Die Arbeitswelt in der Schweiz befindet sich in einem umfassenden Wandel: Die Internationalisierung von Arbeit und Arbeitsteilung, die Alterung der schweizerischen Erwerbsbevölkerung sowie die fortschreitende Technisierung der Arbeitswelt führen zu einer zunehmenden Flexibilisierung von Arbeitsorganisation und Arbeitsverhältnissen. Diese Veränderungen stellen eine wachsende Herausforderung für Politik, Sozialpartner und Individuen dar. Vor allem der Mediensektor sowie die industrielle Produktion...
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ABSTRACTFungal endocarditis (FE) accounts for ~50% of the mortality rate associated with predisposing host conditions. Despite optimal therapeutic strategies, the survival rate remains low. FE is mostly caused by Candida albicans and Aspergillus fumigatus. Previous valvular surgery is the most essential risk factor for Aspergillus endocarditis, which observed in 40–50% of cases. However, native valve FE caused by Aspergillus is uncommon, with only a few reported cases. We hereby report a case of...
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AbstractIntra-abdominal perivascular epithelioid cell tumors (PEComas) are rare mesenchymal tumors. Although no effective therapies have been agreed upon, mTOR inhibitors are currently being investigated as a potential therapy for this extremely rare tumor. We present a case of a 64-year-old male found to have a large intra-abdominal PEComa with multiple metastatic lesions in the liver. Patient underwent surgical resection of the primary lesion in the abdomen and sigmoid colon followed by adjuvant...
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AbstractSecondary glioblastoma is a rare brain tumor characterized by a mutation in isocitrate dehydrogenase, which is reported to lead to epigenetic modification. Patients with secondary glioblastoma experience poor survival and quality-of-life outcomes due to the disease’s aggressiveness and a lack of targeted therapies. In this report, a patient with a secondary glioblastoma was treated with a histone deacetylase inhibitor, an epigenetic drug with potent anti-inflammatory properties, in addition...
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AbstractThe Birt–Hogg–Dubé syndrome is an orphan genetic disease characterized by the development of renal neoplasms, fibrofolliculomas, pulmonary cysts and spontaneous pneumothoraces. Here, we report on the case of a 21-year-old man presenting with a primary event of a persistent spontaneous pneumothorax. Computed tomography images and a positive family history for pneumothoraces led to the suspicion of Birt–Hogg–Dubé syndrome. Genetic testing then confirmed the suspected clinical diagnosis, however...
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Related ArticlesDynamic evaluation of conditional survival in patients with oral squamous cell carcinoma after surgical resection: A large-scale prospective study. Oral Oncol. 2020 Mar 25;104:104639 Authors: Yan L, Chen F, Chen L, Lin J, Chen Q, Bao X, Qiu Y, Lin L, Zheng X, Pan L, Wang J, Hu Z, Liu F, He B, Shi B Abstract OBJECTIVE: To dynamically estimate conditional survival (CS) probabilities for patients with oral squamous cell carcinoma (OSCC)...
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1. Δεν υπάρχει καμία ένδειξη ότι η ομοιοπαθητική λειτουργεί. Η αλήθεια είναι ότι υπάρχουν πάνω από 600 δημοσιευμένες έρευνες έρευνας για την ομοιοπαθητική και άλλες ολοκληρώνονται καθημερινά. Η έρευνα δείχνει την αποτελεσματικότητα της ομοιοπαθητικής για ανθρώπους και ζώα με ευρύ φάσμα οξειών, χρόνιων και επιδημικών καταστάσεων, όπως έκζεμα, άσθμα, ασθένειες του ανώτερου αναπνευστικού, μολύνσεις αυτιών, […]
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Abstract In decision‐making tasks, neural circuits involved in different aspects of information processing may activate the central arousal system, likely through their interconnection with brainstem arousal nuclei, collectively contributing to the observed pupil‐linked phasic arousal. However, the individual components of the phasic arousal associated with different elements of information processing and their effects on behavior remain little known. In this study, we used machine learning techniques...
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Abstract The attenuated avian infectious bronchitis virus (IBV), derived from a wild strain (TW2575/98w) in chicken embryos after 75 passages, is designed as a commercial vaccine strain (TW2575/98vac) to control the disease in Taiwan. The differences in viral infectivity, replication efficiency, and genome sequences between TW2575/98w and TW2575/98vac were determined and compared. TW2575/98vac caused earlier death of chicken embryos and had higher viral replication efficiency....
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Related ArticlesSeasonality and season of birth effect in the UK Biobank cohort. Am J Hum Biol. 2020 Mar 28;:e23417 Authors: Didikoglu A, Canal MM, Pendleton N, Payton A Abstract OBJECTIVES: Humans live in environments that reduce the impact of seasonal cues. However, studies suggest that many aspects of human biology, such as birth, metabolism, health, and death are still annually rhythmic. METHODS: Using UK Biobank, a large (N = 502 536) population-based...
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Related ArticlesSleep patterns and problems among children with 22q11 deletion syndrome. Mol Genet Genomic Med. 2020 Mar 28;:e1153 Authors: Arganbright JM, Tracy M, Hughes SS, Ingram DG Abstract BACKGROUND: To delineate sleep habits and problems in children with 22q11.2 deletion syndrome (22q11DS). METHODS: Thirty children, age 1-15 (mean 6.8) years, participated in the study, which was an internet-based anonymous survey of parents of children...
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Related ArticlesThe association between physical activity, sleep, and quality of life in patients in bio-chemical remission from Cushing's syndrome. Qual Life Res. 2020 Mar 27;: Authors: Moyers SA, Tiemensma J Abstract PURPOSE: Cushing's syndrome can negatively affect patient's quality of life (QoL) after treatment and remission. Exposure to increased cortisol over time can result in visceral obesity, which makes this population vulnerable to cardiovascular...
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Related ArticlesArrhythmias and sleep apnea: physiopathologic link and clinical implications. J Interv Card Electrophysiol. 2020 Mar 28;: Authors: Di Fusco SA, Pignalberi C, Santini L, Colivicchi F, Santini M Abstract Available evidence suggests a pathogenetic role of sleep breathing disorders in both atrial and ventricular arrhythmias with non-negligible clinical implications. Scientific literature has reported convincing findings on the link between...
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Related ArticlesTrekstock RENEW: evaluation of a 12-week exercise referral programme for young adult cancer survivors delivered by a cancer charity. Support Care Cancer. 2020 Mar 27;: Authors: Pugh G, Below N, Fisher A, Reynolds J, Epstone S Abstract PURPOSE: To evaluate the uptake and effect of RENEW, a 12-week exercise referral programme for young adult cancer survivors delivered by Trekstock, a UK-based cancer charity. METHODS: The RENEW...
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Related ArticlesScreening commercial drivers for sleep apnea: are profits and public safety aligned? Sleep. 2020 Mar 27;: Authors: Donovan LM, Kapur VK PMID: 32221540 [PubMed - as supplied by publisher]
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Related ArticlesInjury and Apoptosis in the Palatopharyngeal Muscle in Patients with Obstructive Sleep Apnea-Hypopnea Syndrome. Med Sci Monit. 2020 Mar 28;26:e919501 Authors: Dong J, Niu X, Chen X Abstract BACKGROUND This study aimed to elucidate the possible activity of the mitochondrial-mediated apoptotic pathway (MMAP) in obstructive sleep apnea-hypopnea syndrome (OSAHS). MATERIAL AND METHODS A control group, a mild OSAHS group, a moderate OSAHS group,...
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Related ArticlesThe Utility of Early Tongue Reduction Surgery for Macroglossia in Beckwith-Wiedemann Syndrome. Plast Reconstr Surg. 2020 Apr;145(4):803e-813e Authors: Cohen JL, Cielo CM, Kupa J, Duffy KA, Hathaway ER, Kalish JM, Taylor JA Abstract BACKGROUND: Macroglossia, a cardinal feature of the (epi)genetic disorder Beckwith-Wiedemann syndrome, is associated with obstructive sleep apnea, speech and/or feeding difficulties, and dental or jaw malalignment....
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Related ArticlesComparison of the Sleep Problems Among Adolescents Who Attempted Suicide and Healthy Adolescents. J Nerv Ment Dis. 2020 Apr;208(4):294-298 Authors: Yildiz E, Sac R, Işik Ü, Özaydin MS, Taşar MA, Cakir İ, Alioglu B Abstract The aim of this study was to compare sleep problems among adolescents who attempted suicide and healthy adolescents who never attempted suicide. Adolescents who attempted suicide (study group, n = 103) and healthy adolescents...
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Related ArticlesComparison of the Efficacy of Buspirone and Placebo in Childhood Functional Abdominal Pain: A Randomized Clinical Trial. Am J Gastroenterol. 2020 Mar 26;: Authors: Badihian N, Yaghini O, Badihian S, Shahsanai A, Saneian H Abstract INTRODUCTION: Pharmacological interventions have not been successful in the treatment of childhood functional abdominal pain (FAP) hitherto. Buspirone is suggested to be efficacious in some of the abdominal...
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Related ArticlesNANN's Guideline for Safe Sleep Executive Summary. Adv Neonatal Care. 2020 Apr;20(2):108 Authors: Bagwell GA PMID: 32221137 [PubMed - as supplied by publisher]
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Related ArticlesBoth short and long sleep durations are associated with cognitive impairment among community-dwelling Chinese older adults. Medicine (Baltimore). 2020 Mar;99(13):e19667 Authors: Ding G, Li J, Lian Z Abstract This study aims to examine the association between sleep duration and cognitive impairment in community-dwelling Chinese older adults.The associations between sleep duration and cognitive function have been widely studied across various...
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Related ArticlesNormal tension glaucoma in obstructive sleep apnea syndrome: A structural and functional study. Medicine (Baltimore). 2020 Mar;99(13):e19468 Authors: Chuang LH, Koh YY, Chen HSL, Lo YL, Yu CC, Yeung L, Lai CC Abstract This study characterized and evaluated normal tension glaucoma (NTG) in obstructive sleep apnea syndrome (OSAS).In this retrospective, cross-sectional study, all participants were examined with polysomnography (PSG). Functional...
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Related ArticlesElectrical status epilepticus in sleep affects intrinsically connected networks in patients with benign childhood epilepsy with centrotemporal spikes. Epilepsy Behav. 2020 Mar 25;106:107032 Authors: He W, Liu H, Liu Z, Wu Q Abstract BACKGROUND: Although outcomes of benign childhood epilepsy with centrotemporal spikes (BECTS) are frequently excellent, some atypical forms of BECTS, especially electrical status epilepticus in sleep (ESES),...
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Related ArticlesSIDS associated RYR2 p.Arg2267His variant may lack pathogenicity. J Electrocardiol. 2020 Mar 18;60:23-26 Authors: Kohli U, Nayak HM Abstract Sudden infant death syndrome (SIDS) is the sudden death of an infant under 1 year of age that remains unexplained after death scene and medicolegal investigation, including a complete autopsy and clinical history review. The fatal event typically occurs during sleep and heart rhythm during the event...
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Related ArticlesIs securing normal dentofacial development an indication for tonsil surgery in children? A systematic review and meta-analysis. Int J Pediatr Otorhinolaryngol. 2020 Mar 18;133:110006 Authors: Markkanen S, Rautiainen M, Niemi P, Helminen M, Peltomäki T Abstract OBJECTIVE: Tonsil surgeries are common operations in the field of paediatric otorhinolaryngology. Often, the indication for these operations is hypertrophied tonsils. Paediatric...
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Related ArticlesSlow wave oscillations in Schizophrenia First-Degree Relatives: A confirmatory analysis and feasibility study on slow wave traveling. Schizophr Res. 2020 Mar 24;: Authors: Castelnovo A, Zago M, Casetta C, Zangani C, Donati F, Canevini M, Riedner BA, Tononi G, Ferrarelli F, Sarasso S, D'Agostino A Abstract Abnormal sleep oscillations have recently been proposed as endophenotypes of schizophrenia. However, optimization of methodological...
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Related ArticlesTime trends of delirium rates in the intensive care unit. Heart Lung. 2020 Mar 24;: Authors: Khan SH, Lindroth H, Hendrie K, Wang S, Imran S, Perkins AJ, Gao S, Vahidy FS, Boustani M, Khan BA Abstract BACKGROUND: Effects of clinical practice changes on ICU delirium are not well understood. OBJECTIVES: Determine ICU delirium rates over time. METHODS: Data from a previously described screening cohort of the Pharmacological...
