Nucleic Acid Therapeutics, Ahead of Print.
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Abstract Objective An artificial intelligence (AI)-based algorithm typically requires a considerable amount of training data; however, few training images are available for dementia with Lewy bodies and frontotemporal lobar degeneration. Therefore, this study aims to present the potential of cycle-consistent generative adversarial networks (CycleGAN) to obtain enough number of training images for AI-based computer-aided diagnosis (CAD)...
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Abstract Purpose Pulmonary arterial hypertension (PAH) is a recognized complication of systemic lupus erythematosus (SLE-PAH) patients and its lung pathology shares similarity to idiopathic PAH (IPAH) with distinctive inflammatory feature. FDG-PET reports glucose metabolism from both hyperproliferative and inflammatory cellular elements of vascular pathology in PAH. We explored the application of FDG-PET in reporting SLE-PAH pulmonary...
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Abstract Purpose The functional imaging methods widely used for the diagnosis of Lewy body disease (LBD) are 123I-N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) nortropan (FP-CIT) with dopamine transporter single photon emission computed tomography (DAT-SPECT) and 123I-iodobenzylguanidine (MIBG) myocardial scintigraphy. The aim of this study was to determine whether DAT-SPECT or 123I-MIBG myocardial scintigraphy should be examined...
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Abstract Several studies have demonstrated interactions between the two leaflets in membrane bilayers and the importance of specific lipid species for such interaction and membrane function. We here discuss these investigations with a focus on the sphingolipid and cholesterol-rich lipid membrane domains called lipid rafts, including the small flask-shaped invaginations called caveolae, and the importance of such membrane structures in cell biology and cancer. We discuss the possible...
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Abstract Aim This communication reviews results and toxicity of image-guided high-dose-rate endorectal brachytherapy (HDREBT) boost after external beam radiotherapy (ERT) in medically inoperable patients with rectal cancer. Materials and methods A total of 18 patients with rectal cancer and clinical stage T2-4N0‑2 treated with HDREBT boost after ERT were...
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Abstract Introduction Stereotactic body radiation therapy (SBRT) is considered an effective and safe treatment in patients with low- and intermediate-risk prostate cancer (PC). However, due to a lack of long-term follow-up and late toxicity data, this treatment is not universally accepted. The present study aimed to evaluate outcome and early and late toxicity in a cohort of patients with low- and intermediate-risk PC treated prospectively...
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Abstract Background Microsurgery simulation is an important aspect of surgical training. Animal models have been widely used in simulation training, but they have some limitations including ethical restrictions, cost and availability. This has led to the use of synthetic models that can reduce reliance on animals in line with the 3R (refinement, reduction and replacement) principles. The aim of this paper was to evaluate the face validity...
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Abstract Background The purpose of this study was to assess the effectiveness of a modified fibular flap technique in tibial intercalary defects secondary to tumour. Methods The study included 13 patients diagnosed with osteosarcoma or Ewing sarcoma in the tibia diaphysis between January 2010 and November 2017. The intercalary defect formed in the tibia diaphyseal...
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Abstract The management of sinister cutaneous lesions including malignant melanoma in the clinically frail patient tends to present clinicians with a professional and ethical dilemma on the optimal but yet least invasive management option. We present a case of an 80-year-old female with numerous co-morbidities, presenting with metastatic melanoma, in which electrochemotherapy (ECT) was successfully used to manage her debilitating symptoms of intractable bleeding. ...
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[ Advance Publication ] [ Title ] Contraction-associated proteins expression by human uterine smooth muscle cells depends on maternal serum and progranulin associated with gestational weight gain [ Author ] Kei Tanaka,Makoto Osaka,Satoshi Takemori,Momoe Watanabe,Shinji Tanigaki,Yoichi Kobayashi [ Advance Pub. date ] 2020-04-21 [ DOI ] https://doi.org/10.1507/endocrj.EJ20-0037
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Abstract Objectives We aimed to evaluate the impact of renin–angiotensin system (RAS) inhibitors on outcomes after transcatheter aortic valve replacement (TAVR). Background The impact of RAS inhibitors on outcomes after TAVR was unclear. Methods A systematic review of articles comparing outcomes of patients using and not using RAS inhibitors after TAVR was performed through PubMed, Embase, and Cochrane. Primary outcome was midterm all‐cause mortality. Risk ratios (RRs)...
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Predictive role of Selvester QRS score in patients undergoing transcatheter aortic valve replacement
Abstract Introduction Few data exist regarding the late clinical impact of the Selvester score prediction of myocardial fibrosis after transcatheter aortic valve replacement (TAVR). This study evaluated the predictive power of the Selvester score on survival in patients with aortic stenosis (AS) undergoing TAVR. methods and results Patients with severe AS who had preoperative electrocardiograms were included. Clinical follow‐up was obtained retrospectively. The primary endpoint...
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Abstract Objectives To assess feasibility and early outcomes of using BeGraft Aortic stent in the treatment of aortic coarctation (CoA). Background BeGraft Aortic stent (Bentley InnoMed, Hechingen, Germany) allows large postdilation diameter up to 30 mm. With availability of lengths of 19–59 mm and lower stent profile, they can be used in native and recurrent CoA in adults and in pediatric patients. Materials and methods This is a multicentre retrospective analysis of 12...
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Publication date: Available online 19 April 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Baghban K, Zarifian T, Adibi A, Shati M, Derakhshandeh F
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