Related Articles Microglial Sirtuin 2 Shapes Long-Term Potentiation in Hippocampal Slices. Front Neurosci. 2020;14:614 Authors: Sa de Almeida J, Vargas M, Fonseca-Gomes J, Tanqueiro SR, Belo RF, Miranda-Lourenço C, Sebastião AM, Diógenes MJ, Pais TF Abstract Microglial cells have emerged as crucial players in synaptic plasticity during development and adulthood, and also in neurodegenerative and neuroinflammatory conditions. Here we found that...
Tue Jul 07, 2020 14:45
Related Articles A Guide to Extract Spinal Cord for Translational Stem Cell Biology Research: Comparative Analysis of Adult Human, Porcine, and Rodent Spinal Cord Stem Cells. Front Neurosci. 2020;14:607 Authors: Galuta A, Sandarage R, Ghinda D, Auriat AM, Chen S, Kwan JCS, Tsai EC Abstract Improving the clinical translation of animal-based neural stem/progenitor cell (NSPC) therapies to humans requires an understanding of intrinsic human and...
Tue Jul 07, 2020 14:45
Related Articles EEG Channel-Selection Method for Epileptic-Seizure Classification Based on Multi-Objective Optimization. Front Neurosci. 2020;14:593 Authors: Moctezuma LA, Molinas M Abstract We present a multi-objective optimization method for electroencephalographic (EEG) channel selection based on the non-dominated sorting genetic algorithm (NSGA) for epileptic-seizure classification. We tested the method on EEG data of 24 patients from the...
Tue Jul 07, 2020 14:45
Related Articles A Protocol for Comparing Dry and Wet EEG Electrodes During Sleep. Front Neurosci. 2020;14:586 Authors: Leach S, Chung KY, Tüshaus L, Huber R, Karlen W Abstract Background: Sleep is commonly assessed by recording the electroencephalogram (EEG) of the sleeping brain. As sleep assessments in a lab environment are cumbersome for both the participant and researcher, it would be highly desirable to record sleep EEG with a user-friendly...
Tue Jul 07, 2020 14:45
Related Articles LRRK2 and α-Synuclein: Distinct or Synergistic Players in Parkinson's Disease? Front Neurosci. 2020;14:577 Authors: O'Hara DM, Pawar G, Kalia SK, Kalia LV Abstract Parkinson's disease (PD) is the most common neurodegenerative movement disorder, characterized by prominent degeneration of dopaminergic neurons in the substantia nigra and aggregation of the protein α-synuclein within intraneuronal inclusions known as Lewy bodies....
Tue Jul 07, 2020 14:45
Related Articles Exciting Complexity: The Role of Motor Circuit Elements in ALS Pathophysiology. Front Neurosci. 2020;14:573 Authors: Gunes ZI, Kan VWY, Ye X, Liebscher S Abstract Amyotrophic lateral sclerosis (ALS) is a fatal disease, characterized by the degeneration of both upper and lower motor neurons. Despite decades of research, we still to date lack a cure or disease modifying treatment, emphasizing the need for a much-improved insight...
Tue Jul 07, 2020 14:45
Related Articles Complex Visceral Coupling During Central Sleep Apnea in Cats. Front Neurosci. 2020;14:568 Authors: Limanskaya AV, Busygina II, Levichkina EV, Pigarev IN Abstract Central sleep apnea is a sudden arrest of breathing during sleep caused by the central commands to the thoracoabdominal muscles. It is a widespread phenomenon in both healthy and diseased people, as well as in some animals. However, there is an ongoing debate whether...
Tue Jul 07, 2020 14:45
Related Articles Therapeutic Effects of Transplanted Exosomes Containing miR-29b to a Rat Model of Alzheimer's Disease. Front Neurosci. 2020;14:564 Authors: Jahangard Y, Monfared H, Moradi A, Zare M, Mirnajafi-Zadeh J, Mowla SJ Abstract Alzheimer disease (AD) is a complex neurodegenerative disorder with no definite treatment. The expression of miR-29 family is significantly reduced in AD, suggesting a part for the family members in pathogenesis...
Tue Jul 07, 2020 14:45
Related Articles A Deep Learning-Based Model for Classification of Different Subtypes of Subcortical Vascular Cognitive Impairment With FLAIR. Front Neurosci. 2020;14:557 Authors: Chen Q, Wang Y, Qiu Y, Wu X, Zhou Y, Zhai G Abstract Deep learning methods have shown their great capability of extracting high-level features from image and have been used for effective medical imaging classification recently. However, training samples of medical...
Tue Jul 07, 2020 14:45
Related Articles Evoking Apparent Moving Sensation in the Hand via Transcutaneous Electrical Nerve Stimulation. Front Neurosci. 2020;14:534 Authors: Scarpelli A, Demofonti A, Terracina F, Ciancio AL, Zollo L Abstract The restoration of sensory feedback in amputees plays a fundamental role in the prosthesis control and in the communication on the afferent channel between hand and brain. The literature shows that transcutaneous electrical nerve...
Tue Jul 07, 2020 14:45
Related Articles Editorial: Safety and Tolerability of Psychotropic Compounds. Front Neurosci. 2020;14:509 Authors: Montejo AL, Lourenço M PMID: 32625046 [PubMed]
Tue Jul 07, 2020 14:45
Related Articles BRAF inhibition in melanoma is associated with the dysregulation of histone methylation and histone methyltransferases. Neoplasia. 2020 Jul 03;22(9):376-389 Authors: Grigore F, Yang H, Hanson ND, VanBrocklin MW, Sarver AL, Robinson JP Abstract The development of mutant BRAF inhibitors has improved the outcome for melanoma patients with BRAFV600E mutations. Although the initial response to these inhibitors can be dramatic,...
Tue Jul 07, 2020 14:42
Related Articles Dual inhibition of VEGF and PARP suppresses KRAS-mutant colorectal cancer. Neoplasia. 2020 Jul 03;22(9):365-375 Authors: Zhong L, Wang R, Wang Y, Peng S, Ma Y, Ding S, Yang H, Chen S, Luo X, Wang W Abstract The addition of bevacizumab to chemotherapy has prolonged overall and progression-free survival rates for metastatic colorectal cancer (mCRC). However, KRAS-mutant (KRAS-mut) CRC, lacking an ideal targeted agent, represents...
Tue Jul 07, 2020 14:42
Related Articles Cell cycle exit during bortezomib-induced osteogenic differentiation of mesenchymal stem cells was mediated by Xbp1s-upregulated p21Cip1 and p27Kip1. J Cell Mol Med. 2020 Jul 06;: Authors: Zhang D, Fan R, Lei L, Lei L, Wang Y, Lv N, Chen P, Williamson RA, Wang B, Hu J Abstract Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into a variety of cell types. Bortezomib, the first approved proteasome...
Tue Jul 07, 2020 14:42
Related Articles Targeting p16INK4a Promotes Lipofibroblasts and Alveolar Regeneration After Early Life Injury. Am J Respir Crit Care Med. 2020 Jul 06;: Authors: Zysman M, Ribeiro Baptista B, Essari LA, Taghizadeh S, Thibault de Ménonville C, Giffard C, Issa A, Franco-Montoya ML, Breau M, Souktani R, Aissat A, Caeymaex L, Lizé M, Tran Van Nhieu J, Jung C, Rottier R, Do Cruzeiro M, Adnot S, Epaud R, Chabot F, Lanone S, Boczkowski J, Boyer L Abstract...
Tue Jul 07, 2020 14:42
Intracellular signaling modules linking DNA damage to secretome changes in senescent melanoma cells.
Related Articles Intracellular signaling modules linking DNA damage to secretome changes in senescent melanoma cells. Melanoma Res. 2020 Aug;30(4):336-347 Authors: Chavanet A, Hill KR, Jiménez-Andrade Y, Choo MK, White K, Park JM Abstract Cellular senescence is a major barricade on the path of cancer development, yet proteins secreted from senescent cells exert complex and often discordant effects on subsequent cancer evolution. Somatic...
Tue Jul 07, 2020 14:42
Related Articles [Mechanism of psoralen in aggravating hepatotoxicity induced by CCl_4 by delaying liver regeneration]. Zhongguo Zhong Yao Za Zhi. 2020 Jun;45(12):2916-2923 Authors: Liang PS, Zhou W, Jiang ZZ, Zhang LY Abstract This study aimed to investigate whether psoralen can aggravate hepatotoxicity induced by carbon tetrachloride(CCl_4) by inducing hepatocyte cycle arrest and delaying liver regeneration. Female C57 BL/6 mice aged...
Tue Jul 07, 2020 14:42
Related Articles Antihypertensive drug telmisartan suppresses the proliferation of gastric cancer cells in vitro and in vivo. Oncol Rep. 2020 Jul;44(1):339-348 Authors: Fujita N, Fujita K, Iwama H, Kobara H, Fujihara S, Chiyo T, Namima D, Yamana H, Kono T, Takuma K, Hirata M, Kobayashi K, Kato K, Kamada H, Morishita A, Tsutsui K, Himoto T, Okano K, Suzuki Y, Masaki T Abstract Gastric cancer is one of the most common malignancies diagnosed...
Tue Jul 07, 2020 14:42
Related Articles Aspirin inhibits hepatocellular carcinoma cell proliferation in vitro and in vivo via inducing cell cycle arrest and apoptosis. Oncol Rep. 2020 Aug;44(2):457-468 Authors: Shi T, Fujita K, Gong J, Nakahara M, Iwama H, Liu S, Yoneyama H, Morishita A, Nomura T, Tani J, Takuma K, Tadokoro T, Himoto T, Oura K, Tsutsui K, Kobara H, Masaki T Abstract Aspirin, a nonsteroidal anti‑inflammatory drug (NSAID), is known to inhibit cell...
Tue Jul 07, 2020 14:42
Related Articles Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway. Oncol Rep. 2020 Jul;44(1):103-114 Authors: Yan X, Yang C, Hu W, Chen T, Wang Q, Pan F, Qiu B, Tang B Abstract Keratins are fibrous structural proteins that serve essential roles in forming the stratum corneum and protect the cells in this layer of skin from damage. Keratin 17 (KRT17) is a key member of the...
Tue Jul 07, 2020 14:42
Related Articles Tubeimoside‑1 induces apoptosis in human glioma U251 cells by suppressing PI3K/Akt‑mediated signaling pathways. Mol Med Rep. 2020 Jun 11;: Authors: Cao LJ, Xie HT, Chu ZX, Ma Y, Wang MM, Shi Z Abstract Tubeimoside-1 (TBMS1), a traditional Chinese herb extracted from Bolbostemma paniculatum (Maxim.), induces apoptosis in a number of human cancer cell lines. TBMS1 has been reported to induce apoptosis in human glioma cells,...
Tue Jul 07, 2020 14:42
Related Articles Antihypertensive drug telmisartan inhibits cell proliferation of gastrointestinal stromal tumor cells in vitro. Mol Med Rep. 2020 May 14;: Authors: Kobara H, Fujihara S, Iwama H, Matsui T, Fujimori A, Chiyo T, Tingting S, Kobayashi N, Nishiyama N, Yachida T, Tadokoro T, Oura K, Tani J, Fujita K, Nomura T, Yoneyama H, Morishita A, Okano K, Suzuki Y, Mori H, Masaki T Abstract Gastrointestinal stromal tumors (GISTs) are the...
Tue Jul 07, 2020 14:42
Related Articles Paeonol exerts anti‑tumor activity against colorectal cancer cells by inducing G0/G1 phase arrest and cell apoptosis via inhibiting the Wnt/β‑catenin signaling pathway. Int J Mol Med. 2020 Aug;46(2):675-684 Authors: Liu LH, Shi RJ, Chen ZC Abstract Paeonol is a simple phenolic compound isolated from herbal root bark, which has been reported to possess numerous biological and pharmacological characteristics, including a...
Tue Jul 07, 2020 14:42
Related Articles Isoorientin induces the apoptosis and cell cycle arrest of A549 human lung cancer cells via the ROS‑regulated MAPK, STAT3 and NF‑κB signaling pathways. Int J Oncol. 2020 Aug;57(2):550-561 Authors: Xu WT, Shen GN, Li TZ, Zhang Y, Zhang T, Xue H, Zuo WB, Li YN, Zhang DJ, Jin CH Abstract Isoorientin (ISO) is a naturally occurring C‑glycosyl flavone that has various pharmacological properties, such as anti‑bacterial and anti‑inflammatory...
Tue Jul 07, 2020 14:42
Related Articles MicroRNA‑383‑5p inhibits the proliferation and promotes the apoptosis of gastric cancer cells by targeting cancerous inhibitor of PP2A. Int J Mol Med. 2020 Jul;46(1):397-405 Authors: Li X, Yuan J, Cao Q, Xie A, Chen J Abstract The aberrant expression of microRNA (miRNAor miR)‑383‑5p has been found in numerous types of cancer. However, the function of miR‑383‑5p in gastric cancer (GC) remains elusive and requires further...
Tue Jul 07, 2020 14:42
Related Articles Phorbol myristate acetate induces cellular senescence in rat microglia in vitro. Int J Mol Med. 2020 Jul;46(1):415-426 Authors: Cao D, Li XH, Luo XG, Yu HM, Wan LS, Wei L, Ren Y Abstract The present study aimed to establish a cellular model to test the hypothesis that oncogene-induced senescence (OIS) is triggered by aging-related activation of microglia. Primary microglia were incubated with phorbol 12-myristate 13-acetate...
Tue Jul 07, 2020 14:42
Related Articles Chaetocin Abrogates the Self-Renewal of Bladder Cancer Stem Cells via the Suppression of the KMT1A-GATA3-STAT3 Circuit. Front Cell Dev Biol. 2020;8:424 Authors: Yang Z, Wang H, Zhang N, Xing T, Zhang W, Wang G, Li C, Yu C Abstract Bladder cancer stem cells (BCSCs) have the abilities of self-renewal, differentiation, and metastasis; confer drug resistance; and exhibit high tumorigenicity. We previously identified that the...
Tue Jul 07, 2020 14:42
Related Articles GINS2 affects cell viability, cell apoptosis, and cell cycle progression of pancreatic cancer cells via MAPK/ERK pathway. J Cancer. 2020;11(16):4662-4670 Authors: Zhang M, He S, Ma X, Ye Y, Wang G, Zhuang J, Song Y, Xia W Abstract Background and Objective: GINS complex subunit 2 (GINS2), a member of the GINS complex, is involved in DNA replication. GINS2 is upregulated in a variety of aggressive tumors, such as leukemia,...
Tue Jul 07, 2020 14:42
Related Articles A genome-wide enrichment screen identifies NUMA1-loss as a resistance mechanism against mitotic cell-death induced by BMI1 inhibition. PLoS One. 2020;15(4):e0227592 Authors: Gisler S, Maia ARR, Chandrasekaran G, Kopparam J, van Lohuizen M Abstract BMI1 is a core protein of the polycomb repressive complex 1 (PRC1) that is overexpressed in several cancer types, making it a promising target for cancer therapies. However, the...
Tue Jul 07, 2020 13:41
Related Articles FAM111A protects replication forks from protein obstacles via its trypsin-like domain. Nat Commun. 2020 03 12;11(1):1318 Authors: Kojima Y, Machida Y, Palani S, Caulfield TR, Radisky ES, Kaufmann SH, Machida YJ Abstract Persistent protein obstacles on genomic DNA, such as DNA-protein crosslinks (DPCs) and tight nucleoprotein complexes, can block replication forks. DPCs can be removed by the proteolytic activities of the metalloprotease...
Tue Jul 07, 2020 13:41
Related Articles Acetylation of MORC2 by NAT10 regulates cell-cycle checkpoint control and resistance to DNA-damaging chemotherapy and radiotherapy in breast cancer. Nucleic Acids Res. 2020 04 17;48(7):3638-3656 Authors: Liu HY, Liu YY, Yang F, Zhang L, Zhang FL, Hu X, Shao ZM, Li DQ Abstract MORC family CW-type zinc finger 2 (MORC2) is an oncogenic chromatin-remodeling enzyme with an emerging role in DNA repair. Here, we report a novel function...
Tue Jul 07, 2020 13:41
Related Articles Neoadjuvant therapy for triple-negative breast cancer: potential predictive biomarkers of activity and efficacy of platinum chemotherapy, PARP- and immune-checkpoint-inhibitors. Expert Opin Pharmacother. 2020 Apr;21(6):687-699 Authors: Garufi G, Palazzo A, Paris I, Orlandi A, Cassano A, Tortora G, Scambia G, Bria E, Carbognin L Abstract INTRODUCTION: Despite recent advances in the molecular characterization of triple-negative...
