouragement from the “Women...
13h
Abstract The European Directive 2013/59/EURATOM requires member states of the European Union to ensure justification and optimisation of the radiological procedures and to include information on patient exposure as part of the report of the examinations. The EuroSafe Imaging campaign of the European Society of Radiology created a working group (WG) on “Dosimetry for imaging in clinical practice” with the aim to help with the dosimetry aspects required by European and national...
13h
Abstract Vestibular schwannoma (VS) is a Schwann cell-derived tumour arising from the vestibulocochlear nerve. Although benign, it represents a threat to intracranial structures due to mass effect and carries a small risk of malignant transformation. VS therefore represents an important healthcare burden. We review the literature regarding pathogenesis, risk factors, and diagnosis of VS. The current and future potential management strategies are also discussed. A narrative review...
11h
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