The causes of hypertension are complex and involve both genetic and environmental factors. Environment changes during fetal development have been linked to adult diseases including hypertension. Studies show that timed in utero exposure to the synthetic glucocorticoid (GC) dexamethasone (Dex) results in the development of hypertension in adult rats. Evidence suggests that in utero stress can alter patterns of gene expression, possibly a result of alterations in the topology of the genome by epigenetic...
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The effects of erosion mode, erosion age, and concentration of sulfate solution on mechanical properties of concrete were investigated. The dimensionless relationship model of the stress-strain of concrete on the basis of randomness was proposed. The variation of the elasticity modulus and Poisson’s ratio of the concrete surface attacked by sulfate was studied, and a novel method of using a superficial parameter to characterize the performance change of the concrete surface was recommended. The results...
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Desmoplastic fibroma of the bone (DFB) is a notably rare, lytic, locally aggressive but nonmetastatic, primary benign bone tumor in patients less than 30 years old. As the recommended primary treatment for DFB, wide resection is preferred to curettage from the perspective of recurrence but wide resection of DFB in the pelvis such as in the acetabulum could result in greater functional loss, suggesting the need for conservative treatments. However, there is no report on long-term follow-up following...
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In this paper, three different kinds of steel fibers, being micro (M), end-hooked (H), and corrugated (C), commonly used in engineering applications, are added to high-strength lightweight aggregate concrete (HLAC) to study the effects of steel fiber and volume content ratio of fiber on the compressive, splitting tensile, and flexural strength of HLAC. The range of steel fiber volume content fraction studied is 0.5% to 2.0%. The research shows that different types of steel fiber have different effects...
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In recent years, the development and construction of islands and reefs has been proposed by the government and commercial company. However, as a large cargo carrier cannot reach islands and reefs if the harbor is not available, such type of carrier which has well deck is designed to meet the requirements of delivering people and equipment. It is a possible way to connect the island and supply cargo ships. This paper firstly summarizes the domestic and foreign research progress of hydrodynamic analysis...
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Shewanella algae is an emerging marine zoonotic pathogen and accounts for considerable mortality and morbidity in compromised hosts. However, there is scarce literature related to the understanding of the genetic background of virulence determinants in S. algae. In this study, we aim to determine the occurrence of common virulence genes in S. algae using whole-genome sequence and comparative genomic analysis. Comparative genomics reveals putative-virulence genes related to bile resistance, chemotaxis,...
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The k-means algorithm is sensitive to the outliers. In this paper, we propose a robust two-stage k-means clustering algorithm based on the observation point mechanism, which can accurately discover the cluster centers without the disturbance of outliers. In the first stage, a small subset of the original data set is selected based on a set of nondegenerate observation points. The subset is a good representation of the original data set because it only contains all those points that have a higher...
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In the era of big data, mining and analysis of the enormous amount of data has been widely used to support decision-making. This complex process including huge-volume data collecting, storage, transmission, and analysis could be modeled as workflow. Meanwhile, cloud environment provides sufficient computing and storage resources for big data management and analytics. Due to the clouds providing the pay-as-you-go pricing scheme, executing a workflow in clouds should pay for the provisioned resources....
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Purpose. This study was conducted to evaluate the effect of endoscopic olfactory cleft (OC) opening on olfaction in patients with obstructed OC disease. Materials and Methods. Patients with obstructed OC disease who underwent endoscopic OC opening for treatment were enrolled. The endoscopic olfactory cleft opening was performed under local anesthesia. Under an endoscopy, the middle and superior turbinates were gently lateralized to open the OC using an elevator. The phenyl ethyl alcohol threshold...
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Barley plays an important role in health and civilization of human migration from Africa to Asia, later to Eurasia. We demonstrated the systematic mechanism of functional ingredients in barley to combat chronic diseases, based on PubMed, CNKI, and ISI Web of Science databases from 2004 to 2020. Barley and its extracts are rich in 30 ingredients to combat more than 20 chronic diseases, which include the 14 similar and 9 different chronic diseases between grains and grass, due to the major molecular...
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Feature discretization can reduce the complexity of data and improve the efficiency of data mining and machine learning. However, in the process of multidimensional data discretization, limited by the complex correlation among features and the performance bottleneck of traditional discretization criteria, the schemes obtained by most algorithms are not optimal in specific application scenarios and can even fail to meet the accuracy requirements of the system. Although some swarm intelligence algorithms...
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Currently, spraying is a main means for dust prevention and control in underground coal mines. The dust-suppression efficiency via spraying is highly correlated with the wettability of coal dusts. There are many factors affecting the wettability of coal dust, among which coal’s metamorphic degree has great influence. In order to gain in-depth knowledge of the effects of coal metamorphic degree on coal dust wettability and the dust-suppression efficiency via spraying, 6 coal dust samples with different...
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The dynamic characteristics of an offshore wind turbine with tripod suction buckets are investigated through finite element analysis and full-scale experiments. In finite element analysis, an integrated framework is suggested to create a simple yet accurate high fidelity model. The integrated framework accounts for not only the strain dependency of the soil but also for all dynamics in the seabed, including those of the soil, suction bucket skirt, and cap. Hence, the model accurately describes the...
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This paper proposed an adaptive vector nonsingular terminal sliding mode control (NTSMC) algorithm for the finite-time tracking control of a class of n-order nonlinear dynamical systems with uncertainty. The adaptive vector NTSMC incorporates a vector design idea and novel adaptive updating laws based on the commonly used NTSMC, which consider the common existence of the degree-of-freedom (DOF) directional differences and eliminate the chattering problem. The closed-loop stability of the n-order...
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Background. Hand hygiene in refugee camp settlements remains an important measure against diarrhoeal infections. Refugee settings are characterised by overcrowding and inadequate access to water and hygiene facilities which favour proliferation of faecal-oral diseases. Handwashing with soap and water is therefore an effective way of preventing such diseases. Despite this knowledge, there is limited information about access to functional handwashing facilities in these settings and associated factors...
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Objectives. Hyperuricemia (HUA) is a disease caused by increased production of uric acid (UA) or reduced excretion of UA in the body. Results of an epidemiological survey show that 60% of patients with HUA have hyperlipidemia (HPA). Dendrobium officinalis (DOF) six nostrum (DOS) is based on the theory of traditional Chinese medicine for the transformation of the traditional Chinese nostrum Si Miao Wan. In this article, we aim to discuss the efficacy and mechanism of DOS in reducing UA and regulating...
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The aim of this study is to ensure that the location selection of the officers of the personnel class in the Land Forces Command is effective and needs to be met to determine the criteria used in the selection of the place of appointment or which is the most important and to reveal the preference order to the officers making the choice. In this survey, a face-to-face interview technique and 10 subquestionnaires of captain majors were applied. In the questionnaire technique, the weights of the criteria...
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This paper proposes two kinds of arrangements of buckling-restrained brace dampers to strengthen soft-first-storey structures locally. Two types of near-fault ground motion, with and without pulse, were selected for a study of the seismic response characteristics of soft-first-storey structures with and without buckling-restrained brace dampers, and the effects of different bracing arrangements on improving the seismic performance of soft-first-storey structures were recognized. The results show...
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For cement-based materials, the curing temperature determines the strength gain rate and the value of compressive strength. In this paper, the 5% cement-stabilized macadam mixture is used. Three indoor controlled temperature curing and one outdoor natural curing scenarios are designed and implemented to study the strength development scenario law of compressive strength, and they are standard temperature curing (20°C), constant low temperature curing (10°C), day interaction temperature curing (varying...
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Preeclampsia (PE) is termed as a systemic disease that involves multiple organs; however, the exact etiology is still quite unclear. It is believed that the poor remodeling of uterine spiral arteries triggers PE, thereby causing failed placentation and producing inflammatory factors. The decline of blood flow results in lowering the nutrients and oxygen received by the fetus and augmenting the placental pressure in PE. Decidual immune cells, especially uterine natural killer (uNK) cells, are involved...
