Abstract Objective To investigate the occurrence of olfactory and gustatory dysfunctions in patients with laboratory-confirmed COVID-19 infection. Methods Patients with laboratory-confirmed COVID-19 infection were recruited from 12 European hospitals. The following epidemiological and clinical outcomes have been studied: age, sex, ethnicity, comorbidities,...
Mon Apr 06, 2020 03:00
Abstract Purpose The endoscopic approach to tympanoplasty is gaining popularity, but its adoption for the palisade tympanoplasty technique is unstudied. The aim of the present study was to evaluate the effectiveness of endoscopic cartilage palisade tympanoplasty compared to one-piece composite cartilage-perichondrium grafts for tympanic membrane closure in adult patients with subtotal perforations. ...
Mon Apr 06, 2020 03:00
Abstract Purpose The olfactory groove (OG) is a common site of iatrogenic cerebrospinal fluid (CSF) leak during endoscopic sinus surgery. We aimed to evaluate the prevalence of CSF leak during endoscopic removal of osteomas involving the OG and identify CT findings indicating increased risk of this complication. Methods A retrospective review was conducted...
Mon Apr 06, 2020 03:00
Abstract Aim The aim of this study was to analyze dental and soft tissue profile development in children with normal occlusions to establish age- and gender-specific reference intervals for German children during their active growth period. Subjects and methods The study group consisted of a sample of 31 untreated Caucasian subjects with normal occlusions....
Mon Apr 06, 2020 03:00
Abstract Introduction Glioblastoma is a very aggressive cancer with dismal prognosis despite standard of care including surgical resection, radiation therapy, and chemotherapy. There is interest in applying immunotherapy to glioblastoma as this modality has demonstrated remarkable improvements in the management of several solid tumors including melanoma, renal cell carcinoma, and non-small cell lung cancer. This review aims to provide...
Mon Apr 06, 2020 03:00
Abstract Purpose The neutrophil-to-lymphocyte ratio (NLR) has been reported to relate to the prognosis of various cancers. The aim of this study was to elucidate the efficiency of pre-treatment NLR as a predictor of outcomes of brain metastasis underwent gamma knife radiosurgery (GKRS). Methods We analyzed 195 cases with brain metastasis underwent...
Mon Apr 06, 2020 03:00
Abstract Introduction CD47 over expression has been reported in several tumor subtypes. CD47 interacts with SIRPalpha on macrophages inhibiting phagocytic signal, providing a survival advantage to tumor. CD47, therefore, represents a valuable target for immunotherapy and is currently under clinical investigation. We aimed to study CD47 expression in Hodgkin Reed Sternberg cells (HRS). ...
Mon Apr 06, 2020 20:28
Abstract Background Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) may be an oncogenic gene in renal cell carcinoma (RCC). However, the direct association between COUP-TFII expression and patient survival has not been investigated in patients with RCC, and the molecular oncogenesis of COUP-TFII in RCC remains unclear. Methods ...
Mon Apr 06, 2020 20:28
Abstract Altered aerobic glycolysis is a well-recognized characteristic of cancer cell energy metabolism, known as the Warburg effect. Even in the presence of abundant oxygen, a majority of tumor cells produce substantial amounts of energy through a high glycolytic metabolism, and breast cancer (BC) is no exception. Breast cancer continues to be the second leading cause of cancer-associated mortality in women worldwide. However, the precise role of aerobic glycolysis in the...
Mon Apr 06, 2020 20:28
Abstract Background Primary tumor characteristics, which are readily available to all clinicians, may aid in selecting the optimal adjuvant therapy for patients with breast cancer (BC). Herein, we investigated the relationship between tumor size, hormone receptor and HER2 status, Ki67 and age with axillary lymph node metastases (ALNM) in early-BC patients. Methods...
Mon Apr 06, 2020 20:28
Abstract Background The specific association between PTEN deletion or ERG rearrangement and the recurrence of prostate cancer (PC) treated with radical prostatectomy (RP) or brachytherapy is still unelaborated. Therefore, we performed a comprehensive meta‑analysis to understand the impact of these factors on cancer recurrence. Methods ...
Mon Apr 06, 2020 20:28
Abstract Purpose Patients with diagnosis of diffuse large B-cell lymphoma, who relapse after stem cell transplant (SCT) or are no candidates to SCT, have a poor prognosis and no current treatment is available. Thus, we conduct a rotatory chemotherapy schedule that employed low doses of chemotherapy agents to assess efficacy and toxicity in this setting of patients; the end point was the improved outcome. ...
Mon Apr 06, 2020 20:28
Abstract Colorectal cancer (CRC) has the second-highest tumor incidence and is a leading cause of death by cancer. Nearly 20% of patients with CRC will have metastases at the time of diagnosis, and more than 50% of patients with CRC develop metastatic disease during the course of their disease. A group of experts from the Spanish Society of Medical Oncology, the Spanish Association of Surgeons, the Spanish Society of Radiation Oncology, the Spanish Society of Vascular and Interventional...
