Medicine by Alexandros G. Sfakianakis

Δευτέρα 6 Απριλίου 2020

Phase I Trial of Trametinib with Neoadjuvant Chemoradiation in Patients with Locally Advanced Rectal Cancer

Purpose: The RAS/RAF/MEK/ERK signaling pathway is critical to the development of colorectal cancers, and KRAS, NRAS, and BRAF mutations foster resistance to radiation. We performed a phase I trial to determine the safety of trametinib, a potent MEK1/2 inhibitor, with 5-fluorouracil (5FU) chemoradiation (CRT) in patients with locally advanced rectal cancer (LARC). Experimental Design: Stage II/III rectal cancer patients were enrolled on a phase I study with 3+3 study design, with an expansion cohort...

Clinical Cancer Research Online First Articles

Mon Apr 06, 2020 16:23

Mechanistic insights for optimising PSMA radioligand therapy

PSMA radioligand therapy is a promising new class of therapy for prostate cancer. Heterogeneity of PSMA expression are important factors explaining variability in clinical results. The ability to visualise the target with theranostics provides unique mechanistic insights. Potential clinically-applicable strategies to improve patient selection and optimise therapeutic efficacy are discussed.

Clinical Cancer Research Online First Articles

Mon Apr 06, 2020 16:23

Biomarkers associated with beneficial PD-1 checkpoint blockade in non-small-cell lung cancer (NSCLC) identified using high-plex digital spatial profiling

Purpose: Only a minority of patients with advanced non-small-cell lung cancer (NSCLC) truly benefit from single-agent PD-1 checkpoint blockade, and more robust predictive biomarkers are needed. Experimental Design: We assessed tumor samples from 67 immunotherapy-treated NSCLC cases represented in a tissue microarray, 53 of whom had pre-treatment samples and received monotherapy. Using GeoMx Digital Spatial Profiling system (NanoString), we quantified 39 immune parameters simultaneously in four tissue...

Clinical Cancer Research Online First Articles

Mon Apr 06, 2020 16:23

Mark above section as read

Hormon- und Stoffwechselforschung

Salt Appetite and its Effects on Cardiovascular Risk in Primary Aldosteronism

Horm Metab ResDOI: 10.1055/a-1116-2407First described in 1955 by Jerome W. Conn, primary aldosteronism (PA) today is well established as a relevant cause of secondary hypertension and accounts for about 5–10 % of hypertensives. The importance of considering PA is based on its deleterious target organ damage far beyond the effect of elevated blood pressure and on PA being a potentially curable form of ...

Hormon- und Stoffwechselforschung

Mon Apr 06, 2020 02:00

Effects of Metformin and Sitagliptin Monotherapy on Expression of Intestinal and Renal Sweet Taste Receptors and Glucose Transporters in a Rat Model of Type 2 Diabetes

Horm Metab ResDOI: 10.1055/a-1135-9031Disordered intestinal sweet taste receptors (STRs) are implicated in glucose homeostasis by involving in incretin secretion and glucose absorption. However, the effects of antidiabetic medications on STRs, downstream molecules, and glucose transporters expression are unknown. In our study, ZDF rats (n=24) were randomly treated by metformin (MET, 215.15 mg/kg),...

Hormon- und Stoffwechselforschung

Mon Apr 06, 2020 02:00

Serum Visfatin does not seem to be a Useful Marker to Guide Glucocorticoid Substitution in Adrenal Insufficiency

Horm Metab ResDOI: 10.1055/a-1135-9715Primary adrenal insufficiency (Addison’s disease, AD) requires lifelong steroid substitution. Excess exogenous glucocorticoids promote abdominal obesity, insulin-glucose imbalance, and hypertension. Reliable markers of the adequate glucocorticoid replacement are lacking. Visfatin is a pro-inflammatory adipokine, with enzymatic activity of nicotinamide ...

Hormon- und Stoffwechselforschung

Mon Apr 06, 2020 02:00

Hypokalemia and the Prevalence of Primary Aldosteronism

Horm Metab ResDOI: 10.1055/a-1134-4980Hypokalemia is closely linked with the pathophysiology of primary aldosteronism (PA). Although hypokalemic PA is less common than the normokalemic course of the disease, hypokalemia is of particular importance for the manifestation and development of comorbidities. Specifically, a growing body of evidence demonstrates that hypokalemia in PA patients is associated with a more severe disease course regarding cardiovascular and metabolic morbidity and mortality....

Hormon- und Stoffwechselforschung

Mon Apr 06, 2020 02:00

COMP-Ang-1 Improves Glucose Uptake in db/db Mice with Type 2 Diabetes

Horm Metab ResDOI: 10.1055/a-1126-4402Cartilage oligomeric matrix protein (COMP)-Angiopoietin-1 is a potent angiopoietin-1 (Ang-1) variant that possesses therapeutic potential in angiogenesis and vascular endothelial dysfunction. Noteworthy, we have shown that COMP-Ang-1 improves hyperglycemia and neuroregeneration in ob/ob mice. However, the mechanism of the antidiabetic effect of COMP-Ang-1...

Hormon- und Stoffwechselforschung

Mon Apr 06, 2020 02:00

Age, Gender, and Body Mass Index as Determinants of Surgical Outcome in Primary Aldosteronism

Horm Metab ResDOI: 10.1055/a-1139-1783Although unilateral primary aldosteronism (PA) should be curable by adrenalectomy (ADX), postsurgical outcome is affected by several clinical factors. Herein we reviewe the importance of age, gender, and BMI as determinants of surgical success based on the recent findings including a nation-wide, multicenter study in Japan (JPAS/JRAS). It is important to determine whether ADX...

Hormon- und Stoffwechselforschung

Mon Apr 06, 2020 02:00

Mark above section as read