Objective. Previously, the opening of mitochondrial permeability transition pore (mPTP) was confirmed to play a key role in the pathophysiology of postcardiac arrest syndrome (PCAS). Recently, we demonstrated that limb ischemic postconditioning (LIpostC) alleviated cardiac and cerebral injuries after cardiac arrest and resuscitation. In this study, we investigated whether LIpostC would alleviate the severity of PCAS through inhibiting mPTP opening. Methods. Twenty-four male domestic pigs weighing...
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Destruction of extracellular matrix (ECM) is one of the basic steps of tumor invasion and metastasis. Matrix metalloproteinase (MMP) 9, a kind of zinc-ion-dependent endopeptidase, can degrade almost all protein components in the ECM, destroy the histological barrier of tumor cell invasion, and play a key role in tumor invasion and metastasis. The role of MMP-9 in tumor invasion and metastasis has attracted increasing attention and is considered the main proteolytic enzyme in this process. Although...
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Introduction: G protein-coupled receptor (GPCR) mutations are implicated in many diseases. Most inactivating mutations cause receptor mis-folding and prevent trafficking to the plasma membrane. Pharmacological chaperones can ‘rescue’ cell surface expression of such mutants, presumably by stabilising correct folding of the nascent protein. Objective: Here we examine the scope of intracellularly retained luteinising hormone receptor (LHR) mutants that can be ‘rescued’ by the pharmacological chaperone...
3h
Identifying early predictors of poor quality of life could allow for the identification of patients who may benefit from early referral to palliative and supportive care according to the researchers. (Source: CancerNetwork)
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Mount Sinai Health System announced that they will be using the allogeneic stem cell therapy remestemcel-L in patients with COVID-19, and have already tested the therapy in 10 patients. (Source: CancerNetwork)
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A recent study determined 4 distinct long noncoding RNA-based immune classes for patients with cancer and provided scores for integration into multiomic panels for precision immunotherapy. (Source: CancerNetwork)
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A prognostic survival model, titled PROVIEW, was able to accurately predict changing cancer survival risk over time and may have the potential to be a useful prognostic tool that can be completed by patients. (Source: CancerNetwork)
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A recent study found that switch maintenance therapy after first-line platinum-based chemotherapy led to higher objective response rates and longer progression-free survival for patients of urothelial cancer. (Source: CancerNetwork)
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Results from a subgroup of the TAILORx trial suggested that adjuvant chemoendocrine therapy is associated with significantly greater cancer-related cognitive impairment compared with endocrine therapy alone. (Source: CancerNetwork)
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Researchers outlined recommendations for testing patients with lung cancer for COVID-19, given their specific cumulative risk factors for COVID-19 complications. (Source: CancerNetwork)
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A recent study examined the differences in stage of leading cancer types at diagnosis, treatment and overall survival of patients according to different races and ethnicities. (Source: CancerNetwork)
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This is the first FDA approval for this patient population. (Source: CancerNetwork)
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In our gastrointestinal cancer quiz, you ’ll get a chance to test your knowledge on the BRAF V600E mutation in patients with colorectal cancer. (Source: CancerNetwork)
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The JNCCN outlined strategies and best safety practices during the COVID-19 pandemic for patients, caregivers, and healthcare workers. (Source: CancerNetwork)
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Researchers detailed the challenges presented for lung cancer therapy during the COVID-19 pandemic and how to potentially mitigate them. (Source: CancerNetwork)
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The FDA approved tucatinib in combination with chemotherapy for the treatment of adult patients with advanced forms of HER2-positive breast cancer. (Source: CancerNetwork)
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This study examined delayed targeted intraoperative radiotherapy vs external beam radiotherapy to determine how it impacted patients with breast cancer, finding no statically significant decrease in mastectomy-free survival, distant-disease survival or overall survival. (Source: CancerNetwork)
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The prostate cancer expert discussed guidelines that he and his colleagues culminated for triaging patients with prostate cancer during the COVID-19 pandemic. (Source: CancerNetwork)
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A group of expert medical societies developed joint recommendations for healthcare professionals and patients to guide the prioritization, treatment and triage of breast cancer during the COVID-19 pandemic. (Source: CancerNetwork)
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Researchers found that the potential availability of CAR T-cell therapies for large B-cell lymphomas with lower adverse event rates that are suitable for outpatient administration may reduce the total costs of care. (Source: CancerNetwork)
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Mounting evidence indicates a potential beneficial effect of vigorous-intensity physical activity on hepatocellular carcinoma (HCC). However, the association between moderate-intensity physical activity, such as brisk walking, and the risk of HCC remains largely unknown. Two prospective cohorts of 77,535 women from the Nurses' Health Study and 44,540 men from the Health Professionals Follow-up Study were included. Weekly time spent on physical activities were updated biennially. The Cox proportional...