Mon Apr 06, 2020 20:28
Abstract Purpose Immunotherapy-based approaches are standard first-line treatments for advanced/metastatic lung cancer or for chemoradiotherapy consolidation in locally advanced disease. Uncertainty on how to treat patients at disease progression prompted us to develop a consensus document on post-immunotherapy options in Spain for patients with advanced wild-type lung adenocarcinoma. ...
Mon Apr 06, 2020 20:28
Abstract Purpose Meningiomas are common brain tumors, the majority of which are considered benign. Despite surgery and/or radiation therapy, recurrence rates are approximately 8–10%. One likely cause is the dysregulation of cyclin d-cyclin-dependent kinases 4 and 6 (CDK4/6)-retinoblastoma (Rb) pathway, which controls the cell cycle restriction point. This pathway is commonly dysregulated in anaplastic meningioma cell lines (AM) and...
Mon Apr 06, 2020 03:00
Publication date: Available online 6 April 2020Source: TalantaAuthor(s): Masoud Negahdary
Mon Apr 06, 2020 20:26
Publication date: Available online 6 April 2020Source: TalantaAuthor(s): Monica Mattarozzi, Marco Giannetto, Maria Careri
Mon Apr 06, 2020 20:26
ObjectivesThe aim of this clustered, randomised controlled trial was to assess the effectiveness of a lumbopelvic postural feedback device for changing postural behaviour in a group of healthcare workers. We hypothesised that workers exposed to auditory postural feedback would reduce the number of times forward bending posture is adopted at work.MethodsThis was a participant and assessor blinded, randomised, sham-controlled trial with blocked cluster random allocation. We recruited healthcare workers...
Mon Apr 06, 2020 19:00
Publication date: Available online 5 April 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Martin Björck, Alexei Svetlikov
Mon Apr 06, 2020 19:47
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05329
Mon Apr 06, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00189
Mon Apr 06, 2020 07:00
Abstract Background The posterior regions of the jaws usually represent a significant risk for implant surgery. A non-valid assessment of the available bone height may lead to either perforation of the maxillary sinus floor or encroachment of the inferior alveolar nerve and consequently to implant failure. This study aimed to evaluate the reliability of surgeon’s decision in appraising the appropriate implant length, in respect...
Mon Apr 06, 2020 03:00
Publication date: Available online 5 April 2020Source: Clinical TherapeuticsAuthor(s): Chongjian Li, Yuejin Yang, Yaling Han, Dan Song, Jing Xu, Changdong Guan, Runlin Gao, Hector M. Garcia-Garcia, Ron Waksman, Bo Xu, for the BIOFLOW VI Trial Investigators
Mon Apr 06, 2020 19:26
Background Olfactory dysfunction is a common complaint in patients suffering from chronic rhinosinusitis with nasal polyps (CRSwNP). The purpose of this paper is to critically review all published literature regarding the impact of monoclonal antibodies on CRSwNP‐related olfactory dysfunction. Methodology An electronic literature search was performed in MEDLINE, ScienceDirect, the Cochrane Library electronic databases and multiple trial registries followed by extensive hand‐searching...
Mon Apr 06, 2020 18:32
Background Nasal topical treatments can provide an effective method of disease control for patients suffering from chronic rhinosinusitis (CRS). However, some frequently used formulations lack adequate evaluation on their safety. This study investigated the effect of 0.5% Povidone‐Iodine (Nasodine) on the sinonasal epithelial barrier and ciliated human nasal epithelial cells in vitro. Methodology/Principal Nasodine was applied to air‐liquid interface (ALI) cultures of primary human nasal...
Mon Apr 06, 2020 17:50
Controlling cell adhesion and cell differentiation is necessary to fabricate a tissue with arbitrary properties for tissue engineering applications. A substrate with a porous structure as a cell scaffold allows the diffusion of the cell culture medium through the scaffold. In this work, we show that the femtosecond laser fabricated micro through‐holes in biodegradable polymer films, enhance myoblast adhesion and differentiation, and accelerates proliferation. ChR2‐C2C12 and UT‐C2C12 cells were seeded...
Mon Apr 06, 2020 12:55
Abstract More than 90% of solid kidney tumors are cancerous and have to be treated by surgical resection where surgical outcomes and patient prognosis are dependent on the tumor discrimination. The development of alternative approaches based on a new generation of fiber attenuated total reflection (ATR) probes could aid tumor identification even under intra‐surgical conditions. Herein, fiber ATR IR spectroscopy is employed to distinguish normal and cancerous kidney tissues. Freshly resected tissue...
Sun Apr 05, 2020 19:04
ABSTRACT The aim of this study was to recommend optimal functional ear reconstruction strategies for microtia with congenital aural stenosis. Modified meatoplasty with endoaural‐conchal incision was the core technique of our functional ear reconstruction strategies. If meatoplasty is performed first, it does not appear to significantly increase the risk of skin flap necrosis and infection after autologous cartilage microtia reconstruction. If autologous cartilage microtia reconstruction is performed...
Sun Apr 05, 2020 15:38
Publication date: Available online 6 April 2020Source: Gait & PostureAuthor(s): Jana Holder, Zoe Feja, Stefan van Drongelen, Stefanie Adolf, Harald Böhm, Andrea Meurer, Felix Stief
Mon Apr 06, 2020 18:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου