After the outbreak of the coronavirus 2019-nCov (COVID-19) in Wuhan, China, in December 2019,[1] the disease rapidly became a global pandemic. Infection rates peaked and began to decline in some Asian countries by March 2020, but Europe and the US are now among the most affected regions.[2] Most COVID-19 infections are characterized by only mild symptoms of fever and cough; however, there is a high risk of severe pulmonary infection and death, in particular for the elderly and populations with comorbidities...
Mon Apr 06, 2020 03:00
Dr. Lutfi Kirdar Kartal Training and Research Hospital located in Istanbul is one of the biggest state hospitals in Turkey. Our radiation oncology department has been equipped with Cyberknife, Tomotherapy and three conventional linear accelerators with volumetric modulated arc treatment and intensity modulated radiation treatment capabilities. Brachytherapy can also be performed by three-dimensional brachytherapy planning. There are 15 radiation oncology specialists, 5 radiation oncology residents,...
Mon Apr 06, 2020 03:00
Radiation-induced xerostomia is a common side effect of head and neck radiotherapy, and can have a substantial long-term impact on overall quality of life [1–4]. Baseline patient-reported xerostomia and dose to the salivary glands have been shown to be predictive of late xerostomia [5,6], and a relationship between dose to the parotid glands and decreased post-treatment salivary flow rates has also been demonstrated [7–9]. Reducing the dose received by the parotid glands using 3D conformal or intensity...
Mon Apr 06, 2020 03:00
In the treatment of locally advanced cervical cancer (LACC) patients, the current treatment of choice is the administration of external beam radiotherapy (EBRT) with concomitant chemotherapy and image-guided adaptive brachytherapy. Research has shown that this patient group suffers from a variety of side effects caused by the treatment. Patients report, among others, gastrointestinal (GI) toxicity, genitourinary (GU) toxicity and overall decrease in quality of life (QoL) in both the acute and late...
Mon Apr 06, 2020 03:00
For the treatment of early stage non-small cell lung cancer (NSCLC) and pulmonary oligo-metastases, beyond the standard of anatomical resection, stereotactic body fractionated radiotherapy (SBRT) has become an alternative treatment option. Providing excellent local tumor control SBRT has widely been established for inoperable patients and for those with a high risk of perioperative complications [2–4].
Mon Apr 06, 2020 03:00
Fatal cases of COVID-19 are characterised by acute respiratory distress syndrome (ARDS), sepsis, pneumonia and respiratory failure.[1] The high transmission rate of the virus and the corresponding rapid escalation in the number of infections has resulted in unprecedented strains on healthcare systems worldwide, particularly as healthcare workers struggle to treat COVID-19 pneumonia.
Mon Apr 06, 2020 03:00
Summary Neuroendocrine tumors (NETs) are understudied and have limited systemic treatment options. Prior studies for patients with advanced NETs have demonstrated promising results when antimetabolite agents, including fluoropyrimidines, were combined with temozolomide TMZ. TAS-102 (trifluridine/tipiracil) is an antineoplastic agent that is non-cross resistant with 5-fluorouracil and capecitabine and that has a different toxicity profile. This study evaluated the safety of TAS-102...
Mon Apr 06, 2020 03:00
High Altitude Medicine &Biology, Ahead of Print.
Mon Apr 06, 2020 10:00
The development of biomaterials for orthopedic applications is a crowded space with several large and small companies designing innovative materials. One approach is the use of these materials to deliver therapeutic proteins that enhance healing. Theradaptive has developed a novel method to modify the proteins themselves so that they coat the surface of implants like paint, making them more readily available for cells of the body to interact with. We recently had the opportunity to chat with the...
02:03
Smart Medical Devices Inc., a startup based in Las Vegas, Nevada, believes surgeons should have access to surgical tools and devices that deliver real-time and actionable data. Smart Medical Devices, Inc. was created by three physicians who recognized the inefficiency and inherent risks involved when using current orthopedic drilling technology, and believed there should be a better way. They have created the SMARTdrill which works to simplify the process of drilling and placing screws....
Mon Apr 06, 2020 23:37
Conventional mechanical ventilators are the go-to method when patients in severe respiratory distress need help breathing. As things stand, there’s an unprecedented demand around the world for ventilators to help patients acutely affected by COVID-19. Materialise, a leader in custom 3D manufacturing, has now developed and is moving through regulatory approval a technology that can provide positive end expiratory pressure (PEEP) to the lungs without the use of a true ventilator. The...
Mon Apr 06, 2020 21:14
Outset Medical announced that it received FDA 510(k) clearance for its Tablo Hemodialysis System to be used in the home, expanding its existing labeled indication for use in acute and chronic care facilities. Touted by Outset as a “dialysis clinic on wheels,” Tablo is designed to reduce dialysis cost and complexity. The device needs only an electrical outlet and tap water to operate, as it includes water purification and dialysate production on demand. A touchscreen tablet guides the...
Mon Apr 06, 2020 20:31
Ortho Clinical Diagnostics, a company out of Raritan, New Jersey, has unveiled its SARS-CoV-2 (COVID-19) antibody test, a development that may allow the detection of those who have already fought off the virus, but never knew they had it. This will help with tracking the spread of COVID-19, identify clinical staff that can pretty safely inhabit the space of current COVID-19 patients, and significantly expand the study of the virus. Currently, the viral spread and level of public immunity to the virus...
Mon Apr 06, 2020 18:42
As the United States braces for what many think may be most critical weeks in the coronavirus crisis, many companies are temporarily pivoting their manufacturing capabilities to focus on the mass shortages of PPE and medical equipment. Most notably are car manufacturers that are using their expertise in hardware engineering and manufacturing to produce much-needed ventilators. Tesla is certainly no exception. To date, the company secured a surplus of 1,000 ventilators from China and...
