IJMS, Vol. 21, Pages 4802: Proteomics-Based Machine Learning Approach as an Alternative to Conventional Biomarkers for Differential Diagnosis of Chronic Kidney Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21134802 Authors: Yury E. Glazyrin Dmitry V. Veprintsev Irina A. Ler Maria L. Rossovskaya Svetlana A. Varygina Sofia L. Glizer Tatiana N. Zamay Marina M. Petrova Zoran Minic Maxim V. Berezovski Anna S. Kichkailo Diabetic nephropathy,...
Tue Jul 07, 2020 03:00
IJMS, Vol. 21, Pages 4806: Modelling Epithelial Ovarian Cancer in Mice: Classical and Emerging Approaches International Journal of Molecular Sciences doi: 10.3390/ijms21134806 Authors: Razia Zakarya Viive M. Howell Emily K. Colvin High-grade serous epithelial ovarian cancer (HGSC) is the most aggressive subtype of epithelial ovarian cancer. The identification of germline and somatic mutations along with genomic information unveiled by The Cancer Genome Atlas (TCGA) and other studies...
Tue Jul 07, 2020 03:00
IJMS, Vol. 21, Pages 4800: CPPF, A Novel Microtubule Targeting Anticancer Agent, Inhibits the Growth of a Wide Variety of Cancers International Journal of Molecular Sciences doi: 10.3390/ijms21134800 Authors: Ho Jin Han Chanmi Park Joonsung Hwang Thimmegowda N.R. Sun-Ok Kim Junyeol Han Minsik Woo Shwetha B In-Ja Ryoo Kyung Ho Lee Hyunjoo Cha-Molstad Yong Tae Kwon Bo Yeon Kim Nak-Kyun Soung In the past, several microtubule targeting agents (MTAs)...
Tue Jul 07, 2020 03:00
IJMS, Vol. 21, Pages 4801: IJMS Special Issue “Molecular and Cellular Mechanisms of Preeclampsia”—Editorial International Journal of Molecular Sciences doi: 10.3390/ijms21134801 Authors: Huppertz Over the last few decades, massive research efforts have been put into deciphering the etiology of the pregnancy pathology preeclampsia[...]
Tue Jul 07, 2020 03:00
IJMS, Vol. 21, Pages 4797: Integrative Analyses of Widely Targeted Metabolic Profiling and Transcriptome Data Reveals Molecular Insight into Metabolomic Variations during Apple (Malus domestica) Fruit Development and Ripening International Journal of Molecular Sciences doi: 10.3390/ijms21134797 Authors: Jidi Xu Jinjiao Yan Wenjie Li Qianying Wang Caixia Wang Junxing Guo Dali Geng Qingmei Guan Fengwang Ma The apple is a favorite fruit for human diet and is one...
Tue Jul 07, 2020 03:00
IJMS, Vol. 21, Pages 4796: MicroRNAs as Guardians of the Prostate: Those Who Stand before Cancer. What Do We Really Know about the Role of microRNAs in Prostate Biology? International Journal of Molecular Sciences doi: 10.3390/ijms21134796 Authors: Thomas Andl Kavya Ganapathy Alexia Bossan Ratna Chakrabarti Prostate cancer is the second leading cause of cancer-related deaths of men in the Western world. Despite recent advancement in genomics, transcriptomics and proteomics to...
Tue Jul 07, 2020 03:00
IJMS, Vol. 21, Pages 4795: Gonadal Hormones E2 and P Mitigate Cerebral Ischemia-Induced Upregulation of the AIM2 and NLRC4 Inflammasomes in Rats International Journal of Molecular Sciences doi: 10.3390/ijms21134795 Authors: Pardes Habib Julie Harms Adib Zendedel Cordian Beyer Alexander Slowik Acute ischemic stroke (AIS) is a devastating neurological condition with a lack of neuroprotective therapeutic options, despite the reperfusion modalities thrombolysis and thrombectomy....
Tue Jul 07, 2020 03:00
IJMS, Vol. 21, Pages 4794: Transcriptomic Profile of Primary Culture of Skeletal Muscle Cells Isolated from Semitendinosus Muscle of Beef and Dairy Bulls International Journal of Molecular Sciences doi: 10.3390/ijms21134794 Authors: Ciecierska Motyl Sadkowski The aim of the study was to identify differences in the transcriptomic profiles of primary muscle cell cultures derived from the semitendinosus muscle of bulls of beef breeds (Limousin (LIM) and Hereford (HER)) and a dairy...
Tue Jul 07, 2020 03:00
IJMS, Vol. 21, Pages 4793: Theoretical Investigations on Interactions of Arylsulphonyl Indazole Derivatives as Potential Ligands of VEGFR2 Kinase International Journal of Molecular Sciences doi: 10.3390/ijms21134793 Authors: Czaja Kujawski Śliwa Kurczab Kujawski Stodolna Myślińska Bernard Vascular endothelial growth factor receptor 2 (VEGFR2) is a key receptor in the angiogenesis process. The VEGFR2 expression is upregulated in many cancers so this receptor...
Tue Jul 07, 2020 03:00
JCM, Vol. 9, Pages 2144: Insulin Resistance Predicts Severity of Coronary Atherosclerotic Disease in Non-Diabetic Patients Journal of Clinical Medicine doi: 10.3390/jcm9072144 Authors: Teresa Strisciuglio Raffaele Izzo Emanuele Barbato Giuseppe Di Gioia Iginio Colaiori Antonella Fiordelisi Carmine Morisco Jozef Bartunek Danilo Franco Giuseppe Ammirati Valerio Pergola Livio Imparato Bruno Trimarco Giovanni Esposito Antonio Rapacciuolo Background:...
Tue Jul 07, 2020 03:00
JCM, Vol. 9, Pages 2143: Ehlers–Danlos Syndrome and Hypermobility Syndrome Compared with Other Common Chronic Pain Diagnoses—A Study from the Swedish Quality Registry for Pain Rehabilitation Journal of Clinical Medicine doi: 10.3390/jcm9072143 Authors: Peter Molander Mehmed Novo Andrea Hållstam Monika Löfgren Britt-Marie Stålnacke Björn Gerdle Although chronic pain is common in patients with Ehlers–Danlos syndrome (EDS) and hypermobility syndromes (HMS), little...
Tue Jul 07, 2020 03:00
JCM, Vol. 9, Pages 2141: Intra-Abdominal Nocardiosis—Case Report and Review of the Literature Journal of Clinical Medicine doi: 10.3390/jcm9072141 Authors: Lucas Tramèr Kirsten D. Mertz Rolf Huegli Vladimira Hinic Lorenz Jost Felix Burkhalter Sebastian Wirz Philip E. Tarr Nocardiosis is primarily an opportunistic infection affecting immunosuppressed individuals, in whom it most commonly presents as pulmonary infection and sometimes cerebral abscesses. Isolated abdominal...
Tue Jul 07, 2020 03:00
JCM, Vol. 9, Pages 2142: Minimal Residual Disease in Multiple Myeloma: State of the Art and Future Perspectives Journal of Clinical Medicine doi: 10.3390/jcm9072142 Authors: Roberto Mina Stefania Oliva Mario Boccadoro Minimal residual disease (MRD) detection represents a sensitive tool to appropriately measure the response obtained with therapies for multiple myeloma (MM). The achievement of MRD negativity has superseded the conventional complete response (CR) and has been proposed...
Tue Jul 07, 2020 03:00
JCM, Vol. 9, Pages 2138: High Revision Rates of a Cementless Beta-Titanium Alloy Stem with Contamination-Free Roughened Surface in Primary Total Hip Arthroplasty Journal of Clinical Medicine doi: 10.3390/jcm9072138 Authors: Sandra Stenicka Carola Hanreich Rita Babeluk Bernd Kubista Alexander Giurea Irene Katharina Sigmund Reinhard Windhager Rainer Kotz Richard Lass Optimal osseointegration of cementless total hip arthroplasty is essential for high stability and...
Tue Jul 07, 2020 03:00
JCM, Vol. 9, Pages 2139: Prediabetes Is Independently Associated with Subclinical Carotid Atherosclerosis: An Observational Study in a Non-Urban Mediterranean Population Journal of Clinical Medicine doi: 10.3390/jcm9072139 Authors: Maria Belén Vilanova Josep Franch-Nadal Mireia Falguera Josep Ramon Marsal Sílvia Canivell Esther Rubinat Neus Miró Àngels Molló Manel Mata-Cases Mònica Gratacòs Esmeralda Castelblanco Dídac Mauricio This was a prospective,...
Tue Jul 07, 2020 03:00
JCM, Vol. 9, Pages 2140: The Impact of the 2019 European Guideline for Cardiovascular Risk Management: A Cross-Sectional Study in General Practice Journal of Clinical Medicine doi: 10.3390/jcm9072140 Authors: Rahel Meier Yael Rachamin Thomas Rosemann Stefan Markun The aim of this study was to assess the impact of the 2019 published European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) guideline on cardiovascular (CV) risk management compared with its predecessor...
