Related Articles Establishment of syngeneic murine model for oral cancer therapy. Oral Oncol. 2019 08;95:194-201 Authors: Chen YF, Chang KW, Yang IT, Tu HF, Lin SC Abstract Oral carcinoma (OSCC) is one of the most important causes of cancer death worldwide. OSCC cell lines and preclinical rodent models are crucial to addressing the mechanisms of OSCC and helping the development of new therapeutic strategies and interventions. The establishment...
Tue Jul 07, 2020 13:05
Publication date: August 2020Source: Journal of Human Evolution, Volume 145Author(s): Yasuo Ihara, Kazunobu Ikeya, Atsushi Nobayashi, Yosuke Kaifu
Tue Jul 07, 2020 13:05
Related Articles Metabolic endoscopy: Today's science-tomorrow's treatment. United European Gastroenterol J. 2020 Jul;8(6):685-694 Authors: Hadefi A, Arvanitakis M, Huberty V, Devière J Abstract Obesity, type 2 diabetes mellitus (T2DM) and nonalcoholic steatohepatitis are increasing pandemic metabolic disorders. Lifestyle intervention (LSI) is the cornerstone treatment for these but is successful as standard care alone in only a few patients,...
Tue Jul 07, 2020 14:31
Related Articles A cross- sectional study: long term follow-up care for pediatric cancer survivors in a developing country; Turkey: current status, challenges and future perspectives. Turk J Med Sci. 2020 Jul 06;: Authors: İncesoy Özdemİr S, TaÇyildiz N, Varan A, Kebudİ R, ZÜlfİkar OB, Celkan TT, Şahİn G, ÇorapcioĞlu FV, Keskİn Yildirim Z, Pinarli FG, Olgun HN, Sari N, DaĞdemİr A, ÖzyÖrÜk D, Eren T, Çakir FB, Adakli Aksoy B, Bozkurt C, GÜler E, ÖzgÜven AA, Erbey...
Tue Jul 07, 2020 14:31
Related Articles Surgical care of thoracic malignancies during the COVID-19 pandemic in México: An expert consensus guideline from the Sociedad Mexicana de Oncología (SMeO) and the Sociedad Mexicana de Cirujanos Torácicos Generales (SMCTG). Thorac Cancer. 2020 Jul 06;: Authors: Corona-Cruz J, Alba EG, Iñiguez-García M, López-Saucedo R, Olivares-Torres C, Rodriguez-Cid J, Salazar-Otaola G, Martínez-Said H, Flores RM, Arrieta O Abstract To date,...
Tue Jul 07, 2020 14:31
Related Articles The influence of learning curve of robot-assisted laparoscopy on oncological outcomes in early stage cervical cancer: an observational cohort study. BJOG. 2020 Jul 06;: Authors: Baeten IGT, Hoogendam JP, Schreuder HWR, Jürgenliemk-Schulz IM, Verheijen RHM, Zweemer RP, Gerestein CG Abstract OBJECTIVE: To investigate the learning curve of robot-assisted laparoscopy in early stage cervical cancer and quantify impact on oncological...
Tue Jul 07, 2020 14:31
Related Articles MicroRNA-92b acts as an oncogene by targeting PTEN/AKT in NSCLC. Cell Biochem Funct. 2020 Jul 06;: Authors: Guo JH, Fang HY, Yang JM, Liu SL, Yao QH, Fan YJ, Zhao M, Liu F, Zhang QW, Gao FH Abstract MicroRNAs can act as tumour suppressors or oncogenes by regulating cellular differentiation, proliferation and apoptosis, and the dysregulation of miRNA is involved in the occurrence and development of NSCLC. Here, we provided evidence...
Tue Jul 07, 2020 14:31
Related Articles Minimally important differences for interpreting European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 scores in patients with head and neck cancer. Head Neck. 2020 Jul 06;: Authors: Musoro JZ, Coens C, Singer S, Tribius S, Oosting SF, Groenvold M, Simon C, Machiels JP, Grégoire V, Velikova G, Cocks K, Sprangers MAG, King MT, Bottomley A, EORTC Head and Neck and Quality of Life Groups Abstract...
Tue Jul 07, 2020 14:31
Related Articles Recommendations of the Polish Society of Gynaecologists and Obstetricians for removal of the uterus by vaginal, laparoscopic and abdominal routes. Ginekol Pol. 2020;91(6):352-361 Authors: Stojko R, Malinowski A, Baranowski W, Misiek M, Winkowska E, Pomorski M, Zimmer M Abstract The recommendations represent the current procedure, which may be modified and changed where justified, after a thorough analysis of the given clinical...
