Abstract Toxicometabolomics, essentially applying metabolomics to toxicology of endogenous compounds such as drugs of abuse or new psychoactive substances (NPS), can be investigated by using different in vitro models and dedicated metabolomics techniques to enhance the number of relevant findings. The present study aimed to study the toxicometabolomics of the two NPS α-pyrrolidinobutiophenone (1-phenyl-2-(pyrrolidin-1-yl)butan-1-one, α-PBP) and α-pyrrolidinoheptaphenone (1-phenyl-2-(pyrrolidin-1-yl)heptan-1-one,...
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Abstract The plausibility of human exposure to microplastics has increased within the last years. Microplastics have been found in different food types including seafood, salt, sugar and beverages. So far, human health effects of microplastics after ingestion are unknown. Herein, we designed a novel, three-dimensional in vitro intestinal model consisting of the human intestinal epithelial cell lines Caco-2 and HT29-MTX-E12 as well as human blood monocyte-derived macrophages and...
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Abstract Ginkgo biloba extract (GBE) is used in traditional Chinese medicine as a herbal supplement for improving memory. Exposure of B6C3F1/N mice to GBE in a 2-year National Toxicology Program (NTP) bioassay resulted in a dose-dependent increase in hepatocellular carcinomas (HCC). To identify key microRNAs that modulate GBE-induced hepatocarcinogenesis, we compared the global miRNA expression profiles in GBE-exposed HCC (GBE-HCC) and spontaneous HCC (SPNT-HCC) with age-matched...
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Abstract In the present study, the neurotoxicity and mechanisms of di-(2-ethylhexyl) phthalate (DEHP) exposure on pubertal normal (P-normal) and pubertal type 2 diabetes mellitus (P-T2DM) mice were investigated by typical neurobehavioral methods and transcriptome analysis. Pubertal male ICR mice were orally exposed to DEHP (0.18, 1.8, 18 and 180 mg/kg/d) for 3 weeks. In Open field test, DEHP significantly increased the time in central area staying and decreased the total distance...
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Abstract Organophosphate (OP) threat agents can trigger seizures that progress to status epilepticus, resulting in persistent neuropathology and cognitive deficits in humans and preclinical models. However, it remains unclear whether patients who do not show overt seizure behavior develop neurological consequences. Therefore, this study compared two subpopulations of rats with a low versus high seizure response to diisopropylfluorophosphate (DFP) to evaluate whether acute OP intoxication...
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Abstract The seas worldwide are threatened by a “new” source of pollution: millions of tons of all kind of warfare material have been dumped intentionally after World War I and II, in addition to mine barriers, failed detonations as well as shot down military planes and sunken ship wrecks carrying munitions. For example, in the German parts of the North and Baltic Sea approximately 1.6 million metric tons of toxic conventional explosives (TNT and others) and more than 5000 metric...
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Electronic cigarette and vaping should be discouraged during the new coronavirus SARS-CoV-2 pandemic
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Abstract Diethyl phthalate (DEP) belongs to phthalates with short alkyl chains. It is a substance frequently used to make various products. Thus, humans are widely exposed to DEP from the surrounding environment such as food, soil, air, and water. As previously reported in many studies, DEP is an endocrine disruptor with reproductive toxicity. Monoethyl phthalate (MEP), a major metabolite of DEP in vivo, is a biomarker for DEP exposure assessment. It is also an endocrine disruptor...
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Abstract Suicidal ingestion of organophosphorus (OP) or carbamate (CM) compounds challenges health care systems worldwide, particularly in Southeast Asia. The diagnosis and treatment of OP or CM poisoning is traditionally based on the clinical appearance of the typical cholinergic toxidrome, e.g. miosis, salivation and bradycardia. Yet, clinical signs might be inconclusive or even misleading. A current case report highlights the importance of enzymatic assays to provide rapid...
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In the original publication of the article.
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Abstract The aim of this study was to evaluate changes in voice after septoplasty in adults using the Dr.Speech assessment module in conjunction with subjective evaluation using Voice Handicap Index (VHI). A total of 50 consecutive patients with symptomatic Deviated Nasal Septum (DNS) undergoing septoplasty were included in the study. Patients fit for surgery underwent septoplasty by standard technique. Voice assessment was done by subjective voice evaluation and Acoustic voice...
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Abstract This study has aimed to determine the anatomical site of labyrinthine fistula in patients of chronic suppurative otitis media at our centre. Labyrinthine fistulae (LF) are caused by abnormal communications between the inner ear and surrounding structures resulting in perilymph leakage and hearing loss. Labyrinthine fistula represents as erosive loss of the enchondral bone overlying the semicircular canals without loss of perilymph. The manifestations of fistula like vertigo,...