Tue Jul 07, 2020 03:00
JCM, Vol. 9, Pages 2137: Computerized Cognitive Rehabilitation Training for Ugandan Seniors Living with HIV: A Validation Study Journal of Clinical Medicine doi: 10.3390/jcm9072137 Authors: Amara E. Ezeamama Alla Sikorskii Parvathy R. Sankar Noeline Nakasujja Michael Ssonko Norbert E. Kaminski David Guwatudde Michael J. Boivin Bruno Giordani The feasibility, acceptability and preliminary efficacy of computerized cognitive rehabilitation therapy (CCRT) for mitigating...
Tue Jul 07, 2020 03:00
JCM, Vol. 9, Pages 2136: Neutrophil Extracellular Traps Generation Relates with Early Stage and Vascular Complications in Systemic Sclerosis Journal of Clinical Medicine doi: 10.3390/jcm9072136 Authors: Kevin Didier Delphine Giusti Sebastien Le Jan Christine Terryn Celine Muller Bach Nga Pham Richard Le Naour Frank D. Antonicelli Amelie Servettaz Systemic sclerosis (SSc) is a systemic disease characterized by a great clinical and immunological heterogeneity whose...
Tue Jul 07, 2020 03:00
JCM, Vol. 9, Pages 2135: Hematuria Is Associated with More Severe Acute Tubulointerstitial Nephritis
JCM, Vol. 9, Pages 2135: Hematuria Is Associated with More Severe Acute Tubulointerstitial Nephritis Journal of Clinical Medicine doi: 10.3390/jcm9072135 Authors: Raquel Esteras Jonathan G. Fox Colin C. Geddes Bruce Mackinnon Alberto Ortiz Juan Antonio Moreno Acute tubulointerstitial nephritis (ATIN) is a common cause of acute kidney injury. Although haematuria is a risk factor for the development of renal disease, no previous study has analyzed the significance of haematuria...
Tue Jul 07, 2020 03:00
JFB, Vol. 11, Pages 47: Natural Architectures for Tissue Engineering and Regenerative Medicine Journal of Functional Biomaterials doi: 10.3390/jfb11030047 Authors: Floris Honig Steven Vermeulen Amir A. Zadpoor Jan de Boer Lidy E. Fratila-Apachitei The ability to control the interactions between functional biomaterials and biological systems is of great importance for tissue engineering and regenerative medicine. However, the underlying mechanisms defining the interplay between...
Tue Jul 07, 2020 03:00
J. Imaging, Vol. 6, Pages 66: Investigating Optimal Time Step Intervals of Imaging for Data Quality through a Novel Fully-Automated Cell Tracking Approach Journal of Imaging doi: 10.3390/jimaging6070066 Authors: Feng Wei Yang Lea Tomášová Zeno v. Guttenberg Ke Chen Anotida Madzvamuse Computer-based fully-automated cell tracking is becoming increasingly important in cell biology, since it provides unrivalled capacity and efficiency for the analysis of large datasets. However,...
Tue Jul 07, 2020 03:00
Membranes, Vol. 10, Pages 144: Porous Gelatin Membranes Obtained from Pickering Emulsions Stabilized with h-BNNS: Application for Polyelectrolyte-Enhanced Ultrafiltration Membranes doi: 10.3390/membranes10070144 Authors: Molka Nafti Mateur Danae Gonzalez Gonzalez Ortiz Dorra Jellouli Jellouli Ennigrou Karima Horchani-Naifer Mikhael Bechelany Philippe Miele Céline Pochat-Bohatier In recent years, numerous studies have been conducted to develop biopolymer-based membranes,...
Tue Jul 07, 2020 03:00
Membranes, Vol. 10, Pages 145: Influence of Surface Modification of MK-40 Membrane with Polyaniline on Scale Formation under Electrodialysis Membranes doi: 10.3390/membranes10070145 Authors: Marina A. Andreeva Natalia V. Loza Natalia D. Pis’menskaya Lasaad Dammak Christian Larchet A comprehensive study of the polyaniline influence on mineral scaling on the surface of the heterogeneous MK-40 sulfocationite membrane under electrodialysis has been conducted. Current-voltage...
Tue Jul 07, 2020 03:00
Metabolites, Vol. 10, Pages 277: Early Perturbations in Glucose Utilization in Malaria-Infected Murine Erythrocytes, Liver and Brain Observed by Metabolomics Metabolites doi: 10.3390/metabo10070277 Authors: Arjun Sengupta Soumita Ghosh Shobhona Sharma Haripalsingh M. Sonawat Investigation of glucose utilization during an infection is central to the study of energy metabolism. The heavy utilization of glucose by the malaria parasite, and the consequences of this process, have...