Tue Jul 07, 2020 14:31
Related Articles Current status of breast cancer screening in high-risk women in Japan. Breast Cancer. 2020 Jul 06;: Authors: Tozaki M, Nakamura S Abstract Overseas, the importance for breast MRI screening for high-risk groups has been shown. However, the evidence among Japanese population was lacking. Therefore, we collaborated with the "Study on clinical and genetic characterization of hereditary breast and ovarian cancer and improvement in...
Tue Jul 07, 2020 14:31
Related Articles Patterns of oral mucositis in advanced oral squamous cell carcinoma patients managed with prophylactic photobiomodulation therapy-insights for future protocol development. Lasers Med Sci. 2020 Jul 05;: Authors: de Pauli Paglioni M, Faria KM, Palmier NR, Prado-Ribeiro AC, E Dias RB, da Graça Pinto H, Treister NS, Epstein JB, Migliorati CA, Santos-Silva AR, Brandão TB Abstract To characterize oral sites affected by radiation-induced...
Tue Jul 07, 2020 14:31
Related Articles Recent Progress for the Techniques of MRI-Guided Breast Interventions and their applications on Surgical Strategy. J Cancer. 2020;11(16):4671-4682 Authors: Gao P, Kong X, Song Y, Song Y, Fang Y, Ouyang H, Wang J Abstract With a high sensitivity of breast lesions, MRI can detect suspicious lesions which are occult in traditional breast examination equipment. However, the lower and variable specificity of MRI makes the MRI-guided...
Tue Jul 07, 2020 14:31
Related Articles Consolidative Radiotherapy in Oligometastatic Lung Cancer: Patient Selection With a Prediction Nomogram. Clin Lung Cancer. 2020 May 23;: Authors: Friedes C, Mai N, Hazell S, Fu W, Han P, Bowers M, Levy B, Forde PM, Voong R, Hales RK Abstract BACKGROUND: Patients with stage IV oligometastatic (≤ 3 sites) non-small-cell lung cancer have a progression-free survival (PFS) and overall survival benefit when all sites of metastatic...
Tue Jul 07, 2020 14:31
Related Articles Re: Reconsidering Prostate Cancer Mortality - The Future of PSA Screening: Against increasing PSA threshold to 10 ng/ml. Eur Urol. 2020 Jul 02;: Authors: R Zlotta A, V Carlsson S, Finelli A, E Fleshner N PMID: 32624274 [PubMed - as supplied by publisher]
Tue Jul 07, 2020 14:31
Related Articles Insomnia symptoms increase during pregnancy, but no increase in sleepiness - Associations with symptoms of depression and anxiety. Sleep Med. 2020 Apr 09;72:150-156 Authors: Aukia L, Paavonen EJ, Jänkälä T, Tolvanen M, Korja R, Karlsson L, Karlsson H, Polo-Kantola P Abstract OBJECTIVE: To evaluate alteration in insomnia and sleepiness symptoms during pregnancy and assess early pregnancy risk factors for these symptoms, especially...
Tue Jul 07, 2020 17:00
Related Articles Increased Platelet Aggregation in Children and Adolescents with Sleep Disordered Breathing. Am J Respir Crit Care Med. 2020 Jul 06;: Authors: Kontos A, Willoughby S, Lushington K, Martin J, Wabnitz D, Dorrian J, Kennedy D Abstract OBJECTIVE: Sleep disordered breathing (SDB) is associated with increased vascular resistance in children and adults. Persistent increased vascular resistance damages vascular endothelial cells-a marker...
Tue Jul 07, 2020 17:00
Related Articles Correction: Global Outcome Assessment Life-long after stroke in young adults initiative-the GOAL initiative: study protocol and rationale of a multicentre retrospective individual patient data meta-analysis. BMJ Open. 2020 Jul 05;10(7):e031144corr1 Authors: PMID: 32624478 [PubMed - in process]
Tue Jul 07, 2020 17:03
Related Articles Exploring the multiple policy objectives for primary care networks: a qualitative interview study with national policy stakeholders. BMJ Open. 2020 Jul 05;10(7):e038398 Authors: Checkland K, Hammond J, Warwick-Giles L, Bailey S Abstract OBJECTIVES: English general practice is suffering a workforce crisis, with general practitioners retiring early and trainees reluctant to enter the profession. To address this, additional funding...
Tue Jul 07, 2020 17:03
Related Articles Artificial intelligence method to classify ophthalmic emergency severity based on symptoms: a validation study. BMJ Open. 2020 Jul 05;10(7):e037161 Authors: Ahn H Abstract OBJECTIVES: We investigated the usefulness of machine learning artificial intelligence (AI) in classifying the severity of ophthalmic emergency for timely hospital visits. STUDY DESIGN: This retrospective study analysed the patients who first visited...