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Abstract Fraser syndrome is a rare autosomal recessive disorder with spectrum of malformations. Gamut of abnormal airway includes high arched palate, laryngeal atresia, hypoplasia, laryngeal stenosis etc. Laryngeal intubation difficulties have often been reported in literature. Airway management and decision process leading to emergency tracheostomy in these children has been discussed.
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Abstract Hearing impairment is one of the most common sensory deficit affecting 466 million people globally and in majority of old age people it can not corrected. Since presbycusis is always associated with diminished cognition power resulting in two fold loss in understanding of speech. There is no treatment available till date to regenerate the hair cells but certainly we can augment hearing by preventing and regenerating (apoptosis) atrophy of stria vascularis, spiral neural...
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Publication date: Available online 20 April 2020Source: BiochimieAuthor(s): Libing Liao, Lu Yang, Yanxia Xu, Xiaoli Li, Guangxuan Tan, Beibei Fu, Kelei Duan, Zhiqiang Li, Deshui Yu, Chengwei Li
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Publication date: Available online 20 April 2020Source: BiochimieAuthor(s): Ishfaq Ahmad Ganaie, Md Zubbair Malik, Samar Husain Naqvi, Swatantra Kumar Jain, Saima Wajid
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Publication date: Available online 18 April 2020Source: BiochimieAuthor(s): Dmitry D. Zhdanov, Anna A. Plyasova, Vadim S. Pokrovsky, Marina V. Pokrovskaya, Svetlana S. Alexandrova, Yulia A. Gladilina, Nikolay N. Sokolov
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Publication date: Available online 18 April 2020Source: BiochimieAuthor(s): Hiroshi Otsuka, Akira Fukao, Takumi Tomohiro, Shungo Adachi, Toru Suzuki, Akinori Takahashi, Yoshinori Funakami, Toru Natsume, Tadashi Yamamoto, Kent E. Duncan, Toshinobu Fujiwara
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Publication date: Available online 18 April 2020Source: BiochimieAuthor(s): Sergey Rodin, Sergey A. Kozin, Olga I. Kechko, Vladimir A. Mitkevich, Alexander A. Makarov
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Publication date: Available online 16 April 2020Source: BiochimieAuthor(s): Marco Alifano, Pietro Alifano, Patricia Forgez, Antonio Iannelli
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Publication date: Available online 15 April 2020Source: BiochimieAuthor(s): Xiqian Lan, Vinod Kumar, Alok Jha, Rukhsana Aslam, Haichao Wang, Kehong Chen, Yueming Yu, Weimei He, Feilan Chen, Huairong Luo, Ashwani Malhotra, Pravin C. Singhal
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Publication date: Available online 15 April 2020Source: BiochimieAuthor(s): Dieuwertje E. Kok, Ciara H. O'Flanagan, Michael F. Coleman, Zahra Ashkavand, Stephen D. Hursting, Sergey A. Krupenko
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Ultrasound-guided erector spine plane (ESP) block is widely used in perioperative analgesia for back, chest and abdominal surgery. The extent and distribution of this block remain controversial. This study was...
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Rocuronium-associated injection pain/withdrawal response (RAIPWR) was non-ideal but occurred frequently when injection intravenously during anesthesia induction. Many studies had reported that pretreating with...
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Postoperative pain is the most prominent concern among surgical patients. It has previously been reported that venous cannulation-induced pain (VCP) can be used to predict postoperative pain after laparoscopic...
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Goal directed therapy (GDT) is able to improve mortality and reduce complications in selected high-risk patients undergoing major surgery. The aim of this study is to compare two different strategies of periop...
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Deliberate hypotension is used to provide a bloodless field during functional endoscopic sinus surgery; however, the impact of controlled hypotension during anesthesia on peripheral tissue perfusion has not be...
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Data on the best norepinephrine bolus dose for management of hypotension are limited. The aim of this study was to compare the efficacy and safety of two norepinephrine bolus doses in the rescue management of ...
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Biosensors, Vol. 10, Pages 41: Rapid Nondestructive Detection of Water Content and Granulation in Postharvest “Shatian” Pomelo Using Visible/Near-Infrared Spectroscopy Biosensors doi: 10.3390/bios10040041 Authors: Sai Xu Huazhong Lu Christopher Ference Guangjun Qiu Xin Liang Visible/near-infrared (VIS/NIR) spectroscopy is a powerful tool for rapid, nondestructive fruit quality detection. This technology has been widely applied for quality detection of small, thin-peeled...
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Biosensors, Vol. 10, Pages 40: Identification of Suitable Biomarkers for Stress and Emotion Detection for Future Personal Affective Wearable Sensors Biosensors doi: 10.3390/bios10040040 Authors: Abdulaziz Zamkah Terence Hui Simon Andrews Nilanjan Dey Fuqian Shi R. Simon Sherratt Skin conductivity (i.e., sweat) forms the basis of many physiology-based emotion and stress detection systems. However, such systems typically do not detect the biomarkers present in...