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Raoultella ornithinolytica is a bacterium belonging to the family Enterobacteriacae. It is a rare but emergent cause of human pathologies especially in immunocompromised patients. We described the first case in the literature of isolated external otitis sustained by Raoultella ornithinolytica in an immunocompetent host. A 54-year-old Caucasian man with a history of previous myringoplasty came to our attention reporting otalgia and otorrhea. We performed right ear swab for culture examination, meanwhile...
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Background. Nelumbo nucifera Gaertn stem (Hegeng [HG]) is a traditional Chinese medicine that is used to treat mental symptoms in East Asia. However, scientific evidence is generally lacking to support this traditional claim. Aim of the Study. This study’s aim is to investigate the antidepression effect of HG and to further explore the possible molecular mechanisms that are involved in its actions. Materials and Methods. HG aqueous extract was administered intragastrically for 21 days after the chronic...
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A Planetary Gear Train (PGT) can be used in series-parallel transmission to redistribute powers. Selectable one-way clutches (SOWCs), compared with traditional friction clutches, can simplify controls and diversify patterns especially for hybrid transmissions. In this paper, a nonlinear torsional model of a power-split PGT coupled with three SOWCs is proposed. Piecewise nonlinearities of SOWCs as well as clearance, time-varying mesh stiffness, and synthetic transmission error of the PGT are considered....
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Background. Among many causes of hypertriglyceridemia (HTG), familial chylomicronemia syndrome (FCS) is a rare monogenic disorder that manifests as severe HTG and acute pancreatitis. Among the known causal genes for FCS, mutations in APOC2 only account for 90% post-sessions and appeared to reduce pancreatitis episodes. Experimental ANGPTL3 and APOC3 inhibitors each lowered TG by >50%. Conclusions. Our case demonstrates the importance of delineating and defining the underlying etiology of a rare...
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Background. Hagenia abyssinica (Bruce) J.F. Gmel (Rosaceae) is distributed in the highlands of Ethiopia. The flowers of Hagenia abyssinica (Bruce) J.F. Gmel are used traditionally to treat wound. However, there was no scientific report on wound healing activity of Hagenia abyssinica (Bruce) J.F. Gmel. Thus, this study was initiated to investigate the wound healing and anti-inflammatory activities of 80% methanol crude extract of flowers of Hagenia abyssinica in mice. Objective. The objective of this...
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Clear cell renal cell carcinoma (ccRCC) accounts for 60-70% of renal cell carcinoma (RCC) cases. It is an urgent mission to find more therapeutic targets for advanced ccRCC. Leucine-rich a-2-glycoprotein 1 (LRG1) is a secreted protein associated with a variety of malignancies. Our study focused on the expression and mechanism of LRG1 in ccRCC based on data from The Cancer Genome Atlas (TCGA) and provided primary verification including LRG1 expression detection, LRG1 gene methylation detection, and...
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Novel memristive hyperchaotic system designs and their engineering applications have received considerable critical attention. In this paper, a novel multistable 5D memristive hyperchaotic system and its application are introduced. The interesting aspect of this chaotic system is that it has different types of coexisting attractors, chaos, hyperchaos, periods, and limit cycles. First, a novel 5D memristive hyperchaotic system is proposed by introducing a flux-controlled memristor with quadratic nonlinearity...
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This paper is concerned with deriving some new dynamic Hilbert-type inequalities on time scales. The basic idea in proving the results is using some algebraic inequalities, Hölder’s inequality and Jensen’s inequality, on time scales. As a special case of our results, we will obtain some integrals and their corresponding discrete inequalities of Hilbert’s type.
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Prostate cancer (PCa) is initially driven by excessive androgen receptor (AR) signaling with androgen deprivation therapy (ADT) being a major therapeutic approach to its treatment. However, the development of drug resistance is a significant limitation on the effectiveness of both first-line and more recently developed second-line ADTs. There is a need then to study AR signaling within the context of other oncogenic signaling pathways that likely mediate this resistance. This review focuses on interactions...