3h
We conducted a multi-institutional, placebo-controlled Phase IIB trial of the lignan secoisolariciresinol diglucoside (SDG) found in flaxseed. Benign breast tissue was acquired by random periareolar fine needle aspiration (RPFNA) from pre-menopausal women at increased risk for breast cancer. Those with hyperplasia and ≥2% Ki-67 positive cells were eligible for randomization 2:1 to 50 mg SDG/day (Brevail®) vs placebo for 12 months with repeat bio-specimen acquisition. The primary endpoint was difference...
3h
Abstract This study was performed along the shorelines of Lake Salda in Turkey during the elapsed period from 1975 to 2019 in order to detect shoreline changes. Within this framework, geographic information system, digital shoreline analysis system, Modified Normalized Difference Water Index, and multi-temporal satellite images were utilized. The measurement of shoreline displacement was mainly divided into six analysis regions. In digital shoreline analysis system, several statistical...
3h
Abstract Possible sunshine duration (PSD) determines the solar energy received by the surface of Earth. The objective of this research is to explore the spatial structure of PSD which is closely related to slope and PSD. We chose 40 sample areas representing diversified landforms in China and then computed the PSD by using the digital elevation models (DEMs) with a resolution of 30 m for the sample areas. We define the concept of the spectrum which reveals the relation between...
16h
Imaging software developer Median Technologies has received a disbursement...Read more on AuntMinnieEurope.comRelated Reading: Median Technologies posts solid revenue growth Median Technologies signs finance deal Median posts healthy 6-month revenues Median completes restructuring, previews 2018 results Median sees 6-month revenue decline
3h
Science publisher Springer is offering its artificial intelligence (AI) in...Read more on AuntMinnieEurope.comRelated Reading: Radiographers: Don't forget us when it comes to AI RCR offers guidance on adopting AI during COVID-19 Behold.ai joins forces with Wellbeing on AI for COVID-19 Europe seeks to harness power of AI in COVID-19 crisis Behold.ai trains AI to detect COVID-19 on x-ray
10h
The COVID-19 outbreak "significantly affected" financial results at Philips...Read more on AuntMinnieEurope.comRelated Reading: Philips launches COVID-19 telehealth package Philips boosts production in light of COVID-19 demands Philips, ESR partner on ultrasound program at ECR 2020 Philips reports Q4 growth, but coronavirus begins to bite Philips secures Danish deal for CT scanners
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The regional union of private health professionals in Île-de-France (L'Union...Read more on AuntMinnieEurope.comRelated Reading: Hard truths from COVID-19 front line in Paris Imaging allows clinicians to determine severity of COVID-19 French expert offers 6 imaging tips to defeat COVID-19 VIDI joins forces with French public hospitals to deliver imaging French group calls for more coronavirus protection
21h
Swiss investigators have found a 3D image fusion technique combining CT and...Read more on AuntMinnieEurope.comRelated Reading: 3D 'digital twin' adds personal touch to heart health Cardiac patients gain from 3D printing, AR advances How is 3D printing transforming cardiac care? 3D printing can bolster cardiac management Novel contrast-free MRI technique measures heart strain
21h
The European Board of Radiology has announced that a new European Diploma in...Read more on AuntMinnieEurope.comRelated Reading: EDiR exam in Sweden set for September EBR reschedules 4 EDiR exams EBR offers 2 new self-assessment tests EBR adds features to EDiR app EDiR guidebook now available
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Imaging professionals from across the world shared their experiences of COVID-19...Read more on AuntMinnieEurope.comRelated Reading: What Europe can learn from China in combating COVID-19 Hard truths from COVID-19 front line in Paris Imaging allows clinicians to determine severity of COVID-19 RCR teams up with CoR on coronavirus advisory posters ESR issues statement on imaging's role in COVID-19
