Abstract Functional connectivity analyses for task-based fMRI data are generally preceded by methods for identification of network nodes. As there is no general canonical approach to identifying network nodes, different identification techniques may exert different effects on inferences drawn regarding functional network properties. Here, we compared the impact of two different node identification techniques on estimates of local node importance (based on Degree Centrality, DC)...
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Abstract The limbic system encompasses a collection of brain areas primarily involved in higher cognitive and emotional processing. Altered function in the limbic circuitry may play a major role in various psychiatric disorders. This study aims to provide a high-quality ex vivo diffusion-weighted MRI (DWI) tractographic overview of the Göttingen minipig limbic system pathways, which are currently not well described. This may facilitate future translational large animal studies....
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Abstract This study sought to determine if reducing dopamine D1 receptor (D1R) expression in the dorsal striatum (DS) via RNA-interference alters methamphetamine self-administration. A lentiviral construct containing a short hairpin RNA (shRNA) was used to knock down D1R expression (D1RshRNA). D1RshRNA in male rats increased responding for methamphetamine (i.v.) under a fixed-ratio schedule in an extended access paradigm, compared to D1R-intact rats. D1RshRNA also produced a vertical...
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Tumor incidence increases with advancing aging. Lifelong supplementation of deep ocean minerals significantly suppresses age‐associated tumorigenesis. This tumor‐suppressive action is associated with preventing weight gain and increasing spontaneous physical activity during the first two‐thirds period of life. Abstract Naturally occurring tumor in animals receiving high minerals from deep oceans (DOM: hardness 600 mg/L) from 6 months of age until natural death was firstly assessed in 200 Sprague...
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In a randomized controlled trial, cancer survivors with access to an app‐based cognitive‐behavioral stress‐management intervention (StressProffen) compared with a control group reported a significant reduction in perceived stress level and a significant increase in health‐related quality of life at 3 months. Interventions such as StressProffen, with easy access and use, have the potential to provide low cost, highly accessible psychosocial support for a large group of cancer survivors. Abstract...
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Abstract Introduction : International experience with COVID‐19 suggests it poses a significant risk of infectious transmission to skull base surgeons, due to high nasal viral titers and the unknown potential for aerosol generation during endonasal instrumentation. The purpose of this study was to simulate aerosolization events over a range of endoscopic procedures to gain an evidence‐based aerosol risk assessment. Methods : Aerosolization was simulated in a cadaver using fluorescein...
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by Shivani Choudhary, Samuel K. Buxton, Sreekanth Puttachary, Saurabh Verma, Gunnar R. Mair, Ciaran J. McCoy, Barbara J. Reaves, Adrian J. Wolstenholme, Richard J. Martin, Alan P. Robertson Nematode parasites infect approximately 1.5 billion people globally and are a significant public health concern. There is an accepted need for new, more effective anthelmintic drugs. Nicotinic acetylcholine receptors on parasite nerve and somatic muscle are targets of the cholinomimetic anthelmintics, while...
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We have amended this feature article (BMJ 2020;369:m1297, doi:10.1136/bmj.m1297) in light of Public Health England’s updated guidance on personal protective equipment published the same day as the...
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New guidelines on use of personal protective equipment (PPE) by healthcare workers significantly expands the potential use of eye protection and fluid resistant surgical masks, including to doctors...
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Could machines replace human physicians? Substantial private investments are being devoted to achieving exactly that, and some success has been reported in areas such as breast screening,1 fuelling...
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Regional coordination and bottom-up response of general practitioners in Belgium and the Netherlands
General practitioners are at the core of the healthcare response to the emerging covid-19 epidemic in European health systems.1 The coordination of primary care differs across countries; we describe...
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Steroid inhaler manufacturers are experiencing “significant demand” as people in the UK try to stock up in light of the covid-19 pandemic, causing “distressing shortages,” the Department of Health...
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The government has pledged to carry out 100 000 tests for covid-19 per day in England by the end of April, ramping up its current capacity.The promise by the health secretary Matt Hancock follows...
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We have amended this feature article (BMJ 2020;369:m1297, doi:10.1136/bmj.m1297) in light of Public Health England’s updated guidance on personal protective equipment published the same day as the...
2d
New guidelines on use of personal protective equipment (PPE) by healthcare workers significantly expands the potential use of eye protection and fluid resistant surgical masks, including to doctors...
2d
Could machines replace human physicians? Substantial private investments are being devoted to achieving exactly that, and some success has been reported in areas such as breast screening,1 fuelling...
2d
Regional coordination and bottom-up response of general practitioners in Belgium and the Netherlands
General practitioners are at the core of the healthcare response to the emerging covid-19 epidemic in European health systems.1 The coordination of primary care differs across countries; we describe...
2d
Steroid inhaler manufacturers are experiencing “significant demand” as people in the UK try to stock up in light of the covid-19 pandemic, causing “distressing shortages,” the Department of Health...
