This Viewpoint acknowledges that physicians in clinical roles may be limited in their ability to influence social determinants of patients’ health but proposes they have a role to play in educating others of its importance through teaching and training, diverse student and workforce recruitment, and activism.
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The novel COVID-19 came under limelight few months back (December 2019) and has recently been declared a pandemic by WHO. It has resulted in serious financial implications being faced by dental practices, hospitals and healthcare workers. Dental practice currently is restricted to provision of emergency dental care whereas, many hospitals have also cancelled elective procedures to save finances for COVID-19 treatment which is expensive and unpredictable. In addition, healthcare workers are also facing...
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Publication date: May 2020Source: European Journal of Cancer, Volume 131Author(s): Xiaocong Pang, Xian Su, Zhuo Zhang, Yimin Cui
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Publication date: May 2020Source: European Journal of Cancer, Volume 131Author(s): Yuko Watanabe, Yukie Yamaguchi, Naoko Takamura, Yukitoshi Takahashi, Michiko Aihara
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Publication date: May 2020Source: European Journal of Cancer, Volume 131Author(s): Eleftheria Chorti, Theodora Kanaki, Lisa Zimmer, Eva Hadaschik, Selma Ugurel, Emmanouil Gratsias, Alexander Roesch, Francesco Bonella, Thomas E. Wessendorf, Julia Wälscher, Dirk Theegarten, Dirk Schadendorf, Elisabeth Livingstone
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Publication date: Available online 2 April 2020Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): K. Salaneuve, A. Meunier, K. Aubry
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Publication date: Available online 2 April 2020Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): Y. Xu, H.-B. Ren, L. Jiang, L.-Y. Liu, F.-G. Han, S.-F. Wang
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Publication date: Available online 2 April 2020Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): R.L. Folmer
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Publication date: Available online 2 April 2020Source: Cancer CellAuthor(s): Hunain Alam, Ming Tang, Mayinuer Maitituoheti, Shilpa S. Dhar, Manish Kumar, Chae Young Han, Chandrashekar R. Ambati, Samir B. Amin, Bingnan Gu, Tsai-Yu Chen, Yu-Hsi Lin, Jichao Chen, Florian L. Muller, Nagireddy Putluri, Elsa R. Flores, Francesco J. DeMayo, Laura Baseler, Kunal Rai, Min Gyu Lee
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A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in <em>KRAS</em>-Mutant Lung Cancers
Publication date: Available online 2 April 2020Source: Cancer CellAuthor(s): Stephanie L. Guerra, Ophélia Maertens, Ryan Kuzmickas, Thomas De Raedt, Richard O. Adeyemi, Caroline J. Guild, Shawna Guillemette, Amanda J. Redig, Emily S. Chambers, Man Xu, Hong Tiv, Sandro Santagata, Pasi A. Jänne, Stephen J. Elledge, Karen Cichowski
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Abstract My aim is to depict Psathas’s position on ethnomethodology as a way of doing phenomenological sociology. On this, he contested with others who argued that ethnomethodology is not a phenomenological sociology at all. His claim was that ethnomethodology is a part of the phenomenological movement. In this dispute, he offered two kinds of arguments. On the one hand, he documented the strong phenomenological background of Garfinkel’s ideas. On the other hand, he found in Garfinkel’s...
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Publication date: Available online 2 April 2020Source: New BiotechnologyAuthor(s): Lorenzo Pasotti, Davide De Marchi, Michela Casanova, Ilaria Massaiu, Massimo Bellato, Maria Gabriella Cusella De Angelis, Cinzia Calvio, Paolo Magni
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Abstract In this study, a dataset of X-ray images from patients with common bacterial pneumonia, confirmed Covid-19 disease, and normal incidents, was utilized for the automatic detection of the Coronavirus disease. The aim of the study is to evaluate the performance of state-of-the-art convolutional neural network architectures proposed over the recent years for medical image classification. Specifically, the procedure called Transfer Learning was adopted. With transfer learning,...