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If there is one positive thing to come out of the COVID-19 pandemic, it is...Read more on AuntMinnieEurope.comRelated Reading: Hard truths from COVID-19 front line in Paris Imaging allows clinicians to determine severity of COVID-19 ESR issues statement on imaging's role in COVID-19 French expert offers 6 imaging tips to defeat COVID-19 Chinese team uses PET/CT on COVID-19 patients
3d
Making use of radiomics, an artificial intelligence (AI) algorithm can accurately...Read more on AuntMinnieEurope.comRelated Reading: Ultrasound CADx software can stratify thyroid nodules Ultrasound shows thyroid cancer spike after Fukushima Ultrasound-based CAD pinpoints thyroid nodules TI-RADS works best for classifying thyroid nodules on US Shear-wave elastography assists in thyroid cancer
4d
Reactive oxygen species (ROS) oxidize nucleotide triphosphate pools (e.g., 8-oxodGTP), which may kill cells if incorporated into DNA. Whether cancers avoid poisoning from oxidized nucleotides by preventing incorporation via the oxidized purine diphosphatase MTH1 remains under debate. Also, little is known about DNA polymerases incorporating oxidized nucleotides in cells or how oxidized nucleotides in DNA become toxic. Here we show that replacement of one of the main DNA replicases in human cells,...
3h
TGFβ plays a crucial role in the tumor microenvironment by regulating cell-cell and cell-stroma interactions. We previously demonstrated that TGFβ signaling on myeloid cells regulates expression of CD73, a key enzyme for production of adenosine, a pro-tumorigenic metabolite implicated in regulation of tumor cell behaviors, immune response, and angiogenesis. Here, using an MMTV-PyMT mouse mammary tumor model, we discovered that deletion of TGFβ signaling on myeloid cells (PyMT/TGFβRIILysM) affects...
3h
Zinc finger protein 143 (ZNF143) belongs to the zinc finger protein family and possesses transcription factor activity by binding sequence-specific DNA. The exact biological role of ZNF143 in hepatocellular carcinoma (HCC) has not been investigated. Here we report that ZNF143 is overexpressed in HCC tissues and its overexpression correlates with poor prognosis. Gain- and loss-of-function experiments showed that ZNF143 promoted HCC cell proliferation, colony formation, and tumor growth in vitro and...
3h
Abnormal vasculature in tumors leads to poor tissue perfusion and cytostatic drug delivery. Although drugs inducing vascular normalization, e.g., angiopoietin-2 (Ang2)-blocking antibodies, have shown promising results in preclinical tumor models, clinical studies have so far shown only little efficacy. Since Ang2 is known to play a protective role in stressed endothelial cells, we tested here if Ang2 blocking could enhance radiation-induced tumor vascular damage. Tumor-bearing mice were treated with...
3h
∆Np63 is a transcription factor of the p53 family and has crucial functions in normal development and disease. The expression pattern of ∆Np63 in human cancer suggests dynamic regulation of this isoform during cancer progression and metastasis. Many primary and metastatic tumors express high levels of ∆Np63, while ∆Np63 loss is crucial for tumor dissemination, indicating an oscillatory expression of ∆Np63 during cancer progression. Here we use genetically engineered orthotopic mouse models of breast...
3h
Aberrant activation of histone methyltransferase EZH2 and ribosome synthesis strongly associate with cancer development and progression. We previously found that EZH2 regulates RNA polymerase III-transcribed 5S ribosomal RNA gene transcription. However, whether EZH2 regulates ribosome synthesis is still unknown. Here we report that EZH2 promotes ribosome synthesis by targeting and silencing a long non-coding RNA PHACTR2-AS1 (PAS1). PHACTR2-AS1 directly bound ribosome DNA genes and recruited histone...
3h
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