Tue Jul 07, 2020 03:00
Microorganisms, Vol. 8, Pages 1012: Transcriptomic and Ultrastructural Signatures of K+-Induced Aggregation in Phytophthora parasitica Zoospores Microorganisms doi: 10.3390/microorganisms8071012 Authors: Ilaria Bassani Corinne Rancurel Sophie Pagnotta François Orange Nicolas Pons Kevin Lebrigand Franck Panabières Laurent Counillon Xavier Noblin Eric Galiana Most pathogenic oomycetes of the genus Phytophthora spread in water films as flagellated zoospores. Zoospores...
Tue Jul 07, 2020 03:00
Microorganisms, Vol. 8, Pages 1013: Equine Alphaherpesviruses Require Activation of the Small GTPases Rac1 and Cdc42 for Intracellular Transport Microorganisms doi: 10.3390/microorganisms8071013 Authors: Oleksandr Kolyvushko Maximilian A. Kelch Nikolaus Osterrieder Walid Azab Viruses utilize host cell signaling to facilitate productive infection. Equine herpesvirus type 1 (EHV-1) has been shown to activate Ca2+ release and phospholipase C upon contact with α4β1...
Tue Jul 07, 2020 03:00
Molecules, Vol. 25, Pages 3103: Design, Synthesis and Biological Evaluation of Novel Anthraniloyl-AMP Mimics as PQS Biosynthesis Inhibitors Against Pseudomonas aeruginosa Resistance Molecules doi: 10.3390/molecules25133103 Authors: Shekh Sabir Sujatha Subramoni Theerthankar Das David StC. Black Scott A. Rice Naresh Kumar The Pseudomonas quinolone system (PQS) is one of the three major interconnected quorum sensing signaling systems in Pseudomonas aeruginosa. The virulence...
Tue Jul 07, 2020 03:00
Molecules, Vol. 25, Pages 3104: Juglone Suppresses LPS-induced Inflammatory Responses and NLRP3 Activation in Macrophages Molecules doi: 10.3390/molecules25133104 Authors: Nam-Hun Kim Hong-Ki Kim Ji-Hak Lee Seung-Il Jo Hye-Min Won Gyeong-Seok Lee Hyoun-Su Lee Kung-Woo Nam Wan-Jong Kim Man-Deuk Han The NLRP3 (NACHT, LRR and PYD domains-containing protein 3) inflammasome has been implicated in a variety of diseases, including atherosclerosis, neurodegenerative...
Tue Jul 07, 2020 03:00
Molecules, Vol. 25, Pages 3097: Anticancer Potential and Capsianosides Identification in Lipophilic Fraction of Sweet Pepper (Capsicum annuum L.) Molecules doi: 10.3390/molecules25133097 Authors: Barbara Chilczuk Beata Marciniak Anna Stochmal Łukasz Pecio Renata Kontek Izabella Jackowska Małgorzata Materska This study aimed to determine the health-promoting properties of sweet pepper by comparing the activity of fractions with variable lipophilicity. Fractions from...
Tue Jul 07, 2020 03:00
Molecules, Vol. 25, Pages 3099: Quasi-Isostructural Co(II) and Ni(II) Complexes with Mefenamato Ligand: Synthesis, Characterization, and Biological Activity Molecules doi: 10.3390/molecules25133099 Authors: Michał Gacki Karolina Kafarska Anna Pietrzak Izabela Korona-Głowniak Wojciech M. Wolf Three metal complexes of mefenamato ligand 1 were synthesized: [Co2(mef)4(EtOH)2(H2O)4]: 2; [Co(mef)2(MeOH)4]∙2MeOH: 3; and [Ni(mef)2(MeOH)4]∙2MeOH: 4. Their compositions and properties...
Tue Jul 07, 2020 03:00
Molecules, Vol. 25, Pages 3102: Granzyme B PET Imaging of the Innate Immune Response Molecules doi: 10.3390/molecules25133102 Authors: Kathleen M. Capaccione Mikhail Doubrovin Nikunj Bhatt Akiva Mintz Andrei Molotkov The human immune system is a complex system which protects against invaders and maintains tissue homeostasis. It is broadly divided into the innate and adaptive branches. Granzyme B is serine protease that plays an important role in both and can serve as a biomarker...