Tue Jul 07, 2020 17:03
Related Articles How good is online information on fibromyalgia? An analysis of quality and readability of websites on fibromyalgia in Spanish. BMJ Open. 2020 Jul 05;10(7):e037065 Authors: Alioshkin Cheneguin A, Salvat Salvat I, Romay Barrero H, Torres Lacomba M Abstract OBJECTIVE: To assess the content, quality and readability of websites with information on fibromyalgia in Spanish. METHODS: Websites were retrieved entering the keyword...
Tue Jul 07, 2020 17:03
Related Articles Heparin-binding protein as a biomarker of gastrointestinal dysfunction in critically ill patients: a retrospective cross-sectional study in China. BMJ Open. 2020 Jul 05;10(7):e036396 Authors: Sun JK, Shen X, Sun XP, Wang X, Zhang WH, Shi QK, Mu XW Abstract OBJECTIVE: To investigate the association of plasma heparin-binding protein (HBP) with the development of acute gastrointestinal injury (AGI) in critically ill patients. ...
Tue Jul 07, 2020 17:03
Related Articles Safety and effectiveness of a Tai Chi-based cardiac rehabilitation programme for chronic coronary syndrom patients: study protocol for a randomised controlled trial. BMJ Open. 2020 Jul 05;10(7):e036061 Authors: Ma J, Zhang JW, Li H, Zhao LS, Guo AY, Chen ZH, Yuan W, Gao TM, Li YM, Li CH, Wang HW, Song B, Lu YL, Cui MZ, Wei QY, Lyu SJ, Yin HC Abstract INTRODUCTION: Preliminary evidence from clinical observations suggests that...
Tue Jul 07, 2020 17:03
Related Articles Is reduction of routine radiograph use in patients with distal radius fractures cost effective? Analysis of data from the multicentre, randomised controlled WARRIOR trial. BMJ Open. 2020 Jul 05;10(7):e035370 Authors: van Gerven P, van Dongen JM, Rubinstein SM, Termaat MF, El Moumni M, Zuidema WP, Krijnen P, Schipper IB, van Tulder MW, WARRIOR trial Study Group, WARRIOR-trial Study Group Abstract OBJECTIVE: To assess the cost...
Tue Jul 07, 2020 17:03
Related Articles Treatment strategies for asymptomatic carotid artery stenosis in the era of lipid-lowering drugs: protocol for a systematic review and network meta-analysis. BMJ Open. 2020 Jul 05;10(7):e035094 Authors: Bai X, Feng Y, Li L, Yang K, Wang T, Luo J, Wang X, Ling F, Ma Y, Jiao L Abstract INTRODUCTION: Carotid endarterectomy (CEA), carotid artery stenting (CAS) and best medical therapy (BMT) are the major treatments used for significant...
Tue Jul 07, 2020 17:03
Related Articles Nurses' decision-making about cancer patients' end-of-life skin care in Wales: an exploratory mixed-method vignette study protocol. BMJ Open. 2020 Jul 05;10(7):e034938 Authors: Samuriwo R, Lovell-Smith C, Anstey S, Job C, Hopkinson J Abstract INTRODUCTION: Patients with cancer are at high risk of developing pressure ulcers at the end of life as a result of their underlying condition or cancer treatment. There are many guidelines...
Tue Jul 07, 2020 17:03
Related Articles Work-related psychosocial risk factors for stress-related mental disorders: an updated systematic review and meta-analysis. BMJ Open. 2020 Jul 05;10(7):e034849 Authors: van der Molen HF, Nieuwenhuijsen K, Frings-Dresen MHW, de Groene G Abstract OBJECTIVE: The objective was to conduct an update of a previously published review and meta-analysis on the association between work-related psychosocial risk factors and stress-related...
Tue Jul 07, 2020 17:03
Related Articles Breast cancer application protocol: a randomised controlled trial to evaluate a self-management app for breast cancer survivors. BMJ Open. 2020 Jul 05;10(7):e034655 Authors: Cheng ASK, Liu X, Ng PHF, Kwok CTT, Zeng Y, Feuerstein M Abstract INTRODUCTION: The eHealth technologies that are being designed for chronic disease constitute a global trend towards health assessment and self-management. However, most of these approaches...
Tue Jul 07, 2020 17:03
Related Articles Google Trends-based non-English language query data and epidemic diseases: a cross-sectional study of the popular search behaviour in Taiwan. BMJ Open. 2020 Jul 05;10(7):e034156 Authors: Chang YW, Chiang WL, Wang WH, Lin CY, Hung LC, Tsai YC, Suen JL, Chen YH Abstract OBJECTIVE: This study developed a surveillance system suitable for monitoring epidemic outbreaks and assessing public opinion in non-English-speaking countries....
Tue Jul 07, 2020 17:03
Related Articles Establishing a taxonomy of potential hazards associated with communicating medical science in the age of disinformation. BMJ Open. 2020 Jul 05;10(7):e035626 Authors: Grimes DR, Brennan LJ, O'Connor R Abstract OBJECTIVES: Disinformation on medical matters has become an increasing public health concern. Public engagement by scientists, clinicians and patient advocates can contribute towards public understanding of medicine. However,...
