Future Oncology, Ahead of Print.
Mon Apr 06, 2020 05:24
Future Oncology, Ahead of Print.
Mon Apr 06, 2020 05:08
Future Oncology, Ahead of Print.
Mon Apr 06, 2020 04:49
Future Oncology, Ahead of Print.
Mon Apr 06, 2020 04:23
Background. The interleukin-12 (IL-12) family consists of four members, namely, IL-12, IL-23, IL-27, and IL-35. The aim of this study was to examine the expression of circulating IL-12, IL-23, IL-27, and IL-35 in hypertensive patients. Methods. Blood samples were collected from hypertensive patients and nonhypertensive (control) subjects, and protein multifactorial monitor kits were used to measure the plasma IL-12, IL-23, IL-27, and IL-35 levels in each sample. In addition, all enrolled subjects...
Mon Apr 06, 2020 18:05
Mouse sex chromosomes are enriched for co-amplified gene families, present in tens to hundreds of copies. Co-amplification of Slx/Slxl1 on the X chromosome and Sly on the Y chromosome are involved in dose-dependent meiotic drive, however the role of other co-amplified genes remains poorly understood. Here we demonstrate that the co-amplified gene family on the X chromosome, Srsx, along with two additional partial gene annotations, is actually part of a larger transcription unit, which we name Laidx....
Mon Apr 06, 2020 22:56
No abstract available
Wed Apr 01, 2020 03:00
No abstract available
Wed Apr 01, 2020 03:00
No abstract available
Wed Apr 01, 2020 03:00
No abstract available
Wed Apr 01, 2020 03:00
No abstract available
Wed Apr 01, 2020 03:00
J Neurol Surg B 2020; 81: A1-DOI: 10.1055/s-0040-1702292Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Mon Apr 06, 2020 02:00
Although the last two decades have seen a broad improvement in overall survival, colorectal cancer (CRC) is still the second leading cause of cancer deaths worldwide. Patient populations continue to face poor disease prognoses due to the challenges of early detection and the molecular subtypes driving their CRC. Consequently, many patients present with metastatic CRC, which often limits options and shifts treatment focus away from curative interventions. BRAFV600E mutations are present in approximately...
Mon Apr 06, 2020 16:23
Purpose: The standard treatment of patients with locally advanced rectal cancer consists of preoperative chemoradiotherapy (CRT) followed by surgery. However, the response of individual tumors to CRT is extremely diverse, presenting a clinical dilemma. This broad variability in treatment response is likely attributable to intratumor heterogeneity (ITH). Experimental Design: We addressed the impact of ITH on response to CRT by establishing single cell-derived cell lines (SCDCLs) from a treatment-naïve...
Mon Apr 06, 2020 16:23
Purpose: The RAS/RAF/MEK/ERK signaling pathway is critical to the development of colorectal cancers, and KRAS, NRAS, and BRAF mutations foster resistance to radiation. We performed a phase I trial to determine the safety of trametinib, a potent MEK1/2 inhibitor, with 5-fluorouracil (5FU) chemoradiation (CRT) in patients with locally advanced rectal cancer (LARC). Experimental Design: Stage II/III rectal cancer patients were enrolled on a phase I study with 3+3 study design, with an expansion cohort...
Mon Apr 06, 2020 16:23
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