Tue Jul 07, 2020 13:41
A phenylphthalimide derivative, TC11, induces apoptosis by degrading MCL1 in multiple myeloma cells.
Related Articles A phenylphthalimide derivative, TC11, induces apoptosis by degrading MCL1 in multiple myeloma cells. Biochem Biophys Res Commun. 2020 01 01;521(1):252-258 Authors: Ichikawa D, Nakamura M, Murota W, Osawa S, Matsushita M, Yanagawa H, Hattori Y Abstract To date, the prognosis of multiple myeloma (MM) in patients harboring cytogenetic abnormalities (CA) involving t (4; 14) and deletion of chromosome 17 remains poor despite recent...
Tue Jul 07, 2020 13:41
Related Articles Intrinsically Disordered SRC-3/AIB1 Protein Undergoes Homeostatic Nuclear Extrusion by Nuclear Budding While Ectopic Expression Induces Nucleophagy. Cells. 2019 10 19;8(10): Authors: Cabrita MA, Renart LI, Lau R, Pratt MAC Abstract SRC-3/AIB1 (Amplified in Breast Cancer-1) is a nuclear receptor coactivator for the estrogen receptor in breast cancer cells. It is also an intrinsically disordered protein when not engaged with...
Tue Jul 07, 2020 13:41
Related Articles Defining and Modulating 'BRCAness'. Trends Cell Biol. 2019 09;29(9):740-751 Authors: Byrum AK, Vindigni A, Mosammaparast N Abstract The concept of 'BRCAness' defines the pathogenesis and vulnerability of multiple cancers. The canonical definition of BRCAness is a defect in homologous recombination repair, mimicking BRCA1 or BRCA2 loss. In turn, BRCA-deficient cells utilize error-prone DNA-repair pathways, causing increased...
Tue Jul 07, 2020 13:41
Related Articles The structure of the checkpoint clamp 9-1-1 complex and clamp loader Rad24-RFC in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2019 08 06;515(4):688-692 Authors: Liu W Abstract The 9-1-1 complex is a circular heterotrimeric complex composed of Rad9-Hus1-Rad1. In response to DNA damage, the 9-1-1 complex will be loaded onto the DNA damage site by clamp loader Rad24-RFC to activate the cell cycle checkpoint. The C-terminal...
Tue Jul 07, 2020 13:41
Related Articles The synergistic effect of PFK15 with metformin exerts anti-myeloma activity via PFKFB3. Biochem Biophys Res Commun. 2019 07 23;515(2):332-338 Authors: Liu X, Zhao Y, Zhang E, Yan H, Lv N, Cai Z Abstract High glucose metabolism provides sufficient energy for cancer cells and is enabled by metabolic enzymes. PFKFB3 (6-phosphofructo-2-kinase) accelerates the synthesis of fructose 2,6-bisphosphate (F2,6P2), which is a powerful...
Tue Jul 07, 2020 13:41
Related Articles A novel mechanism of irinotecan targeting MDM2 and Bcl-xL. Biochem Biophys Res Commun. 2019 06 25;514(2):518-523 Authors: Lee B, Min JA, Nashed A, Lee SO, Yoo JC, Chi SW, Yi GS Abstract Irinotecan is a strong anticancer drug whose mechanism of action has been reported only for the inhibition of DNA topoisomerase I (Topo I) through its active metabolite SN-38. In this study, we present a new mechanism of Irinotecan which inhibits...
Tue Jul 07, 2020 13:41
Related Articles Combined Aurora Kinase A (AURKA) and WEE1 Inhibition Demonstrates Synergistic Antitumor Effect in Squamous Cell Carcinoma of the Head and Neck. Clin Cancer Res. 2019 06 01;25(11):3430-3442 Authors: Lee JW, Parameswaran J, Sandoval-Schaefer T, Eoh KJ, Yang DH, Zhu F, Mehra R, Sharma R, Gaffney SG, Perry EB, Townsend JP, Serebriiskii IG, Golemis EA, Issaeva N, Yarbrough WG, Koo JS, Burtness B Abstract PURPOSE: Human papillomavirus...
Tue Jul 07, 2020 13:41
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