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Related ArticlesIs consumption of fast-food and carbonated soft drink associated with anxiety-induced sleep disturbance among adolescents? A population-based study. Clin Nutr ESPEN. 2020 Apr;36:162-165 Authors: Khan A, Uddin R Abstract BACKGROUND & AIMS: Unhealthy dietary behaviours have been associated with poor sleep among adolescents in many developed countries; however, evidence is lacking from resource-limited settings. This study aimed to examine...
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Related ArticlesPediatric Warthin-like Mucoepidermoid Carcinoma: Report of Two Cases with One Persistent/Recurrent as Conventional Mucoepidermoid Carcinoma. Head Neck Pathol. 2020 Mar 27;: Authors: Daoud EV, McLean-Holden AC, Pfeifer CM, Timmons CF, Oliai BR, Bishop JA Abstract Mucoepidermoid carcinoma (MEC) is the most common primary salivary gland malignancy. While salivary gland neoplasia is rare in children, MEC is much more likely to occur in...
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Related ArticlesThe added value of postmortem magnetic resonance imaging in cases of hanging compared to postmortem computed tomography and autopsy. Forensic Sci Med Pathol. 2020 Mar 27;: Authors: Deininger-Czermak E, Heimer J, Tappero C, Thali MJ, Gascho D Abstract The purpose of this study was to evaluate the added value of postmortem magnetic resonance imaging (MRI) compared to postmortem computed tomography (CT) and autopsy in cases of fatal...
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Related Articles[Dizziness and vertigo in a tertiary ENT emergency department]. HNO. 2020 Mar 27;: Authors: Comolli L, Goeldlin M, Gaschen J, Kammer C, Sauter TC, Caversaccio MD, Kalla R, Fischer U, Mantokoudis G Abstract BACKGROUND: Although vestibular symptoms are amongst the most frequent reasons for seeking emergency medical help, many patients remain undiagnosed. OBJECTIVE: In this cross-sectional study, we investigated the spectrum...
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Related ArticlesPresenting pre-radiotherapy dental status of head and neck cancer patients in the novel radiation era. Br Dent J. 2020 Mar;228(6):435-440 Authors: Patel V, Patel D, Browning T, Patel S, McGurk M, Sassoon I, Guerrero Urbano T, Fenlon M Abstract Objectives Dental assessment remains a key intervention for head and neck cancer (HNC) patients pre-radiotherapy (RT). The purpose of this study was to identify the variation in dental status...
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Related ArticlesNeck lymph node status on survival of regionally recurrent or persistent nasopharyngeal carcinoma. Sci Rep. 2020 Mar 27;10(1):5622 Authors: Yeung DCM, Yeung Z, Wong EWY, Vlantis AC, Chan JYK Abstract The aim of this study was to evaluate the impact of lymph node status from neck dissection pathological specimens on the survival for isolated regional nodal recurrence or persistence after primary treatment of nasopharyngeal carcinoma....
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Related ArticlesTranscriptomics in cancer revealed by Positron Emission Tomography radiomics. Sci Rep. 2020 Mar 27;10(1):5660 Authors: Tixier F, Cheze-le-Rest C, Schick U, Simon B, Dufour X, Key S, Pradier O, Aubry M, Hatt M, Corcos L, Visvikis D Abstract Metabolic images from Positron Emission Tomography (PET) are used routinely for diagnosis, follow-up or treatment planning purposes of cancer patients. In this study we aimed at determining if radiomic...
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Related ArticlesThe Cochlear Cleft: CT Correlation With Histopathology. Otol Neurotol. 2020 Mar 19;: Authors: Pucetaite M, Quesnel AM, Juliano AF, Curtin HD, Reinshagen KL Abstract OBJECTIVE: To show the histologic correlate of the cochlear cleft, a small low density focus just anterior to the oval window seen on computed tomography (CT) in three temporal bone specimens. PATIENTS: Three temporal bone specimens donated to the National Temporal...
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Related ArticlesHold the Salt: History of Salt Restriction as a First-line Therapy for Menière's Disease. Otol Neurotol. 2020 Mar 19;: Authors: Shim T, Strum DP, Mudry A, Monfared A Abstract OBJECTIVES: To determine the historical origins of the usage of the salt restriction diet as an intervention for Menière's disease (MD). METHODS: Articles on MD and salt restriction were identified using Pubmed and Google scholar. Original manuscripts...
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