Tue Jul 07, 2020 17:03
Objectives Chronic rhinosinusitis (CRS), like other sinonasal diseases, may be associated with avoidance of daily activities. Our goal was to identify characteristics associated with avoidance of activities due to CRS. Materials and Methods A total of 194 CRS patients were recruited. CRS symptom burden was assessed with the 22‐item Sinonasal Outcome Test (SNOT‐22). SNOT‐22 nasal, sleep, ear/facial discomfort and emotional/psychological subdomain scores were calculated. Depressed mood was assessed...
Mon Jul 06, 2020 21:52
Objectives/Hypothesis Oxidative stress has been postulated to play an important role in chronic rhinosinusitis. Nrf2 is a transcription factor that is involved in the regulation of multiple antioxidant genes, and its function has been previously shown to be important in sinonasal inflammation. Although the sinonasal implications of whole body Nrf2 −/− has been reported, the function of sinonasal epithelial expression of Nrf2 has not been studied. The primary aim of this study was to generate...
Mon Jul 06, 2020 21:38
Objective Radiotherapy of head and neck cancer (HNCA) causes dysfunction through radiation‐induced fibrosis (RIF). We hypothesize that the degree of cervical fibrosis is associated with swallowing dysfunction. This study evaluated the association between cervical fibrosis and swallowing dysfunction in patients after radiation therapy for HNCA. Study Design Cross sectional study Methodology A convenience sample of patients with dysphagia who were at least 1 year post radiation therapy...
Mon Jul 06, 2020 21:35
Objectives Adverse events are common occurrences in hospitals that detract from quality of care. There are few data on errors in otolaryngology (ENT) and even fewer data comparing ENT to other services. Methods We retrospectively reviewed adverse event data collected across a regional hospital network from July 2014 to August 2017. We examined categories of adverse events that occurred most commonly in ENT and compared the number of adverse events reported in ENT to those reported across all...
Mon Jul 06, 2020 21:29
Objective: Surgery followed by postoperative radiation therapy (RT) is the standard of care for soft tissue sarcomas (STS) of the head and neck that are high grade or have close or positive margins. Methods: The authors retrospectively reviewed adult patients with head and neck STS treated with RT at a single institution between 1981 and 2017. All patients who were 19 years and older with STS of the head and neck—excluding rhabdomyosarcoma, angiosarcoma, and Ewing tumors—were included...
Tue Jun 30, 2020 03:00
Appropriate medical management can be an alternative in those patients with submacular cysticercosis in whom achieving good visual outcome with vitreoretinal surgery is not possible. We report the case of a 25-year-old female who presented complaining of blurred vision in her left eye associated with photopsias and metamorphopsias of 3 months duration. Initial visual acuity in the right eye was 20/20 and 20/100 in the left eye. Upon indirect ophthalmoscopy in the left eye, a yellow-white, dome-shaped,...
Tue Jul 07, 2020 09:42
Galactosialidosis is a rare metabolic disorder resulting from mutations in the CTSA gene. Few studies have reported on the ocular findings of galactosialidosis type IIb in detail. We report on a case of galactosialidosis, the diagnosis of which was suggested by bilateral macular cherry-red spots, which is an indication of lysosomal storage disease. In this case, retinal and systemic dysfunctions were mild. Genetic studies revealed an abnormality of relevant protective proteins, and thus a definitive...
Tue Jul 07, 2020 09:41
Added risk portended by diabetes in addition to hypertension has been related to an amplification of endothelial dysfunction. β-blockers are widely used for cardiovascular diseases and improve the endothelial function compared with a placebo. However, the effect of β-blockers on the endothelial progenitor cells (EPCs) function in diabetes is still unknown. Five β-blockers (metoprolol, atenolol, propranolol, bisoprolol, and nebivolol) were tested in EPC functional screening. Metoprolol improved EPC...
Tue Jul 07, 2020 03:00
Understanding characteristics of torso motion and arm swing of older adults is important. A comprehensive database of three-dimensional thoracic and pelvic kinematics and arm swing maximum velocity of older adults during overground walking is still lacking. Moreover, the relationships between these variables are not fully understood. Therefore, we investigated age and gender effects of three-dimensional thoracic and pelvic ranges of motion and arm swing maximum velocity in 113 healthy old adults...
Tue Jul 07, 2020 03:00
Background Previous studies have shown that music preferences are influenced by cultural “rules”, and some others have suggested a universal preference for some features over others. Methods We investigated cultural differences on the “consonance effect”, consisting in higher pleasantness judgments for consonant compared to dissonant chords—according to the Western definition of music: Italian and Himalayan participants were asked to express pleasantness judgments for consonant and dissonant...
Tue Jul 07, 2020 03:00
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