Tue Jul 07, 2020 03:00
Molecules, Vol. 25, Pages 3094: Thiyl Radicals: Versatile Reactive Intermediates for Cyclization of Unsaturated Substrates Molecules doi: 10.3390/molecules25133094 Authors: Dylan M. Lynch Eoin M. Scanlan Sulfur centered radicals are widely employed in chemical synthesis, in particular for alkene and alkyne hydrothiolation towards thioether bioconjugates. The steadfast radical chain process that enables efficient hydrothiolation has been explored in the context of cascade reactions...
Tue Jul 07, 2020 03:00
Molecules, Vol. 25, Pages 3096: A Nano Drug Delivery System Based on Angelica sinensis Polysaccharide for Combination of Chemotherapy and Immunotherapy Molecules doi: 10.3390/molecules25133096 Authors: Min-Zhe Wang Xin He Zhe Yu Hong Wu Tie-Hong Yang Combination of chemotherapy and immunotherapy has been a promising strategy in cancer treatment. Polysaccharides from Angelica sinensis (AP), a well-known Chinese herbal medicine, have been proved to have good immunomodulatory...
Tue Jul 07, 2020 03:00
Molecules, Vol. 25, Pages 3095: Adsorption Capacity of Vitamin B12 and Creatinine on Highly-Mesoporous Activated Carbons Obtained from Lignocellulosic Raw Materials Molecules doi: 10.3390/molecules25133095 Authors: Tudor Lupaşcu Oleg Petuhov Nina Ţîmbaliuc Silvia Cibotaru Andrei Rotaru Enterosorbents are widely-used materials for human body detoxification, which function by immobilizing and eliminating endogenous and exogenous toxins. Here, activated carbons, obtained from...
Tue Jul 07, 2020 03:00
Molecules, Vol. 25, Pages 3098: Unravelling the Potential of Salivary Volatile Metabolites in Oral Diseases. A Review Molecules doi: 10.3390/molecules25133098 Authors: Jorge A. M. Pereira Priscilla Porto-Figueira Ravindra Taware Pritam Sukul Srikanth Rapole José S. Câmara Fostered by the advances in the instrumental and analytical fields, in recent years the analysis of volatile organic compounds (VOCs) has emerged as a new frontier in medical diagnostics. VOCs analysis...
Tue Jul 07, 2020 03:00
Molecules, Vol. 25, Pages 3093: The GABAB Receptor—Structure, Ligand Binding and Drug Development Molecules doi: 10.3390/molecules25133093 Authors: Linn Samira Mari Evenseth Mari Gabrielsen Ingebrigt Sylte The γ-aminobutyric acid (GABA) type B receptor (GABAB-R) belongs to class C of the G-protein coupled receptors (GPCRs). Together with the GABAA receptor, the receptor mediates the neurotransmission of GABA, the main inhibitory neurotransmitter in the central nervous...
Tue Jul 07, 2020 03:00
Molecules, Vol. 25, Pages 3101: The Inhibitory Activity of Anthraquinones Against Pathogenic Protozoa, Bacteria, and Fungi and the Relationship to Structure Molecules doi: 10.3390/molecules25133101 Authors: Mendel Friedman Alexander Xu Rani Lee Daniel N. Nguyen Tina A. Phan Sabrina M. Hamada Rima Panchel Christina C. Tam Jong H. Kim Luisa W. Cheng Kirkwood M. Land Plant-derived anthraquinones were evaluated in cell assays for their inhibitory activities...
Tue Jul 07, 2020 03:00
Molecules, Vol. 25, Pages 3100: Molecular Features and Metal Ions that Influence 10-23 DNAzyme Activity Molecules doi: 10.3390/molecules25133100 Authors: Hannah Rosenbach Julian Victor Manuel Etzkorn Gerhard Steger Detlev Riesner Ingrid Span Deoxyribozymes (DNAzymes) with RNA hydrolysis activity have a tremendous potential as gene suppression agents for therapeutic applications. The most extensively studied representative is the 10-23 DNAzyme consisting of a catalytic...
Tue Jul 07, 2020 03:00
Molecules, Vol. 25, Pages 3089: New Paracyclophanylthiazoles with Anti-Leukemia Activity: Design, Synthesis, Molecular Docking, and Mechanistic Studies Molecules doi: 10.3390/molecules25133089 Authors: Ashraf A Aly Stefan Bräse Alaa A. Hassan Nasr K. Mohamed Lamiaa E. Abd El-Haleem Martin Nieger Nesrin M. Morsy Elshimaa M. N. Abdelhafez A new series of methyl 2-(2-(4′-[2.2]paracyclophanyl)-hydrazinylidene)-3-substituted-4-oxothiazolidin-5-ylidene)acetates...
Tue Jul 07, 2020 03:00
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