Δευτέρα 6 Απριλίου 2020

Topical pilocarpine for xerostomia in patients with head and neck cancer treated with radiotherapy.

Topical pilocarpine for xerostomia in patients with head and neck cancer treated with radiotherapy.:

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Topical pilocarpine for xerostomia in patients with head and neck cancer treated with radiotherapy.

Oral Dis. 2020 Apr 05;:

Authors: de Sousa Pereira RM, Bastos MDR, Ferreira MP, de Freitas O, de Macedo LD, de Oliveira HF, Ricz HMA, Motta ACF, Macedo AP, Tirapelli C, Pedrazzi V

Abstract

OBJECTIVE: To evaluate a pilocarpine spray as a treatment for xerostomia in patients treated with radiotherapy (RT) for head and neck cancer (HNC).

METHODS: This was a placebo-controlled, double-blind, crossover clinical trial of patients complaining of dry mouth after RT for HNC. Forty patients were randomly assigned to either placebo or pilocarpine (1.54%) spray and instructed to use 3 times a day for three months. After one-month washout period, patients were crossed over to receive placebo or pilocarpine. The assessments were salivary flow (Stimulated Whole Saliva Flow-SWSF), xerostomia (Xerostomia Inventory - XI) and quality of life (QoL/Oral Health Impact Profile - OHIP-14), assessed at baseline, one hour (only SWSF), and at one, two and three months of treatment.

RESULTS: Posttreatment SWFS was not statistically different between pilocarpine and placebo regardless of the treatment sequence (paired T test; p>0.05), except for the SWFS rates at two months after therapy. When comparing pilocarpine with placebo in the time points, there was no significant difference (p>0.05) for QoL or XI. Significant differences of improvement in QoL and xerostomia experience appeared along time for pilocarpine group.

CONCLUSION: The topical application of pilocarpine spray tested was similar to placebo on SWSF assessments in patients treated with RT for HNC.

PMID: 32248594 [PubMed - as supplied by publisher]

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