Mon Apr 06, 2020 16:31
The popular OTC and prescription heartburn pill is linked to NDMA, an environmental contaminant. (Dean Hochman/)As if things in the world of healthcare weren’t chaotic enough, last week the FDA pulled the popular heartburn medicine ranitidine, brand name Zantac, from the shelves due to a possible cancer link. This follows months of investigation first prompted by Valisure, a small start-up pharmacy that looked into the chemistry of the popular medication.Here’s what people with heartburn should know...
01:00
Mandrills in captivity may have different social behaviors, but in the wild, the baboons practice strict distancing. (cmophoto.net/Unsplash/)Dana Hawley is a professor of biological sciences at Virginia Tech. Julia Buck is an assistant professor of biology at University of North Carolina Wilmington. This story originally featured on The Conversation.Social distancing to combat COVID-19 is profoundly impacting society, leaving many people wondering whether it will actually work. As disease ecologists,...
Mon Apr 06, 2020 23:00
Quick and simple coffee within minutes of opening your eyes. (Alex via Unsplash/)Not all pod coffee machines are created equal. These options are like having a barista only a button away, meaning you will never need to leave your house for a hot cup to-go again. Your first morning sip is worth investing in, and these coffee makers are easy to use and provide delicious results. You’ll get a perfect cup of coffee morning, noon, or night—and the machine will never spell your name wrong.It will leave...
Mon Apr 06, 2020 20:33
Even if you're right next to each other, sometimes sharing can be complicated. (You X Ventures / Unsplash/)You probably do a lot of sharing from your phone—photos, files, links—which is why both Android and iOS have a sharing button prominently displayed on most parts of their interfaces.As a refresher, on Android phones, the “share” button looks like a “less-than” sign, with a circle at each point, whereas on iPhones, it’s an arrow pointing out of a rectangle. But no matter which platform you’re...
Mon Apr 06, 2020 19:34
From left to right, gear in the Level A, B, and C categories on display at a Weapons of Mass Destruction Civil Support Team facility in Scotia, New York. (Senior Master Sgt. Gizara / National Guard/)Follow all of PopSci’s COVID-19 coverage here, including the most recent numbers and tips on how to make your own masks.The coronavirus pandemic has understandably spurred millions to think about how they protect themselves—and others—in public spaces. And now, the Centers for Disease Control and Prevention...
Mon Apr 06, 2020 23:48
Shower time will zoom by. (Depositphotos/)Take singing in the shower to the next level with a waterproof Bluetooth speaker. Mount it to the wall, place it on the sink, or float it in the tub while you rub-a-dub-dub. Having tunes or podcasts on while you wash up adds an extra layer of stimulation to your wake-up routine. If you’re drawing a bath and looking to relax, light some candles and crank the slow jams. Here are our favorite options available today.Comes with slick hardshell case. (Amazon/)This...
Mon Apr 06, 2020 17:22
A clearer display for more immersive watching and gaming. (Fredrick Tendong via Unsplash/)Your reasons for wanting a laptop may vary, as will the performance expectations you have for it. But as the laptop continues to gain popularity as the epicenter of your entertainment media landscape, just being portable isn’t enough. It has to deliver gorgeous high-def imagery.For those looking for a laptop that brings optimal image quality, there are a lot of options, particularly in the gaming laptop space....
Mon Apr 06, 2020 16:12
Craters on Mars suggest the planet takes quite a beating. (University of Arizona/HiRISE-LPL /)In December 2018, a 33-foot-wide meteor exploded over the Bering Sea. In June 2018, a smaller meteor, about 9- to 12-feet wide, exploded over Botswana and rained meteorites onto the desert. In 2013, a 60-foot meteor exploded over Chelyabinsk, Russia, with a shockwave strong enough to destroy buildings and injure more than a thousand people. This kind of airblast only occurs about once or twice per century....
Mon Apr 06, 2020 15:00
Cullin-7 (CUL7) is a member of the DOC domain-containing cullin family and is involved in the regulation of cell transformation. However, the clinical significance, potential mechanism and upstream regulators ...
Mon Apr 06, 2020 03:00
Human ovarian cancer specific transcript 2 (HOST2) is a long non-coding RNA (lncRNA) reported to be specifically high expressed in human ovarian cancer. However, the mechanism that how HOST2 regulates triple n...
Sun Apr 05, 2020 03:00
Circular RNAs (circRNAs) are a novel class of noncoding RNAs that regulate gene expression at the transcriptional or posttranscriptional level. According to recent studies, circRNAs are involved in the pathoge...
Sun Apr 05, 2020 03:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Mon Apr 06, 2020 10:00
In their article, Johnston and colleagues explore whether incorporation of a frailty measure improves predictions of the costs of care and more fairly reimburses providers participating in Medicare value-based payment programs. The editorialists discuss the findings and believe we must stop the financial disincentives to caring for the frail elderly.
00:56
Background:Medicare uses the Centers for Medicare & Medicaid Services Hierarchical Condition Category (CMS-HCC) model to predict patients' annualized Medicare costs in value-based payment programs. The CMS-HCC model does not include measures of frailty, and prior research shows that it systematically underpredicts costs for frail Medicare beneficiaries.Objective:To determine whether a claims-based frailty index can improve Medicare cost prediction.Design:Retrospective cohort study.Setting:Medicare...
00:56
Caring for patients with the novel coronavirus infection is placing great stress on health care systems and health care workers. On the basis of their experiences responding to other pandemics, the authors summarize lessons learned and offer some best practices for facilitating organizational resilience and supporting health care workers during the COVID-19 pandemic.
Mon Apr 06, 2020 03:00
Mon Apr 06, 2020 03:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου