Medicine by Alexandros G. Sfakianakis

Zinc Oxide Nanoparticles Induce Mitochondrial Biogenesis Impairment and Cardiac Dysfunction in Human iPSC-Derived Cardiomyocytes

Nanofibrous Scaffolds Containing Hydroxyapatite and Microfluidic-Prepared Polyamidoamin/BMP-2 Plasmid Dendriplexes for Bone Tissue Engineering Applications

Therapeutic Effect of Doxorubicin-Chlorin E6-Loaded Mesoporous Silica Nanoparticles Combined with Ultrasound on Triple-Negative Breast Cancer

Exosome Derived from Coronary Serum of Patients with Myocardial Infarction Promotes Angiogenesis Through the miRNA-143/IGF-IR Pathway

Core–Shell Imidazoline–Functionalized Mesoporous Silica Superparamagnetic Hybrid Nanoparticles as a Potential Theranostic Agent for Controlled Delivery of Platinum(II) Compound

Synthesis, Characterization, Biomedical Application, Molecular Dynamic Simulation and Molecular Docking of Schiff Base Complex of Cu(II) Supported on Fe3O4/SiO2/APTS

One-Step Synthesis of Polypyrrole-Coated Gold Nanoparticles for Use as a Photothermally Active Nano-System

Nanoparticle Drug Delivery System for Glioma and Its Efficacy Improvement Strategies: A Comprehensive Review

The Antibacterial Mechanism of Silver Nanoparticles and Its Application in Dentistry

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Peat Properties, Dominant Vegetation Type and Microbial Community Structure in a Tropical Peatland

Abstract Tropical peatlands are an important carbon store and source of greenhouse gases, but the microbial component, particularly community structure, remains poorly understood. While microbial communities vary between tropical peatland land uses, and with biogeochemical gradients, it is unclear if their structure varies at smaller spatial scales as has been established for a variety of peat properties. We assessed the abundances of PLFAs and GDGTs, two membrane spanning lipid...

Assessing the Ecological Status of the Seekoeivlei Wetland, South Africa: a Nematode Community Case Study

Abstract The nematofauna of the Seekoeivlei Wetland in the north-eastern Free State province of South Africa was studied in order to determine its ecological status. Nematodes were collected in three different surveys, in October 2011, and in February and May 2012. Samples were taken from three sites within the reserve, each representing a different habitat. A total of 37 genera belonging to 21 nematode families were identified. The highest nematode diversity was observed during...

Effects of Drying-Rewetting Frequency on Vertical and Lateral Loss of Soil Organic Carbon in a Tidal Salt Marsh

Abstract Tidal salt marshes, as “blue carbon” ecosystems, play a critical role in mitigation of global climate change since their large soil organic carbon (SOC) pool. Drying-rewetting cycles induced by periodic tides have profound influence on soil carbon cycling in tidal salt marshes. However, the magnitude and mechaanism of the effects of drying-rewetting frequency on SOC loss in tidal salt marshes is still uncertain. Here, we conducted a mesocosm experiment to identify how...

Modeling the Supporting Ecosystem Services of Depressional Wetlands in Agricultural Landscapes

Abstract We explored how a geographic information system modeling approach could be used to quantify supporting ecosystem services related to the type, abundance, and distribution of landscape components. Specifically, we use the Integrated Valuation of Ecosystem Services and Tradeoffs model to quantify habitats that support amphibians and birds, floral resources that support pollinators, native-plant communities that support regional biodiversity, and above- and below-ground carbon...

Vegetation Changes in T H e Poyang Lake Wetland Linked to the Three Gorges Dam: an Assessment Based on Moderate Resolution Imaging Spectroradiometer (MODIS) Observations from 2000 to 2012

Abstract Vegetation changes in the Poyang Lake wetland related to the construction of the Three Gorges Dam (TGD) and climate change have received increasing attention in recent decades. However, due to the high spatial heterogeneity, the changes in wetland vegetation have not been well quantified at a large spatial scale. We addressed this challenge by using Moderate Resolution Imaging Spectroradiometer (MODIS) data from 2000 to 2012. Using a Mann-Kendall (MK) test, statistically...

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Cost Considerations for clinicians prescribing biologic drugs: Who Pays?

Defective SEC61α1 underlies a novel cause of autosomal dominant severe congenital neutropenia

The molecular cause of severe congenital neutropenia (SCN) is unknown in 30-50% of patients. SEC61A1 encodes the α subunit of the SEC61 complex, which governs endoplasmic reticulum protein transport and passive calcium leakage. Recently, mutations in SEC61A1 were reported to be pathogenic in common variable immunodeficiency and glomerulocystic kidney disease.