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Abstract As reperfusion therapies have become more widely used in acute myocardial infarction patients, ischemia-induced myocardial damage has been markedly reduced, but reperfusion-induced cardiac injury has become increasingly evident. The features of cardiac ischemia–reperfusion (I/R) injury include microvascular perfusion defects, platelet activation and sequential cardiomyocyte death due to additional ischemic events at the reperfusion stage. Microvascular obstruction, defined...
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Background: CD8+ regulatory T cells (CD8+ Tregs) are relatively recently described T cell subsets that have been shown to regulate various T cell responses and appear to play a role in autoimmunity. However, their effects on B cells have not been explored. Objectives: In this investigation we examine the effect of CD8+ Tregs on various subsets of peripheral B cells include naïve B cells, transitional B cells, marginal zone B cells, IgM memory B cells, class switched memory B cells, and plasmablasts,...
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Abstract Sphingosine-1-phosphate (S1P) is an anabolic clastokine. Colony Stimulating Factor 1 (CSF1) induces expression of the rate limiting enzyme required for S1P synthesis, sphingosine kinase 1 (SPHK1) in bone in vivo, and in osteoclasts in vitro. To study the mechanism of CSF1-induced SPHK1 gene expression, a 2608 bp fragment of the murine SPHK1 gene (− 2497 to + 111 bp relative to the transcription start site) was cloned and transfected into pZen cells (murine fibroblasts...
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Related ArticlesIsolated sudden onset anosmia in COVID-19 infection. A novel syndrome? Rhinology. 2020 Apr 02;: Authors: Gane SB, Kelly C, Hopkins C Abstract BACKGROUND: The amelioration of the current COVID pandemic relies on swift and efficient case finding as well as stringent social distancing measures. Current advice suggests that fever or new onset dry cough are the commonest presenting complaints. METHODOLOGY: We present a case report...
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Related ArticlesQuantification of airflow in the sinuses following functional endoscopic sinus surgery. Rhinology. 2020 Apr 02;: Authors: Siu J, Dong J, Inthavong K, Shang Y, Douglas RG Abstract BACKGROUND: Despite functional endoscopic sinus surgery (FESS) being the standard of care in medically recalcitrant chronic rhinosinusitis (CRS), its effect on sinus ventilation has not been fully characterized. Airflow simulations can help improve our understanding...
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Publication date: Available online 3 April 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): J.W. Nolte, M. Alders, L.H.E. Karssemakers, A.G. Becking, R.C.M. Hennekam
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Publication date: Available online 3 April 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): P. Onclin, H.J.A. Meijer, B. van Minnen, A. Vissink, G.M. Raghoebar
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Xuelian Su, Haijing Zhou, Guangjie Bao, Jizeng Wang, Lin Liu, Qian Zheng, Manli Guo, and Jinting ZhangStem cell apoptosis exists widely in embryonic development, tissue regeneration, repair, aging and pathophysiology of disease. The molecular mechanism of stem cell apoptosis has been extensively investigated. However, alterations in biomechanics and nanomorphology have rarely been studied. Therefore, an apoptosis model was established for bone marrow mesenchymal stem cells (BMSCs) and the reconstruction...
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First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Jie Sun is first author on ‘The transcription factor Spalt and human homologue SALL4 induce cell invasion via the dMyc-JNK pathway in Drosophila’, published in BiO. Jie conducted the research described in this article while a PhD student in Dr Jie Shen's lab at the Department of Entomology and MOA Key Laboratory...
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Thomas B. Layton, Lynn Williams, Huw Colin-York, Fiona E. McCann, Marisa Cabrita, Marc Feldmann, Cameron Brown, Weilin Xie, Marco Fritzsche, Dominic Furniss, and Jagdeep NanchahalMechanical force is a fundamental regulator of cell phenotype. Myofibroblasts are central mediators of fibrosis, a major unmet clinical need characterised by the deposition of excessive matrix proteins. Traction forces of myofibroblasts play a key role in remodelling the matrix and modulate the activities of embedded stromal...