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Cancers, Vol. 12, Pages 1013: Correlation of PKM2 and CD44 Protein Expression with Poor Prognosis in Platinum-Treated Epithelial Ovarian Cancer: A Retrospective Study Cancers doi: 10.3390/cancers12041013 Authors: Chara Papadaki Stavroula Manolakou Eleni Lagoudaki Spyros Pontikakis Despo Ierodiakonou Konstantinos Vogiatzoglou Ippokratis Messaritakis Maria Trypaki Linda Giannikaki Maria Sfakianaki Antonia Kalykaki Dimitrios Mavroudis Maria Tzardi...
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Cancers, Vol. 12, Pages 1011: Expansion of Circulating Tumor Cells from Patients with Locally Advanced Pancreatic Cancer Enable Patient Derived Xenografts and Functional Studies for Personalized Medicine Cancers doi: 10.3390/cancers12041011 Authors: Lianette Rivera-Báez Ines Lohse Eric Lin Shreya Raghavan Sarah Owen Ramdane Harouaka Kirk Herman Geeta Mehta Theodore S. Lawrence Meredith A. Morgan Kyle C. Cuneo Sunitha Nagrath Improvement...
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Cancers, Vol. 12, Pages 1014: Contribution of Macrophages and T Cells in Skeletal Metastasis Cancers doi: 10.3390/cancers12041014 Authors: Mendoza-Reinoso McCauley Fournier Bone is a common site for metastases with a local microenvironment that is highly conducive for tumor establishment and growth. The bone marrow is replete with myeloid and lymphoid linage cells that provide a fertile niche for metastatic cancer cells promoting their survival and growth. Here, we discuss...
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Cancers, Vol. 12, Pages 1012: Gonadotroph Tumors Show Subtype Differences That Might Have Implications for Therapy Cancers doi: 10.3390/cancers12041012 Authors: Ilie Vasiljevic Louvet Jouanneau Raverot Gonadotroph tumors, although frequent, are poorly studied and understood, being usually included in the larger nonfunctioning pituitary neuroendocrine tumors (PitNETs) group. Moreover, in comparison to the other types of PitNETs, no established medical treatment...
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Cancers, Vol. 12, Pages 1010: Weekends-Off Lenvatinib for Unresectable Hepatocellular Carcinoma Improves Therapeutic Response and Tolerability toward Adverse Events Cancers doi: 10.3390/cancers12041010 Authors: Iwamoto Suzuki Shimose Niizeki Nakano Shirono Okamura Noda Kamachi Nakamura Masuda Sakaue Tanaka Nakano Sakai Yamaguchi Kuromatsu Koga Torimura Background: Although lenvatinib has become...
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Cancers, Vol. 12, Pages 1009: Personalized Medicine: Recent Progress in Cancer Therapy Cancers doi: 10.3390/cancers12041009 Authors: Valentina Gambardella Noelia Tarazona Juan Miguel Cejalvo Pasquale Lombardi Marisol Huerta Susana Roselló Tania Fleitas Desamparados Roda Andres Cervantes Translational research has revolutionized how we develop new treatments for cancer patients. The change from an organ-centric concept guiding treatment choice towards...
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Cancers, Vol. 12, Pages 1006: P66Shc: A Pleiotropic Regulator of B Cell Trafficking and a Gatekeeper in Chronic Lymphocytic Leukemia Cancers doi: 10.3390/cancers12041006 Authors: Laura Patrussi Nagaja Capitani Cosima T. Baldari Neoplastic B cells from chronic lymphocytic leukemia patients (CLL) have a profound deficiency in the expression of p66Shc, an adaptor protein with pro-apoptotic and pro-oxidant activities. This defect results in leukemic B cell resistance to apoptosis...
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Cancers, Vol. 12, Pages 1007: Insights into Genetic Susceptibility to Melanoma by Gene Panel Testing: Potential Pathogenic Variants in ACD, ATM, BAP1, and POT1 Cancers doi: 10.3390/cancers12041007 Authors: Pastorino Andreotti Dalmasso Vanni Ciccarese Mandalà Spadola Pizzichetta Ponti Tibiletti Sala Genuardi Chiurazzi Maccanti Manoukian Sestini Danesi Zampiga Starza Stanganelli Ballestrero...
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Cancers, Vol. 12, Pages 1008: Public Adverse Event Data Insights into the Safety of Pembrolizumab in Melanoma Patients Cancers doi: 10.3390/cancers12041008 Authors: Schaefer Sachpekidis Diella Doerks Kratz Meisel Jackson Soldatos Immune checkpoint inhibition represents an important therapeutic option for advanced melanoma patients. Results from clinical studies have shown that treatment with the PD-1 inhibitors Pembrolizumab and Nivolumab provides...
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