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The real-time and high-continuity requirements of the edge computing network gain more and more attention because of its active defence problem, that is, a data-driven complex problem. Due to the dual constraints of the hybrid feature of edge computing networks and the uncertainty of new attack features, implementing active defence measures such as detection, evasion, trap, and control is essential for the security protection of edge computing networks with high real-time and continuity requirements....
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Objective. Painful ophthalmoplegia includes nonspecific magnetic resonance imaging (MRI) manifestations and various clinical features including orbital pain and cranial nerve palsies. Treatment for painful ophthalmoplegia remains controversial. The aim of this report was to describe detailed clinical features, MRI findings, treatments, and prognosis of patients with painful ophthalmoplegia. Patients and Methods. We retrospectively investigated four cases of patients with painful ophthalmoplegia diagnosed...
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Cancers are one of the major challenges faced by modern medicine both because of their impact in terms of the amount of cases and of the ineffectiveness of therapies used today. A concrete support to the fight against them can be found in the analysis and understanding of the molecular mechanisms involving molecular chaperones. In particular, HSP60 and HSP10 seem to play an important role in carcinogenesis, supporting tumours in their proliferation, survival, and metastasis. Efforts must be directed...
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The problem of unmeasured parameters estimation for distributed control systems is studied in this paper. The Takagi–Sugeno fuzzy model which can appropriate any nonlinear systems is employed, and based on the model, an observer-based fuzzy H∞ filter which has robustness against time-delay, external noise, and system uncertainties is designed. The sufficient condition for the existence of the desired filter is derived in terms of linear matrix inequalities (LMIs) solutions. Moreover, the underdetermined...
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Personalized recommender systems, as effective approaches for alleviating information overload, have received substantial attention in the last decade. Learning effective latent factors plays the most important role in recommendation methods. Several recent works extracted latent factors from user-generated content such as ratings and reviews and suffered from the sparsity problem and the unbalanced distribution problem. To tackle these problems, we enrich the latent representations by incorporating...
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Evaluation of Treatment Patterns and Direct Costs Associated with the Management of Neuropathic Pain
Background. Neuropathic pain has a prevalence of 2–17% in the general population. Diagnosis and treatment of neuropathic pain are not fully described in different populations. The aim was to determine the treatment patterns and direct costs of care associated with the management of neuropathic pain from the onset of the first symptom to up to two years after diagnosis. Methods. From a drug-claim database, a cohort of randomly selected outpatients diagnosed with neuropathic pain was obtained from...
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The gas-assisted injection molding (GAIM) process is so complicated that increasing reliance has been placed on CAE (Computer Aided Engineering) as a tool for both mold designers and process engineers. In this paper, a 3D theoretical model and numerical scheme is presented to simulate the GAIM process, in which an equal-order velocity-pressure formulation method is employed to eliminate the pressure oscillation. In addition, the whole flow field including the gas and melt regions is calculated using...
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Objective. Our goal was to clarify the significance of SUV max for predicting occult lymph node metastasis and prognosis in early-stage tongue squamous cell carcinoma (SCC). Methods. cT1-2N0 tongue SCC patients who underwent a preoperative PET-CT examination were prospectively enrolled. The association between SUV max and occult lymph node metastasis was analyzed. The main study endpoint was locoregional control (LRC). The Cox model was used to determine the independent factors. Results. A total...
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Due to environmental and energy conservation concerns, a thrust towards low-cost lightweight materials has resulted in renewed interest in the development of sustainable materials that can replace nonbiodegradable and environmentally unfriendly materials in reinforced composites. In this study, mechanical properties of a hybrid composite consisting of polyester resin reinforced with a blend of sisal and cattail fibres were evaluated. The composite was fabricated using a hand lay-up technique at varying...
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With the continuous improvement of the rare earth’s international status, the status of rare Chinese earth has gradually become prominent all over the world. When China enjoys the advantages of large reserves of rare-earth resources, at the same time, Chinese rare-earth enterprises are lagging in technology and lacking innovation capabilities. The rare-earth industry is mainly concentrated on the separation and smelting process, which has an indelible impact on the ecological environment around the...
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