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The government has pledged to carry out 100 000 tests for covid-19 per day in England by the end of April, ramping up its current capacity.The promise by the health secretary Matt Hancock follows...
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In the global outbreak of covid-19, people are self-isolating at home, cities are blocked, and schools, museums, and stores are closed.1 Medical students and retired doctors are convened to deal with...
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As covid-19 makes its way through the US, in some locations doctors, nurses, and other healthcare workers are facing the frightening prospect of work without personal protective equipment (PPE). A...
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Accurate and interpretable data are essential in guiding our approach to the covid-19 pandemic. Basic epidemiological principles are currently being flouted.1 Mostly, as in your article,2 case...
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Kids can learn through playAdam Dobson, head of early years foundation stage at Thames View Infants School, Barking, says, “As an early years teacher, and a parent of a five year old, I’ve...
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For healthcare staff at the front line of the covid-19 pandemic, work has suddenly become a frightening place. Impossible decisions threaten long term psychological damage from moral injury, say Neil...
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On 11 March, Rishi Sunak, the chancellor of the exchequer, presented his first budget and promised an extra £5bn (€5.7bn; $6.2bn) for public services to help them deal with covid-19.1What is the £5bn...
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In the global outbreak of covid-19, people are self-isolating at home, cities are blocked, and schools, museums, and stores are closed.1 Medical students and retired doctors are convened to deal with...
2d
As covid-19 makes its way through the US, in some locations doctors, nurses, and other healthcare workers are facing the frightening prospect of work without personal protective equipment (PPE). A...
2d
Accurate and interpretable data are essential in guiding our approach to the covid-19 pandemic. Basic epidemiological principles are currently being flouted.1 Mostly, as in your article,2 case...
2d
Kids can learn through playAdam Dobson, head of early years foundation stage at Thames View Infants School, Barking, says, “As an early years teacher, and a parent of a five year old, I’ve...
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Abstract A substantial proportion of epithelial ovarian cancer (EOC) arises in the fallopian tube and other epithelia of the upper genital tract; these epithelia may incur damage and neoplastic transformation following sexually transmitted infections (STI) and pelvic inflammatory disease. We investigated the hypothesis that past STI infection, particularly Chlamydia trachomatis, is associated with higher EOC risk in a nested case‐control study within the European Prospective Investigation into...
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Star bene con se stessi e con gli altri è certamente un obiettivo ambizioso e faticoso da raggiungere, ma perseguibile con facilità proprio partendo dal Leggi tutto
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In this landmark paper, Denny-Brown published cases of severe sensory ataxia found at autopsy to have sensory ganglionopathy in association with bronchogenic carcinomaPrimary sensory neuropathy with muscular changes associated with carcinomaAuthors: Denny-Brown DYear published: 1948Number of times cited: 475The concept of paraneoplastic disorders is relatively recent in the clinical neurosciences, and one that remains incompletely understood to this day, particularly in terms of therapy. By means...
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ObjectiveTo describe the pathological features of Guillain-Barré syndrome focusing on macrophage-associated myelin lesions.MethodsLongitudinal sections of sural nerve biopsy specimens from 11 patients with acute inflammatory demyelinating polyneuropathy (AIDP) exhibiting macrophage-associated demyelinating lesions were examined using electron microscopy. A total of 1205 nodes of Ranvier were examined to determine the relationship of the macrophage-associated demyelinating lesions with the nodal regions....
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Acute severe colitis is a medical emergency and requires prompt treatment with intravenous steroids. Infliximab is typically used as rescue therapy in those who fail to respond to corticosteroids. This article outlines the altered pharmacokinetics of infliximab in acute severe UC and summarised the latest published data surrounding accelerated infliximab dosing.
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This prospective service evaluation aimed to determine if integrated psychological support for patients with inflammatory bowel disease (IBD) enhanced outcomes. 75 patients were assessed and treated by a specialist liaison psychiatric service between 2015 and 2017; 43 received psychiatric intervention alone, 32 were referred for psychological intervention by clinical health psychologist; 26 completed this. Pre–post data (n=15 available) included global impression, quality of life, and psychiatric...
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Abstract Background Musculus depressor septi nasi and its tendon, the dermocartilaginous ligament, play an important role in external nasal valve and nasal respiration. If the ligament is cut during septorhinoplasty operations, nasal functions of the nose and facial expressions are affected. Therefore, the aim of this study was to investigate the role of M. depressor septi nasi in nasal respiration at open rhinoplasty operations using...
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In this narrative medicine essay, a resident physician with asthma describes her internal deliberations about public vs private good after a decision to retreat from direct-patient care to telemedicine to protect her health during the coronavirus pandemic.
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This Viewpoint introduces the notion of a polysocial risk score, much like a polygenic risk score, which might help predict the risk that varying combinations of social conditions contribute to specific health outcomes.
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