Janus kinase inhibition in complement component 1 deficiency

Human Th1 and Th2 Cells Targeting Rhinovirus and Allergen Coordinately Promote Allergic Asthma.

Asthmatic patients who are allergic are uniquely susceptible to acute wheezing episodes provoked by rhinovirus. However, the underlying immune mechanisms and interaction between RV and allergy remain enigmatic, and current paradigms are controversial.

Simultaneous skin biome and keratinocyte genomic capture reveals microbiome differences by depth of sampling

An academic allergy unit during COVID-19 pandemic in Italy

Recently, Codispoti et al1 delineated the clinical and academic challenges that the coronavirus disease 2019 (COVID-19) pandemic raised at their Division of Allergy and Immunology. They rapidly coordinated a lot of stressful changes in established practices to meet academic and health care needs. Besides congratulating the authors for their promptness, we here share our experience in getting across the COVID-19 pandemic in our Allergy Clinic, at Humanitas Research Hospital in Milan, where the epidemic...

Cutaneous barrier leakage and gut inflammation drive skin disease in Omenn Syndrome

Severe early-onset erythroderma and gut inflammation, with massive tissue infiltration of oligoclonal activated T cells are the hallmark of Omenn Syndrome (OS).

Biomarkers of severity and threshold of allergic reactions during oral peanut challenges

Oral food challenge (OFC) is the gold-standard to assess peanut allergy (PA) but involves a risk of allergic reactions of unpredictable severity.

Effect of intravenous immunoglobulin G therapy on natural killer cell function related to Fc gamma receptor gene expression

Allergic Sensitization Does Not Differ Between Childhood- and Adolescent-Onset Asthma in Women

Targeting ICOS expressed on CXCR5+PD-1+ T helper cells suppresses the progression of pemphigus vulgaris

Pemphigus vulgaris (PV) is an autoimmune bullous disease mediated by autoantibodies against desmoglein 3 (DSG3). Inducible T-cell costimulator (ICOS) is a costimulatory receptor expressed on T cells and influences the activity of T follicular helper (Tfh) cells in various autoimmune diseases, but the roles of ICOS and Tfh cells in PV remain unclear.

Clinical and Translational Allergy - Latest Articles

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Impact on quality of life and safety of sublingual and subcutaneous immunotherapy in children with severe house dust mite and pollen-associated allergic rhinoconjunctivitis

Pollen and house dust mite (HDM) subcutaneous immunotherapy (SLIT) and pollen subcutaneous immunotherapy (SCIT) are effective therapies for children with allergic rhinoconjunctivitis (AR). There are no previou...

Clinical and Translational Allergy - Latest Articles

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Editorial Board

Publication date: 15 May 2020Source: Experimental Cell Research, Volume 390, Issue 2Author(s):

Rac1-dependent phagocytosis of apoptotic cells by oral squamous cell carcinoma cells: A possible driving force for tumor progression

Publication date: Available online 19 April 2020Source: Experimental Cell ResearchAuthor(s): Manabu Yamazaki, Satoshi Maruyama, Tatsuya Abé, Masayuki Tsuneki, Hiroko Kato, Kenji Izumi, Jun-ichi Tanuma, Jun Cheng, Takashi Saku

Injured tubular epithelial cells activate fibroblasts to promote kidney fibrosis through miR-150-containing exosomes

Publication date: Available online 18 April 2020Source: Experimental Cell ResearchAuthor(s): Han Guan, Rui Peng, Likai Mao, Fang Fang, Bin Xu, Ming Chen

LINC00612 functions as a ceRNA for miR-214–5p to promote the proliferation and invasion of osteosarcoma in vitro and in vivo

Publication date: Available online 18 April 2020Source: Experimental Cell ResearchAuthor(s): Yuelai Zhou, Xiaolei Li, Huilin Yang

Growth differentiation factor 15 facilitates lung fibrosis by activating macrophages and fibroblasts

Publication date: Available online 17 April 2020Source: Experimental Cell ResearchAuthor(s): Yasuhiro Takenouchi, Keisuke Kitakaze, Kazuhito Tsuboi, Yasuo Okamoto

ALDH1A1+ ovarian cancer stem cells co-expressing surface markers CD24, EPHA1 and CD9 form tumours in vivo

Publication date: Available online 17 April 2020Source: Experimental Cell ResearchAuthor(s): Rohit P. Nagare, Smarakan Sneha, Syama Krishnapriya, Balaji Ramachandran, Kanchan Murhekar, Sekar Vasudevan, Aboo Shabna, Trivadi S. Ganesan