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Peihong Su, Chong Yin, Dijie Li, Chaofei Yang, Xue Wang, Jiawei Pei, Ye Tian, and Airong QianMicrotubule actin crosslinking factor 1 (MACF1) is a widely expressed cytoskeletal linker and plays an essential role in various cells’ functions by mediating cytoskeleton organization and dynamics. However, the role of MACF1 on preosteoblast migration is not clear. Here, by using MACF1 knockdown and overexpressed MC3T3-E1 cells, we found MACF1 positively regulated preosteoblast migration induced by cell...
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First Person is a series of interviews with the first authors of a selection of papers published in Biology Open (BiO), helping early-career researchers promote themselves alongside their papers. David Pirovich is first author on ‘Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase enhances formation of the blood-clot lysis protein plasmin’, published in BiO. David is a PhD candidate in the lab of Dr Patrick Skelly at Tufts University, North Grafton, MA, USA, investigating novel moonlighting...
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Jie Sun, Junzheng Zhang, Dan Wang, and Jie ShenCancer cell metastasis is a leading cause of mortality in cancer patients. Therefore, revealing the molecular mechanism of cancer cell invasion is of great significance for the treatment of cancer. In human patients, the hyperactivity of transcription factor Spalt-like 4 (SALL4) is sufficient to induce malignant tumorigenesis and metastasis. Here, we found that when ectopically expressing the Drosophila homologue spalt (sal) or human SALL4 in Drosophila,...
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David B. Pirovich, Akram A. Da'dara, and Patrick J. SkellySchistosomes are intravascular blood flukes that cause the parasitic disease schistosomiasis. In agreement with Schistosoma mansoni (Sm) proteomic analysis, we show here that the normally intracellular glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is also found at the parasite surface; live worms from all intravascular life stages display GAPDH activity. Suppressing GAPDH gene expression using RNA interference significantly...
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Courtney E. Petersen, Matthew J. Wolf, and Jeremy T. SmythStore-operated Ca2+ entry (SOCE) is an essential Ca2+ signaling mechanism present in most animal cells. SOCE refers to Ca2+ influx that is activated by depletion of sarco/endoplasmic reticulum (S/ER) Ca2+ stores. The main components of SOCE are STIM and Orai. STIM proteins function as S/ER Ca2+ sensors, and upon S/ER Ca2+ depletion STIM rearranges to S/ER-plasma membrane junctions and activates Orai Ca2+ influx channels. Studies have implicated...
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Haiyan Wang, Ning Ma, Wenyue Li, and Zuomin WangRecently, microRNA-96-5p (miR-96-5p) has been reported to function as both a tumor suppressor and oncogene in several cancer types, including gastric cancer, hepatocellular cancer and lung cancer. However, the biological function of miR-96-5p and its precise mechanisms in oral squamous cell carcinoma (OSCC) have not been well clarified. The aim of this study was to study the roles of miR-96-5p/FOXF2 axis in OSCC. In this study, the miR-96-5p level...
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Parametric generation of three-dimensional gait for robot-assisted rehabilitation [RESEARCH ARTICLE]
Di Shi, Wuxiang Zhang, Xilun Ding, and Lei SunFor robot-assisted rehabilitation and assessment of patients with motor dysfunction, the parametric generation of their normal gait as the input for the robot is essential to match with the features of the patient to a greater extent. In addition, the gait needs to be in three-dimensional space, which meets the physiological structure of the human better, rather than only on a sagittal plane. Thus, a method for the parametric generation of three-dimensional...
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Abstract On-treatment steroids for countering immune checkpoint inhibitor-induced inflammatory responses (irAEs) are a hallmark of cancer immunotherapy. However, the suppressive nature of steroids has raised questions regarding their ability to compromise the function of the ‘proliferative burst’ of effector T cells induced by immune checkpoint antibodies. We investigated the effector functions and the co-inhibitory receptor profile of stimulated peripheral blood mononuclear cells...
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